William E. Rote

2.4k citations

35 papers · 1.5k indexed · h-index 21

Impact in

Internal Medicine top 2%
- Venous Thromboembolism Diagnosis and Management
Hematology top 2%
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments

Papers in ⓘ

Hematology 23
- Blood Coagulation and Thrombosis Mechanisms 20
- Hemophilia Treatment and Research 7
- Platelet Disorders and Treatments 4
Cardiology and Cardiovascular Medicine 18
- Atrial Fibrillation Management and Outcomes 9
- Acute Myocardial Infarction Research 7
- Renin-Angiotensin System Studies 3

Co-authors: George P. Vlasuk (13 shared papers)Benedict R. Lucchesi (11 shared papers)Marcel Levi (6 shared papers)Jason Paragas (1 shared paper)Joan B. Geisbert (1 shared paper)Lisa E. Hensley (1 shared paper)Peter B. Jahrling (1 shared paper)Howard A. Young (1 shared paper)
Journals: Journal of Cardiovascular Pharmacology (5 papers)Circulation (3 papers)Kidney International Reports (3 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)Journal of the American College of Cardiology (2 papers)
Partner nations: United States Netherlands Australia

In The Last Decade

William E. Rote

35 papers receiving 1.5k citations

Peers

Countries citing papers authored by William E. Rote

Since Specialization

Citations

This map shows the geographic impact of William E. Rote's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William E. Rote with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William E. Rote more than expected).

Fields of papers citing papers by William E. Rote

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William E. Rote. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William E. Rote. The network helps show where William E. Rote may publish in the future.

