Owen J. Sansom

51.4k citations

311 papers · 23.8k indexed · 11 hit papers · h-index 80

Molecular Biology top 0.1%
Oncology top 0.1%
Cancer Research top 0.1%
Cell Biology top 0.1%
Immunology top 0.5%

Co-authors: Alan R. Clarke Rachel A. Ridgway Jennifer P. Morton Hans Clevers Nick Barker Valerie G. Brunton Dimitris Athineos Marc van de Wetering
Topics: Wnt/β-catenin signaling in development and cancer (57 papers)Cancer Cells and Metastasis (48 papers)Genetic factors in colorectal cancer (39 papers)
Cited by: Oncology Cancer Research Cell Biology
Journals: Nature Science Cell
Partner nations: United Kingdom United States Netherlands

In The Last Decade

Owen J. Sansom

302 papers receiving 23.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Crypt stem cells as the cells-of-origin of intestinal cancer

2008 1.6k citations Rachel A. Ridgway, Alan R. Clarke et al. profile →
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

2009 1.4k citations Valerie G. Brunton, Jennifer P. Morton et al. profile →
Mutant p53 Drives Invasion by Promoting Integrin Recycling

2009 641 citations Brendan Doyle, Ee Hong Tan et al. profile →
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

2004 636 citations Owen J. Sansom, Karen R. Reed et al. profile →
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

2012 582 citations Luke Boulter, Thomas G. Bird et al. profile →
p53 status determines the role of autophagy in pancreatic tumour development

2013 576 citations Mathias T. Rosenfeldt, Jennifer P. Morton et al. profile →
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

2012 562 citations Kevin Myant, Owen J. Sansom et al. profile →
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

2017 479 citations Jennifer P. Morton, Owen J. Sansom et al. profile →
Modulating the therapeutic response of tumours to dietary serine and glycine starvation

2017 420 citations Dimitris Athineos, Gillian Mackay et al. profile →
Hepatic progenitor cells of biliary origin with liver repopulation capacity

2015 345 citations Wei‐Yu Lu, Thomas G. Bird et al. profile →
Therapeutic targeting of tumour myeloid cells

2023 168 citations Simon T. Barry, Owen J. Sansom et al. profile →

Peers

Countries citing papers authored by Owen J. Sansom

Since Specialization

Citations

This map shows the geographic impact of Owen J. Sansom's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Owen J. Sansom with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Owen J. Sansom more than expected).

Fields of papers citing papers by Owen J. Sansom

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Owen J. Sansom. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Owen J. Sansom. The network helps show where Owen J. Sansom may publish in the future.

