Marc van de Wetering

48.8k citations

84 papers · 32.9k indexed · 23 hit papers · h-index 59

Molecular Biology top 0.05%
Oncology top 0.05%
Genetics top 0.1%
Cancer Research top 0.2%
Surgery top 0.5%

Co-authors: Hans Clevers Johan H. van Es Nick Barker Daniel E. Stange Toshiro Sato Hugo J.G. Snippert Maaike van den Born Peter J. Peters
Topics: Wnt/β-catenin signaling in development and cancer (25 papers)Cancer Cells and Metastasis (24 papers)Cancer-related gene regulation (17 papers)
Cited by: Oncology Molecular Biology Cancer Research
Journals: Nature Science Cell
Partner nations: Netherlands United States United Kingdom

In The Last Decade

Marc van de Wetering

82 papers receiving 32.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

2009 5.1k citations Hugo J.G. Snippert, Marc van de Wetering et al. Nature profile →
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

2010 1.9k citations Johan H. van Es, Hugo J.G. Snippert et al. Nature profile →
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

2002 1.6k citations Marc van de Wetering, Elena Sancho et al. Cell profile →
Crypt stem cells as the cells-of-origin of intestinal cancer

2008 1.6k citations Nick Barker, Johan H. van Es et al. Nature profile →
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 1.6k citations Miranda Molenaar, Marc van de Wetering et al. Cell profile →
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

2010 1.2k citations Nick Barker, Meritxell Huch et al. profile →
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

2013 1.1k citations Meritxell Huch, Johan H. van Es et al. Nature profile →
Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 1.0k citations Marc van de Wetering, Rossana Cavallo et al. Cell profile →
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

2011 976 citations Wim de Lau, Nick Barker et al. Nature profile →
β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

2002 889 citations Eduard Batlle, Jeffrey T. Henderson et al. Cell profile →
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

2002 868 citations Marc van de Wetering, Hans Clevers et al. profile →
Lineage Tracing Reveals Lgr5 ⁺ Stem Cell Activity in Mouse Intestinal Adenomas

2012 822 citations Arnout Schepers, Hugo J.G. Snippert et al. Science profile →
Sequential cancer mutations in cultured human intestinal stem cells

2015 789 citations Jarno Drost, René Overmeer et al. Nature profile →
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

2012 694 citations Bon‐Kyoung Koo, Daniel E. Stange et al. Nature profile →
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

2014 609 citations Sina Bartfeld, Marc van de Wetering et al. profile →
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

2012 584 citations Johan H. van Es, Marc van de Wetering et al. profile →
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 572 citations Jeroen P. Roose, Miranda Molenaar et al. Nature profile →
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

2012 562 citations Daniel E. Stange, Arnout Schepers et al. profile →
Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

2009 546 citations Laurens G. van der Flier, Mariëlle van Gijn et al. Cell profile →
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

2013 535 citations Meritxell Huch, Marc van de Wetering et al. profile →
Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

2013 395 citations Daniel E. Stange, Bon‐Kyoung Koo et al. Cell profile →
Intra-tumour diversification in colorectal cancer at the single-cell level

2018 376 citations Marc van de Wetering, Hans Clevers et al. Nature profile →
Xenograft and organoid model systems in cancer research

2019 283 citations Margit Bleijs, Marc van de Wetering et al. profile →

Peers

Countries citing papers authored by Marc van de Wetering

Since Specialization

Citations

This map shows the geographic impact of Marc van de Wetering's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marc van de Wetering with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marc van de Wetering more than expected).

Fields of papers citing papers by Marc van de Wetering

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marc van de Wetering. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marc van de Wetering. The network helps show where Marc van de Wetering may publish in the future.

