Keisuke Kuida

17.3k citations

83 papers · 14.6k indexed · 5 hit papers · h-index 49

Impact in

Immunology top 0.2%
- Immune Response and Inflammation
- interferon and immune responses
- Immune Cell Function and Interaction
Molecular Biology top 0.2%
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology

Papers in

Immunology 25
- T-cell and B-cell Immunology 10
- Immune Cell Function and Interaction 7
- Immune Response and Inflammation 6
- interferon and immune responses 4
Endocrinology 5

Co-authors: Richard A. Flavell Michael Su Pasko Rakić Hajime Karasuyama Chia‐Yi Kuan George Ku David J. Livingston Matthew W. Harding
Journals: Proceedings of the National Academy of Sciences (6 papers)Science (5 papers)Molecular Cancer Therapeutics (5 papers)The Journal of Immunology (4 papers)Cell Death and Differentiation (4 papers)
Partner nations: United States Japan Australia

In The Last Decade

Keisuke Kuida

83 papers receiving 14.3k citations

Hit Papers

5 papers align trajectories log scale

Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis 2006 · 980 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2006 Science
1998 Cell
1997 Science
1996 Nature
1995 Science

Peers

Countries citing papers authored by Keisuke Kuida

Since Specialization

Citations

This map shows the geographic impact of Keisuke Kuida's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keisuke Kuida with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keisuke Kuida more than expected).

