Howard A. Young

38.3k total citations · 9 hit papers
369 papers, 31.4k citations indexed

About

Howard A. Young is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Howard A. Young has authored 369 papers receiving a total of 31.4k indexed citations (citations by other indexed papers that have themselves been cited), including 232 papers in Immunology, 127 papers in Molecular Biology and 104 papers in Oncology. Recurrent topics in Howard A. Young's work include Immune Cell Function and Interaction (140 papers), T-cell and B-cell Immunology (74 papers) and Cytokine Signaling Pathways and Interactions (64 papers). Howard A. Young is often cited by papers focused on Immune Cell Function and Interaction (140 papers), T-cell and B-cell Immunology (74 papers) and Cytokine Signaling Pathways and Interactions (64 papers). Howard A. Young collaborates with scholars based in United States, Japan and Italy. Howard A. Young's co-authors include John R. Ortaldo, Kenneth J. Hardy, Edward M. Scolnick, Jay H. Bream, Joost J. Oppenheim, Thomas Y. Shih, Tomoaki Hoshino, Robert H. Wiltrout, Paritosh Ghosh and William J. Murphy and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Howard A. Young

364 papers receiving 30.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 1.9k citations Howard A. Young et al. profile →
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 858 citations Howard A. Young, Giorgio Trinchieri et al. The Journal of Experimental Medicine profile →
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN- gamma production.

1988 825 citations Howard A. Young et al. The Journal of Immunology profile →
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

2000 719 citations Howard A. Young et al. profile →
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 644 citations Howard A. Young et al. profile →
Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 617 citations Patrick Hwu, Réjean Lapointe et al. The Journal of Immunology profile →
Cytokines: From Clinical Significance to Quantification

2021 569 citations Howard A. Young et al. profile →
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 566 citations Howard A. Young et al. profile →
Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

2018 343 citations Heekyong Bae, Howard A. Young et al. profile →

Peers

Countries citing papers authored by Howard A. Young

Since Specialization

Citations

This map shows the geographic impact of Howard A. Young's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Howard A. Young with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Howard A. Young more than expected).

Fields of papers citing papers by Howard A. Young

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Howard A. Young. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Howard A. Young. The network helps show where Howard A. Young may publish in the future.

