John Silke

36.7k total citations · 9 hit papers
188 papers, 19.8k citations indexed

About

John Silke is a scholar working on Molecular Biology, Immunology and Cancer Research. According to data from OpenAlex, John Silke has authored 188 papers receiving a total of 19.8k indexed citations (citations by other indexed papers that have themselves been cited), including 149 papers in Molecular Biology, 73 papers in Immunology and 40 papers in Cancer Research. Recurrent topics in John Silke's work include Cell death mechanisms and regulation (93 papers), Ubiquitin and proteasome pathways (39 papers) and NF-κB Signaling Pathways (37 papers). John Silke is often cited by papers focused on Cell death mechanisms and regulation (93 papers), Ubiquitin and proteasome pathways (39 papers) and NF-κB Signaling Pathways (37 papers). John Silke collaborates with scholars based in Australia, Germany and Switzerland. John Silke's co-authors include David L. Vaux, Paul G. Ekert, James E. Vince, Pascal Meier, Anne M. Verhagen, Miha Pakusch, W. Wei‐Lynn Wong, Lisa Connolly, Richard J. Simpson and Robert L. Moritz and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

John Silke

183 papers receiving 19.5k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 1.8k citations Anne M. Verhagen, Paul G. Ekert et al. profile →
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

2007 879 citations James E. Vince, W. Wei‐Lynn Wong et al. profile →
Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

2006 861 citations John Silke et al. profile →
Linear ubiquitination prevents inflammation and regulates immune signalling

2011 725 citations Andrew I. Webb, Holly Anderton et al. profile →
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

2009 596 citations James E. Vince, David Komander et al. profile →
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

2015 510 citations Kate E. Lawlor, Holly Anderton et al. Nature Communications profile →
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

2014 468 citations Joanne M. Hildebrand, Isabelle S. Lucet et al. profile →
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

2013 416 citations James E. Vince, John Silke et al. Cell Death and Differentiation profile →
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

2024 180 citations Pascal Meier, Arnaud J. Legrand et al. Nature reviews. Cancer profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
John Silke	15.6k	6.8k	3.6k	3.5k	2.7k	188	19.8k
Karen O’Rourke	15.5k 1.0×	7.8k 1.1×	4.3k 1.2×	3.5k 1.0×	2.1k 0.8×	44	20.2k
Wim Declercq	10.3k 0.7×	5.1k 0.7×	2.1k 0.6×	1.9k 0.5×	2.7k 1.0×	133	16.0k
Éric Solary	12.5k 0.8×	5.3k 0.8×	2.2k 0.6×	4.9k 1.4×	1.9k 0.7×	369	21.5k
Tullia Lindsten	13.2k 0.8×	8.4k 1.2×	2.5k 0.7×	4.2k 1.2×	3.8k 1.4×	98	22.8k
Yuri Lazebnik	14.7k 0.9×	3.4k 0.5×	2.2k 0.6×	3.7k 1.1×	2.0k 0.7×	53	19.3k
Philippe Bouillet	10.7k 0.7×	5.6k 0.8×	1.5k 0.4×	3.1k 0.9×	1.9k 0.7×	155	16.5k
Razqallah Hakem	10.7k 0.7×	3.4k 0.5×	2.2k 0.6×	3.0k 0.8×	1.8k 0.7×	94	13.8k
Teresa Fernandes‐Alnemri	18.0k 1.1×	7.9k 1.2×	1.8k 0.5×	2.0k 0.6×	2.5k 0.9×	73	21.4k
Shin Yonehara	10.3k 0.7×	9.0k 1.3×	1.7k 0.5×	3.3k 0.9×	1.9k 0.7×	172	18.7k
Bing Su	11.0k 0.7×	5.6k 0.8×	3.1k 0.9×	2.7k 0.8×	944 0.3×	178	17.7k

Countries citing papers authored by John Silke

Since Specialization

Citations

This map shows the geographic impact of John Silke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Silke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Silke more than expected).

Fields of papers citing papers by John Silke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Silke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Silke. The network helps show where John Silke may publish in the future.

