Edward B. Lee

26.7k citations

208 papers · 10.6k · 4 hit papers · h-index 53

Impact in

Neurology top 0.1%
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
Physiology top 0.2%
- Alzheimer's disease research and treatments

Papers in

Physiology 108
- Alzheimer's disease research and treatments 98
Neurology 99
- Parkinson's Disease Mechanisms and Treatments 67
- Amyotrophic Lateral Sclerosis Research 42
- Neurological diseases and metabolism 21
- Neuroinflammation and Neurodegeneration Mechanisms 12

Co-authors: John Q. Trojanowski (109 shared papers)Virginia M.‐Y. Lee (58 shared papers)David J. Irwin (95 shared papers)Vivianna M. Van Deerlin (50 shared papers)Murray Grossman (71 shared papers)Linda K. Kwong (10 shared papers)Corey T. McMillan (58 shared papers)John Robinson (29 shared papers)
Journals: Acta Neuropathologica (30 papers)Brain (14 papers)Alzheimer s & Dementia (14 papers)Journal of Neuropathology & Experimental Neurology (10 papers)Acta Neuropathologica Communications (9 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

Edward B. Lee

199 papers receiving 10.5k citations

Edward B. Lee's Hit Papers

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Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology 2024 · 73 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2024 Nature Biotechnology
2021 Nature Methods
2013 Annals of Neurology
2011 Nature reviews. Neuroscience

Peers

Countries citing papers authored by Edward B. Lee

Since Specialization

Citations

This map shows the geographic impact of Edward B. Lee's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward B. Lee with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward B. Lee more than expected).

Fields of papers citing papers by Edward B. Lee

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward B. Lee. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward B. Lee. The network helps show where Edward B. Lee may publish in the future.

