John Silke

36.7k total citations · 9 hit papers
188 papers, 19.8k citations indexed

About

John Silke is a scholar working on Molecular Biology, Immunology and Cancer Research. According to data from OpenAlex, John Silke has authored 188 papers receiving a total of 19.8k indexed citations (citations by other indexed papers that have themselves been cited), including 149 papers in Molecular Biology, 73 papers in Immunology and 40 papers in Cancer Research. Recurrent topics in John Silke's work include Cell death mechanisms and regulation (93 papers), Ubiquitin and proteasome pathways (39 papers) and NF-κB Signaling Pathways (37 papers). John Silke is often cited by papers focused on Cell death mechanisms and regulation (93 papers), Ubiquitin and proteasome pathways (39 papers) and NF-κB Signaling Pathways (37 papers). John Silke collaborates with scholars based in Australia, Germany and Switzerland. John Silke's co-authors include David L. Vaux, Paul G. Ekert, James E. Vince, Pascal Meier, Anne M. Verhagen, Miha Pakusch, W. Wei‐Lynn Wong, Lisa Connolly, Richard J. Simpson and Robert L. Moritz and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

John Silke

183 papers receiving 19.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 1.8k citations Anne M. Verhagen, Paul G. Ekert et al. Cell profile →
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

2007 879 citations James E. Vince, W. Wei‐Lynn Wong et al. Cell profile →
Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

2006 861 citations John Silke et al. Cell profile →
Linear ubiquitination prevents inflammation and regulates immune signalling

2011 725 citations Andrew I. Webb, Holly Anderton et al. profile →
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

2009 596 citations Rebecca Feltham, James E. Vince et al. Molecular Cell profile →
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

2015 510 citations Nufail Khan, Holly Anderton et al. Nature Communications profile →
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

2014 468 citations Joanne M. Hildebrand, Isabelle S. Lucet et al. profile →
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

2013 416 citations James E. Vince, John Silke et al. Cell Death and Differentiation profile →
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

2024 180 citations Pascal Meier, John Silke et al. profile →

Peers

Countries citing papers authored by John Silke

Since Specialization

Citations

This map shows the geographic impact of John Silke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Silke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Silke more than expected).

Fields of papers citing papers by John Silke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Silke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Silke. The network helps show where John Silke may publish in the future.

