Edwin Cuppen

49.3k total citations · 10 hit papers
278 papers, 19.9k citations indexed

About

Edwin Cuppen is a scholar working on Molecular Biology, Cancer Research and Genetics. According to data from OpenAlex, Edwin Cuppen has authored 278 papers receiving a total of 19.9k indexed citations (citations by other indexed papers that have themselves been cited), including 161 papers in Molecular Biology, 99 papers in Cancer Research and 71 papers in Genetics. Recurrent topics in Edwin Cuppen's work include Cancer Genomics and Diagnostics (78 papers), Genetic factors in colorectal cancer (30 papers) and CRISPR and Genetic Engineering (29 papers). Edwin Cuppen is often cited by papers focused on Cancer Genomics and Diagnostics (78 papers), Genetic factors in colorectal cancer (30 papers) and CRISPR and Genetic Engineering (29 papers). Edwin Cuppen collaborates with scholars based in Netherlands, United States and Germany. Edwin Cuppen's co-authors include Eugène Berezikov, Ronald H.A. Plasterk, Isaäc J. Nijman, Hans Clevers, Ruben van Boxtel, Victor Guryev, Artem Tarasov, Albert J. Vilella, Pjotr Prins and Ewart de Bruijn and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Edwin Cuppen

270 papers receiving 19.6k citations

Hit Papers

Sambamba: fast processing of NGS alignment formats 2007 2026 2013 2019 2015 2013 2015 2007 2014 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Sambamba: fast processing of NGS alignment formats
    2015 1.3k citations Edwin Cuppen, Isaäc J. Nijman et al. Bioinformatics profile →
  2. Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
    2013 1.0k citations Valentina Sasselli, Nobuo Sasaki et al. profile →
  3. Sequential cancer mutations in cultured human intestinal stem cells
    2015 789 citations Jarno Drost, Ruben van Boxtel et al. profile →
  4. Mammalian Mirtron Genes
    2007 585 citations Edwin Cuppen et al. profile →
  5. Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
    2014 539 citations Jarno Drost, Ruben van Boxtel et al. profile →
  6. A systematic genome-wide analysis of zebrafish protein-coding gene function
    2013 445 citations Ewart de Bruijn, Isaäc J. Nijman et al. profile →
  7. MutationalPatterns: comprehensive genome-wide analysis of mutational processes
    2018 357 citations Francis Blokzijl, Roel Janssen et al. profile →
  8. Pan-cancer landscape of homologous recombination deficiency
    2020 277 citations Luan Nguyen, John W.M. Martens et al. Nature Communications profile →
  9. Pan-cancer whole-genome comparison of primary and metastatic solid tumours
    2023 125 citations Francisco Martínez-Jiménez, Luan Nguyen et al. profile →
  10. A pan-cancer analysis of the microbiome in metastatic cancer
    2024 94 citations Arne van Hoeck, Edwin Cuppen et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Edwin Cuppen Netherlands 70 11.8k 5.6k 3.9k 3.7k 1.5k 278 19.9k
Mario F. Fraga Spain 74 16.8k 1.4× 4.3k 0.8× 2.5k 0.6× 2.9k 0.8× 959 0.6× 237 22.0k
George W. Bell United States 47 18.4k 1.6× 8.2k 1.5× 5.2k 1.3× 1.9k 0.5× 1.1k 0.8× 75 25.0k
Stefan Mundlos Germany 77 17.3k 1.5× 2.6k 0.5× 3.5k 0.9× 7.6k 2.0× 1.5k 1.0× 337 25.0k
Samuel Aparício Canada 63 11.1k 0.9× 3.7k 0.7× 2.7k 0.7× 3.4k 0.9× 952 0.6× 168 17.2k
Jussi Taipale Finland 61 19.6k 1.7× 2.4k 0.4× 4.7k 1.2× 4.0k 1.1× 1.1k 0.7× 110 24.2k
Stanley F. Nelson United States 72 11.0k 0.9× 2.2k 0.4× 2.4k 0.6× 3.8k 1.0× 840 0.6× 208 18.8k
Joakim Lundeberg Sweden 67 10.9k 0.9× 2.3k 0.4× 2.2k 0.6× 2.3k 0.6× 792 0.5× 317 18.0k
Jane E. Visvader Australia 70 14.6k 1.2× 5.9k 1.1× 13.2k 3.4× 2.8k 0.7× 2.4k 1.6× 182 25.0k
Philippe Batut United States 6 18.0k 1.5× 4.4k 0.8× 2.6k 0.7× 3.4k 0.9× 1.4k 0.9× 7 29.4k
Michael T. McManus United States 67 15.4k 1.3× 8.2k 1.5× 1.3k 0.3× 2.1k 0.6× 1.2k 0.8× 202 20.9k

Countries citing papers authored by Edwin Cuppen

Since Specialization
Citations

This map shows the geographic impact of Edwin Cuppen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edwin Cuppen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edwin Cuppen more than expected).

