William E. Klunk

77.6k total citations · 18 hit papers
342 papers, 44.3k citations indexed

About

William E. Klunk is a scholar working on Physiology, Psychiatry and Mental health and Radiology, Nuclear Medicine and Imaging. According to data from OpenAlex, William E. Klunk has authored 342 papers receiving a total of 44.3k indexed citations (citations by other indexed papers that have themselves been cited), including 196 papers in Physiology, 193 papers in Psychiatry and Mental health and 72 papers in Radiology, Nuclear Medicine and Imaging. Recurrent topics in William E. Klunk's work include Alzheimer's disease research and treatments (193 papers), Dementia and Cognitive Impairment Research (191 papers) and Functional Brain Connectivity Studies (53 papers). William E. Klunk is often cited by papers focused on Alzheimer's disease research and treatments (193 papers), Dementia and Cognitive Impairment Research (191 papers) and Functional Brain Connectivity Studies (53 papers). William E. Klunk collaborates with scholars based in United States, United Kingdom and Australia. William E. Klunk's co-authors include Chester A. Mathis, John C. Morris, Bradley T. Hyman, Steven T. DeKosky, David S. Knopman, Clifford R. Jack, Martin N. Rossor, Richard C. Mohs, Jennifer J. Manly and Claudia H. Kawas and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

William E. Klunk

335 papers receiving 43.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

2011 13.8k citations Guy M. McKhann, David S. Knopman et al. Alzheimer s & Dementia profile →
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory

2005 1.6k citations William E. Klunk, Chester A. Mathis et al. profile →
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ ₄₂ in humans

2005 960 citations William E. Klunk, Chester A. Mathis et al. profile →
[ ¹¹ C]PIB in a nondemented population

2006 833 citations William E. Klunk, Chester A. Mathis et al. Neurology profile →
Synthesis and Evaluation of ¹¹C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents

2003 828 citations Chester A. Mathis, Daniel P. Holt et al. profile →
Imaging β-amyloid burden in aging and dementia

2007 813 citations William E. Klunk, Chester A. Mathis et al. Neurology profile →
Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

2008 799 citations Howard Aizenstein, Julie C. Price et al. profile →
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

2008 758 citations Val J. Lowe, David S. Knopman et al. profile →
The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

2014 690 citations William E. Klunk, Julie C. Price et al. Alzheimer s & Dementia profile →
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

2008 681 citations Miloš D. Ikonomović, William E. Klunk et al. profile →
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

2011 638 citations Victor L. Villemagne, Pierrick Bourgeat et al. profile →
Brain Imaging in Alzheimer Disease

2012 623 citations William E. Klunk et al. profile →
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

2009 618 citations Eric M. Reiman, Kewei Chen et al. Proceedings of the National Academy of Sciences profile →
-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

2007 616 citations Chester A. Mathis, William E. Klunk et al. profile →
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B

2005 544 citations Julie C. Price, William E. Klunk et al. profile →
Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation.

1989 538 citations William E. Klunk et al. profile →
11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

2010 536 citations Martin N. Rossor, William E. Klunk et al. profile →
Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue

2015 450 citations William E. Klunk, Chester A. Mathis et al. profile →

Peers

Countries citing papers authored by William E. Klunk

Since Specialization

Citations

This map shows the geographic impact of William E. Klunk's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William E. Klunk with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William E. Klunk more than expected).

Fields of papers citing papers by William E. Klunk

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William E. Klunk. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William E. Klunk. The network helps show where William E. Klunk may publish in the future.

