Hiroko Tsutsui

20.8k total citations · 8 hit papers
144 papers, 17.2k citations indexed

About

Hiroko Tsutsui is a scholar working on Immunology, Molecular Biology and Epidemiology. According to data from OpenAlex, Hiroko Tsutsui has authored 144 papers receiving a total of 17.2k indexed citations (citations by other indexed papers that have themselves been cited), including 84 papers in Immunology, 49 papers in Molecular Biology and 21 papers in Epidemiology. Recurrent topics in Hiroko Tsutsui's work include Inflammasome and immune disorders (41 papers), Immune Response and Inflammation (39 papers) and Immune Cell Function and Interaction (31 papers). Hiroko Tsutsui is often cited by papers focused on Inflammasome and immune disorders (41 papers), Immune Response and Inflammation (39 papers) and Immune Cell Function and Interaction (31 papers). Hiroko Tsutsui collaborates with scholars based in Japan, United States and China. Hiroko Tsutsui's co-authors include Kenji Nakanishi, Haruki Okamura, Shizuo Akira, Tomohiro Yoshimoto, Kiyoshi Takeda, Osamu Adachi, Taro Kawai, Makoto Matsumoto, Masafumi Sakagami and Masashi Kurimoto and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Hiroko Tsutsui

140 papers receiving 16.9k citations

Hit Papers

Cloning of a new cytokine that induces IFN-γ production b... 1995 2026 2005 2015 1995 1998 2001 1997 1998 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Cloning of a new cytokine that induces IFN-γ production by T cells
    1995 2.2k citations Haruki Okamura, Hiroko Tsutsui et al. profile →
  2. Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
    1998 1.7k citations Osamu Adachi, Taro Kawai et al. Immunity profile →
  3. Interleukin-18 Regulates Both Th1 and Th2 Responses
    2001 1.1k citations Kenji Nakanishi, Tomohiro Yoshimoto et al. profile →
  4. Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
    1997 996 citations Keisuke Kuida, Hiroko Tsutsui et al. profile →
  5. Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice
    1998 783 citations Hiroko Tsutsui, Tomohiro Yoshimoto et al. Immunity profile →
  6. SOCS-1 Participates in Negative Regulation of LPS Responses
    2002 552 citations Hiroko Tsutsui, Ekihiro Seki et al. Immunity profile →
  7. Hepatocyte growth factor gene therapy of liver cirrhosis in rats
    1999 505 citations Hiroko Tsutsui, Jiro Fujimoto et al. profile →
  8. Interleukin-18 in Health and Disease
    2019 393 citations Koubun Yasuda, Kenji Nakanishi et al. International Journal of Molecular Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Hiroko Tsutsui Japan 54 10.3k 7.0k 2.7k 1.7k 1.7k 144 17.2k
Haruki Okamura Japan 62 11.0k 1.1× 8.4k 1.2× 2.5k 0.9× 1.4k 0.8× 2.1k 1.3× 238 18.7k
Kenji Nakanishi Japan 60 12.4k 1.2× 6.1k 0.9× 2.1k 0.8× 2.2k 1.3× 1.7k 1.0× 128 18.4k
Charles O. Elson United States 76 12.6k 1.2× 6.2k 0.9× 3.9k 1.4× 3.3k 2.0× 1.8k 1.1× 218 23.7k
Luciano Adorini Italy 80 10.8k 1.0× 4.8k 0.7× 4.4k 1.6× 3.0k 1.8× 4.3k 2.6× 338 24.8k
Klaus Pfeffer Germany 77 14.1k 1.4× 9.2k 1.3× 4.7k 1.7× 2.5k 1.5× 4.1k 2.5× 266 28.3k
Paul J. Godowski United States 51 9.8k 0.9× 6.6k 1.0× 3.0k 1.1× 1.3k 0.8× 1.8k 1.1× 64 18.6k
Ivan J. Fuss United States 62 10.1k 1.0× 4.9k 0.7× 3.0k 1.1× 2.8k 1.7× 2.0k 1.2× 120 18.3k
Thomas T. MacDonald United Kingdom 83 10.1k 1.0× 5.6k 0.8× 4.5k 1.7× 4.5k 2.7× 2.6k 1.6× 320 23.8k
Carl F. Ware United States 79 13.4k 1.3× 5.6k 0.8× 3.7k 1.4× 1.1k 0.7× 4.4k 2.7× 257 21.3k
Christoph Becker Germany 67 9.3k 0.9× 6.8k 1.0× 2.1k 0.8× 2.3k 1.4× 4.6k 2.8× 187 20.1k

Countries citing papers authored by Hiroko Tsutsui

Since Specialization
Citations

This map shows the geographic impact of Hiroko Tsutsui's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroko Tsutsui with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroko Tsutsui more than expected).

Fields of papers citing papers by Hiroko Tsutsui

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroko Tsutsui. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroko Tsutsui. The network helps show where Hiroko Tsutsui may publish in the future.

