Alex Gregorieff

7.8k total citations · 6 hit papers
31 papers, 5.7k citations indexed

About

Alex Gregorieff is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Alex Gregorieff has authored 31 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 22 papers in Molecular Biology, 11 papers in Oncology and 11 papers in Genetics. Recurrent topics in Alex Gregorieff's work include Wnt/β-catenin signaling in development and cancer (12 papers), Digestive system and related health (11 papers) and Cancer Cells and Metastasis (8 papers). Alex Gregorieff is often cited by papers focused on Wnt/β-catenin signaling in development and cancer (12 papers), Digestive system and related health (11 papers) and Cancer Cells and Metastasis (8 papers). Alex Gregorieff collaborates with scholars based in Canada, Netherlands and United States. Alex Gregorieff's co-authors include Hans Clevers, Harry Begthel, Daniel Pinto, Jeffrey L. Wrana, Maaike van den Born, Yu Liu, Johan H. van Es, Menno F. Kielman, Olivier Destrée and Helen McNeill and has published in prestigious journals such as Nature, Cell and Nature Communications.

In The Last Decade

Alex Gregorieff

31 papers receiving 5.7k citations

Hit Papers

Canonical Wnt signals are essential for homeostasis of th... 2003 2026 2010 2018 2003 2012 2005 2005 2015 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    2003 796 citations Daniel Pinto, Alex Gregorieff et al. Genes & Development profile →
  2. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
    2012 584 citations Johan H. van Es, Toshiro Sato et al. Nature Cell Biology profile →
  3. Wnt signalling induces maturation of Paneth cells in intestinal crypts
    2005 518 citations Johan H. van Es, Philippe Jay et al. Nature Cell Biology profile →
  4. Wnt signaling in the intestinal epithelium: from endoderm to cancer
    2005 516 citations Alex Gregorieff, Hans Clevers Genes & Development profile →
  5. Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
    2015 440 citations Alex Gregorieff, Jeffrey L. Wrana et al. Nature profile →
  6. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell
    2019 322 citations Arshad Ayyaz, Sandeep Kumar et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Alex Gregorieff Canada 21 3.6k 1.9k 1.4k 1.3k 692 31 5.7k
Laurens G. van der Flier Netherlands 11 3.1k 0.8× 2.1k 1.1× 1.2k 0.9× 479 0.4× 579 0.8× 12 5.3k
Robert G. Vries Netherlands 16 3.0k 0.8× 2.5k 1.4× 945 0.7× 589 0.5× 1.2k 1.7× 25 6.1k
Miranda Cozijnsen Netherlands 11 3.3k 0.9× 2.9k 1.5× 1.2k 0.9× 450 0.4× 771 1.1× 13 5.9k
George Hausmann Switzerland 27 3.8k 1.1× 1.3k 0.7× 712 0.5× 638 0.5× 346 0.5× 37 5.1k
Madelon M. Maurice Netherlands 40 4.6k 1.3× 1.8k 1.0× 773 0.5× 826 0.7× 334 0.5× 73 6.6k
Wim de Lau Netherlands 15 3.2k 0.9× 1.6k 0.9× 837 0.6× 359 0.3× 444 0.6× 20 4.5k
Kim B. Jensen Denmark 32 2.0k 0.6× 1.3k 0.7× 713 0.5× 947 0.8× 465 0.7× 78 4.3k
Douglas J. Winton United Kingdom 40 4.0k 1.1× 3.0k 1.6× 1.4k 1.0× 789 0.6× 666 1.0× 78 6.6k
Yumi Kanegae Japan 36 3.6k 1.0× 1.2k 0.6× 1.9k 1.3× 335 0.3× 523 0.8× 94 5.9k
Andrea Haegebarth Germany 24 5.4k 1.5× 4.1k 2.2× 1.9k 1.3× 786 0.6× 1.1k 1.5× 47 9.0k

Countries citing papers authored by Alex Gregorieff

Since Specialization
Citations

This map shows the geographic impact of Alex Gregorieff's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alex Gregorieff with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alex Gregorieff more than expected).

Fields of papers citing papers by Alex Gregorieff

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alex Gregorieff. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alex Gregorieff. The network helps show where Alex Gregorieff may publish in the future.