Co-authorship network of co-authors of John Silke

This figure shows the co-authorship network connecting the top 25 collaborators of John Silke. A scholar is included among the top collaborators of John Silke based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Silke. John Silke is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy 2025 ·Scientific Reports ·(unknown), (unknown), (unknown), Lorraine A. O’Reilly, John Silke, Christopher Angel, Antonio Celentano, Lachlan Whitehead, Michael McCullough, Tami Yap	4
2	Intracellular zinc protects tumours from T cell-mediated cytotoxicity 2024 ·Cell Death and Differentiation ·Emily J. Lelliott, (unknown), Katherine Ganio, Jessica Michie, Shelly Wang, (unknown), Natasha Silke, Antonio Ahn, Kelly M. Ramsbottom, A. J. Brennan, Andrew J. Freeman, Shom Goel, Stephin J. Vervoort, Conor J. Kearney, Paul A. Beavis, Christopher A. McDevitt, John Silke, Jane Oliaro	3
3	AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells 2024 ·FEBS Journal ·Lin Liu, John Silke	2
4	cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation 2023 ·The EMBO Journal ·Fabian Schorn, (unknown), (unknown), (unknown), (unknown), Lars M. Schiffmann, (unknown), (unknown), Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashkar	11
5	A regulatory region on RIPK 2 is required for XIAP binding and NOD signaling activity 2020 ·EMBO Reports ·(unknown), Laura F. Dagley, Che A. Stafford, Fynn M. Hansen, (unknown), Aleksandra Bankovacki, Andrew I. Webb, Isabelle S. Lucet, John Silke, Ueli Nachbur	9
6	Antagonism of IAPs Enhances CAR T-cell Efficacy 2019 ·Cancer Immunology Research ·Jessica Michie, Paul A. Beavis, Andrew J. Freeman, Stephin J. Vervoort, Kelly M. Ramsbottom, Vignesh Narasimhan, Emily J. Lelliott, Najoua Lalaoui, Robert G. Ramsay, Ricky W. Johnstone, John Silke, Phillip K. Darcy, Ilia Voskoboinik, Conor J. Kearney, Jane Oliaro	77
7	Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs 2019 ·Nature Communications ·Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, (unknown), Joanne M. Hildebrand, R. Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi‐Akahane, Sotaro Uemura, John Silke, Hideo Yagita∥, Masayuki Miura, Hiroyasu Nakano	2
8	Antagonism of IAPs enhances CAR T cell efficacy 2019 ·European Journal of Immunology ·Jessica Michie, (unknown), (unknown), (unknown), (unknown), Vignesh Narasimhan, (unknown), Najoua Lalaoui, Robert G. Ramsay, (unknown), John Silke, (unknown), Ilia Voskoboinik, (unknown), Jane Oliaro	1
9	A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs 2018 ·Nature Communications ·Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, (unknown), Joanne M. Hildebrand, R. Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi‐Akahane, Sotaro Uemura, John Silke, Hideo Yagita∥, Masayuki Miura, Hiroyasu Nakano	64
10	Tumor immune evasion arises through loss of TNF sensitivity 2018 ·Science Immunology ·Conor J. Kearney, Stephin J. Vervoort, Simon J. Hogg, Kelly M. Ramsbottom, Andrew J. Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin Brown, Deborah A. Knight, Vivien R. Sutton, Paul A. Beavis, Ilia Voskoboinik, Phillip K. Darcy, John Silke, Joseph A. Trapani, Ricky W. Johnstone, Jane Oliaro	254
11	Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors 2018 ·Molecular Cancer Therapeutics ·Dilys T.H. Leung, (unknown), (unknown), (unknown), Maria Alexiadis, John Silke, Thomas W. Jobling, Peter J. Fuller, Simon Chu	15
12	MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death 2017 ·Molecular Cell ·Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, (unknown), Chun Kim, (unknown), Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M. Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier	239
13	Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding 2010 ·Journal of Biological Chemistry ·Rebecca Feltham, Maryline Moulin, James E. Vince, Peter D. Mace, W. Wei‐Lynn Wong, Holly Anderton, Catherine L. Day, David L. Vaux, John Silke	36
14	Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment 2008 ·Journal of Biological Chemistry ·Peter D. Mace, Katrin Linke, Rebecca Feltham, Frances‐Rose Schumacher, Clyde A. Smith, David L. Vaux, John Silke, Catherine L. Day	137
15	IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis breakdown → 2007 ·Cell ·James E. Vince, W. Wei‐Lynn Wong, Nufail Khan, Rebecca Feltham, Diep Chau, Afsar U. Ahmed, Christopher A. Benetatos, Srinivas K. Chunduru, Stephen M. Condon, Mark A. McKinlay, Robert Brink, Martin Leverkus, Vinay Tergaonkar, Pascal Schneider, Bernard A. Callus, Frank Köentgen, David L. Vaux, John Silke	879
16	Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs 2006 ·Cell Death and Differentiation ·A. M. W. Verhagen, Tobias Kratina, Christine J. Hawkins, John Silke, Paul G. Ekert, David L. Vaux	74
17	Apaf-1, Caspase-2 and Caspase-9 accelerate apoptosis, but do not determine whether factor-deprived cells die 2004 ·Pediatric Research ·(unknown), Stuart H. Read, John Silke, (unknown), Hitto Kaufmann, Christine J. Hawkins, Robert E. Gerl, (unknown), David L. Vaux	0
18	Mammalian mitochondrial IAP binding proteins 2003 ·Biochemical and Biophysical Research Communications ·David L. Vaux, John Silke	178
19	HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins 2002 ·Journal of Biological Chemistry ·Anne M. Verhagen, John Silke, Paul G. Ekert, Miha Pakusch, Hitto Kaufmann, Lisa Connolly, Catherine L. Day, Anjali Tikoo, Richard Burke, Carolyn N. Wrobel, Robert L. Moritz, Richard J. Simpson, David L. Vaux	423
20	The Drosophila caspase DRONC is regulated by DIAP1 2000 ·The EMBO Journal ·Pascal Meier, John Silke, Sally J. Leevers, Gérard I. Evan	286

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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