Co-authorship network of co-authors of William E. Klunk

This figure shows the co-authorship network connecting the top 25 collaborators of William E. Klunk. A scholar is included among the top collaborators of William E. Klunk based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William E. Klunk. William E. Klunk is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Effect of blood collection tube containing protease inhibitors on the pre‐analytical stability of Alzheimer's disease plasma biomarkers 2024 ·Journal of Neurochemistry ·(unknown), Xuemei Zeng, (unknown), Anuradha Sehrawat, (unknown), James Boslett, William E. Klunk, Tharick A. Pascoal, Victor L. Villemagne, Ann D. Cohen, (unknown), Nathan A. Yates, Thomas K. Karikari	3
2	Large‐scale validation of an improved and resource‐saving immunoprecipitation‐mass spectrometry assay for plasma amyloid‐β biomarkers in Alzheimer's disease 2024 ·Alzheimer s & Dementia ·(unknown), Xuemei Zeng, (unknown), Anuradha Sehrawat, (unknown), William E. Klunk, Miloš D. Ikonomović, Tharick A. Pascoal, Kirk I. Erickson, Victor L. Villemagne, Ann D. Cohen, Nathan A. Yates, Irene Esteban‐Cornejo, Oscar L. López, Beth E. Snitz, Sarah Berman, Robert A. Sweet, Thomas K. Karikari	1
3	Longitudinal multicenter head‐to‐head harmonization of tau‐PET tracers: an overview of the HEAD study cohort 2024 ·Alzheimer s & Dementia ·Firoza Z Lussier, Guilherme Povala, (unknown), (unknown), (unknown), Debra Fine, (unknown), (unknown), Belén Pascual, Brian A. Gordon, Val J. Lowe, Hwamee Oh, David N. Soleimani‐Meigooni, Pedro Rosa‐Neto, Dana Tudorascu, William J. Jagust, William E. Klunk, Suzanne L. Baker, Tharick A. Pascoal	1
4	Universal tau PET scale (Uniτ) – The HEAD Study 2024 ·Alzheimer s & Dementia ·Guilherme Povala, (unknown), Bruna Bellaver, Firoza Z Lussier, (unknown), Pâmela C.L. Ferreira, Bruno Zatt, Dana Tudorascu, Brian J. Lopresti, William J. Jagust, William E. Klunk, Val J. Lowe, David N. Soleimani‐Meigooni, Hwamee Oh, Belén Pascual, Brian A. Gordon, Pedro Rosa‐Neto, Tharick A. Pascoal	1
5	Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology 2024 ·Alzheimer s & Dementia ·Mahnaz Shekari, David Vállez García, Lyduine E. Collij, Daniele Altomare, Fiona Heeman, Hugh Pemberton, (unknown), Santiago Bullich, Christopher Buckley, Andrew Stephens, Gill Farrar, Giovanni B. Frisoni, William E. Klunk, Frederik Barkhof, Juan Domingo Gispert	14
6	Creating Universal Tau PET Scale (Uniτ) Parametric Images – The HEAD Study 2024 ·Alzheimer s & Dementia ·Guilherme Povala, (unknown), Bruna Bellaver, Firoza Z Lussier, (unknown), Pâmela C.L. Ferreira, (unknown), Bruno Zatt, Dana Tudorascu, William J. Jagust, William E. Klunk, Val J. Lowe, David N. Soleimani‐Meigooni, Hwamee Oh, Belén Pascual, Brian A. Gordon, Pedro Rosa‐Neto, Suzanne L. Baker, Tharick A. Pascoal	1
7	AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome 2023 ·Alzheimer s & Dementia ·Sigan L. Hartley, Benjamin L. Handen, Dana Tudorascu, Laisze Lee, Annie Cohen, Emily K. Schworer, (unknown), Matthew Zammit, William E. Klunk, Charles M. Laymon, Davneet Minhas, (unknown), Shahid Zaman, Beau M. Ances, Gregory M. Preboske, Bradley T. Christian	7
8	Biostatistical Estimation of Tau Threshold Hallmarks (BETTH) Algorithm for Human Tau PET Imaging Studies 2023 ·Journal of Nuclear Medicine ·Alexandra Gogola, Brian J. Lopresti, Dana Tudorascu, Beth E. Snitz, Davneet Minhas, Vincent Doré, Miloš D. Ikonomović, C. Elizabeth Shaaban, (unknown), Pierrick Bourgeat, N. Scott Mason, Howard Aizenstein, Chester A. Mathis, William E. Klunk, Christopher C. Rowe, Oscar L. López, Ann D. Cohen, Victor L. Villemagne, (unknown)	8
9	Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome 2022 ·Neurobiology of Aging ·Stephanie Brown, Elijah Mak, I. C. H. Clare, (unknown), (unknown), (unknown), Elizabeth C. Jones, Young T. Hong, Tim D. Fryer, Jonathan Coles, Franklin I. Aigbirhio, Dana Tudorascu, Annie Cohen, Bradley T. Christian, Benjamin L. Handen, William E. Klunk, David Menon, Peter J. Nestor, Anthony Holland, Shahid Zaman	4
