Zhe Nie

1.0k citations

23 papers · 736 indexed · h-index 12

Organic Chemistry top 10%
- Synthesis and Characterization of Heterocyclic Compounds 2
Molecular Biology
- Biochemical and Molecular Research 5
- Chemical Synthesis and Analysis 3
- Epigenetics and DNA Methylation 3
- Histone Deacetylase Inhibitors Research 3
Molecular Medicine
Computational Theory and Mathematics top 10%
Pharmacology
Genetics
- Chronic Lymphocytic Leukemia Research 6
Cellular and Molecular Neuroscience
- Neurotransmitter Receptor Influence on Behavior 3
Immunology
- Galectins and Cancer Biology 2

Co-authors: Stephen A. Margosiak Robert J. Almassy Kraig M. Yager Krzysztof Appelt April M. Averill V. I. Nikulin Ying Su K.S. Gajiwala
Cited by: Organic Chemistry Molecular Biology Molecular Medicine
Journals: Blood (3 papers)Biochemistry (1 paper)FEBS Letters (1 paper)
Partner nations: United States Switzerland

In The Last Decade

Zhe Nie

23 papers receiving 722 citations

Peers

Countries citing papers authored by Zhe Nie

Since Specialization

Citations

This map shows the geographic impact of Zhe Nie's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Zhe Nie with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Zhe Nie more than expected).

