Timothy A. Springer

110.3k citations

536 papers · 91.5k indexed · 42 hit papers · h-index 153

Impact in

Immunology and Allergy top 0.01%
- Cell Adhesion Molecules Research
Immunology top 0.01%
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction

Papers in

Immunology and Allergy 329
- Cell Adhesion Molecules Research 329
Immunology 232
- T-cell and B-cell Immunology 69
- Immunotherapy and Immune Responses 60
- Immune Cell Function and Interaction 52

Co-authors: Michael L. Dustin Christopher V. Carman Steven D. Marlin Junichi Takagi Michael B. Lawrence Donald E. Staunton Robert Rothlein Michael Diamond
Journals: The Journal of Immunology (73 papers)Proceedings of the National Academy of Sciences (65 papers)Journal of Biological Chemistry (54 papers)The Journal of Cell Biology (30 papers)The Journal of Experimental Medicine (28 papers)
Partner nations: United States Germany Japan

In The Last Decade

Timothy A. Springer

534 papers receiving 88.8k citations

Hit Papers

15 papers align trajectories log scale

von Willebrand factor, Jedi knight of the bloodstream 2014 · 321 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2014 Blood
2011 Nature
2007 Annual Review of Immunology
2004 Nature
2003 Science
2002 Cell
1999 Immunity
1998 Proceedings of the National Academy of Sciences
1997 The Journal of Experimental Medicine
1997 Proceedings of the National Academy of Sciences
1996 The Journal of Experimental Medicine
1996 Journal of Clinical Investigation
1995 Annual Review of Physiology
1995 Nature
1995 The Journal of Cell Biology
1994 Proceedings of the National Academy of Sciences
1991 Cell
1991 Cell
1990 Cell
1990 Nature
1990 Immunological Reviews
1990 The Journal of Cell Biology
1989 Nature
1989 Nature
1988 The Journal of Cell Biology
1988 The Journal of Immunology
1988 Nature
1988 The Journal of Experimental Medicine
1988 Cell
1987 Annual Review of Medicine
1987 Annual Review of Immunology
1987 Cell
1986 The Journal of Immunology
1986 The Journal of Immunology
1985 The Journal of Infectious Diseases
1983 The Journal of Immunology
1983 The Journal of Experimental Medicine
1982 The Journal of Experimental Medicine
1982 Proceedings of the National Academy of Sciences
1981 The Journal of Immunology
1979 European Journal of Immunology
1978 European Journal of Immunology

Peers

Countries citing papers authored by Timothy A. Springer

Since Specialization

Citations

This map shows the geographic impact of Timothy A. Springer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Timothy A. Springer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Timothy A. Springer more than expected).

