Frédéric J. de Sauvage

48.7k total citations · 20 hit papers
148 papers, 31.0k citations indexed

About

Frédéric J. de Sauvage is a scholar working on Molecular Biology, Genetics and Oncology. According to data from OpenAlex, Frédéric J. de Sauvage has authored 148 papers receiving a total of 31.0k indexed citations (citations by other indexed papers that have themselves been cited), including 95 papers in Molecular Biology, 34 papers in Genetics and 31 papers in Oncology. Recurrent topics in Frédéric J. de Sauvage's work include Hedgehog Signaling Pathway Studies (54 papers), Epigenetics and DNA Methylation (22 papers) and Platelet Disorders and Treatments (19 papers). Frédéric J. de Sauvage is often cited by papers focused on Hedgehog Signaling Pathway Studies (54 papers), Epigenetics and DNA Methylation (22 papers) and Platelet Disorders and Treatments (19 papers). Frédéric J. de Sauvage collaborates with scholars based in United States, France and Switzerland. Frédéric J. de Sauvage's co-authors include Melissa R. Junttila, Nico Ghilardi, Austin Gurney, Suzie J. Scales, Lee L. Rubin, Arnon Rosenthal, Noelyn M. Kljavin, Ming-Hong Xie, Hua Tian and Sudeepta Aggarwal and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Frédéric J. de Sauvage

148 papers receiving 30.3k citations

Hit Papers

Influence of tumour micro-enviro... 1994 2026 2004 2015 2013 2008 2003 1994 1998 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Influence of tumour micro-environment heterogeneity on therapeutic response
    2013 2.0k citations Frédéric J. de Sauvage et al. profile →
  2. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    2008 1.5k citations Dimitry M. Danilenko, Zora Modrušan et al. profile →
  3. Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
    2003 1.5k citations Nico Ghilardi, Frédéric J. de Sauvage et al. profile →
  4. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
    1994 1.1k citations Frédéric J. de Sauvage, Austin Gurney et al. profile →
  5. Activating Smoothened mutations in sporadic basal-cell carcinoma
    1998 1.1k citations Frédéric J. de Sauvage et al. profile →
  6. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    1996 908 citations Frédéric J. de Sauvage et al. profile →
  7. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    2011 904 citations Hua Tian, Søren Warming et al. profile →
  8. Characterization of a multicomponent receptor for GDNF
    1996 893 citations Frédéric J. de Sauvage et al. profile →
  9. Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
    2009 833 citations Charles M. Rudin, Robert L. Yauch et al. profile →
  10. A paracrine requirement for hedgehog signalling in cancer
    2008 770 citations Robert L. Yauch, Stephen E. Gould et al. profile →
  11. Targeting the Hedgehog pathway in cancer
    2006 770 citations Frédéric J. de Sauvage et al. profile →
  12. Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
    2009 761 citations Charles M. Rudin, Christine L. Hann et al. profile →
  13. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
    2006 692 citations Marcel Batten, Sothy Yi et al. profile →
  14. Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
    2009 670 citations Robert L. Yauch, Gerrit J.P. Dijkgraaf et al. Science profile →
  15. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
    2017 558 citations Felipe de Sousa e Melo, Noelyn M. Kljavin et al. profile →
  16. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
    2009 534 citations Suzie J. Scales, Frédéric J. de Sauvage profile →
  17. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
    1994 519 citations Frédéric J. de Sauvage et al. profile →
  18. The great escape: tumour cell plasticity in resistance to targeted therapy
    2019 475 citations Frédéric J. de Sauvage et al. profile →
  19. Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration
    2013 427 citations Ciara Metcalfe, Noelyn M. Kljavin et al. profile →
  20. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
    2016 412 citations Frédéric J. de Sauvage et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Frédéric J. de Sauvage United States 86 17.7k 8.0k 6.5k 4.7k 2.8k 148 31.0k
Joan S. Brugge United States 111 25.6k 1.4× 10.2k 1.3× 5.2k 0.8× 3.9k 0.8× 5.1k 1.9× 259 41.9k
Karl Tryggvason Sweden 96 15.1k 0.9× 4.8k 0.6× 4.1k 0.6× 4.5k 0.9× 6.8k 2.5× 384 34.3k
Lothar Hennighausen United States 94 14.7k 0.8× 11.0k 1.4× 10.1k 1.6× 7.0k 1.5× 3.5k 1.3× 332 32.0k
Martine F. Roussel United States 83 19.4k 1.1× 12.4k 1.6× 4.0k 0.6× 2.6k 0.5× 3.3k 1.2× 242 27.9k
Hartmut Beug Austria 82 16.1k 0.9× 7.4k 0.9× 3.4k 0.5× 4.2k 0.9× 3.4k 1.2× 254 25.3k
Daniel Birnbaum France 93 17.3k 1.0× 12.8k 1.6× 4.0k 0.6× 3.5k 0.8× 7.5k 2.7× 558 31.8k
Thomas M. Roberts United States 84 19.6k 1.1× 7.6k 1.0× 3.4k 0.5× 3.4k 0.7× 2.6k 0.9× 309 28.9k
A. Thomas Look United States 101 21.0k 1.2× 8.2k 1.0× 7.0k 1.1× 2.9k 0.6× 5.4k 2.0× 385 40.5k
Jon C. Aster United States 96 20.4k 1.2× 7.9k 1.0× 5.5k 0.9× 1.4k 0.3× 3.8k 1.4× 278 32.0k
Leonard D. Shultz United States 92 10.5k 0.6× 7.9k 1.0× 14.0k 2.2× 5.4k 1.1× 2.0k 0.7× 452 32.2k

