Felipe de Sousa e Melo

13.4k total citations · 4 hit papers
34 papers, 5.7k citations indexed

About

Felipe de Sousa e Melo is a scholar working on Oncology, Molecular Biology and Pathology and Forensic Medicine. According to data from OpenAlex, Felipe de Sousa e Melo has authored 34 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 24 papers in Oncology, 20 papers in Molecular Biology and 10 papers in Pathology and Forensic Medicine. Recurrent topics in Felipe de Sousa e Melo's work include Cancer Cells and Metastasis (15 papers), Wnt/β-catenin signaling in development and cancer (10 papers) and Genetic factors in colorectal cancer (8 papers). Felipe de Sousa e Melo is often cited by papers focused on Cancer Cells and Metastasis (15 papers), Wnt/β-catenin signaling in development and cancer (10 papers) and Genetic factors in colorectal cancer (8 papers). Felipe de Sousa e Melo collaborates with scholars based in Netherlands, United States and France. Felipe de Sousa e Melo's co-authors include Louis Vermeulen, Jan Paul Medema, Tijana Borovski, Dick J. Richel, Joan H. de Jong, Hans M. Rodermond, Jurriaan B. Tuynman, Evelyn Fessler, Maartje van der Heijden and Frédéric J. de Sauvage and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Nature Medicine.

In The Last Decade

Felipe de Sousa e Melo

34 papers receiving 5.6k citations

Hit Papers

Wnt activity defines colon cancer stem cells and is regul... 2010 2026 2015 2020 2010 2015 2013 2017 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    2010 1.4k citations Louis Vermeulen, Felipe de Sousa e Melo et al. Nature Cell Biology profile →
  2. The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
    2015 607 citations Tim J. Schuijt, Jacqueline M. Lankelma et al. Gut profile →
  3. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
    2013 572 citations Felipe de Sousa e Melo, Xin Wang et al. Nature Medicine profile →
  4. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
    2017 558 citations Felipe de Sousa e Melo, Jonathan M. Harnoss et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Felipe de Sousa e Melo Netherlands 24 3.3k 3.1k 1.4k 897 533 34 5.7k
Lopa Mishra United States 49 2.7k 0.8× 3.8k 1.2× 1.5k 1.1× 911 1.0× 819 1.5× 169 7.8k
Courtney W. Houchen United States 48 2.4k 0.7× 3.0k 0.9× 1.2k 0.9× 396 0.4× 472 0.9× 134 5.9k
Andra R. Frost United States 44 1.8k 0.5× 3.3k 1.0× 1.1k 0.8× 563 0.6× 622 1.2× 120 5.7k
Taro Yamashita Japan 46 2.8k 0.8× 4.5k 1.4× 2.9k 2.0× 580 0.6× 614 1.2× 240 9.4k
Thomas Longerich Germany 45 1.4k 0.4× 3.3k 1.0× 1.8k 1.3× 495 0.6× 706 1.3× 205 7.4k
Emina H. Huang United States 35 4.1k 1.2× 2.7k 0.9× 1.4k 1.0× 464 0.5× 791 1.5× 110 7.3k
Nathalie Wong Hong Kong 46 1.6k 0.5× 4.6k 1.4× 3.0k 2.1× 450 0.5× 566 1.1× 120 7.4k
Pei‐Yi Chu Taiwan 37 1.5k 0.4× 2.6k 0.8× 1.1k 0.8× 330 0.4× 726 1.4× 210 4.7k
Jian Ma China 41 1.8k 0.5× 3.7k 1.2× 2.1k 1.5× 357 0.4× 576 1.1× 126 6.1k
Kaori Shima United States 40 3.2k 0.9× 2.3k 0.7× 1.3k 0.9× 1.8k 2.0× 720 1.4× 81 5.7k

Countries citing papers authored by Felipe de Sousa e Melo

Since Specialization
Citations

This map shows the geographic impact of Felipe de Sousa e Melo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Felipe de Sousa e Melo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Felipe de Sousa e Melo more than expected).

Fields of papers citing papers by Felipe de Sousa e Melo

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Felipe de Sousa e Melo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Felipe de Sousa e Melo. The network helps show where Felipe de Sousa e Melo may publish in the future.

