John Kyriakis

25.2k citations

87 papers · 21.6k indexed · 11 hit papers · h-index 57

Molecular Biology top 0.1%
- Melanoma and MAPK Pathways 37
- Protein Kinase Regulation and GTPase Signaling 31
- Heat shock proteins research 12
- Cell death mechanisms and regulation 9
- Signaling Pathways in Disease 6
Aging top 0.5%
Cancer Research top 0.5%
Cell Biology top 0.2%
- Cellular Mechanics and Interactions 11
- Endoplasmic Reticulum Stress and Disease 10
- Hippo pathway signaling and YAP/TAZ 6
Immunology top 0.5%

Co-authors: Joseph Avruch James R. Woodgett Eleni Nikolakaki Papia T. Banerjee Xianfeng Zhang Leonard I. Zon Elizabeth A. Rubie Thomas Force
Cited by: Molecular Biology Aging Cancer Research
Journals: Journal of Biological Chemistry (28 papers)Nature (7 papers)Proceedings of the National Academy of Sciences (5 papers)
Partner nations: United States Canada Japan

In The Last Decade

John Kyriakis

87 papers receiving 21.2k citations

Hit Papers

11 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2012 Physiological Reviews
2001 Physiological Reviews
1996 Nature
1996 BioEssays
1996 Journal of Biological Chemistry
1994 Nature
1994 Nature
1994 Trends in Biochemical Sciences
1993 Nature
1992 Nature
1991 Nature

Peers

Countries citing papers authored by John Kyriakis

Since Specialization

Citations

This map shows the geographic impact of John Kyriakis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Kyriakis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Kyriakis more than expected).

