John R. Ortaldo

21.2k citations

252 papers · 17.8k indexed · 5 hit papers · h-index 72

Impact in

Immunology top 0.05%
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Reproductive System and Pregnancy
Oncology top 0.5%
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research

Papers in

Immunology 219
- Immune Cell Function and Interaction 192
- T-cell and B-cell Immunology 106
- Immunotherapy and Immune Responses 42
- Immune Response and Inflammation 26
Oncology 61
- Cytokine Signaling Pathways and Interactions 26
- CAR-T cell therapy research 18

Co-authors: Ronald B. Herberman Howard A. Young R B Herberman Anna Mason Robin Winkler-Pickett Llewellyn H. Mason Daniel W. McVicar Guy D. Bonnard
Journals: The Journal of Immunology (84 papers)Journal of Leukocyte Biology (18 papers)The Journal of Experimental Medicine (13 papers)Cellular Immunology (12 papers)JNCI Journal of the National Cancer Institute (9 papers)
Partner nations: United States Italy Japan

In The Last Decade

John R. Ortaldo

252 papers receiving 16.9k citations

Hit Papers

5 papers align trajectories log scale

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2 1994 · 517 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1994 Nature
1993 The Journal of Experimental Medicine
1981 Science
1979 Nature
1979 Immunological Reviews

Peers

Countries citing papers authored by John R. Ortaldo

Since Specialization

Citations

This map shows the geographic impact of John R. Ortaldo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John R. Ortaldo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John R. Ortaldo more than expected).

Fields of papers citing papers by John R. Ortaldo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John R. Ortaldo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John R. Ortaldo. The network helps show where John R. Ortaldo may publish in the future.

