Johan H. van Es

56.3k total citations · 31 hit papers
131 papers, 41.4k citations indexed

About

Johan H. van Es is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Johan H. van Es has authored 131 papers receiving a total of 41.4k indexed citations (citations by other indexed papers that have themselves been cited), including 76 papers in Molecular Biology, 40 papers in Oncology and 32 papers in Genetics. Recurrent topics in Johan H. van Es's work include Cancer Cells and Metastasis (34 papers), Wnt/β-catenin signaling in development and cancer (33 papers) and Digestive system and related health (22 papers). Johan H. van Es is often cited by papers focused on Cancer Cells and Metastasis (34 papers), Wnt/β-catenin signaling in development and cancer (33 papers) and Digestive system and related health (22 papers). Johan H. van Es collaborates with scholars based in Netherlands, United States and United Kingdom. Johan H. van Es's co-authors include Hans Clevers, Nick Barker, Maaike van den Born, Marc van de Wetering, Daniel E. Stange, Toshiro Sato, Hugo J.G. Snippert, Peter J. Peters, Harry Begthel and Pekka Kujala and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Johan H. van Es

124 papers receiving 41.0k citations

Hit Papers

Single Lgr5 stem cells build crypt-villus structur... 1997 2026 2006 2016 2009 2007 2011 2010 2008 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    2009 5.1k citations Hugo J.G. Snippert, Marc van de Wetering et al. Nature profile →
  2. Identification of stem cells in small intestine and colon by marker gene Lgr5
    2007 4.3k citations Nick Barker, Johan H. van Es et al. Nature profile →
  3. Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
    2011 2.6k citations Daniel E. Stange, Johan H. van Es et al. profile →
  4. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    2010 1.9k citations Johan H. van Es, Hugo J.G. Snippert et al. Nature profile →
  5. Crypt stem cells as the cells-of-origin of intestinal cancer
    2008 1.6k citations Nick Barker, Johan H. van Es et al. Nature profile →
  6. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
    2010 1.4k citations Hugo J.G. Snippert, Johan H. van Es et al. Cell profile →
  7. Caught up in a Wnt storm: Wnt signaling in cancer
    2003 1.3k citations Rachel H. Giles, Johan H. van Es et al. profile →
  8. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    2005 1.2k citations Johan H. van Es, Mariëlle van Gijn et al. Nature profile →
  9. Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
    2010 1.2k citations Nick Barker, Pekka Kujala et al. Cell stem cell profile →
  10. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    2013 1.1k citations Johan H. van Es, Vivian Li et al. Nature profile →
  11. Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF
    1997 1.0k citations Marc van de Wetering, Johan H. van Es et al. Cell profile →
  12. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    2011 976 citations Nick Barker, Vivian Li et al. Nature profile →
  13. Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
    2012 822 citations Arnout Schepers, Hugo J.G. Snippert et al. Science profile →
  14. Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    2008 758 citations Viljar Jaks, Nick Barker et al. profile →
  15. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
    2012 694 citations Daniel E. Stange, Marc van de Wetering et al. Nature profile →
  16. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
    2018 588 citations Helmuth Gehart, Carmen López‐Iglesias et al. Cell profile →
  17. Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
    2010 585 citations Hugo J.G. Snippert, Andrea Haegebarth et al. Science profile →
  18. De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine
    2004 584 citations Harry Begthel, Maaike van den Born et al. Science profile →
  19. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
    2012 584 citations Johan H. van Es, Marc van de Wetering et al. profile →
  20. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
    2012 562 citations Daniel E. Stange, Arnout Schepers et al. The EMBO Journal profile →
  21. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
    2009 546 citations Mariëlle van Gijn, Pekka Kujala et al. Cell profile →
  22. Mutations in the APC tumour suppressor gene cause chromosomal instability
    2001 545 citations Jeroen Kuipers, Johan H. van Es et al. profile →
  23. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    2013 535 citations Marc van de Wetering, Vivian Li et al. The EMBO Journal profile →
  24. Wnt signalling induces maturation of Paneth cells in intestinal crypts
    2005 518 citations Johan H. van Es, Mariëlle van Gijn et al. profile →
  25. Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells
    2012 488 citations Johan H. van Es, Hans Clevers et al. profile →
  26. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
    2013 421 citations Johan H. van Es, Hans Clevers et al. profile →
  27. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
    2016 412 citations Onur Başak, Kay Wiebrands et al. Cell stem cell profile →
  28. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
    2015 401 citations Johan H. van Es, Hans Clevers et al. Cell profile →
  29. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
    2013 395 citations Daniel E. Stange, Onur Başak et al. Cell profile →
  30. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
    2016 370 citations Mauro J. Muraro, Kay Wiebrands et al. Cell stem cell profile →
  31. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 Kip1 and p57 Kip2
    2008 315 citations Orbicia Riccio, Mariëlle van Gijn et al. EMBO Reports profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Johan H. van Es Netherlands 72 23.1k 17.7k 8.0k 5.8k 4.6k 131 41.4k
Nick Barker Singapore 62 23.9k 1.0× 15.2k 0.9× 6.9k 0.9× 4.5k 0.8× 3.8k 0.8× 119 38.8k
Marc van de Wetering Netherlands 59 20.7k 0.9× 13.0k 0.7× 6.2k 0.8× 3.9k 0.7× 3.9k 0.9× 84 32.9k
Toshiro Sato Japan 61 12.1k 0.5× 12.3k 0.7× 5.5k 0.7× 4.2k 0.7× 3.0k 0.7× 245 28.3k
Kohei Miyazono Japan 123 41.5k 1.8× 12.8k 0.7× 4.3k 0.5× 4.0k 0.7× 8.3k 1.8× 463 57.4k
Peter ten Dijke Netherlands 130 40.4k 1.7× 12.5k 0.7× 4.5k 0.6× 4.7k 0.8× 6.9k 1.5× 487 57.0k
Carl‐Henrik Heldin Sweden 132 41.7k 1.8× 14.1k 0.8× 4.7k 0.6× 4.5k 0.8× 8.9k 1.9× 494 62.7k
Anita B. Roberts United States 120 31.6k 1.4× 10.4k 0.6× 5.7k 0.7× 4.9k 0.8× 5.6k 1.2× 288 53.4k
Toshio Suda Japan 120 32.9k 1.4× 17.0k 1.0× 4.1k 0.5× 4.2k 0.7× 7.3k 1.6× 730 59.1k
David T. Scadden United States 101 18.7k 0.8× 10.3k 0.6× 2.9k 0.4× 3.1k 0.5× 5.0k 1.1× 389 43.6k
Rik Derynck United States 118 38.9k 1.7× 17.3k 1.0× 5.2k 0.6× 3.9k 0.7× 8.8k 1.9× 211 57.0k