Co-authorship network of co-authors of Hiroko Tsutsui

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroko Tsutsui. A scholar is included among the top collaborators of Hiroko Tsutsui based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroko Tsutsui. Hiroko Tsutsui is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Sudo, Makoto, Hiroko Tsutsui, & Jiro Fujimoto. (2024). Carbon Ion Irradiation Activates Anti-Cancer Immunity. International Journal of Molecular Sciences. 25(5). 2830–2830. 4 indexed citations
3.
Sudo, Makoto, Hiroko Tsutsui, Shuhei Hayashi, et al.. (2023). Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy. Cellular Physiology and Biochemistry. 57(4). 212–225. 8 indexed citations
4.
5.
Kawashima, Tadaomi, Akemi Kosaka, Huimin Yan, et al.. (2013). Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β. Immunity. 38(6). 1187–1197. 159 indexed citations
6.
Kawashima, Tadaomi, Kyoko Hayashi, Akemi Kosaka, et al.. (2011). Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses. International Immunopharmacology. 11(12). 2017–2024. 99 indexed citations
7.
Matsumoto, Koichiro, Keiko Kan‐o, Satoru Fukuyama, et al.. (2010). Essential Role of B7-H1 in Double-Stranded RNA–Induced Augmentation of an Asthma Phenotype in Mice. American Journal of Respiratory Cell and Molecular Biology. 45(1). 31–39. 11 indexed citations
8.
Yamanaka, Keiichi, Koji Habe, Ichiro Kurokawa, et al.. (2006). Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment. The Journal of Immunology. 177(12). 8315–8319. 120 indexed citations
9.
Murakami, Takaaki, Keiichi Yamanaka, Ichiro Kurokawa, et al.. (2006). A novel acoustic evaluation system of scratching in mouse dermatitis: Rapid and specific detection of invisibly rapid scratch in an atopic dermatitis model mouse. Life Sciences. 79(22). 2144–2150. 22 indexed citations
10.
Fujimori, Yoshihiro, Hiroko Tsutsui, Kiyoshi Matsui, et al.. (2004). Involvement of Interleukin-18 in Acute Graft-Versus-Host Disease in Mice. Transplantation. 78(9). 1245–1250. 11 indexed citations
11.
Fujimori, Yoshihiro, Hiroko Tsutsui, Kiyoshi Matsui, et al.. (2004). Differential Upregulation of Interleukin-18 Receptor α Chain Between CD4 + and CD8 + T Cells During Acute Graft-Versus-Host Disease in Mice. Journal of Interferon & Cytokine Research. 24(5). 291–296. 6 indexed citations
12.
Okamoto, Takuya, Naoko Yamada, Tohru Tsujimura, et al.. (2004). Inhibition by Interleukin-18 of the Growth of Dunn Osteosarcoma Cells. Journal of Interferon & Cytokine Research. 24(3). 161–167. 14 indexed citations
13.
Fujimori, Yoshihiro, Tomohiro Yoshimoto, Kiyoshi Matsui, et al.. (2002). Short Communication: Increased Expression of Interleukin-18 Receptor on T Lymphocytes in Patients with Acute Graft-versus-Host Disease After Allogeneic Bone Marrow Transplantation. Journal of Interferon & Cytokine Research. 22(7). 751–754. 9 indexed citations
14.
Seki, Ekihiro, Hiroko Tsutsui, Noriko M. Tsuji, et al.. (2002). Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice. The Journal of Immunology. 169(7). 3863–3868. 224 indexed citations
15.
Nakamoto, Yasunari, Shuichi Kaneko, Hong Fan, et al.. (2002). Prevention of Hepatocellular Carcinoma Development Associated with Chronic Hepatitis by Anti-Fas Ligand Antibody Therapy. The Journal of Experimental Medicine. 196(8). 1105–1111. 59 indexed citations
16.
Adachi, Keishi, Hiroko Tsutsui, Shin‐ichiro Kashiwamura, et al.. (2001). Plasmodium   berghei Infection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism. The Journal of Immunology. 167(10). 5928–5934. 177 indexed citations
17.
Seki, Ekihiro, Hiroko Tsutsui, Hiroki Nakano, et al.. (2001). Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β. The Journal of Immunology. 166(4). 2651–2657. 204 indexed citations
18.
Mizoguchi, Y, Hiroko Tsutsui, Takayuki Arai, et al.. (1985). Immunological studies on asymptomatic HB virus carrier. Effects of sex hormones on termination of immunological tolerance.. Kanzo. 26(5). 578–581. 1 indexed citations
19.
Tsutsui, Hiroko, Takayuki Arai, Y Sakagami, et al.. (1984). The protective effects of saikosaponin on the liver cell injury induced by adcc reaction and activated macrophages in vitro. Kanzo. 25(1). 40–46. 1 indexed citations
20.
Mizoguchi, Y, Hiroko Tsutsui, Takeyuki Monna, Sukeo Yamamoto, & Seiji Morisawa. (1983). Lipid peroxide formation in liver cells, induced by antibody-dependent cell-mediated cytotoxic reaction.. PubMed. 32(9). 979–84. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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