Co-authorship network of co-authors of Alex Gregorieff

This figure shows the co-authorship network connecting the top 25 collaborators of Alex Gregorieff. A scholar is included among the top collaborators of Alex Gregorieff based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alex Gregorieff. Alex Gregorieff is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Westfall, Susan, Tayla M. Olsen, Danielle Karo‐Atar, et al.. (2025). A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection. Cell. 188(12). 3135–3151.e22. 2 indexed citations
2.
Meli, Alexandre P., Laura Weichselbaum, Erwan Pernet, et al.. (2023). Bcl-6 expression by CD4+ T cells determines concomitant immunity and host resistance across distinct parasitic infections. Mucosal Immunology. 16(6). 801–816. 1 indexed citations
3.
Karo‐Atar, Danielle, Shaida Ouladan, Susan Westfall, et al.. (2022). Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity. The Journal of Experimental Medicine. 219(9). 17 indexed citations
4.
Yang, Hao, Alex Gregorieff, Jun‐Li Liu, et al.. (2022). An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling. Frontiers in Immunology. 13. 961457–961457. 14 indexed citations
5.
Zhang, Huairong, Qing Li, George Zogopoulos, et al.. (2021). REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway. Communications Biology. 4(1). 688–688. 18 indexed citations
6.
Ouladan, Shaida & Alex Gregorieff. (2021). Taking a Step Back: Insights into the Mechanisms Regulating Gut Epithelial Dedifferentiation. International Journal of Molecular Sciences. 22(13). 7043–7043. 7 indexed citations
7.
Ayyaz, Arshad, Sandeep Kumar, Bruno Sangiorgi, et al.. (2019). Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature. 569(7754). 121–125. 322 indexed citations breakdown →
8.
Hirsch, Calley, et al.. (2018). Use of Organoids to Characterize Signaling Pathways in Cancer Initiation. Methods in molecular biology. 1765. 315–331. 1 indexed citations
9.
Christova, Tania, Alex Gregorieff, Liang Zhang, et al.. (2018). A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nature Communications. 9(1). 3510–3510. 76 indexed citations
10.
Gregorieff, Alex & Jeffrey L. Wrana. (2017). Hippo signalling in intestinal regeneration and cancer. Current Opinion in Cell Biology. 48. 17–25. 46 indexed citations
11.
Reginensi, Antoine, Rizaldy P. Scott, Alex Gregorieff, et al.. (2013). Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genetics. 9(3). e1003380–e1003380. 224 indexed citations
12.
Es, Johan H. van, Toshiro Sato, Marc van de Wetering, et al.. (2012). Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nature Cell Biology. 14(10). 1099–1104. 584 indexed citations breakdown →
13.
Varelas, Xaralabos, Bryan W. Miller, Richelle Sopko, et al.. (2010). The Hippo Pathway Regulates Wnt/β-Catenin Signaling. Developmental Cell. 18(4). 579–591. 464 indexed citations
14.
Gregorieff, Alex & Hans Clevers. (2010). In Situ Hybridization to Identify Gut Stem Cells. Current Protocols in Stem Cell Biology. 12(1). Unit 2F.1–Unit 2F.1. 27 indexed citations
15.
Wehkamp, Jan, Guoxing Wang, Irmgard Kübler, et al.. (2007). The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-4. The Journal of Immunology. 179(5). 3109–3118. 220 indexed citations
16.
Muncan, Vanesa, Owen J. Sansom, Leon G.J. Tertoolen, et al.. (2006). Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc. Molecular and Cellular Biology. 26(22). 8418–8426. 203 indexed citations
17.
Gregorieff, Alex & Hans Clevers. (2005). Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes & Development. 19(8). 877–890. 516 indexed citations breakdown →
18.
Es, Johan H. van, Philippe Jay, Alex Gregorieff, et al.. (2005). Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nature Cell Biology. 7(4). 381–386. 518 indexed citations breakdown →
19.
Gregorieff, Alex, Rudolf Grosschedl, & Hans Clevers. (2004). Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos. The EMBO Journal. 23(8). 1825–1833. 102 indexed citations
20.
Pinto, Daniel, Alex Gregorieff, Harry Begthel, & Hans Clevers. (2003). Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes & Development. 17(14). 1709–1713. 796 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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