Countries citing papers authored by Johan H. van Es

Since Specialization
Citations

This map shows the geographic impact of Johan H. van Es's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Johan H. van Es with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Johan H. van Es more than expected).

Fields of papers citing papers by Johan H. van Es

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Johan H. van Es. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Johan H. van Es. The network helps show where Johan H. van Es may publish in the future.

Co-authorship network of co-authors of Johan H. van Es

This figure shows the co-authorship network connecting the top 25 collaborators of Johan H. van Es. A scholar is included among the top collaborators of Johan H. van Es based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Johan H. van Es. Johan H. van Es is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Krueger, Daniel, Willem Kasper Spoelstra, Rutger N.U. Kok, et al.. (2025). Epithelial tension controls intestinal cell extrusion. Science. 389(6764). eadr8753–eadr8753. 2 indexed citations
2.
Lin, Lin, Johan H. van Es, Jay P. Slack, et al.. (2025). Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities. Advanced Science. 12(46). e06738–e06738.
3.
Es, Johan H. van, et al.. (2024). Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools. STAR Protocols. 5(3). 103189–103189. 5 indexed citations
4.
Es, Johan H. van, Cornelia Brunner, Jovan Mircetic, et al.. (2024). Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome. Molecular Cancer. 23(1). 39–39. 9 indexed citations
5.
Geurts, Maarten H., Shashank Gandhi, Matteo Boretto, et al.. (2023). One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids. Nature Communications. 14(1). 4998–4998. 32 indexed citations
6.
Veenendaal, Tineke, Juan M. Durán, Ishier Raote, et al.. (2020). The function of GORASPs in Golgi apparatus organization in vivo. The Journal of Cell Biology. 219(9). 27 indexed citations
7.
Murata, Kazutaka, Unmesh Jadhav, Shariq Madha, et al.. (2020). Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell stem cell. 26(3). 377–390.e6. 157 indexed citations
8.
Lõhmussaar, Kadi, Oded Kopper, Jeroen Korving, et al.. (2020). Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids. Nature Communications. 11(1). 2660–2660. 83 indexed citations
9.
Gehart, Helmuth, Johan H. van Es, Karien M. Hamer, et al.. (2019). Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping. Cell. 176(5). 1158–1173.e16. 219 indexed citations
10.
Başak, Onur, Teresa G. Krieger, Mauro J. Muraro, et al.. (2018). Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Proceedings of the National Academy of Sciences. 115(4). E610–E619. 121 indexed citations
11.
Chakrabarti, Rumela, Toni Celià-Terrassa, Sushil Kumar, et al.. (2018). Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 360(6396). 147 indexed citations
12.
Sasaki, Nobuo, Norman Sachs, Kay Wiebrands, et al.. (2016). Reg4 + deep crypt secretory cells function as epithelial niche for Lgr5 + stem cells in colon. Proceedings of the National Academy of Sciences. 113(37). E5399–407. 206 indexed citations
13.
Başak, Onur, Jeroen Korving, Joep Beumer, et al.. (2014). Mapping early fate determination in L gr5 + crypt stem cells using a novel K i67‐ RFP allele. The EMBO Journal. 33(18). 2057–2068. 119 indexed citations
14.
Es, Johan H. van, Renée A. Douma, Sanne M Schreuder, et al.. (2013). Clinical impact of findings supporting an alternative diagnosis on computed tomography pulmonary angiography in patients with suspected pulmonary embolism. Journal of Thrombosis and Haemostasis. 11. 1 indexed citations
15.
Schepers, Arnout, Hugo J.G. Snippert, Daniel E. Stange, et al.. (2012). Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas. Science. 337(6095). 730–735. 822 indexed citations breakdown →
16.
Snippert, Hugo J.G., Andrea Haegebarth, Maria Kasper, et al.. (2010). Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin. Science. 327(5971). 1385–1389. 585 indexed citations breakdown →
17.
Riccio, Orbicia, Mariëlle van Gijn, Luca Pellegrinet, et al.. (2008). Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 Kip1 and p57 Kip2. EMBO Reports. 9(4). 377–383. 315 indexed citations breakdown →
18.
Barker, Nick, Johan H. van Es, Jeroen Kuipers, et al.. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 449(7165). 1003–1007. 4255 indexed citations breakdown →
19.
Es, Johan H. van & Hans Clevers. (2005). Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends in Molecular Medicine. 11(11). 496–502. 122 indexed citations
20.
Es, Johan H. van, Rachel H. Giles, & Hans Clevers. (2001). The Many Faces of the Tumor Suppressor Gene APC. Experimental Cell Research. 264(1). 126–134. 108 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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