Fields of papers citing papers by Keisuke Kuida

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keisuke Kuida. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keisuke Kuida. The network helps show where Keisuke Kuida may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Keisuke Kuida, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Keisuke Kuida Line = papers co-authored together Keisuke Kuida links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	558P A phase I study of rebastinib and carboplatin in patients with metastatic solid tumours Annals of Oncology ·Filip Jankú, A. W. Tolcher, Lee S. Rosen, Cherie Taglienti, Keisuke Kuida, F. Ferroni, Rodrigo Ruiz‐Soto, Pamela N. Münster	2020	2
2	839P A phase Ib/II study of rebastinib and paclitaxel in advanced or metastatic platinum-resistant ovarian cancer Annals of Oncology ·E.P. Hamilton, Bolton Da, Rebecca C. Arend, Christina Chu, Debra L. Richardson, Jennifer R. Diamond, Pornsuang Prakopkaew, David. N. Kariuki, Hassan Khodaverd, Aishwarya Gadwal, Keisuke Kuida, F. Ferroni, Debra Castillo Part, John L. Hays	2020	1
3	A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies Clinical Cancer Research ·Dejan Juric, Johann S. de Bono, Patricia LoRusso, John Nemunaitis, Elisabeth I. Heath, Eunice L. Kwak, T. Macarulla Mercadé, Elena Geuna, Maria J. de Miguel, Chirag Patel, Keisuke Kuida, Serap Sankoh, Eric H. Westin, Fabian Zohren, Yaping Shou, Josep Tabernero	2017	76
4	An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) Biochemical and Biophysical Research Communications ·Hiroyuki Sumi, Masakazu Inazuka, Megumi Morimoto, Noora Heiskanen, Kentaro Hashimoto, Tomoyasu Ishikawa, Keisuke Kuida, Peter G. Smith, Sei Yoshida, Masato Yabuki	2016	9
5	Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells Developmental Cell ·Keiko Nonomura, Yoshifumi Yamaguchi, Kun Li, Masato Koike, Yasuo Uchiyama, Kenichi Nakazato, Atsushi Mochizuki, Asako Sakaue‐Sawano, Atsushi Miyawaki, Hiroki Yoshida, Keisuke Kuida, Masayuki Miura	2013	73
6	TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens Molecular Cancer Therapeutics ·K. Tomura, Kohei Honda, Concha Marín-Barnuevo Fabo, Hitoshi Miyashita, Ю А Ильин, Saomi Murai, Noriko Uchiyama, Maki Hasegawa, Tomohiro Kawamoto, Takashi Sato, Takashi Ichikawa, Khairunnisa’ Harun, Zhe Nie, Anne Fransas, Johnny Yang, Keisuke Kuida, Erik Kupperman	2011	64
7	The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection Nature Immunology ·Dario S. Zamboni, Koichi S. Kobayashi, Tiana Kohlsdorf, Yasunori Ogura, E. Michelle Long, Russell E. Vance, Keisuke Kuida, Sanjeev Mariathasan, Vishva M. Dixit, Richard A. Flavell, William F. Dietrich, Craig R. Roy	2006	416
8	The initiator caspase, caspase‐10β, and the BH‐3‐only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro‐apoptotic activities in the extrinsic and intrinsic pathways Genes to Cells ·Katsuya Kominami, Chiyo Takagi, Tomoko Kurata, Atsushi Kitayama, Masami Nozaki, Tatsuya Sawasaki, Keisuke Kuida, Yaeta Endo, Noboru MANABE, Naoto Ueno, Kazuhiro Sakamaki	2006	12
9	c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo Circulation Research ·Zhili Shao, Kausik Bhattacharya, Eileen Hsich, Larry Park, Brian Walters, Ursula A. Germann, Yow‐Ming Wang, John Kyriakis, Ramon Mohanlal, Keisuke Kuida, Mark Namchuk, Francesco G. Salituro, Yung‐Mae Yao, Weimin Hou, Xin Chen, Mark Aronovitz, Philip N. Tsichlis, Susmita Bhattacharya, Thomas Force, Heiko Kilter	2005	106
10	Functions of MAP Kinases: Insights from Gene-Targeting Studies The Journal of Biochemistry ·Keisuke Kuida	2004	75
11	Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis Developmental Biology ·Koji Oishi, Sachiko Kamakura, Rıfat Resul Sevinç, Takeshi Yoshimatsu, Keisuke Kuida, Masato Nakafuku, Norihisa Masuyama, Yukiko Gotoh	2004	76
12	Amyloid Beta Peptide-Induced Cerebral Neuronal Loss Is Mediated By Caspase-3 In Vivo Journal of Neuropathology & Experimental Neurology ·Hiroshi Takuma, Takami Tomiyama, Keisuke Kuida, Hiroshi Mori	2004	53
13	Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome Nature ·Vanessa S. Marsden, Liam O’Connor, Lorraine A. O’Reilly, John Silke, Donald Metcalf, Paul G. Ekert, David C.S. Huang, Francesco Cecconi, Keisuke Kuida, Kevin J. Tomaselli, Sophie Roy, D. W. Nicholson, David L. Vaux, Philippe Bouillet, Jerry M. Adams, Andreas Strasser	2002	477
14	Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β The Journal of Immunology ·Ekihiro Seki, Hiroko Tsutsui, Hiroki Nakano, Noriko M. Tsuji, Katsuaki Hoshino, Osamu Adachi, Keishi Adachi, Craker, Keisuke Kuida, Osamu Takeuchi, Haruki Okamura, Jiro Fujimoto, Shizuo Akira, Kenji Nakanishi	2001	204
15	Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo Cell Death and Differentiation ·Eriko Fujita, 兼安秀人, Koko Urase, Keisuke Kuida, Takashi Momoi	2001	103
16	Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. PubMed ·Elizabeth E. Eynon, Ferenc Livák, Keisuke Kuida, David G. Schatz, Richard A. Flavell	1999	17
17	Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9 Cell ·Keisuke Kuida, Tarik F. Haydar, Chia‐Yi Kuan, Yong Gu, Choji Taya, Hajime Karasuyama, Michael Su, Pasko Rakić, Richard A. Flavell Hit paper breakdown →	1998	1369
18	Interleukin-1β converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis European Journal of Cancer ·Hitoshi Ikeda, Yohko Nakamura, Takaki Hiwasa, S Sakiyama, Keisuke Kuida, Michael Su, Akira Nakagawara	1997	13
19	LOK Is a Novel Mouse STE20-like Protein Kinase That Is Expressed Predominantly in Lymphocytes Journal of Biological Chemistry ·Satomi Kuramochi, Tetsuo Moriguchi, Keisuke Kuida, Henning E. Kuckuk, Kentaro Semba, Eisuke Nishida, Hajime Karasuyama	1997	65
20	Characterization of rat LECAM‐1 (L‐selectin) by the use of monoclonal antibodies and evidence for the presence of soluble LECAM‐1 in rat sera European Journal of Immunology ·Takuya Tamatani, Fujiko Kitamura, Keisuke Kuida, M Shirao, H.R.Abdul Maqin, Makoto Suematsu, Geert W. Schmid‐Schönbein, Kazuyoshi Watanabe, Susumu Tsurufuji, Masayuki Miyasaka	1993	76

About Keisuke Kuida

Keisuke Kuida is a scholar working on Immunology, Endocrinology, Molecular Biology, Immunology and Allergy and Hematology, having authored 83 papers that have together received 14.6k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (29 papers), T-cell and B-cell Immunology (10 papers), Immune Cell Function and Interaction (7 papers), PI3K/AKT/mTOR signaling in cancer (6 papers), Chronic Myeloid Leukemia Treatments (6 papers), Autophagy in Disease and Therapy (6 papers), Immune Response and Inflammation (6 papers) and interferon and immune responses (4 papers). The work is most often cited by research in Immunology (4.4k citations), Molecular Biology (10.0k citations), Developmental Neuroscience (552 citations), Cell Biology (1.3k citations) and Cancer Research (1.2k citations). Keisuke Kuida has collaborated with scholars based in United States, Japan and Australia. Frequent co-authors include Richard A. Flavell, Michael Su, Pasko Rakić, Hajime Karasuyama, Chia‐Yi Kuan, George Ku, David J. Livingston, Matthew W. Harding, Timothy S. Zheng and Yong Gu. Their work appears in journals such as Proceedings of the National Academy of Sciences, Science, Molecular Cancer Therapeutics, The Journal of Immunology and Cell Death and Differentiation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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