10	Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome 2021 ·Neurobiology of Aging ·(unknown), (unknown), (unknown), Matthew Zammit, Andrew L. Alexander, Bradley T. Christian, Benjamin L. Handen, Annie Cohen, William E. Klunk, Charles M. Laymon, Beau M. Ances, David T. Plante, Ozioma C. Okonkwo, Sigan L. Hartley	27
11	Leisure Activity, Brain β‐amyloid, and Episodic Memory in Adults with Down Syndrome 2019 ·Developmental Neurobiology ·Iulia Mihaila, Benjamin L. Handen, Bradley T. Christian, Patrick J. Lao, Karly Alex Cody, William E. Klunk, Dana Tudorascu, Annie Cohen, Ozioma C. Okonkwo, Sigan L. Hartley	13
12	Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging 2018 ·Digital Commons@Becker (Washington University School of Medicine) ·Qi Yan, Kwangsik Nho, Jorge L. Del‐Aguila, Xingbin Wang, Shannon L. Risacher, Kang-Hsien Fan, Beth E. Snitz, Howard Aizenstein, Chester A. Mathis, Oscar L. López, F. Yesim Demirci, Eleanor Feingold, William E. Klunk, Andrew J. Saykin, Carlos Cruchaga, M. Ilyas Kamboh	1
13	Comparison of longitudinal Aβ in nondemented elderly and Down syndrome 2018 ·Neurobiology of Aging ·Dana Tudorascu, Stewart Anderson, Davneet Minhas, (unknown), Diane Comer, Patrick J. Lao, Sigan L. Hartley, Charles M. Laymon, Beth E. Snitz, Brian J. Lopresti, Sterling C. Johnson, Julie C. Price, Chester A. Mathis, Howard Aizenstein, William E. Klunk, Benjamin L. Handen, Brad T. Christian, Ann D. Cohen	12
14	NUMBER OF STEPS NEEDED FOR RELIABLE GAIT VARIABILITY MEASUREMENT 2016 ·The Gerontologist ·Victoria N. Poole, (unknown), Brad Manor, Ikechukwu Iloputaife, Michael Esterman, Lewis A. Lipsitz, Neelesh K. Nadkarni, Subashan Perera, Beth E. Snitz, Julie C. Price, Jeff D. Williamson, Steven T. DeKosky, William E. Klunk, Oscar L. López	10
15	The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup 2011 ·Alzheimer s & Dementia ·Guy M. McKhann, David S. Knopman, Howard Chertkow, Bradley T. Hyman, Claudia H. Kawas, William E. Klunk, Walter J. Koroshetz, Jennifer J. Manly, Richard C. Mohs, John C. Morris, Martin N. Rossor, (unknown), Creighton H. Phelps	199
16	Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [ ¹¹ C]PiB 2010 ·Neurology ·Susan M. Resnick, Jitka Sojkova, Zhou Yu, Youzhong An, (unknown), Daniel P. Holt, Robert F. Dannals, Chester A. Mathis, William E. Klunk, Luigi Ferrucci, Michael A. Kraut, Dean F. Wong	212
17	Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease breakdown → 2009 ·Proceedings of the National Academy of Sciences ·Eric M. Reiman, Kewei Chen, Xiaofen Liu, Daniel Bandy, Meixiang Yu, Wendy Lee, Napatkamon Ayutyanont, Jennifer Keppler, Stephanie Reeder, Jessica B. Langbaum, Gene E. Alexander, William E. Klunk, Chester A. Mathis, Julie C. Price, Howard Aizenstein, Steven T. DeKosky, Richard J. Caselli	618
18	Imaging Alzheimer Pathology in Late-Life Depression With PET and Pittsburgh Compound-B 2008 ·Alzheimer Disease & Associated Disorders ·Meryl A. Butters, William E. Klunk, Chester A. Mathis, Julie C. Price, Scott K. Ziolko, Jessica A. Hoge, Nicholas D. Tsopelas, Brian J. Lopresti, Charles F. Reynolds, Steven T. DeKosky, Carolyn C. Meltzer	107
19	The Role of Biomarkers in Clinical Trials for Alzheimer Disease 2006 ·Alzheimer Disease & Associated Disorders ·Leon J. Thal, Kejal Kantarci, Eric M. Reiman, William E. Klunk, Michael W. Weiner, Henrik Zetterberg, Douglas Galasko, Domenico Praticò, Sue Griffin, Dale Schenk, Eric Siemers	179
20	Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice 2005 ·Journal of Clinical Investigation ·Robert P. Brendza, Brian J. Bacskai, John R. Cirrito, Kelly Simmons, Jesse Skoch, William E. Klunk, Chester A. Mathis, Kelly R. Bales, Steven M. Paul, Bradley T. Hyman, David M. Holtzman	23

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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