Karen H. Ashe

22.6k total citations · 9 hit papers
88 papers, 15.7k citations indexed

About

Karen H. Ashe is a scholar working on Physiology, Cellular and Molecular Neuroscience and Molecular Biology. According to data from OpenAlex, Karen H. Ashe has authored 88 papers receiving a total of 15.7k indexed citations (citations by other indexed papers that have themselves been cited), including 75 papers in Physiology, 42 papers in Cellular and Molecular Neuroscience and 29 papers in Molecular Biology. Recurrent topics in Karen H. Ashe's work include Alzheimer's disease research and treatments (74 papers), Neuroscience and Neuropharmacology Research (22 papers) and Nuclear Receptors and Signaling (18 papers). Karen H. Ashe is often cited by papers focused on Alzheimer's disease research and treatments (74 papers), Neuroscience and Neuropharmacology Research (22 papers) and Nuclear Receptors and Signaling (18 papers). Karen H. Ashe collaborates with scholars based in United States, Germany and Japan. Karen H. Ashe's co-authors include Linda Kotilinek, George A. Carlson, Bradley T. Hyman, Michael A. Kuskowski, Linda H. Younkin, Kathleen R. Zahs, Takeshi Kawarabayashi, James Cleary, Marcus A. Westerman and Dennis J. Selkoe and has published in prestigious journals such as Science, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Karen H. Ashe

88 papers receiving 15.4k citations

Hit Papers

Tau Suppression in a Neurodegenerative Mouse Model Improv... 2000 2026 2008 2017 2005 2004 2012 2001 2010 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
    2005 1.5k citations Karen S. SantaCruz, Jada Lewis et al. Science profile →
  2. Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
    2004 1.4k citations James Cleary, Dominic M. Walsh et al. Nature Neuroscience profile →
  3. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
    2012 1.1k citations Alix de Calignon, Manuela Polydoro et al. Neuron profile →
  4. Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease
    2001 881 citations Linda H. Younkin, Karen H. Ashe et al. Journal of Neuroscience profile →
  5. Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
    2010 822 citations Linda Kotilinek, Marianne Grant et al. Neuron profile →
  6. Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
    2000 741 citations Giselle P. Lim, Fu Yang et al. Journal of Neuroscience profile →
  7. The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease
    2002 592 citations Marcus A. Westerman, Ami Mariash et al. Journal of Neuroscience profile →
  8. Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model
    2004 557 citations Giselle P. Lim, Bruce Teter et al. Neuron profile →
  9. Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
    2005 529 citations Martin Ramsden, Linda Kotilinek et al. Journal of Neuroscience profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Karen H. Ashe United States 45 11.9k 5.5k 4.9k 3.9k 3.1k 88 15.7k
Kelly R. Bales United States 66 12.1k 1.0× 6.1k 1.1× 3.9k 0.8× 3.8k 1.0× 2.8k 0.9× 126 17.1k
Dave Morgan United States 47 12.0k 1.0× 5.8k 1.1× 4.0k 0.8× 5.5k 1.4× 2.6k 0.8× 106 17.8k
Salvatore Oddo United States 66 13.6k 1.1× 7.4k 1.3× 5.5k 1.1× 4.2k 1.1× 3.9k 1.2× 115 20.2k
Chad A. Dickey United States 54 10.1k 0.8× 8.2k 1.5× 3.5k 0.7× 3.7k 1.0× 2.2k 0.7× 119 17.9k
Greg M. Cole United States 58 10.7k 0.9× 5.7k 1.0× 3.4k 0.7× 3.2k 0.8× 2.8k 0.9× 100 16.9k
Tara L. Spires‐Jones United Kingdom 64 11.2k 0.9× 5.7k 1.0× 6.1k 1.2× 4.3k 1.1× 2.4k 0.8× 150 16.5k
Steven M. Paul United States 66 11.6k 1.0× 5.6k 1.0× 3.7k 0.8× 3.8k 1.0× 2.6k 0.8× 117 16.4k
Marcia N. Gordon United States 54 14.5k 1.2× 6.9k 1.3× 4.8k 1.0× 6.2k 1.6× 3.2k 1.0× 135 20.7k
Cynthia A. Lemere United States 59 11.6k 1.0× 6.1k 1.1× 3.1k 0.6× 5.9k 1.5× 2.5k 0.8× 130 17.4k
Robert Vassar United States 62 10.9k 0.9× 6.5k 1.2× 4.6k 0.9× 2.8k 0.7× 3.9k 1.2× 135 18.9k

Countries citing papers authored by Karen H. Ashe

Since Specialization
Citations

This map shows the geographic impact of Karen H. Ashe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karen H. Ashe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karen H. Ashe more than expected).