Co-authors

The 25 scholars most cited alongside Edward B. Lee, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Edward B. Lee Line = papers co-authored together Edward B. Lee links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 208 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis Annals of Neurology ·Johannes Brettschneider, Kelly Del Tredici, Jon B. Toledo, John Robinson, David J. Irwin, Murray Grossman, EunRan Suh, Vivianna M. Van Deerlin, Elisabeth McCarty Wood, Young Min Baek, Linda K. Kwong, Edward B. Lee, Lauren Elman, Leo McCluskey, Lubin Fang, Simone Feldengut, Albert C. Ludolph, Virginia M.‐Y. Lee, Heiko Braak, John Q. Trojanowski Hit paper breakdown →	2013	750
2	Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration Nature reviews. Neuroscience ·Edward B. Lee, Virginia M.‐Y. Lee, John Q. Trojanowski Hit paper breakdown →	2011	515
3	SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network Nature Methods ·Jian Hu, Xiangjie Li, Kyle Coleman, Amelia Schroeder, Nan Ma, David J. Irwin, Edward B. Lee, Russell T. Shinohara, Mingyao Li Hit paper breakdown →	2021	450
4	Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies Acta Neuropathologica ·Manuela Neumann, Linda K. Kwong, Edward B. Lee, Elisabeth Kremmer, Andrew Flatley, Yan Xu, Mark S. Forman, Dirk Troost, Hans A. Kretzschmar, John Q. Trojanowski, Virginia M.‐Y. Lee	2009	445
5	Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice Journal of Clinical Investigation ·Lionel M. Igaz, Linda K. Kwong, Edward B. Lee, Alice Chen‐Plotkin, Eric A. Swanson, Travis L. Unger, Joe Malunda, Yan Xu, Matthew J. Winton, John Q. Trojanowski, Virginia M.‐Y. Lee	2011	324
6	Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model Proceedings of the National Academy of Sciences ·Bin Zhang, Arpita Maiti, Sharon Shively, Fara Lakhani, Gaye McDonald-Jones, Jennifer Bruce, Edward B. Lee, Sharon X. Xie, Sonali Joyce, Chi Li, Philip M. Toleikis, Virginia M.‐Y. Lee, John Q. Trojanowski	2004	312
7	Targeting Amyloid-β Peptide (Aβ) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in Aβ Precursor Protein (APP) Transgenic Mice Journal of Biological Chemistry ·Edward B. Lee, Lewis Z. Leng, Bin Zhang, Linda K. Kwong, John Q. Trojanowski, Ted Abel, Virginia M.‐Y. Lee	2005	231
8	TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord Acta Neuropathologica ·Johannes Brettschneider, Kimihito Arai, Kelly Del Tredici, Jon B. Toledo, John Robinson, Edward B. Lee, Satoshi Kuwabara, Kazumoto Shibuya, David J. Irwin, Lubin Fang, Vivianna M. Van Deerlin, Lauren Elman, Leo McCluskey, Albert C. Ludolph, Virginia M.‐Y. Lee, Heiko Braak, John Q. Trojanowski	2014	201
9	Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine Acta Neuropathologica ·David J. Irwin, Nigel J. Cairns, Murray Grossman, Corey T. McMillan, Edward B. Lee, Vivianna M. Van Deerlin, Virginia M.‐Y. Lee, John Q. Trojanowski	2014	200
10	Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited Journal of Neuroscience ·Orly Lazarov, Gerardo Morfini, Edward B. Lee, Mohamed H. Farah, Anita Szodorai, Scott R. DeBoer, Vassilis E. Koliatsos, Stefan Kins, Virginia M.‐Y. Lee, Philip C. Wong, Donald L. Price, Scott T. Brady, Sangram S. Sisodia	2005	180
11	Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies Acta Neuropathologica ·Mark Yarchoan, Jon B. Toledo, Edward B. Lee, Zoe Arvanitakis, Hala Kazi, Li-Ying Han, Natalia Louneva, Virginia M.‐Y. Lee, Sangwon F. Kim, John Q. Trojanowski, Steven E. Arnold	2014	164
12	Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo Nature Communications ·Sílvia Porta, Yan Xu, Clark R. Restrepo, Linda K. Kwong, Bin Zhang, Hannah J. Brown, Edward B. Lee, John Q. Trojanowski, Virginia M.‐Y. Lee	2018	160
13	Olfactory epithelium amyloid‐β and paired helical filament‐tau pathology in Alzheimer disease Annals of Neurology ·Steven E. Arnold, Edward B. Lee, Paul J. Moberg, Lauren Stutzbach, Hala Kazi, Liying Han, Virginia M.‐Y. Lee, John Q. Trojanowski	2009	160
14	TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss Neuron ·Rosa Chiara Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John Robinson, Edward B. Lee, Jamie Rose, Stanley H. Appel, Virginia M.‐Y. Lee, John Q. Trojanowski, Tara L. Spires‐Jones, Paul E. Schulz, Lawrence Rajendran	2017	157
15	Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration Acta Neuropathologica ·Edward B. Lee, Sílvia Porta, G. Michael Baer, Yan Xu, EunRan Suh, Linda K. Kwong, Lauren Elman, Murray Grossman, Virginia M.‐Y. Lee, David J. Irwin, Vivianna M. Van Deerlin, John Q. Trojanowski	2017	156
16	APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease Acta Neuropathologica ·Aivi T. Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A. Azevedo, EunRan Suh, Vivianna M. Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B. Lee	2020	147
17	Deep clinical and neuropathological phenotyping of Pick disease Annals of Neurology ·David J. Irwin, Johannes Brettschneider, Corey T. McMillan, Felicia Cooper, Christopher A. Olm, Steven E. Arnold, Vivianna M. Van Deerlin, William W. Seeley, Bruce L. Miller, Edward B. Lee, Virginia M.‐Y. Lee, Murray Grossman, John Q. Trojanowski	2015	147
18	Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion Acta Neuropathologica ·Johannes Brettschneider, Vivianna M. Van Deerlin, John Robinson, Linda K. Kwong, Edward B. Lee, Yousuf Ali, Nathaniel Safren, Mervyn J. Monteiro, Jon B. Toledo, Lauren Elman, Leo McCluskey, David J. Irwin, Murray Grossman, Laura Molina‐Porcel, Virginia M.‐Y. Lee, John Q. Trojanowski	2012	143
19	Modulation of Nuclear Factor-κB Activity by Indomethacin Influences Aβ Levels but Not Aβ Precursor Protein Metabolism in a Model of Alzheimer's Disease American Journal Of Pathology ·Syaun Sung, Hengxuan Yang, Kunihiro Uryu, Edward B. Lee, Lei Zhao, Diana W. Shineman, John Q. Trojanowski, Virginia M.‐Y. Lee, Domenico Praticò	2004	137
20	Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology Annals of Neurology ·Roy H. Hamilton, Sunil V. Patel, Edward B. Lee, Eric M. Jackson, Joanna Lopinto, Steven E. Arnold, Christopher M. Clark, Anuj Basil, Leslie M. Shaw, Sharon X. Xie, M. Sean Grady, John Q. Trojanowski	2010	135

About Edward B. Lee

Edward B. Lee is a scholar working on Physiology, Neurology, Psychiatry and Mental health, Molecular Biology and Neurology, having authored 208 papers that have together received 10.6k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (98 papers), Parkinson's Disease Mechanisms and Treatments (67 papers), Dementia and Cognitive Impairment Research (55 papers), Amyotrophic Lateral Sclerosis Research (42 papers), Neurological diseases and metabolism (21 papers), Neurogenetic and Muscular Disorders Research (17 papers), Neuroinflammation and Neurodegeneration Mechanisms (12 papers) and Advanced Neuroimaging Techniques and Applications (11 papers). The work is most often cited by research in Neurology (4.9k citations), Neurology (1.9k citations), Physiology (4.2k citations), Genetics (1.6k citations) and Psychiatry and Mental health (1.4k citations). Edward B. Lee has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include John Q. Trojanowski, Virginia M.‐Y. Lee, David J. Irwin, Vivianna M. Van Deerlin, Murray Grossman, Linda K. Kwong, Corey T. McMillan, John Robinson, Sharon X. Xie and EunRan Suh. Their work appears in journals such as Acta Neuropathologica, Brain, Alzheimer s & Dementia, Journal of Neuropathology & Experimental Neurology and Acta Neuropathologica Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Edward B. Lee

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Edward B. Lee

Edward B. Lee's Hit Papers

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Fields of papers citing papers by Edward B. Lee

All Works

About Edward B. Lee

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