John R. Cirrito

21.2k total citations · 10 hit papers
103 papers, 16.1k citations indexed

About

John R. Cirrito is a scholar working on Physiology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, John R. Cirrito has authored 103 papers receiving a total of 16.1k indexed citations (citations by other indexed papers that have themselves been cited), including 81 papers in Physiology, 31 papers in Cellular and Molecular Neuroscience and 22 papers in Neurology. Recurrent topics in John R. Cirrito's work include Alzheimer's disease research and treatments (80 papers), Neuroscience and Neuropharmacology Research (24 papers) and Neuroinflammation and Neurodegeneration Mechanisms (20 papers). John R. Cirrito is often cited by papers focused on Alzheimer's disease research and treatments (80 papers), Neuroscience and Neuropharmacology Research (24 papers) and Neuroinflammation and Neurodegeneration Mechanisms (20 papers). John R. Cirrito collaborates with scholars based in United States, Germany and France. John R. Cirrito's co-authors include David M. Holtzman, Floy R. Stewart, Jin‐Moo Lee, Ping Yan, Kelly R. Bales, Randall J. Bateman, Patrick C. May, Mary Beth Finn, Steven Mennerick and Ronald B. DeMattos and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

John R. Cirrito

102 papers receiving 15.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

2015 1.2k citations David M. Holtzman, John R. Cirrito et al. profile →
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

2009 1.2k citations Miranda M. Lim, Randall J. Bateman et al. Science profile →
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

2005 1.0k citations John R. Cirrito, Mary Beth Finn et al. profile →
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

2012 854 citations Paige E. Cramer, John R. Cirrito et al. Science profile →
Neuronal activity regulates the regional vulnerability to amyloid-β deposition

2011 690 citations Adam W. Bero, Ping Yan et al. profile →
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

2016 571 citations Thomas E. Mahan, John R. Cirrito et al. The Journal of Experimental Medicine profile →
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

2019 537 citations Jerrah K. Holth, Sarah K. Fritschi et al. Science profile →
P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

2005 517 citations John R. Cirrito Journal of Clinical Investigation profile →
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

2012 489 citations Pascal E. Sanchez, Lei Zhu et al. Proceedings of the National Academy of Sciences profile →
Neuronal activity regulates extracellular tau in vivo

2014 422 citations Kaoru Yamada, Jerrah K. Holth et al. The Journal of Experimental Medicine profile →

Peers

Countries citing papers authored by John R. Cirrito

Since Specialization

Citations

This map shows the geographic impact of John R. Cirrito's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John R. Cirrito with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John R. Cirrito more than expected).

Fields of papers citing papers by John R. Cirrito

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John R. Cirrito. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John R. Cirrito. The network helps show where John R. Cirrito may publish in the future.