Co-authorship network of co-authors of Howard A. Young

This figure shows the co-authorship network connecting the top 25 collaborators of Howard A. Young. A scholar is included among the top collaborators of Howard A. Young based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Howard A. Young. Howard A. Young is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Dietary therapy of murine primary biliary cholangitis induces hepatocellular steatosis: A cautionary tale 2024 ·Liver International ·Weici Zhang, (unknown), Patrick S.C. Leung, Koichi Tsuneyama, (unknown), Manuel Rojas, Luke S. Heuer, William M. Ridgway, Aftab A. Ansari, Howard A. Young, Charles R. Mackay, M. Eric Gershwin	2
2	Chronic Low-Level IFN-γ Expression Disrupts Mitochondrial Complex I Activity in Renal Macrophages: An Early Mechanistic Driver of Lupus Nephritis Pathogenesis 2024 ·International Journal of Molecular Sciences ·(unknown), Su‐Kyung Shin, (unknown), (unknown), (unknown), Howard A. Young, Eun‐Young Kwon	1
3	Systemic inflammatory Th1 cytokines during Trypanosoma cruzi infection disrupt the typical anatomical cell distribution and phenotypic/functional characteristics of various cell subsets within the thymus 2024 ·Microbes and Infection ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Laura Fozzatti, (unknown), Howard A. Young, Deborah L. Hodge, Fabio M. Cerbán, Cinthia Carolina Stempin, Ana Rosa Pérez, María Cecilia Rodriguez‐Galán	0
4	IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells 2023 ·The Journal of Immunology ·Maria Cimpean, Molly P. Keppel, Anastasiia Gainullina, Changxu Fan, (unknown), (unknown), Amanda Swain, Ana Kolicheski, (unknown), Howard A. Young, Ting Wang, Maxim N. Artyomov, Megan A. Cooper	5
5	Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development 2019 ·PLoS Pathogens ·(unknown), Fabio M. Cerbán, (unknown), Deborah L. Hodge, Jimena Tosello, Eva V. Acosta Rodríguez, (unknown), Adriana Gruppi, (unknown), Howard A. Young, María Cecilia Rodriguez‐Galán	20
6	Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells 2018 ·Nature Immunology ·Fiamma Salerno, Sander Engels, Maartje van den Biggelaar, Floris P. J. van Alphen, Aurélie Guislain, (unknown), Deborah L. Hodge, Sarah E. Bell, Jan Paul Medema, Marieke von Lindern, Martin Turner, Howard A. Young, Monika C. Wolkers	85
7	The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex‐biased autoimmunity 2017 ·Hepatology ·Heekyong Bae, Deborah L. Hodge, Guoxiang Yang, Patrick S.C. Leung, Sathi Babu Chodisetti, Julio C. Valencia, Michael Sanford, (unknown), Ziaur S. M. Rahman, Koichi Tsuneyama, Gary L. Norman, M. Eric Gershwin, Howard A. Young	46
8	NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay 2015 ·Cancer Research ·Lisa A. Ridnour, Robert Y.S. Cheng, Jonathan M. Weiss, Sukhbir Kaur, David R. Soto‐Pantoja, Debashree Basudhar, Julie L. Heinecke, Charles A. Stewart, William DeGraff, Anastasia L. Sowers, Angela Thetford, Aparna H. Kesarwala, David D. Roberts, Howard A. Young, James B. Mitchell, Giorgio Trinchieri, Robert H. Wiltrout, David A. Wink	35
9	Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias 2009 ·Cancer Research ·Deborah L. Hodge, Jun Yang, Matthew D. Buschman, Paul Schaughency, (unknown), (unknown), Yili Yang, Ram Savan, Jeff Subleski, Xiao-Ming Yin, Thomas P. Loughran, Howard A. Young	50
10	The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis 2007 ·The Journal of Experimental Medicine ·Zachary Roberts, Nadège Goutagny, Pin‐Yu Perera, Hiroki Kato, Himanshu Kumar, Taro Kawai, Shizuo Akira, Ram Savan, David Van Echo, Katherine A. Fitzgerald, Howard A. Young, Lai‐Ming Ching, Stefanie N. Vogel	127
11	The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever 2007 ·Genome biology ·Kathleen Rubins, Lisa E. Hensley, Victoria Wahl‐Jensen, (unknown), Howard A. Young, Douglas S. Reed, Peter B. Jahrling, Patrick O. Brown, David A. Relman, (unknown)	80
12	Role of Natural Killer Cells in Innate Protection against Lethal Ebola Virus Infection 2004 ·The Journal of Experimental Medicine ·Kelly L. Warfield, Jeremy G. Perkins, Dana L. Swenson, Emily M. Deal, Catharine M. Bosio, M. Javad Aman, Wayne M. Yokoyama, Howard A. Young, Sina Bavari	113
13	Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice 2003 ·Journal of Clinical Investigation ·Mahtab Moayeri, Diana C. Haines, Howard A. Young, Stephen H. Leppla	246
14	Redox-active Protein Thioredoxin Prevents Proinflammatory Cytokine- or Bleomycin-induced Lung Injury 2003 ·American Journal of Respiratory and Critical Care Medicine ·Tomoaki Hoshino, Hajime Nakamura, Masaki Okamoto, Seiya Kato, Shinichi Araya, (unknown), Kōtaro Ōizumi, Howard A. Young, Hisamichi Aizawa, Junji Yodoi	131
15	Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization 2001 ·Journal of Clinical Investigation ·Alessandra Mazzoni, Howard A. Young, Jessica H. Spitzer, Alberto Visintin, David M. Segal	255
16	Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization 2001 ·Journal of Clinical Investigation ·Alessandra Mazzoni, Howard A. Young, Jessica H. Spitzer, Alberto Visintin, David M. Segal	271
17	Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes 2000 ·European Journal of Immunology ·Réjean Lapointe, John Toso, Cherié Butts, Howard A. Young, Patrick Hwu	76
18	The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element 1996 ·Molecular and Cellular Biology ·Jianping Ye, Marco Cippitelli, (unknown), John R. Ortaldo, Howard A. Young	157
19	Characterization of Interleukin 2 and Phorbol Myristate Acetate Augmentation of Expression of Transfected Human Interferon-γ Genomic DNA 1988 ·Journal of Interferon Research ·Howard A. Young, (unknown), Elizabeth J. Kovacs, (unknown), Francis W. Ruscetti	9
20	Detection of c- rel -Related Transcripts in Mouse Hematopoietic Tissues, Fractionated Lymphocyte Populations, and Cell Lines 1987 ·Molecular and Cellular Biology ·Elise Brownell, Bonnie J. Mathieson, Howard A. Young, (unknown), James N. Ihle, Nancy R. Rice	10

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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