Harry Begthel

29.9k citations

59 papers · 18.8k indexed · 16 hit papers · h-index 41

Impact in

Oncology top 0.1%
- Cancer Cells and Metastasis
Cancer Research top 0.5%
- Cancer Genomics and Diagnostics

Papers in

Oncology 21
- Cancer Cells and Metastasis 17
Genetics 20
- Digestive system and related health 15

Co-authors: Hans Clevers Johan H. van Es Maaike van den Born Nick Barker Jeroen Korving Peter J. Peters Pekka Kujala Miranda Cozijnsen
Journals: Nature (7 papers)Cell stem cell (7 papers)Proceedings of the National Academy of Sciences (7 papers)Nature Communications (5 papers)Cell Reports (5 papers)
Partner nations: Netherlands Switzerland United States

In The Last Decade

Harry Begthel

57 papers receiving 18.7k citations

Hit Papers

15 papers align trajectories log scale

Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution 2021 · 171 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2021 Cell Reports
2018 Cell
2016 Cell stem cell
2015 Nature
2014 Gastroenterology
2014 Cell
2013 The EMBO Journal
2010 Cell stem cell
2010 Science
2009 Cell
2008 Nature
2007 Nature
2005 Nature
2005 Nature Cell Biology
2004 Science
2003 Genes & Development

Peers

Countries citing papers authored by Harry Begthel

Since Specialization

Citations

This map shows the geographic impact of Harry Begthel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Harry Begthel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Harry Begthel more than expected).

Fields of papers citing papers by Harry Begthel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Harry Begthel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Harry Begthel. The network helps show where Harry Begthel may publish in the future.