Fields of papers citing papers by Edwin Cuppen

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edwin Cuppen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edwin Cuppen. The network helps show where Edwin Cuppen may publish in the future.

Co-authorship network of co-authors of Edwin Cuppen

This figure shows the co-authorship network connecting the top 25 collaborators of Edwin Cuppen. A scholar is included among the top collaborators of Edwin Cuppen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Edwin Cuppen. Edwin Cuppen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Martínez-Jiménez, Francisco, Peter Priestley, Charles Shale, et al.. (2023). Genetic immune escape landscape in primary and metastatic cancer. Nature Genetics. 55(5). 820–831. 50 indexed citations
3.
Angus, Lindsay, Marcel Smid, Saskia M. Wilting, et al.. (2023). Genomic Alterations Associated with Estrogen Receptor Pathway Activity in Metastatic Breast Cancer Have a Differential Impact on Downstream ER Signaling. Cancers. 15(17). 4416–4416. 3 indexed citations
4.
Vermeij, Wilbert P., Marjolein P. Baar, Ewart Kuijk, et al.. (2022). Different responses to DNA damage determine ageing differences between organs. Aging Cell. 21(4). e13562–e13562. 27 indexed citations
5.
Manders, Freek, Arianne M. Brandsma, Jurrian K. de Kanter, et al.. (2022). MutationalPatterns: the one stop shop for the analysis of mutational processes. BMC Genomics. 23(1). 134–134. 88 indexed citations
6.
Cameron, Daniel, et al.. (2021). VIRUSBreakend: Viral Integration Recognition Using Single Breakends. Bioinformatics. 37(19). 3115–3119. 12 indexed citations
7.
Vöhringer, Harald, Arne van Hoeck, Edwin Cuppen, & Moritz Gerstung. (2021). Learning mutational signatures and their multidimensional genomic properties with TensorSignatures. Nature Communications. 12(1). 3628–3628. 24 indexed citations
8.
Nguyen, Luan, Myrthe Jager, Ruby Lieshout, et al.. (2021). Precancerous liver diseases do not cause increased mutagenesis in liver stem cells. Communications Biology. 4(1). 1301–1301. 9 indexed citations
9.
Roepman, Paul, Ewart de Bruijn, Stef van Lieshout, et al.. (2021). Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics. Journal of Molecular Diagnostics. 23(7). 816–833. 39 indexed citations
10.
Smid, Marcel, Job van Riet, Lindsay Angus, et al.. (2021). Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features. Nature Communications. 12(1). 574–574. 45 indexed citations
11.
Haar, Joris van de, Louisa R. Hoes, Paul Roepman, et al.. (2021). Limited evolution of the actionable metastatic cancer genome under therapeutic pressure. Nature Medicine. 27(9). 1553–1563. 36 indexed citations
12.
Tops, Bastiaan B.J., Elisabeth M. P. Steeghs, Veerle M.H. Coupé, et al.. (2021). Micro-costing diagnostics in oncology: from single-gene testing to whole- genome sequencing. Expert Review of Pharmacoeconomics & Outcomes Research. 21(3). 403–413. 23 indexed citations
13.
Kretzschmar, Kai, Arne van Hoeck, Henk W. P. van den Toorn, et al.. (2020). Single-cell derived tumor organoids display diversity in HLA class I peptide presentation. Nature Communications. 11(1). 5338–5338. 50 indexed citations
14.
Middelkamp, Sjors, Helena T. A. van Tol, Diana C.J. Spierings, et al.. (2020). Sperm DNA damage causes genomic instability in early embryonic development. Science Advances. 6(16). eaaz7602–eaaz7602. 54 indexed citations
15.
Roest, Bastiaan van der, Nicolle Besselink, Roel Janssen, et al.. (2019). 5-Fluorouracil treatment induces characteristic T>G mutations in human cancer. Nature Communications. 10(1). 4571–4571. 138 indexed citations
16.
Roosmalen, Markus J. van, Ivo Renkens, Marleen M. Nieboer, et al.. (2017). Mapping and phasing of structural variation in patient genomes using nanopore sequencing. Nature Communications. 8(1). 1326–1326. 249 indexed citations
17.
Drost, Jarno, Ruben van Boxtel, Francis Blokzijl, et al.. (2017). Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science. 358(6360). 234–238. 312 indexed citations
18.
Kuijk, Ewart, Francis Blokzijl, Meritxell Huch, et al.. (2016). Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Scientific Reports. 6(1). 22154–22154. 47 indexed citations
19.
Vermaat, Joost S.P., Isaäc J. Nijman, Marco J. Koudijs, et al.. (2011). Primary Colorectal Cancers and Their Subsequent Hepatic Metastases Are Genetically Different: Implications for Selection of Patients for Targeted Treatment. Clinical Cancer Research. 18(3). 688–699. 119 indexed citations
20.
Wansleeben, Carolien, Harma Feitsma, Mireille Montcouquiol, et al.. (2010). Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development. 137(7). 1067–1073. 78 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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