Co-authors

The 25 scholars most cited alongside John R. Ortaldo, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John R. Ortaldo Line = papers co-authored together John R. Ortaldo links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development The Journal of Immunology ·Amir M. Alhajjat, Beverly Strong, Amanda E. Lee, Lucas Turner, Ram K Wadhwani, John R. Ortaldo, Jonathan W. Heusel, Aimen F. Shaaban	2015	6
2	mTOR Kinase Inhibitor AZD8055 Enhances the Immunotherapeutic Activity of an Agonist CD40 Antibody in Cancer Treatment Cancer Research ·Qun Jiang, Jonathan M. Weiss, Timothy Back, Tim Hon Man Chan, John R. Ortaldo, Sylvie M. Guichard, Robert H. Wiltrout	2011	71
3	Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells Blood ·Sophie Laffont, Cyril Seillet, John R. Ortaldo, Jérôme D. Coudert, Jean‐Charles Guéry	2008	83
4	Pertussis toxin as an adjuvant suppresses the number and function of CD4⁺CD25⁺ T regulatory cells European Journal of Immunology ·Xin Chen, Robin Winkler-Pickett, Nicholas H. Carbonetti, John R. Ortaldo, Joost J. Oppenheim, O. M. Zack Howard	2006	82
5	Expression of IFN-γ Upon Triggering of Activating Ly49D NK Receptors In Vitro and In Vivo: Costimulation with IL-12 or IL-18 Overrides Inhibitory Receptors The Journal of Immunology ·John R. Ortaldo, Howard A. Young	2003	51
6	Human B Cell Activation by Autologous NK Cells Is Regulated by CD40-CD40 Ligand Interaction: Role of Memory B Cells and CD5+ B Cells The Journal of Immunology ·Isaac Blanca, Earl W. Bere, Howard A. Young, John R. Ortaldo	2001	78
7	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells European Journal of Immunology ·Tomoaki Hoshino, Hideo Yagita, John R. Ortaldo, Robert H. Wiltrout, Howard A. Young	2000	148
8	The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e Growth Factors ·Svetozar Grgurevich, Diana Linnekin, Tiziana Musso, Xiaoying Zhang, William S. Modi, Luigi Varesio, Francis W. Ruscetti, John R. Ortaldo, Daniel W. McVicar	1997	20
9	The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element Molecular and Cellular Biology ·Jianping Ye, Marco Cippitelli, Linda Dorman, John R. Ortaldo, Howard A. Young	1996	157
10	Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. The Journal of Experimental Medicine ·Chris M. Bacon, Daniel W. McVicar, John R. Ortaldo, R.C. Rees, John J. O’Shea, J A Johnston	1995	297
11	Quantitative analysis of rod-cored vesicles and dense granules of large granular lymphocytes in the liver, spleen, and peripheral blood of rats Cell and Tissue Research ·Kenji Kaneda, Anne M. Pilaro, Thoma J. Sayers, Kunio Nagashima, Matthew A. Gonda, John R. Ortaldo, Robert H. Wiltrout	1994	3
12	IL-7 regulation of cytotoxic lymphocytes: Pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocyte subsets Cellular Immunology ·Mark J. Smyth, Y Norihisa, Jeffrey R. Gerard, Howard A. Young, John R. Ortaldo	1991	44
13	IL-8 gene expression and production in human peripheral blood lymphocyte subsets The Journal of Immunology ·Mark J. Smyth, Claus Zachariae, Y Norihisa, John R. Ortaldo, Atsushi Hishinuma, Koji Matsushima	1991	92
14	Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes. The Journal of Experimental Medicine ·Joyce Frey, Tamar Bino, R R Kantor, David M. Segal, S L Giardina, John Roder, Stephen K. Anderson, John R. Ortaldo	1991	36
15	Methylation patterns of the T cell receptor beta -chain gene in T cells, large granular lymphocytes, B cells, and monocytes. The Journal of Immunology ·Shigeru Sakamoto, John R. Ortaldo, Howard A. Young	1988	19
16	LGL-1: a non-polymorphic antigen expressed on a major population of mouse natural killer cells. The Journal of Immunology ·Llewellyn H. Mason, S L Giardina, Toby T. Hecht, John R. Ortaldo, Bonnie J. Mathieson	1988	66
17	IFN-gamma treatment of K562 cells inhibits natural killer cell triggering and decreases the susceptibility to lysis by cytoplasmic granules from large granular lymphocytes. The Journal of Immunology ·Alvar Grönberg, Mats Ferm, Joanne Ng, Craig W. Reynolds, John R. Ortaldo	1988	47
18	Characterization and functions of natural killer cells Annales de l Institut Pasteur Immunologie ·John R. Ortaldo, Bonnie J. Mathieson, Robert H. Wiltrout	1988	9
19	Binding of Human Alpha-Interferons to Natural Killer Cells Journal of Interferon Research ·Jerome A. Langer, John R. Ortaldo, Sidney Pestka	1986	22
20	Augmentation of Human Natural Killer Cell Activity by Interferon: Conditions Required for Boosting and Characteristics of the Effector Cells Journal of Interferon Research ·John R. Ortaldo, Nicholas P. Lang, Tuomo Timonen, Ronald B. Herberman	1981	15

About John R. Ortaldo

John R. Ortaldo is a scholar working on Immunology, Oncology, Radiology, Nuclear Medicine and Imaging, Hematology and Immunology and Allergy, having authored 252 papers that have together received 17.8k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (192 papers), T-cell and B-cell Immunology (106 papers), Immunotherapy and Immune Responses (42 papers), Monoclonal and Polyclonal Antibodies Research (33 papers), Cytokine Signaling Pathways and Interactions (26 papers), Immune Response and Inflammation (26 papers), CAR-T cell therapy research (18 papers) and Glycosylation and Glycoproteins Research (18 papers). The work is most often cited by research in Immunology (13.6k citations), Oncology (4.5k citations), Hematology (1.3k citations), Immunology and Allergy (584 citations) and Virology (406 citations). John R. Ortaldo has collaborated with scholars based in United States, Italy and Japan. Frequent co-authors include Ronald B. Herberman, Howard A. Young, R B Herberman, Anna Mason, Robin Winkler-Pickett, Llewellyn H. Mason, Daniel W. McVicar, Guy D. Bonnard, Stephen K. Anderson and John J. O’Shea. Their work appears in journals such as The Journal of Immunology, Journal of Leukocyte Biology, The Journal of Experimental Medicine, Cellular Immunology and JNCI Journal of the National Cancer Institute.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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