Fields of papers citing papers by Zhe Nie

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Zhe Nie. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Zhe Nie. The network helps show where Zhe Nie may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Zhe Nie, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Zhe Nie Line = papers co-authored together Zhe Nie links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury Journal of Medicinal Chemistry ·H. Rachel Lagiakos,Yefen Zou,Hideyuki Igawa,Éric Therrien,Morgan Lawrenz,Mitsunori Kato,Mats Svensson,Felicia Gray,Kristian Jensen,Markus K. Dahlgren,Robert Pelletier,Karen H. Dingley,Jeffrey A. Bell,Zhijian Liu,Yuansong Jiang,Hua Zhou,R.J. Skene,Zhe Nie	2024	4
2	SGR‐1505‐101: A PHASE 1, OPEN‐LABEL, MULTICENTER, DOSE‐ESCALATION STUDY OF SGR‐1505 AS MONOTHERAPY IN SUBJECTS WITH MATURE B‐CELL MALIGNANCIES Hematological Oncology ·Adam J. Olszewski,Douglas Kahn,Byunggil Yoo,Zhe Nie,Goran Krilov,Jerome Tan,Hamish Wright,(unknown),Yin Wu,Karen Akinsanya	2023	1
3	A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, K _p,uu Journal of Chemical Information and Modeling ·Morgan Lawrenz,Mats Svensson,Mitsunori Kato,Karen H. Dingley,Jackson Chief Elk,Zhe Nie,Yefen Zou,Zachary Kaplan,H. Rachel Lagiakos,Hideyuki Igawa,Éric Therrien	2023	11
4	A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of Sgr-1505 As Monotherapy in Subjects with Mature B-Cell Malignancies Blood ·Adam J. Olszewski,David Kahn,Byong Kwon Yoo,Joanne Tan,Vipul K Gupta,Edgar Schuck,Zhe Nie,Goran Krilov,D. Hamish Wright,Daniel Weiß,Jean E. Lachowicz,Karen Akinsanya,Yin Wu	2023	3
5	Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors Bioorganic & Medicinal Chemistry Letters ·Zhe Nie,Lihong Shi,Chon Lai,Christophe Severin,Jiangchun Xu,Joselyn R. Del Rosario,Ryan Stansfield,Robert W. Cho,Toufike Kanouni,James M. Veal,Jeffrey A. Stafford,Young K. Chen	2018	12
6	Structure-based design and discovery of potent and selective KDM5 inhibitors Bioorganic & Medicinal Chemistry Letters ·Zhe Nie,Lihong Shi,Chon Lai,Shawn M. O’Connell,Jiangchun Xu,Ryan Stansfield,David J. Hosfield,James M. Veal,Jeffrey A. Stafford	2018	32
7	TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor Activity in Multiple Dosing Regimens Molecular Cancer Therapeutics ·Yuichi Hikichi,Kohei Honda,Kouki Hikami,Hitoshi Miyashita,Isao Kaieda,Saomi Murai,Noriko Uchiyama,Maki Hasegawa,Tomohiro Kawamoto,Takashi Sato,Takashi Ichikawa,Sheldon Cao,Zhe Nie,Lilly Zhang,Johnny Yang,Keisuke Kuida,Erik Kupperman	2011	64
8	Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme FEBS Letters ·K.S. Gajiwala,Stephen A. Margosiak,Jia Lu,Joseph Cortez,Ying Su,Zhe Nie,Krzysztof Appelt	2009	50
9	Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2 Bioorganic & Medicinal Chemistry Letters ·Zhe Nie,Carin Perretta,Philip Erickson,Stephen A. Margosiak,Robert J. Almassy,Jia Lu,April M. Averill,Kraig M. Yager,Shaosong Chu	2007	82
10	Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities Bioorganic & Medicinal Chemistry Letters ·Zhe Nie,Carin Perretta,Philip Erickson,Stephen A. Margosiak,Jia Lu,April M. Averill,Robert J. Almassy,Shaosong Chu	2007	80
11	Synthesis and Monoamine Transporter Binding Properties of 2,3-Cyclo Analogues of 3β-(4‘-Aminophenyl)-2β-tropanemethanol Journal of Medicinal Chemistry ·F. Ivy Carroll,Bruce E. Blough,Xiaodong Huang,Zhe Nie,S. Wayne Mascarella,Jeffrey R. Deschamps,Hernán A. Navarro	2006	2
12	Structure-Based Design, Synthesis, and Study of Potent Inhibitors of β-Ketoacyl-acyl Carrier Protein Synthase III as Potential Antimicrobial Agents Journal of Medicinal Chemistry ·Zhe Nie,Carin Perretta,Jia Lu,Ying Su,Stephen A. Margosiak,K.S. Gajiwala,Joseph Cortez,V. I. Nikulin,Kraig M. Yager,Krzysztof Appelt,Shaosong Chu	2005	83
13	Synthesis and Monoamine Transporter Binding Properties of 3β-(3‘,4‘-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters Journal of Medicinal Chemistry ·F. Ivy Carroll,Bruce E. Blough,Zhe Nie,Michael J. Kuhar,Leonard L. Howell,Hernán A. Navarro	2005	13
14	Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors Bioorganic & Medicinal Chemistry Letters ·Martina E. Tedder,Zhe Nie,Stephen A. Margosiak,Shaosong Chu,Victoria A. Feher,Robert J. Almassy,Krzysztof Appelt,Kraig M. Yager	2004	22
15	Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2‘-deoxyuridine 5‘-Monophosphate Biochemistry ·Ruth L. Saxl,James Reston,Zhe Nie,Thomas I. Kalman,Frank Maley	2003	8
16	Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors Journal of Medicinal Chemistry ·Xiaoming Li,Sam Chu,Victoria A. Feher,Mitra Khalili,Zhe Nie,Stephen A. Margosiak,V. I. Nikulin,James C. Levin,Kelly G. Sprankle,Martina E. Tedder,Robert J. Almassy,Krzysztof Appelt,Kraig M. Yager	2003	141
17	Synthesis and Transporter Binding Properties of 3β-[4‘-(Phenylalkyl, -phenylalkenyl, and -phenylalkynl)phenyl]tropane-2β-carboxylic Acid Methyl Esters: Evidence of a Remote Phenyl Binding Domain on the Dopamine Transporter Journal of Medicinal Chemistry ·Bruce E. Blough,Kathryn I. Keverline,Zhe Nie,Hernán A. Navarro,Michael J. Kuhar,F. Ivy Carroll	2002	14
18	5-PROPYNYLPYRIMIDINE NUCLEOSIDE DERIVATIVES: RATIONALLY DESIGNED MECHANISM-BASED INACTIVATORS OF THYMIDYLATE SYNTHASE Nucleosides Nucleotides & Nucleic Acids ·Thomas I. Kalman,Zhe Nie,Ashwini Kamat	2001	7
19	Rational Design of Selective Antimetabolites of DNA-Thymine Biosynthesis: 5-Propynylpyrimidine Nucleoside Derivatives Nucleosides Nucleotides & Nucleic Acids ·Thomas I. Kalman,Zhe Nie	2000	6
20	Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2′-deoxyuridine 5′-phosphate Bioorganic & Medicinal Chemistry Letters ·Thomas I. Kalman,Zhe Nie,Ashwini Kamat	2000	5

About Zhe Nie

Zhe Nie is a scholar working on Genetics, Physiology and Molecular Biology, having authored 23 papers that have together received 736 indexed citations. Recurring topics across this work include Chronic Lymphocytic Leukemia Research (6 papers), Biochemical and Molecular Research (5 papers), Chemical Synthesis and Analysis (3 papers), Epigenetics and DNA Methylation (3 papers), Histone Deacetylase Inhibitors Research (3 papers), Neurotransmitter Receptor Influence on Behavior (3 papers), Synthesis and Characterization of Heterocyclic Compounds (2 papers) and Galectins and Cancer Biology (2 papers). The work is most often cited by research in Organic Chemistry (308 citations), Molecular Biology (407 citations) and Molecular Medicine (26 citations). Zhe Nie has collaborated with scholars based in United States and Switzerland. Frequent co-authors include Stephen A. Margosiak, Robert J. Almassy, Kraig M. Yager, Krzysztof Appelt, April M. Averill, V. I. Nikulin, Ying Su, K.S. Gajiwala, Victoria A. Feher and James C. Levin. Their work appears in journals such as Blood, Biochemistry and FEBS Letters.

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