Co-authors

The 25 scholars most cited alongside Harry Begthel, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Harry Begthel Line = papers co-authored together Harry Begthel links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Nature Communications ·Julian R. Buissant des Amorie, Max A. Betjes, Jochem H. Bernink, Joris H. Hageman, Veerle Geurts, Harry Begthel, Dimitrios Laskaris, Maria C. Heinz, Ingrid Jordens, Tiba Vinck, Ronja M. Houtekamer, Ingrid Verlaan-Klink, Sascha R. Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J. Tans, Jeroen S. van Zon, Hugo J.G. Snippert	2025	2
2	Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages Nature Communications ·Laurens H. G. Verweij, Seok‐Young Kim, Dimitrios Laskaris, Lin Lin, Gijs J. F. van Son, Femke Ringnalda, Harry Begthel, Ravian L. van Ineveld, Chris Winkel, Jay P. Slack, Anne C. Rios, Karin Sanders, Jacco van Rheenen, Marc van de Wetering, Hans Clevers	2025	0
3	Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids Scientific Reports ·Cayetano Pleguezuelos‐Manzano, Wouter A. G. Beenker, Gijs J. F. van Son, Harry Begthel, Gimano D. Amatngalim, Jeffrey M. Beekman, Hans Clevers, Jeroen den Hertog	2025	6
4	Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7 Proceedings of the National Academy of Sciences ·Matteo Boretto, Maarten H. Geurts, Shashank Gandhi, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine M.L. Roodhart, Johan H. van Es, Wei Wu, Hans Clevers	2024	9
5	Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation Science ·Lin Lin, Jeff DeMartino, Daisong Wang, Gijs J. F. van Son, Reinier van der Linden, Harry Begthel, Jeroen Korving, Amanda Andersson-Rolf, Stieneke van den Brink, Carmen López‐Iglesias, Willine J. van de Wetering, Aleksandra Balwierz, Thanasis Margaritis, Marc van de Wetering, Peter J. Peters, Jarno Drost, Johan H. van Es, Hans Clevers	2023	21
6	One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids Nature Communications ·Maarten H. Geurts, Shashank Gandhi, Matteo Boretto, Ninouk Akkerman, Lucca L. M. Derks, Gijs J. F. van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M. Chuva de Sousa Lopes, Johan H. van Es, Ruben van Boxtel, Hans Clevers	2023	32
7	BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states Cell Reports ·Joep Beumer, Jens Puschhof, Fjodor Yousef Yengej, Lianzheng Zhao, Adriana Martínez-Silgado, Marloes Blotenburg, Harry Begthel, Charelle Boot, Alexander van Oudenaarden, Ye‐Guang Chen, Hans Clevers	2022	70
8	Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation Cell stem cell ·Gui-Wei He, Lin Lin, Jeff DeMartino, Xuan Zheng, Nadzeya Staliarova, Talya L. Dayton, Harry Begthel, Willine J. van de Wetering, Eduard Bodewes, Jeroen S. van Zon, Sander J. Tans, Carmen López‐Iglesias, Peter J. Peters, Wei Wu, Daniel Kotlarz, Christoph Klein, Thanasis Margaritis, Frank C. P. Holstege, Hans Clevers	2022	93
9	Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism Proceedings of the National Academy of Sciences ·Jelte van der Vaart, Lynn Bosmans, Stijn F. Sijbesma, Kèvin Knoops, Willine J. van de Wetering, Henny G. Otten, Harry Begthel, Inne H.M. Borel Rinkes, Jeroen Korving, Eef G.W.M. Lentjes, Carmen López‐Iglesias, Peter J. Peters, Hanneke M. van Santen, Menno R. Vriens, Hans Clevers	2021	35
10	Modelling of primary ciliary dyskinesia using patient‐derived airway organoids EMBO Reports ·Jelte van der Vaart, Lena Böttinger, Maarten H. Geurts, Willine J. van de Wetering, Kèvin Knoops, Norman Sachs, Harry Begthel, Jeroen Korving, Carmen López‐Iglesias, Peter J. Peters, Kerem Eitan, Alex Gileles‐Hillel, Hans Clevers	2021	36
11	Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids Nature Communications ·Kadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P.H. Vreuls, Johan H. van Es, Hans Clevers	2020	83
12	Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells Nature Communications ·Nesrin Tüysüz, Louis van Bloois, Stieneke van den Brink, Harry Begthel, Monique M.A. Verstegen, Luis J. Cruz, Lijian Hui, Luc J. W. van der Laan, Jeroen de Jonge, Robert G. Vries, Eric Braakman, Enrico Mastrobattista, Jan J. Cornelissen, Hans Clevers, Derk ten Berge	2017	59
13	Reg4 ⁺ deep crypt secretory cells function as epithelial niche for Lgr5 ⁺ stem cells in colon Proceedings of the National Academy of Sciences ·Nobuo Sasaki, Norman Sachs, Kay Wiebrands, Saskia I. J. Ellenbroek, Arianna Fumagalli, Anna Lyubimova, Harry Begthel, Maaike van den Born, Johan H. van Es, Wouter R. Karthaus, Vivian Li, Carmen López‐Iglesias, Peter J. Peters, Jacco van Rheenen, Alexander van Oudenaarden, Hans Clevers	2016	206
14	Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure Scientific Reports ·Ewart Kuijk, Shauna Rasmussen, Francis Blokzijl, Meritxell Huch, Helmuth Gehart, Pim W. Toonen, Harry Begthel, Hans Clevers, Aron M. Geurts, Edwin Cuppen	2016	47
15	Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin Science ·Hugo J.G. Snippert, Andrea Haegebarth, Maria Kasper, Viljar Jaks, Johan H. van Es, Nick Barker, Marc van de Wetering, Maaike van den Born, Harry Begthel, Robert G. Vries, Daniel E. Stange, Rune Toftgård, Hans Clevers Hit paper breakdown →	2010	585
16	Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate Cell ·Laurens G. van der Flier, Mariëlle van Gijn, Pantelis Hatzis, Pekka Kujala, Andrea Haegebarth, Daniel E. Stange, Harry Begthel, Maaike van den Born, Victor Guryev, Irma M. Oving, Johan H. van Es, Nick Barker, Peter J. Peters, Marc van de Wetering, Hans Clevers Hit paper breakdown →	2009	546
17	Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex Developmental Cell ·Jean Paul ten Klooster, Marnix Jansen, Jin Yuan, Viola Oorschot, Harry Begthel, Valeria Di Giacomo, Frédéric Colland, John de Koning, Madelon M. Maurice, Peter Hornbeck, Hans Clevers	2009	125
18	Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia EMBO Reports ·Anna-Pavlina G. Haramis, Adam Hurlstone, Yme van der Velden, Harry Begthel, Maaike van den Born, G. Johan A. Offerhaus, Hans Clevers	2006	130
19	Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc Molecular and Cellular Biology ·Vanesa Muncan, Owen J. Sansom, Leon G.J. Tertoolen, Toby J. Phesse, Harry Begthel, Elena Sancho, Alicia M. Cole, Alex Gregorieff, Ignacio Moreno de Alborán, Hans Clevers, Alan R. Clarke	2006	203
20	Wnt signalling induces maturation of Paneth cells in intestinal crypts Nature Cell Biology ·Johan H. van Es, Philippe Jay, Alex Gregorieff, Mariëlle van Gijn, Suzanne Jonkheer, Pantelis Hatzis, Andrea Thiele, Maaike van den Born, Harry Begthel, Thomas Brabletz, Makoto M. Taketo, Hans Clevers Hit paper breakdown →	2005	518

About Harry Begthel

Harry Begthel is a scholar working on Oncology, Genetics, Molecular Biology, Hepatology and Cancer Research, having authored 59 papers that have together received 18.8k indexed citations. Recurring topics across this work include Wnt/β-catenin signaling in development and cancer (20 papers), Cancer Cells and Metastasis (17 papers), Digestive system and related health (15 papers), Cancer-related gene regulation (9 papers), Cancer Genomics and Diagnostics (6 papers), Pancreatic function and diabetes (6 papers), Epigenetics and DNA Methylation (6 papers) and Genetic factors in colorectal cancer (4 papers). The work is most often cited by research in Oncology (8.8k citations), Cancer Research (2.3k citations), Molecular Biology (10.5k citations), Genetics (3.8k citations) and Hepatology (875 citations). Harry Begthel has collaborated with scholars based in Netherlands, Switzerland and United States. Frequent co-authors include Hans Clevers, Johan H. van Es, Maaike van den Born, Nick Barker, Jeroen Korving, Peter J. Peters, Pekka Kujala, Miranda Cozijnsen, Andrea Haegebarth and Marc van de Wetering. Their work appears in journals such as Nature, Cell stem cell, Proceedings of the National Academy of Sciences, Nature Communications and Cell Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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