Fields of papers citing papers by John Kyriakis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Kyriakis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Kyriakis. The network helps show where John Kyriakis may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John Kyriakis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Kyriakis Line = papers co-authored together John Kyriakis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	SOK1 Translocates from the Golgi to the Nucleus upon Chemical Anoxia and Induces Apoptotic Cell Death Journal of Biological Chemistry ·Cinoelia Leal De Souza,Miguel Fidalgo,Árpàd Molnár,John Kyriakis,Thomas Force,Juan Zalvide,Celia M. Pombo	2008	43
2	Thinking Outside the Box about Ras Journal of Biological Chemistry ·John Kyriakis	2008	17
3	Dissection of a Signaling Pathway by Which Pathogen-associated Molecular Patterns Recruit the JNK and p38 MAPKs and Trigger Cytokine Release Journal of Biological Chemistry ·Jian Zhong,John Kyriakis	2007	56
4	Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein Proceedings of the National Academy of Sciences ·Deborah Chadee,Da-Zhong Xu,Gene Hung,Ali Andalibi,David Lim,Zhijun Luo,David H. Gutmann,John Kyriakis	2006	78
5	Helix-Loop-Helix Protein p8, a Transcriptional Regulator Required for Cardiomyocyte Hypertrophy and Cardiac Fibroblast Matrix Metalloprotease Induction Molecular and Cellular Biology ·Sandro Goruppi,Richard D. Patten,Thomas Force,John Kyriakis	2006	44
6	c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo Circulation Research ·Zhili Shao,Kausik Bhattacharya,Eileen Hsich,Larry Park,Brian Walters,Ursula A. Germann,Yow‐Ming Wang,John Kyriakis,Ramon Mohanlal,Keisuke Kuida,Mark Namchuk,Francesco G. Salituro,Yung‐Mae Yao,Weimin Hou,Xin Chen,Mark Aronovitz,Philip N. Tsichlis,Susmita Bhattacharya,Thomas Force,Heiko Kilter	2005	106
7	The Pro-hypertrophic Basic Helix-Loop-Helix Protein p8 Is Degraded by the Ubiquitin/Proteasome System in a Protein Kinase B/Akt- and Glycogen Synthase Kinase-3-dependent Manner, whereas Endothelin Induction of p8 mRNA and Renal Mesangial Cell Hypertrophy Require NFAT4 Journal of Biological Chemistry ·Sandro Goruppi,John Kyriakis	2004	35
8	A Novel Role for Mixed Lineage Kinase 3 (MLK3) in B-Raf Activation and Cell proliferation Cell Cycle ·Deborah Chadee,John Kyriakis	2004	31
9	Gene 33 Is an Endogenous Inhibitor of Epidermal Growth Factor (EGF) Receptor Signaling and Mediates Dexamethasone-induced Suppression of EGF Function Journal of Biological Chemistry ·Da-Zhong Xu,Anthony Makkinje,John Kyriakis	2004	91
10	Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation American Journal of Physiology-Cell Physiology ·Bernard A.J. Roelen,Ori S. Cohen,Malay K. Raychowdhury,Deborah Chadee,Ying E. Zhang,John Kyriakis,Alessandro Alessandrini,Herbert Y. Lin	2003	52
11	Phosphatidylinositol 3′-Kinase-dependent Activation of Renal Mesangial Cell Ki-Ras and ERK by Advanced Glycation End Products Journal of Biological Chemistry ·Da-Zhong Xu,John Kyriakis	2003	49
12	Activation of the MKK4‐JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2‐β isoform FEBS Letters ·Ville Hietakangas,Iina Elo,Sujud Sujud,Eleanor T. Coffey,John Kyriakis,John Eriksson,Lea Sistonen	2001	9
13	Signaling by the Germinal Center Kinase Family of Protein Kinases Journal of Biological Chemistry ·John Kyriakis	1999	126
14	Activation of the Ste20-like Oxidant Stress Response Kinase-1 during the Initial Stages of Chemical Anoxia-induced Necrotic Cell Death Journal of Biological Chemistry ·Celia M. Pombo,Zhi Hao Shao,John Kyriakis,Joseph V. Bonventre,Thomas Force	1997	39
15	MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase Journal of Biological Chemistry ·Syu‐ichi Hirai,Masaru Katoh,Masaaki Terada,John Kyriakis,Leonard I. Zon,Ajay Rana,Joseph Avruch,Shigeo Ohno	1997	161
16	Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-α Activation of SAPK in Melanoma Cells Journal of Biological Chemistry ·Amelia Martí,Zhijun Luo,Casey Cunningham,Yasutaka Ohta,John H. Hartwig,Thomas P. Stossel,John Kyriakis,Joseph Avruch	1997	144
17	Reconstitution of novel signalling cascades responding to cellular stresses Philosophical Transactions of the Royal Society B Biological Sciences ·James R. Woodgett,John Kyriakis,M. Àngels Solé i Sanosa,Leonard I. Zon,Brent W. Zanke,Dennis J. Templeton,(unknown)	1996	38
18	Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1breakdown → Nature ·Gülcan Çolak,손종문,V.S. Hegade,John Kyriakis,Leonard I. Zon,James R. Woodgett,Dennis J. Templeton	1994	659
19	Raf-1 activates MAP kinase-kinasebreakdown → Nature ·John Kyriakis,Harald App,Xianfeng Zhang,Papia T. Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch	1992	1117
20	Insulin, epidermal growth factor and fibroblast growth factor elicit distinct patterns of protein tyrosine phosphorylation in BC3H1 cells Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·John Kyriakis,Joseph Avruch	1990	6

About John Kyriakis

John Kyriakis is a scholar working on Cell Biology, Molecular Biology, Aging, Cancer Research and Oncology, having authored 87 papers that have together received 21.6k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (37 papers), Protein Kinase Regulation and GTPase Signaling (31 papers), Heat shock proteins research (12 papers), Cellular Mechanics and Interactions (11 papers), Endoplasmic Reticulum Stress and Disease (10 papers), Cell death mechanisms and regulation (9 papers), Signaling Pathways in Disease (6 papers) and Hippo pathway signaling and YAP/TAZ (6 papers). The work is most often cited by research in Molecular Biology (16.1k citations), Aging (336 citations), Cancer Research (2.9k citations), Cell Biology (3.0k citations) and Immunology (3.1k citations). John Kyriakis has collaborated with scholars based in United States, Canada and Japan. Frequent co-authors include Joseph Avruch, James R. Woodgett, Eleni Nikolakaki, Papia T. Banerjee, Xianfeng Zhang, Leonard I. Zon, Elizabeth A. Rubie, Thomas Force, Ulf R. Rapp and Mir F. Ahmad. Their work appears in journals such as Journal of Biological Chemistry, Nature, Proceedings of the National Academy of Sciences, Molecular and Cellular Biology and Circulation Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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