Nick Barker

52.4k total citations · 20 hit papers
119 papers, 38.8k citations indexed

About

Nick Barker is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Nick Barker has authored 119 papers receiving a total of 38.8k indexed citations (citations by other indexed papers that have themselves been cited), including 83 papers in Molecular Biology, 63 papers in Oncology and 26 papers in Genetics. Recurrent topics in Nick Barker's work include Cancer Cells and Metastasis (56 papers), Wnt/β-catenin signaling in development and cancer (40 papers) and Digestive system and related health (24 papers). Nick Barker is often cited by papers focused on Cancer Cells and Metastasis (56 papers), Wnt/β-catenin signaling in development and cancer (40 papers) and Digestive system and related health (24 papers). Nick Barker collaborates with scholars based in Singapore, Netherlands and United Kingdom. Nick Barker's co-authors include Hans Clevers, Johan H. van Es, Marc van de Wetering, Maaike van den Born, Vladimír Kořínek, Hugo J.G. Snippert, Peter J. Peters, Pekka Kujala, Patrice J. Morin and Daniel E. Stange and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Nick Barker

115 papers receiving 38.3k citations

Hit Papers

Single Lgr5 stem cells build crypt-villus structur... 1997 2026 2006 2016 2009 2007 1997 1997 2010 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    2009 5.1k citations Hugo J.G. Snippert, Nick Barker et al. Nature profile →
  2. Identification of stem cells in small intestine and colon by marker gene Lgr5
    2007 4.3k citations Nick Barker, Johan H. van Es et al. Nature profile →
  3. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
    1997 3.3k citations Nick Barker, Hans Clevers et al. Science profile →
  4. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
    1997 2.9k citations Nick Barker, Hans Clevers et al. Science profile →
  5. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    2010 1.9k citations Johan H. van Es, Hugo J.G. Snippert et al. Nature profile →
  6. Crypt stem cells as the cells-of-origin of intestinal cancer
    2008 1.6k citations Nick Barker, Johan H. van Es et al. Nature profile →
  7. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
    2010 1.4k citations Hugo J.G. Snippert, Johan H. van Es et al. profile →
  8. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    1998 1.3k citations Nick Barker, Hans Clevers et al. profile →
  9. Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
    2010 1.2k citations Nick Barker, Pekka Kujala et al. profile →
  10. Organoids as an in vitro model of human development and disease
    2016 1.1k citations Si Hui Tan, Nick Barker et al. profile →
  11. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    2011 976 citations Nick Barker, Pekka Kujala et al. Nature profile →
  12. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
    2013 928 citations Nick Barker Nature Reviews Molecular Cell Biology profile →
  13. Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    2008 758 citations Viljar Jaks, Nick Barker et al. profile →
  14. Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling
    2005 614 citations Marieke Essers, Nick Barker et al. Science profile →
  15. Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
    2010 585 citations Hugo J.G. Snippert, Andrea Haegebarth et al. Science profile →
  16. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
    2012 584 citations Johan H. van Es, Maaike van den Born et al. profile →
  17. Mining the Wnt pathway for cancer therapeutics
    2006 582 citations Nick Barker, Hans Clevers profile →
  18. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
    2012 562 citations Daniel E. Stange, Johan H. van Es et al. The EMBO Journal profile →
  19. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
    2009 546 citations Pekka Kujala, Andrea Haegebarth et al. profile →
  20. The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
    1999 507 citations Nick Barker, Hans Clevers et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Nick Barker Singapore 62 23.9k 15.2k 6.9k 4.5k 3.8k 119 38.8k
Johan H. van Es Netherlands 72 23.1k 1.0× 17.7k 1.2× 8.0k 1.2× 5.8k 1.3× 4.6k 1.2× 131 41.4k
Marc van de Wetering Netherlands 59 20.7k 0.9× 13.0k 0.9× 6.2k 0.9× 3.9k 0.9× 3.9k 1.1× 84 32.9k
Peter ten Dijke Netherlands 130 40.4k 1.7× 12.5k 0.8× 4.5k 0.7× 4.7k 1.1× 6.9k 1.8× 487 57.0k
Chu‐Xia Deng United States 119 31.1k 1.3× 9.0k 0.6× 7.8k 1.1× 3.0k 0.7× 5.5k 1.5× 414 47.2k
Kohei Miyazono Japan 123 41.5k 1.7× 12.8k 0.8× 4.3k 0.6× 4.0k 0.9× 8.3k 2.2× 463 57.4k
Anita B. Roberts United States 120 31.6k 1.3× 10.4k 0.7× 5.7k 0.8× 4.9k 1.1× 5.6k 1.5× 288 53.4k
André J. van Wijnen United States 94 25.7k 1.1× 6.4k 0.4× 3.3k 0.5× 3.4k 0.8× 7.4k 2.0× 732 36.8k
David T. Scadden United States 101 18.7k 0.8× 10.3k 0.7× 2.9k 0.4× 3.1k 0.7× 5.0k 1.3× 389 43.6k
Rik Derynck United States 118 38.9k 1.6× 17.3k 1.1× 5.2k 0.8× 3.9k 0.9× 8.8k 2.3× 211 57.0k
Toshio Suda Japan 120 32.9k 1.4× 17.0k 1.1× 4.1k 0.6× 4.2k 0.9× 7.3k 1.9× 730 59.1k