Co-authorship network of co-authors of John Silke

This figure shows the co-authorship network connecting the top 25 collaborators of John Silke. A scholar is included among the top collaborators of John Silke based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Silke. John Silke is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Jiou, Jenny, Simon A. Cobbold, Kinglun Kingston Mak, et al.. (2025). The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro. Life Science Alliance. 8(6). e202503243–e202503243. 1 indexed citations

O’Reilly, Lorraine A., John Silke, Christopher Angel, et al.. (2025). Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy. Scientific Reports. 15(1). 2555–2555. 4 indexed citations

Lelliott, Emily J., Katherine Ganio, Jessica Michie, et al.. (2024). Intracellular zinc protects tumours from T cell-mediated cytotoxicity. Cell Death and Differentiation. 31(12). 1707–1716. 3 indexed citations

Liu, Lin & John Silke. (2024). AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells. FEBS Journal. 292(5). 990–994. 2 indexed citations

Meier, Pascal, Arnaud J. Legrand, Dieter Adam, & John Silke. (2024). Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer. 24(5). 299–315. 180 indexed citations breakdown →

Silke, John, et al.. (2024). RIPK1 and necroptosis role in premature ageing. Nature Cell Biology. 26(4). 508–509. 1 indexed citations

Schorn, Fabian, Lars M. Schiffmann, Nieves Peltzer, et al.. (2023). cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation. The EMBO Journal. 42(22). e113614–e113614. 11 indexed citations

Mohammed, Ali, Antonio Celentano, Rita Paolini, et al.. (2023). High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death. Cell Death and Disease. 14(7). 453–453. 14 indexed citations

Liu, Zikou, Laura F. Dagley, Kristy Shield‐Artin, et al.. (2021). Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis. The EMBO Journal. 40(23). e103718–e103718. 49 indexed citations

10.

Dagley, Laura F., Che A. Stafford, Fynn M. Hansen, et al.. (2020). A regulatory region on RIPK 2 is required for XIAP binding and NOD signaling activity. EMBO Reports. 21(11). e50400–e50400. 9 indexed citations

11.

Ebert, Gregor, Sash Lopaticki, Matthew T. O’Neill, et al.. (2020). Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection. Cell Reports. 30(13). 4343–4354.e4. 19 indexed citations

12.

Michie, Jessica, Paul A. Beavis, Andrew J. Freeman, et al.. (2019). Antagonism of IAPs Enhances CAR T-cell Efficacy. Cancer Immunology Research. 7(2). 183–192. 77 indexed citations

13.

Murai, Shin, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, et al.. (2019). Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nature Communications. 10(1). 2 indexed citations

14.

Michie, Jessica, Vignesh Narasimhan, Najoua Lalaoui, et al.. (2019). Antagonism of IAPs enhances CAR T cell efficacy. European Journal of Immunology. 49. 1 indexed citations

15.

Leung, Dilys T.H., Maria Alexiadis, John Silke, et al.. (2018). Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors. Molecular Cancer Therapeutics. 18(2). 364–375. 15 indexed citations

16.

Kearney, Conor J., Stephin J. Vervoort, Simon J. Hogg, et al.. (2018). Tumor immune evasion arises through loss of TNF sensitivity. Science Immunology. 3(23). 254 indexed citations

17.

Murai, Shin, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, et al.. (2018). A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nature Communications. 9(1). 1923–1923. 64 indexed citations

18.

Wong, W. Wei‐Lynn, James E. Vince, Najoua Lalaoui, et al.. (2014). cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 123(16). 2562–2572. 128 indexed citations

19.

Read, Stuart H., John Silke, Hitto Kaufmann, et al.. (2004). Apaf-1, Caspase-2 and Caspase-9 accelerate apoptosis, but do not determine whether factor-deprived cells die. Pediatric Research. 55(4).

20.

Verhagen, Anne M., John Silke, Paul G. Ekert, et al.. (2002). HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins. Journal of Biological Chemistry. 277(1). 445–454. 423 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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