Co-authors

The 25 scholars most cited alongside William E. Rote, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William E. Rote Line = papers co-authored together William E. Rote links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 35 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys The Lancet ·Thomas W. Geisbert, Lisa E. Hensley, Peter B. Jahrling, Thomas Larsen, Joan B. Geisbert, Jason Paragas, Howard A. Young, T. Fredeking, William E. Rote, George P. Vlasuk	2003	295
2	Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism. PubMed ·Todd Hembrough, Glenn M. Swartz, Adonia E. Papathanassiu, George P. Vlasuk, William E. Rote, Shawn J. Green, Victor S. Pribluda	2003	160
3	Dose-Response Study of Recombinant Factor VIIa/Tissue Factor Inhibitor Recombinant Nematode Anticoagulant Protein c2 in Prevention of Postoperative Venous Thromboembolism in Patients Undergoing Total Knee Replacement Circulation ·Agnes Lee, Giancarlo Agnelli, Harry Büller, Jeffrey S. Ginsberg, John A. Heit, William E. Rote, George P. Vlasuk, Lorrie Costantini, Jim A. Julian, Philip C. Comp, Jan van der Meer, Franco Piovella, Gary E. Raskob, Michael Gent	2001	139
4	Neutrophil inhibitory factor is neuroprotective after focal Ischemia in rats Annals of Neurology ·Ning Jiang, Matthew Moyle, Howard R. Soule, William E. Rote, Michael Chopp	1995	120
5	Activation of Coagulation by Administration of Recombinant Factor VIIa Elicits Interleukin 6 (IL-6) and IL-8 Release in Healthy Human Subjects Clinical and Vaccine Immunology ·Evert de Jonge, Philip W. Friederich, George P. Vlasuk, William E. Rote, Margaretha B. Vroom, Marcel Levi, Tom van der Poll	2003	80
6	Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplastyAppendix Journal of the American College of Cardiology ·Arno H. Moons, Ron J.G. Peters, Nick R. Bijsterveld, Jan J. Piek, Martin H. Prins, George P. Vlasuk, William E. Rote, Harry R. Büller	2003	77
7	Ability of Recombinant Factor VIIa to Generate Thrombin During Inhibition of Tissue Factor in Human Subjects Circulation ·Philip W. Friederich, Marcel Levi, Kenneth A. Bauer, George P. Vlasuk, William E. Rote, Daan Breederveld, Tijmen Keller, Marco Spataro, Samad Barzegar, Harry R. Büller	2001	64
8	Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia* Critical Care Medicine ·Anita W. Rijneveld, Sebastiaan Weijer, Paul Bresser, Sandrine Florquin, George P. Vlasuk, William E. Rote, C. Arnold Spek, Pieter H. Reitsma, Jaring S. van der Zee, Marcel Levi, Tom van der Poll	2006	62
9	Purification and characterization of platelet aggregation inhibitors from snake venoms Thrombosis Research ·Mohit Trikha, William E. Rote, Peter J. Manley, Benedict R. Lucchesi, Francis S. Markland	1994	58
10	Inhibition of the Tissue Factor/Factor VIIa Pathway Does Not Influence the Inflammatory or Antibacterial Response to Abdominal Sepsis Induced byEscherichia coliin Mice The Journal of Infectious Diseases ·Sebastian Weijer, Saskia H. H. F. Schoenmakers, Sandrine Florquin, Marcel Levi, George P. Vlasuk, William E. Rote, Pieter H. Reitsma, C. Arnold Spek, Tom van der Poll	2004	43
11	Study Design of the Phase 3 Sparsentan Versus Irbesartan (DUPLEX) Study in Patients With Focal Segmental Glomerulosclerosis Kidney International Reports ·Radko Komers, Ulysses Diva, Jula K. Inrig, Andrea Loewen, Howard Trachtman, William E. Rote	2020	40
12	Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin‐10 response in human endotoxemia Journal of Thrombosis and Haemostasis ·A C J M de Pont, A.H.M. Moons, Evert de Jonge, Joost C.M. Meijers, G P Vlasuk, William E. Rote, H. R. Büller, Tom van der Poll, Marcel Levi	2004	32
13	Potent and Selective Thrombin Inhibitors Incorporating the Constrained Arginine Mimic l-3-Piperidyl(N-guanidino)alanine at P₁ Journal of Medicinal Chemistry ·Odile E. Levy, J. Edward Semple, Michael Lim, John Reiner, William E. Rote, E. W. Dempsey, Brigitte M. Richard, Erli Zhang, Al Tulinsky, William C. Ripka, Ruth F. Nutt	1996	27
14	Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates Bioorganic & Medicinal Chemistry Letters ·Susan Y. Tamura, J. Edward Semple, John Reiner, Erick A. Goldman, Terence K. Brunck, Marguerita Lim-Wilby, Stephen H. Carpenter, William E. Rote, Gerard L. Oldeshulte, Brigitte M. Richard, Ruth F. Nutt, William C. Ripka	1997	26
15	Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery Cardiovascular Research ·William E. Rote, S.W. Werns, James H. Davis, Larry P. Feigen, Kenneth S. Kilgore, Benedict R. Lucchesi	1993	24
16	Chimeric 7E3 prevents carotid artery thrombosis in cynomolgus monkeys. Stroke ·William E. Rote, Mark Nedelman, Dun-Xue Mu, Peter J. Manley, Hannah Weisman, Margaret Cunningham, B R Lucchesi	1994	23
17	Pharmacokinetics and anticoagulant properties of the factor VIIa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man Thrombosis and Haemostasis ·Annette Bradbury, Lily Lopez-Kinninger, S M Colón, Peter W. Bergum, Steven L. Maki, William E. Rote, George P. Vlasuk	2003	22
18	Antithrombotic Efficacy of a Recombinant Nematode Anticoagulant Peptide (rNAP5) in Canine Models of Thrombosis after Single Subcutaneous Administration Journal of Pharmacology and Experimental Therapeutics ·Sam Rebello, Howard S. Blank, William E. Rote, George P. Vlasuk, Benedict R. Lucchesi	1997	22
19	IgA Nephropathy Patient Baseline Characteristics in the Sparsentan PROTECT Study Kidney International Reports ·Jonathan Barratt, Brad H. Rovin, Muh Geot Wong, Charles E. Alpers, Stewart Bieler, Ping He, Jula K. Inrig, Radko Komers, Hiddo J.L. Heerspink, Alex Mercer, Irene L. Noronha, Jai Radhakrishnan, Michelle N. Rheault, William E. Rote, Howard Trachtman, Hernán Trimarchi, Vlado Perkovic	2023	20
20	Orally Effective CVS-1123 Prevents Coronary Artery Thrombosis in the Conscious Dog Circulation ·Geoffrey R. Cousins, Gregory S. Friedrichs, Yuji Sudo, Sam Rebello, William E. Rote, George P. Vlasuk, Thomas G. Nolan, Christine Mendoza, Benedict R. Lucchesi	1996	20

About William E. Rote

William E. Rote is a scholar working on Hematology, Cardiology and Cardiovascular Medicine, Internal Medicine, Molecular Biology and Nephrology, having authored 35 papers that have together received 1.5k indexed citations. Recurring topics across this work include Blood Coagulation and Thrombosis Mechanisms (20 papers), Atrial Fibrillation Management and Outcomes (9 papers), Hemophilia Treatment and Research (7 papers), Acute Myocardial Infarction Research (7 papers), Venous Thromboembolism Diagnosis and Management (6 papers), Platelet Disorders and Treatments (4 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (3 papers) and Renin-Angiotensin System Studies (3 papers). The work is most often cited by research in Internal Medicine (283 citations), Hematology (556 citations), Infectious Diseases (318 citations), Immunology and Allergy (93 citations) and Cardiology and Cardiovascular Medicine (318 citations). William E. Rote has collaborated with scholars based in United States, Netherlands and Australia. Frequent co-authors include George P. Vlasuk, Benedict R. Lucchesi, Marcel Levi, Jason Paragas, Joan B. Geisbert, Lisa E. Hensley, Peter B. Jahrling, Howard A. Young, Thomas W. Geisbert and Thomas Larsen. Their work appears in journals such as Journal of Cardiovascular Pharmacology, Circulation, Kidney International Reports, Journal of Pharmacology and Experimental Therapeutics and Journal of the American College of Cardiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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