Fields of papers citing papers by Timothy A. Springer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Timothy A. Springer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Timothy A. Springer. The network helps show where Timothy A. Springer may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Timothy A. Springer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Timothy A. Springer Line = papers co-authored together Timothy A. Springer links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy Cancer Immunology Research ·Aiping Jiang, Qin Yan, Timothy A. Springer	2022	8
2	Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging Blood ·Giulia D’Annunzio, Yan Jiang, Darren Yang, Timothy A. Springer, Wesley P. Wong	2022	11
3	Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange Blood ·عمرو محمد رضا عبد الغنی, Larry Toronto, Timothy A. Springer, Alan Brown	2022	19
4	Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association Blood ·Hongxia Fu, Yan Jiang, Wesley P. Wong, Timothy A. Springer	2021	11
5	Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP eLife ·Dennis Klug, Sarah Goellner, Jessica Kehrer, Julia M. Sattler, Kadali Vara Prasad, Mirko Singer, Chafen Lu, Timothy A. Springer, Friedrich Frischknecht	2020	13
6	The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis Blood ·Xianchi Dong, Nina C. Leksa, Ekta Seth Chhabra, Joseph W. Arndt, Qi Lü, Kevin E. Knockenhauer, Robert Peters, Timothy A. Springer	2019	56
7	Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation The EMBO Journal ·Viet Q. Le, Roxana E. Iacob, Yuan Tian, W. J. Zhong, Justin Jackson, Yang Su, Bo Zhao, John R. Engen, Michelle Pirruccello, Timothy A. Springer	2018	27
8	Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions Proceedings of the National Academy of Sciences ·Vinay Swaminathan, Joseph Mathew Kalappurakkal, Shalin B. Mehta, Pontus Nordenfelt, Travis I. Moore, Nobuyasu Koga, David Baker, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Timothy A. Springer, Clare M. Waterman	2017	92
9	Distinct recognition of complement iC3b by integrins α _X β ₂ and α _M β ₂ Proceedings of the National Academy of Sciences ·Shutong Xu, Jianchuan Wang, Jia‐Huai Wang, Timothy A. Springer	2017	39
10	Flow-induced elongation of von Willebrand factor precedes tension-dependent activation Nature Communications ·Hongxia Fu, Yan Jiang, Darren Yang, Friedrich Scheiflinger, Wesley P. Wong, Timothy A. Springer	2017	150
11	Structures of the Toxoplasma gliding motility adhesin Proceedings of the National Academy of Sciences ·Gaojie Song, Timothy A. Springer	2014	31
12	Structure-Guided Design of a High-Affinity Platelet Integrin α _IIb β ₃ Receptor Antagonist That Disrupts Mg ²⁺ Binding to the MIDAS Science Translational Medicine ·Jieqing Zhu, Won Suk Choi, Sarah Hirsch, Ana Negri, Jianghai Zhu, Мария Андреевна Понятая, Jihong Li, Min Shen, Wenwei Huang, Daniel W. Bougie, Mark Rasmussen, Richard H. Aster, Craig J. Thomas, Marta Filizola, Timothy A. Springer, Barry S. Coller	2012	73
13	Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling Blood ·Jieqing Zhu, Christopher V. Carman, Minsoo Kim, Motomu Shimaoka, Timothy A. Springer, Bing‐Hao Luo	2007	101
14	Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity Proceedings of the National Academy of Sciences ·Moonsoo M. Jin, Guang‐Ling Song, Christopher V. Carman, Yong‐Sung Kim, Nathan S. Astrof, Motomu Shimaoka, Lixu Mou, Timothy A. Springer	2006	63
15	The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2 The Journal of Cell Biology ·Minsoo Kim, Christopher V. Carman, Wei Yang, Azucena Salas, Timothy A. Springer	2004	193
16	Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring Proceedings of the National Academy of Sciences ·Wei Yang, Motomu Shimaoka, Azucena Salas, Junichi Takagi, Timothy A. Springer	2004	77
17	Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins Science ·Minsoo Kim, Christopher V. Carman, Timothy A. Springer Hit paper breakdown →	2003	636
18	Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin β subunits Proceedings of the National Academy of Sciences ·Junichi Takagi, Natalia Beglova, Padmaja Yalamanchili, Stephen C. Blacklow, Timothy A. Springer	2001	52
19	The Leukocyte Integrins Advances in immunology ·H. M. Courtois, Richard A. Larson, Ángel L. Corbí, Michael L. Dustin, Donald E. Staunton, Timothy A. Springer	1989	458
20	Monoclonal Antibodies Specific for Rat IgG1, IgG2a, and IgG2b Subclasses, and Kappa Chain Monotypic and Allotypic Determinants: Reagents for Use with Rat Monoclonal Antibodies Hybridoma ·Timothy A. Springer, Alok Bhattacharya, JENNIFER TRY CARDOZA, Francisco Sánchez‐Madrid	1982	86

About Timothy A. Springer

Timothy A. Springer is a scholar working on Immunology and Allergy, Immunology, Radiology, Nuclear Medicine and Imaging, Hematology and Cell Biology, having authored 536 papers that have together received 91.5k indexed citations. Recurring topics across this work include Cell Adhesion Molecules Research (329 papers), Monoclonal and Polyclonal Antibodies Research (219 papers), Platelet Disorders and Treatments (87 papers), Glycosylation and Glycoproteins Research (84 papers), T-cell and B-cell Immunology (69 papers), Immunotherapy and Immune Responses (60 papers), Immune Cell Function and Interaction (52 papers) and Biochemical and Structural Characterization (52 papers). The work is most often cited by research in Immunology and Allergy (43.0k citations), Immunology (43.4k citations), Hematology (14.1k citations), Radiology, Nuclear Medicine and Imaging (16.3k citations) and Cell Biology (10.6k citations). Timothy A. Springer has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include Michael L. Dustin, Christopher V. Carman, Steven D. Marlin, Junichi Takagi, Michael B. Lawrence, Donald E. Staunton, Robert Rothlein, Michael Diamond, Conrad C. Bleul and Bing‐Hao Luo. Their work appears in journals such as The Journal of Immunology, Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, The Journal of Cell Biology and The Journal of Experimental Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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