Co-authorship network of co-authors of Owen J. Sansom

This figure shows the co-authorship network connecting the top 25 collaborators of Owen J. Sansom. A scholar is included among the top collaborators of Owen J. Sansom based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Owen J. Sansom. Owen J. Sansom is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo 2024 ·Nature Communications ·Arafath K. Najumudeen,Sigrid K. Fey,(unknown),Catriona A. Ford,Kathryn Gilroy,Nuray Gündüz,Rachel A. Ridgway,E. S. Anderson,Douglas Strathdee,William Clark,Colin Nixon,Jennifer P. Morton,Andrew D. Campbell,Owen J. Sansom	8
2	Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression 2022 ·Cancer Research ·Rachana Patel,Catriona A. Ford,Lisa Rodgers,Linda Rushworth,Janis Fleming,Ernest Mui,Tong Zhang,David G. Watson,Victoria H. Lynch,Gillian Mackay,David Sumpton,Owen J. Sansom,Johan Vande Voorde,Hing Y. Leung	20
3	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut 2022 ·Biology Open ·(unknown),(unknown),Sanne M. van Neerven,Nina E. de Groot,(unknown),(unknown),(unknown),(unknown),Karen-Sue Carlson,Joshua D.G. Leach,Owen J. Sansom,Olivier Boulard,Mathias Chamaillard,Louis Vermeulen,Jan Paul Medema,David J. Huels	8
4	Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data 2022 ·Disease Models & Mechanisms ·(unknown),Raheleh Amirkhah,James G. Jackson,Tamsin R.M. Lannagan,Kathryn Gilroy,Sudhir B. Malla,Keara L. Redmond,(unknown),Simon S. McDade,Tim Maughan,Simon J. Leedham,Andrew D. Campbell,Owen J. Sansom,Mark Lawler,Philip D. Dunne	3
5	Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma 2018 ·Cancer Research ·Brittany L. Allen-Petersen,Tyler Risom,Zipei Feng,Zhiping Wang,(unknown),(unknown),Katherine R. Pelz,Jennifer P. Morton,Owen J. Sansom,Charles D. Lopez,Brett C. Sheppard,Dale J. Christensen,Michael Ohlmeyer,Goutham Narla,Rosalie C. Sears	62
6	AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival 2018 ·Clinical Cancer Research ·Emilio Cosimo,Anuradha Tarafdar,(unknown),(unknown),(unknown),Mark Catherwood,Jodie Hay,Karen Dunn,(unknown),Sylvie M. Guichard,Declan O’Rourke,(unknown),Owen J. Sansom,Sabina Cosulich,Alison M. McCaig,Alison M. Michie	23
7	Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten -Deficient Mouse Model of Prostate Carcinogenesis 2017 ·Cancer Research ·Carolyn J. Loveridge,Ernest Mui,Rachana Patel,Ee Hong Tan,Imran Ahmad,Michelle Welsh,Julie Galbraith,Ann Hedley,Colin Nixon,Karen Blyth,Owen J. Sansom,Hing Y. Leung	15
8	Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer 2017 ·Cancer Research ·Zenobia D’Costa,Keaton Jones,Abul Kalam Azad,Ruud van Stiphout,Su Yin Lim,Ana L. Gomes,Paul Kinchesh,Sean Smart,W. Gillies McKenna,Francesca M. Buffa,Owen J. Sansom,Ruth J. Muschel,Eric O’Neill,Emmanouil Fokas	51
9	mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer 2016 ·Cancer Research ·David R. Driscoll,Saadia A. Karim,Makoto Sano,David M. Gay,Wright Jacob,Jun Yu,Yusuke Mizukami,Aarthi Gopinathan,Duncan I. Jodrell,T.R. Jeffry Evans,Nabeel Bardeesy,Michael N. Hall,Brian Quattrochi,David S. Klimstra,Simon T. Barry,Owen J. Sansom,Brian C. Lewis,Jennifer P. Morton	58
10	Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer 2015 ·Cancer Discovery ·Armin Wiegering,(unknown),Thomas Jamieson,(unknown),Melanie Hüttenrauch,(unknown),(unknown),Colin Nixon,Steffi Herold,Susanne Walz,(unknown),Christoph‐Thomas Germer,Andreas Rosenwald,Owen J. Sansom,Martin Eilers	84
11	Global Increase of p16INK4a in APC-Deficient Mouse Liver Drives Clonal Growth of p16INK4a-Negative Tumors 2014 ·Molecular Cancer Research ·Elke Ueberham,(unknown),(unknown),Beate K. Straub,Daniel Teupser,Kai Schönig,Albert Braeuning,Anne Kathrin Höhn,Boris Jerchow,Walter Birchmeier,Frank Gaunitz,Thomas Arendt,Owen J. Sansom,Rolf Gebhardt,Uwe Ueberham	5