Co-authorship network of co-authors of Felipe de Sousa e Melo

This figure shows the co-authorship network connecting the top 25 collaborators of Felipe de Sousa e Melo. A scholar is included among the top collaborators of Felipe de Sousa e Melo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Felipe de Sousa e Melo. Felipe de Sousa e Melo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Nalawansha, Dhanusha A., Kate S. Ashton, Weixian Deng, et al.. (2025). LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation. Nature Communications. 16(1). 7812–7812. 2 indexed citations
2.
Qu, Xueping, Habib Hamidi, Radia Marie Johnson, et al.. (2025). Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer. Nature Communications. 16(1). 4332–4332. 3 indexed citations
3.
Rodvold, Jeffrey J., Matthew Grimmer, Scot A. Marsters, et al.. (2024). ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway. Cancer Research Communications. 4(10). 2734–2755. 7 indexed citations
4.
Thakur, Avinash, Stephen E. Miller, Nicholas P. D. Liau, et al.. (2023). Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/β-Catenin Signaling via LRP6 Coreceptor Clustering. ACS Chemical Biology. 18(4). 772–784. 3 indexed citations
5.
Johnson, Radia Marie, Xueping Qu, Ling‐Yuh Huw, et al.. (2022). ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer. Nature Communications. 13(1). 5478–5478. 24 indexed citations
6.
Piskol, Robert, Ling Huw, Ismail Sergin, et al.. (2019). A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer. Clinical Cancer Research. 25(14). 4431–4442. 40 indexed citations
7.
Nile, Aaron H., Felipe de Sousa e Melo, Susmith Mukund, et al.. (2018). A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nature Chemical Biology. 14(6). 582–590. 66 indexed citations
8.
Trinh, Anne, Kari Trumpi, Felipe de Sousa e Melo, et al.. (2016). Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. Clinical Cancer Research. 23(2). 387–398. 132 indexed citations
9.
Fessler, Evelyn, Jarno Drost, Sander R. van Hooff, et al.. (2016). TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Molecular Medicine. 8(7). 745–760. 120 indexed citations
10.
Fessler, Evelyn, Marnix Jansen, Felipe de Sousa e Melo, et al.. (2016). A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype. Oncogene. 35(46). 6026–6037. 46 indexed citations
11.
Schuijt, Tim J., Jacqueline M. Lankelma, Brendon P. Scicluna, et al.. (2015). The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut. 65(4). 575–583. 607 indexed citations breakdown →
12.
Storm, Elaine E., Steffen Durinck, Felipe de Sousa e Melo, et al.. (2015). Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. Nature. 529(7584). 97–100. 181 indexed citations
13.
Melo, Felipe de Sousa e, Xin Wang, Marnix Jansen, et al.. (2013). Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nature Medicine. 19(5). 614–618. 572 indexed citations breakdown →
14.
Kemper, Kristel, Miranda Versloot, Katherine Cameron, et al.. (2012). Mutations in the Ras–Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer. Clinical Cancer Research. 18(11). 3132–3141. 76 indexed citations
15.
Fessler, Evelyn, Feline E. Dijkgraaf, Felipe de Sousa e Melo, & Jan Paul Medema. (2012). Cancer stem cell dynamics in tumor progression and metastasis: Is the microenvironment to blame?. Cancer Letters. 341(1). 97–104. 111 indexed citations
16.
Jong, Joan H. de, Hans M. Rodermond, Cheryl Zimberlin, et al.. (2012). Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis. Scientific Reports. 2(1). 271–271. 15 indexed citations
17.
Melo, Felipe de Sousa e, Selçuk Çolak, Joyce Y. Buikhuisen, et al.. (2011). Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients. Cell stem cell. 9(5). 476–485. 260 indexed citations
18.
Borovski, Tijana, Felipe de Sousa e Melo, Louis Vermeulen, & Jan Paul Medema. (2011). Cancer Stem Cell Niche: The Place to Be. Cancer Research. 71(3). 634–639. 408 indexed citations
19.
Melo, Felipe de Sousa e & Jan Paul Medema. (2011). Axing Wnt signals. Cell Research. 22(1). 9–11. 5 indexed citations
20.
Vermeulen, Louis, Felipe de Sousa e Melo, Maartje van der Heijden, et al.. (2010). Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nature Cell Biology. 12(5). 468–476. 1433 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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