Fields of papers citing papers by Karen H. Ashe

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karen H. Ashe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karen H. Ashe. The network helps show where Karen H. Ashe may publish in the future.

Co-authorship network of co-authors of Karen H. Ashe

This figure shows the co-authorship network connecting the top 25 collaborators of Karen H. Ashe. A scholar is included among the top collaborators of Karen H. Ashe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karen H. Ashe. Karen H. Ashe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Pockes, Steffen, Michael A. Walters, & Karen H. Ashe. (2022). Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias. Translational research. 254. 34–40. 8 indexed citations
3.
Strasser, Jessica M., Gurpreet Singh, Kathryn M. Nelson, et al.. (2022). Characterization of caspase‐2 inhibitors based on specific sites of caspase‐2‐mediated proteolysis. Archiv der Pharmazie. 355(9). e2200095–e2200095. 3 indexed citations
4.
Zhou, Xianxiao, Mei Chen, Weiming Xia, et al.. (2021). Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice. European Journal of Neuroscience. 55(9-10). 2971–2985. 10 indexed citations
5.
Liu, Peng, Benjamin R. Smith, Lisa J. Kemper, et al.. (2020). A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals. Scientific Reports. 10(1). 3869–3869. 24 indexed citations
6.
Ashe, Karen H.. (2020). The biogenesis and biology of amyloid β oligomers in the brain. Alzheimer s & Dementia. 16(11). 1561–1567. 31 indexed citations
7.
Grant, Marianne, Małgorzata Rózga, Gunnar Brinkmalm, et al.. (2019). Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments. PLoS ONE. 14(2). e0212815–e0212815. 11 indexed citations
8.
Benzow, Kellie, Colleen L. Forster, Lisa J. Kemper, et al.. (2019). Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nature Communications. 10(1). 2479–2479. 118 indexed citations
9.
Kemper, Lisa J., Chris Hlynialuk, Kellie Benzow, et al.. (2019). Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice. Journal of Neuroscience. 40(1). 220–236. 14 indexed citations
10.
Liu, Peng, Benjamin R. Smith, Jean Paul Vonsattel, et al.. (2019). A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients. Acta Neuropathologica Communications. 7(1). 111–111. 31 indexed citations
11.
Smith, Benjamin R., Kathryn M. Nelson, Lisa J. Kemper, et al.. (2019). A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta Neuropathologica Communications. 7(1). 124–124. 23 indexed citations
12.
Lesné, Sylvain, Mathew A. Sherman, Marianne Grant, et al.. (2013). Brain amyloid-β oligomers in ageing and Alzheimer’s disease. Brain. 136(5). 1383–1398. 354 indexed citations
13.
Calignon, Alix de, Manuela Polydoro, Marc Suárez‐Calvet, et al.. (2012). Propagation of Tau Pathology in a Model of Early Alzheimer's Disease. Neuron. 73(4). 685–697. 1062 indexed citations breakdown →
14.
Calignon, Alix de, Manuela Polydoro, Marc Suárez‐Calvet, et al.. (2012). Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease. Neuron. 76(2). 461–461. 23 indexed citations
15.
Kotilinek, Linda, Marcus A. Westerman, Qinwen Wang, et al.. (2008). Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity. Brain. 131(3). 651–664. 187 indexed citations
16.
Ashe, Karen H.. (2006). In Search of the Molecular Basis of Memory Loss in Alzheimer Disease. Alzheimer Disease & Associated Disorders. 20(4). 200–201. 5 indexed citations
17.
Ramsden, Martin, Linda Kotilinek, Colleen L. Forster, et al.. (2005). Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L). Journal of Neuroscience. 25(46). 10637–10647. 529 indexed citations breakdown →
18.
SantaCruz, Karen S., Jada Lewis, Tara L. Spires‐Jones, et al.. (2005). Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function. Science. 309(5733). 476–481. 1537 indexed citations breakdown →
19.
Cleary, James, Dominic M. Walsh, J. Hofmeister, et al.. (2004). Natural oligomers of the amyloid-β protein specifically disrupt cognitive function. Nature Neuroscience. 8(1). 79–84. 1417 indexed citations breakdown →
20.
Lim, Giselle P., Fu Yang, Tinyi Chu, et al.. (2000). Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease. Journal of Neuroscience. 20(15). 5709–5714. 741 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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