Co-authorship network of co-authors of Marc van de Wetering

This figure shows the co-authorship network connecting the top 25 collaborators of Marc van de Wetering. A scholar is included among the top collaborators of Marc van de Wetering based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Marc van de Wetering. Marc van de Wetering is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages 2025 ·Nature Communications ·(unknown),Seok‐Young Kim,(unknown),(unknown),Gijs J. F. van Son,Femke Ringnalda,Harry Begthel,Ravian L. van Ineveld,Chris Winkel,Jay P. Slack,Anne C. Rios,(unknown),Jacco van Rheenen,Marc van de Wetering,Hans Clevers	0
2	Organoid drug profiling identifies methotrexate as a therapy for SCCOHT, a rare pediatric cancer 2025 ·Science Advances ·Seok‐Young Kim,(unknown),Marijn A. Vermeulen,Femke Ringnalda,Lennart Kester,József Zsíros,Selma Eising,Jan J. Molenaar,(unknown),Marc van de Wetering,Hans Clevers	2
3	Single‐cell multi‐omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC ‐unique features 2025 ·International Journal of Cancer ·(unknown),(unknown),(unknown),Sabrina Ladstätter,René Overmeer,Péter Brázda,Marc van de Wetering,Farzin Pourfarzad,Robert G. Vries,Wout Megchelenbrink,Christoph Bock,Lucia Altucci,Hendrik G. Stunnenberg	0
4	Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities 2023 ·Oncogene ·(unknown),Justin Williams,(unknown),Femke Ringnalda,(unknown),(unknown),Natalia Moreno,Aniello Federico,N. Franke,Mariëtte E.G. Kranendonk,Santhosh A. Upadhyaya,Kornelius Kerl,Marc van de Wetering,Hans Clevers,Marcel Kool,Eelco W. Hoving,Martine F. Roussel,Jarno Drost	15
5	Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation 2023 ·Science ·(unknown),Jeff DeMartino,Daisong Wang,Gijs J. F. van Son,Reinier van der Linden,Harry Begthel,Jeroen Korving,Amanda Andersson-Rolf,Stieneke van den Brink,Carmen López‐Iglesias,Willine J. van de Wetering,Aleksandra Balwierz,Thanasis Margaritis,Marc van de Wetering,Peter J. Peters,Jarno Drost,Johan H. van Es,Hans Clevers	21
6	Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells 2023 ·Cancer Research Communications ·Lindy L. Visser,Margit Bleijs,Thanasis Margaritis,Marc van de Wetering,Frank C. P. Holstege,Hans Clevers	11
7	Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy 2018 ·Proceedings of the National Academy of Sciences ·Onur Başak,Teresa G. Krieger,Mauro J. Muraro,Kay Wiebrands,Daniel E. Stange,(unknown),N.C. Rivron,Marc van de Wetering,Johan H. van Es,Alexander van Oudenaarden,Benjamin D. Simons,Hans Clevers	121
8	Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epitheliumbreakdown → 2013 ·Cell ·Daniel E. Stange,Bon‐Kyoung Koo,Meritxell Huch,(unknown),Onur Başak,Anna Lyubimova,Pekka Kujala,Sina Bartfeld,Jan Köster,Jessica H. Geahlen,Peter J. Peters,Johan H. van Es,Marc van de Wetering,Jason C. Mills,Hans Clevers	395
9	Lineage Tracing Reveals Lgr5 ⁺ Stem Cell Activity in Mouse Intestinal Adenomasbreakdown → 2012 ·Science ·Arnout Schepers,Hugo J.G. Snippert,Daniel E. Stange,Maaike van den Born,Johan H. van Es,Marc van de Wetering,Hans Clevers	822
10	Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles 2010 ·PLoS ONE ·Michal Mokrý,Pantelis Hatzis,Ewart de Bruijn,Jan Köster,Rogier Versteeg,Jurian Schuijers,Marc van de Wetering,Victor Guryev,Hans Clevers,Edwin Cuppen	34
11	Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fatebreakdown → 2009 ·Cell ·Laurens G. van der Flier,Mariëlle van Gijn,Pantelis Hatzis,Pekka Kujala,Andrea Haegebarth,Daniel E. Stange,Harry Begthel,Maaike van den Born,Victor Guryev,Irma M. Oving,Johan H. van Es,Nick Barker,Peter J. Peters,Marc van de Wetering,Hans Clevers	546
12	Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected 2004 ·Journal of Biological Chemistry ·(unknown),(unknown),Gerwin Huls,Marc van de Wetering,Mahmoud Loghman‐Adham,Albert Ong,James P. Calvet,Hans Clevers,Martijn H. Breuning,Hans van Dam,Dorien J.M. Peters	35
13	WNT Signaling and Lymphocyte Development 2002 ·Cell ·Marc van de Wetering,Wim de Lau,Hans Clevers	107
14	Identification of Two Novel Regulated Serines in the N Terminus of β-Catenin 2002 ·Experimental Cell Research ·Mascha van Noort,Marc van de Wetering,Hans Clevers	38
15	β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinBbreakdown → 2002 ·Cell ·Eduard Batlle,Jeffrey T. Henderson,(unknown),(unknown),Elena Sancho,Gerwin Huls,Jan Meeldijk,Jennifer Robertson,Marc van de Wetering,Tony Pawson,Hans Clevers	889
16	Clonal Acquisition of the Ly49A NK Cell Receptor Is Dependent on the trans-Acting Factor TCF-1 1999 ·Immunity ·Werner Held,Béatrice Kunz,Bente Lowin Kropf,Marc van de Wetering,Hans Clevers	73
17	The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressorsbreakdown → 1998 ·Nature ·Jeroen P. Roose,Miranda Molenaar,(unknown),(unknown),(unknown),Petra Moerer,Marc van de Wetering,Olivier Destrée,Hans Clevers	572
18	Genomic organization of the segment polarity gene pan in Drosophila melanogaster 1998 ·Molecular and General Genetics MGG ·Dennis Dooijes,Moniek van Beest,Marc van de Wetering,(unknown),Tamara L. Jones,Hans Clevers,Mark A. Mortin	4
19	Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCFbreakdown → 1997 ·Cell ·Marc van de Wetering,Rossana Cavallo,Dennis Dooijes,Moniek van Beest,Johan H. van Es,Joseph Loureiro,(unknown),Deborah A. Hursh,Tamara L. Jones,Amy Bejsovec,Mark Peifer,Mark A. Mortin,Hans Clevers	1046
20	Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. 1991 ·The Journal of Experimental Medicine ·Mariëtte A. Oosterwegel,Marc van de Wetering,Dennis Dooijes,Leo W. J. Klomp,Astar Winoto,Katia Georgopoulos,Frits Meijlink,Hans Clevers	122

About Marc van de Wetering

Marc van de Wetering is a scholar working on Microbiology, Oncology and Genetics, having authored 84 papers that have together received 32.9k indexed citations. Recurring topics across this work include Wnt/β-catenin signaling in development and cancer (25 papers), Cancer Cells and Metastasis (24 papers) and Cancer-related gene regulation (17 papers). The work is most often cited by research in Oncology (13.0k citations), Molecular Biology (20.7k citations) and Cancer Research (3.9k citations). Marc van de Wetering has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Hans Clevers, Johan H. van Es, Nick Barker, Daniel E. Stange, Toshiro Sato, Hugo J.G. Snippert, Maaike van den Born, Peter J. Peters, Pekka Kujala and Arie Abo. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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