12	Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1 2013 ·Cancer Discovery ·Anni Laine,Harri Sihto,Christophé Côme,Mathias T. Rosenfeldt,Aleksandra Zwolińska,Minna Niemelä,Anchit Khanna,Edward K. L. Chan,Veli‐Matti Kähäri,Pirkko‐Liisa Kellokumpu‐Lehtinen,Owen J. Sansom,Gérard I. Evan,Melissa R. Junttila,Kevin M. Ryan,Jean‐Christophe Marine,Heikki Joensuu,Jukka Westermarck	101
13	Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma 2013 ·Cancer Research ·Rachel V. Guest,Luke Boulter,Timothy J. Kendall,(unknown),Robert Walker,Stephen J. Wigmore,Owen J. Sansom,Stuart J. Forbes	90
14	Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling 2013 ·Proceedings of the National Academy of Sciences ·Thomas G. Bird,Wei‐Yu Lu,Luke Boulter,Sabrina Gordon-Keylock,Rachel A. Ridgway,Michael J. Williams,(unknown),James A. Thomas,Davina Wojtacha,Adriana Rosa Gambardella,Owen J. Sansom,John P. Iredale,Stuart J. Forbes	132
15	Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer 2013 ·Cancer Research ·Max Nobis,Ewan J. McGhee,Jennifer P. Morton,Juliane P. Schwarz,Saadia A. Karim,Jean A. Quinn,Mike Edward,Andrew D. Campbell,Lynn McGarry,T.R. Jeffry Evans,Valerie G. Brunton,Margaret C. Frame,Neil O. Carragher,Yingxiao Wang,Owen J. Sansom,Paul Timpson,Kurt I. Anderson	99
16	Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53 2011 ·Cancer Research ·Paul Timpson,Ewan J. McGhee,Jennifer P. Morton,Alex von Kriegsheim,Juliane P. Schwarz,Saadia A. Karim,Brendan Doyle,Jean A. Quinn,Neil O. Carragher,Mike Edward,Michael F. Olson,Margaret C. Frame,Valerie G. Brunton,Owen J. Sansom,Kurt I. Anderson	109
17	MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma 2011 ·Clinical Cancer Research ·Nigel B. Jamieson,(unknown),Jennifer P. Morton,Asif Ali,Euan J. Dickson,(unknown),Owen J. Sansom,T.R. Jeffry Evans,Colin J. McKay,Karin A. Oien	175
18	Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss 2010 ·Cancer Research ·Alicia M. Cole,Kevin Myant,Karen R. Reed,Rachel A. Ridgway,Dimitris Athineos,Gijs R. van den Brink,Vanesa Muncan,Hans Clevers,Alan R. Clarke,Peter Sicinski,Owen J. Sansom	65
19	Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer 2009 ·Proceedings of the National Academy of Sciences ·Jennifer P. Morton,Paul Timpson,Saadia A. Karim,Rachel A. Ridgway,Dimitris Athineos,Brendan Doyle,Nigel B. Jamieson,Karin A. Oien,Andrew M. Lowy,Valerie G. Brunton,Margaret C. Frame,T.R. Jeffry Evans,Owen J. Sansom	465
20	Mutations in Apc and p53 Synergize to Promote Mammary Neoplasia 2005 ·Cancer Research ·Valérie S. Méniel,Trevor Hay,Anthony Douglas-Jones,Owen J. Sansom,Alan R. Clarke	14

About Owen J. Sansom

Owen J. Sansom is a scholar working on Oncology, Cancer Research and Cell Biology, having authored 311 papers that have together received 23.8k indexed citations. Recurring topics across this work include Wnt/β-catenin signaling in development and cancer (57 papers), Cancer Cells and Metastasis (48 papers) and Genetic factors in colorectal cancer (39 papers). The work is most often cited by research in Oncology (8.8k citations), Cancer Research (4.9k citations) and Cell Biology (3.5k citations). Owen J. Sansom has collaborated with scholars based in United Kingdom, United States and Netherlands. Frequent co-authors include Alan R. Clarke, Rachel A. Ridgway, Jennifer P. Morton, Hans Clevers, Nick Barker, Valerie G. Brunton, Dimitris Athineos, Marc van de Wetering, Harry Begthel and Johan H. van Es. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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