Co-authorship network of co-authors of John R. Cirrito

This figure shows the co-authorship network connecting the top 25 collaborators of John R. Cirrito. A scholar is included among the top collaborators of John R. Cirrito based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John R. Cirrito. John R. Cirrito is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice 2025 ·Journal of Pharmacology and Experimental Therapeutics ·Gunnar Nordvall, Ping Yan, Lotta Agholme, Johan Lundkvist, Johan Sandin, Henrik Biverstål, Bengt Winblad, Henrik Zetterberg, Rebecka Klintenberg, Mats Ferm, John R. Cirrito, Jin‐Moo Lee	1
2	Capacitive Biosensor for Rapid Detection of Avian (H5N1) Influenza and E. coli in Aerosols 2025 ·ACS Sensors ·(unknown), Xu Meng, Y. Li, (unknown), (unknown), (unknown), John R. Cirrito, Carla M. Yuede, (unknown), Michael D. Vahey, Astha Joshi, (unknown), Adrianus C. M. Boon, Yin-Yuan Huang, Joseph V. Puthussery, Rajan K. Chakrabarty	4
3	circRNAs mediate the effect of chronic lysosomal dysfunction on Alzheimer’s disease pathology 2023 ·Alzheimer s & Dementia ·(unknown), Abdallah M. Eteleeb, Niko-Petteri Nykänen, (unknown), (unknown), Oscar Harari, John R. Cirrito, Mark S. Sands, Bruno A. Benítez	1
4	Real-time environmental surveillance of SARS-CoV-2 aerosols 2023 ·Nature Communications ·Joseph V. Puthussery, (unknown), (unknown), (unknown), Benjamin J. Sumlin, (unknown), (unknown), Nishit Shetty, (unknown), (unknown), David L. Brody, Thomas J. Esparza, Traci L. Bricker, Adrianus C. M. Boon, Carla M. Yuede, John R. Cirrito, Rajan K. Chakrabarty	30
5	Rapid Direct Detection of SARS-CoV-2 Aerosols in Exhaled Breath at the Point of Care 2023 ·ACS Sensors ·(unknown), Nishit Shetty, (unknown), Joseph V. Puthussery, Benjamin J. Sumlin, (unknown), (unknown), (unknown), David L. Brody, Thomas J. Esparza, Jane A. O’Halloran, Rachel M. Presti, Traci L. Bricker, Adrianus C. M. Boon, Carla M. Yuede, John R. Cirrito, Rajan K. Chakrabarty	15
6	Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia 2022 ·Annals of Clinical and Translational Neurology ·Rebecca L. Miller, Dhruva D. Dhavale, (unknown), (unknown), Jialu Liu, Erin Franklin, Chandana Buddhala, Susan K. Loftin, John R. Cirrito, Richard J. Perrin, Nigel J. Cairns, Meghan C. Campbell, Joel S. Perlmutter, Paul T. Kotzbauer	28
7	The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans breakdown → 2019 ·Science ·Jerrah K. Holth, Sarah K. Fritschi, Chanung Wang, Nigel P. Pedersen, John R. Cirrito, Thomas E. Mahan, Mary Beth Finn, Melissa Manis, Joel C. Geerling, Patrick M. Fuller, Brendan P. Lucey, David M. Holtzman	537
8	Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice 2018 ·The Journal of Experimental Medicine ·Angie C.A. Chiang, Stephanie Fowler, (unknown), Susan G. Hilsenbeck, (unknown), John R. Cirrito, Pritam Das, Joanna L. Jankowsky	15
9	microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain 2015 ·Journal of Neuroscience ·Jaekwang Kim, Hyejin Yoon, Takahiro Horie, (unknown), Jessica L. Restivo, Noemí Rotllán, Cristina M. Ramírez, Philip B. Verghese, Masafumi Ihara, Hyang-Sook Hoe, Christine Esau, Carlos Fernández‐Hernando, David M. Holtzman, John R. Cirrito, Koh Ono, Jungsu Kim	102
10	Antisense Reduction of Tau in Adult Mice Protects against Seizures 2013 ·Journal of Neuroscience ·Sarah L. DeVos, (unknown), Guojun Chen, (unknown), Kaoru Yamada, Floy R. Stewart, Dorothy R. Schuler, Susan E. Maloney, David F. Wozniak, Frank Rigo, C. Frank Bennett, John R. Cirrito, David M. Holtzman, Timothy M. Miller	250
11	Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model breakdown → 2012 ·Proceedings of the National Academy of Sciences ·Pascal E. Sanchez, Lei Zhu, Laure Verret, Keith Vossel, Anna G. Orr, John R. Cirrito, Nino Devidze, Kaitlyn Ho, (unknown), Jorge J. Palop, Lennart Mucke	489
12	ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models breakdown → 2012 ·Science ·Paige E. Cramer, John R. Cirrito, Daniel W. Wesson, (unknown), J. Colleen Karlo, (unknown), Brad T. Casali, Jessica L. Restivo, (unknown), Michael J. James, Kurt R. Brunden, Donald A. Wilson, Gary E. Landreth	854
13	Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain 2012 ·Journal of Neuroscience ·Adam W. Bero, Adam Q. Bauer, Floy R. Stewart, Brian R. White, John R. Cirrito, Marcus E. Raichle, Joseph P. Culver, David M. Holtzman	142
14	Opposing Synaptic Regulation of Amyloid-β Metabolism by NMDA ReceptorsIn Vivo 2011 ·Journal of Neuroscience ·Deborah K. Verges, Jessica L. Restivo, (unknown), David M. Holtzman, John R. Cirrito	52
15	Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle breakdown → 2009 ·Science ·(unknown), Miranda M. Lim, Randall J. Bateman, James J. Lee, (unknown), John R. Cirrito, Nobuhiro Fujiki, Seiji Nishino, David M. Holtzman	1152
16	Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-β Peptide, Partial Restoration via γ-Secretase Inhibition 2008 ·Journal of Neuroscience ·Byung Hee Han, Meng‐Liang Zhou, (unknown), Robert P. Brendza, Hans H. Dietrich, Jessica Koenigsknecht-Talboo, John R. Cirrito, Eric Milner, David M. Holtzman, Gregory J. Zipfel	111
17	Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy 2007 ·American Journal Of Pathology ·Wesley Farris, Sonja G. Schütz, John R. Cirrito, Ganesh M. Shankar, Xiaoyan Sun, (unknown), Malcolm A. Leissring, Dominic M. Walsh, Wei Qiao Qiu, David M. Holtzman, Dennis J. Selkoe	126
18	Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism 2006 ·Journal of Neuroscience ·Ke‐Jie Yin, John R. Cirrito, Ping Yan, Xiao Hu, Qingli Xiao, (unknown), Randall J. Bateman, Haowei Song, Fong‐Fu Hsu, John Turk, Jan Xu, Chung Y. Hsu, Jason C. Mills, David M. Holtzman, Jin‐Moo Lee	307
19	Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice 2005 ·Journal of Clinical Investigation ·Robert P. Brendza, Brian J. Bacskai, John R. Cirrito, Kelly Simmons, Jesse Skoch, William E. Klunk, Chester A. Mathis, Kelly R. Bales, Steven M. Paul, Bradley T. Hyman, David M. Holtzman	23
20	Amyloid β and Alzheimer disease therapeutics: the devil may be in the details 2003 ·Journal of Clinical Investigation ·John R. Cirrito, David M. Holtzman	1

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