Countries citing papers authored by Nick Barker

Since Specialization
Citations

This map shows the geographic impact of Nick Barker's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nick Barker with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nick Barker more than expected).

Fields of papers citing papers by Nick Barker

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nick Barker. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nick Barker. The network helps show where Nick Barker may publish in the future.

Co-authorship network of co-authors of Nick Barker

This figure shows the co-authorship network connecting the top 25 collaborators of Nick Barker. A scholar is included among the top collaborators of Nick Barker based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nick Barker. Nick Barker is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhang, Shuning, Lihua Peng, Shyamal Goswami, et al.. (2025). Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid. Nature Microbiology. 10(3). 765–783. 9 indexed citations
2.
Chin, Hui San, Jinming Cheng, Maria T. K. Zaldivia, et al.. (2025). MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration. Nature Communications. 16(1). 2829–2829. 3 indexed citations
3.
Hailstock, Taylor, et al.. (2024). Lgr5 + intestinal stem cells are required for organoid survival after genotoxic injury. Development. 151(23).
4.
5.
Lim, Hui Yi Grace, et al.. (2023). Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium. Current topics in developmental biology. 153. 281–326. 7 indexed citations
6.
Lim, Hui Yi Grace, et al.. (2023). Gastric epithelial stem cells in development, homeostasis and regeneration. Development. 150(18). 5 indexed citations
7.
Leung, Carly, et al.. (2020). Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation. Cell Reports. 33(12). 108535–108535. 22 indexed citations
8.
Xue, Yuezhen, Nick Barker, Shawn Hoon, et al.. (2019). Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo. Cancer Research. 79(14). 3595–3607. 22 indexed citations
9.
Flanagan, Dustin J., Nick Barker, Elizabeth A. Mason, et al.. (2019). Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations. Cancer Research. 79(5). 970–981. 84 indexed citations
10.
Leung, Carly, Si Hui Tan, & Nick Barker. (2018). Recent Advances in Lgr5 + Stem Cell Research. Trends in Cell Biology. 28(5). 380–391. 108 indexed citations
11.
Flanagan, Dustin J., Nick Barker, Cameron J. Nowell, et al.. (2017). Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models & Mechanisms. 10(8). 971–980. 20 indexed citations
12.
Horvay, Katja, Thierry Jardé, Franca Casagranda, et al.. (2015). Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. The EMBO Journal. 34(10). 1319–1335. 43 indexed citations
13.
Tan, David Wei‐Min & Nick Barker. (2014). Intestinal Stem Cells and Their Defining Niche. Current topics in developmental biology. 107. 77–107. 91 indexed citations
14.
Barker, Nick. (2013). Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nature Reviews Molecular Cell Biology. 15(1). 19–33. 928 indexed citations breakdown →
15.
Nam, Ki Taek, Ryan O'Neal, Robert J. Coffey, et al.. (2011). Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut. 61(12). 1678–1685. 42 indexed citations
16.
Snippert, Hugo J.G., Andrea Haegebarth, Maria Kasper, et al.. (2010). Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin. Science. 327(5971). 1385–1389. 585 indexed citations breakdown →
17.
Barker, Nick & Hans Clevers. (2010). Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells. Gastroenterology. 138(5). 1681–1696. 270 indexed citations
18.
Bongers, Gerold, David Maussang, Luciana R. Muniz, et al.. (2010). The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. Journal of Clinical Investigation. 120(11). 3969–3978. 89 indexed citations
19.
Barker, Nick, Johan H. van Es, Jeroen Kuipers, et al.. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 449(7165). 1003–1007. 4255 indexed citations breakdown →
20.
Essers, Marieke, et al.. (2005). Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling. Science. 308(5725). 1181–1184. 614 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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