Countries citing papers authored by Frédéric J. de Sauvage

Since Specialization
Citations

This map shows the geographic impact of Frédéric J. de Sauvage's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frédéric J. de Sauvage with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frédéric J. de Sauvage more than expected).

Fields of papers citing papers by Frédéric J. de Sauvage

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frédéric J. de Sauvage. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frédéric J. de Sauvage. The network helps show where Frédéric J. de Sauvage may publish in the future.

Co-authorship network of co-authors of Frédéric J. de Sauvage

This figure shows the co-authorship network connecting the top 25 collaborators of Frédéric J. de Sauvage. A scholar is included among the top collaborators of Frédéric J. de Sauvage based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frédéric J. de Sauvage. Frédéric J. de Sauvage is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Cox, Christian, Elaine E. Storm, Varun N. Kapoor, et al.. (2021). IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage. Science Immunology. 6(59). 36 indexed citations
2.
Halpern, Keren Bahar, Hassan Massalha, Rachel K. Zwick, et al.. (2020). Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nature Communications. 11(1). 1936–1936. 100 indexed citations
3.
Castillo‐Azofeifa, David, Elena N. Fazio, Roy Nattiv, et al.. (2019). Atoh1 + secretory progenitors possess renewal capacity independent of Lgr5 + cells during colonic regeneration. The EMBO Journal. 38(4). 55 indexed citations
4.
Piskol, Robert, Ling Huw, Ismail Sergin, et al.. (2019). A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer. Clinical Cancer Research. 25(14). 4431–4442. 40 indexed citations
5.
Hegde, Ganapati V., Jennifer M. Giltnane, Lisa Crocker, et al.. (2019). NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma. eLife. 8. 9 indexed citations
6.
Lee, Genee Y., Peter M. Haverty, Li Li, et al.. (2014). Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes. Cancer Research. 74(11). 3114–3126. 125 indexed citations
7.
Metcalfe, Ciara, Bruno Alicke, Ailey Crow, et al.. (2013). PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition. Cancer Research. 73(23). 7034–7042. 44 indexed citations
8.
Brais, Rebecca, Susan E. Davies, Maria O’Donovan, et al.. (2012). Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials. Pancreatology. 12(1). 8–15. 39 indexed citations
9.
Metcalfe, Ciara & Frédéric J. de Sauvage. (2011). Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists. Cancer Research. 71(15). 5057–5061. 134 indexed citations
10.
Wong, Harvey, Bruno Alicke, Kristina West, et al.. (2011). Pharmacokinetic–Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation. Clinical Cancer Research. 17(14). 4682–4692. 96 indexed citations
11.
Batten, Marcel, Nandhini Ramamoorthi, Noelyn M. Kljavin, et al.. (2010). IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. The Journal of Experimental Medicine. 207(13). 2895–2906. 163 indexed citations
12.
Dijkgraaf, Gerrit J.P., Bruno Alicke, Lasse Weinmann, et al.. (2010). Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance. Cancer Research. 71(2). 435–444. 293 indexed citations
13.
Tian, Hua, Christopher A. Callahan, Kelly DuPree, et al.. (2009). Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proceedings of the National Academy of Sciences. 106(11). 4254–4259. 332 indexed citations
14.
Yauch, Robert L., Gerrit J.P. Dijkgraaf, Bruno Alicke, et al.. (2009). Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma. Science. 326(5952). 572–574. 670 indexed citations breakdown →
15.
Tiedt, Ralph, Jörn Coers, Sandra Ziegler, et al.. (2008). Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood. 113(8). 1768–1777. 44 indexed citations
16.
Gray, Daniel C., Adrian M. Jubb, Deborah Hogue, et al.. (2005). Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers. Cancer Research. 65(21). 9751–9761. 149 indexed citations
17.
Broxmeyer, Hal E., Scott Cooper, Laurence A. Lasky, & Frédéric J. de Sauvage. (2005). Identification of a Massive Reserve of Hematopoietic Progenitors in Mice. Stem Cells and Development. 14(2). 105–110. 14 indexed citations
18.
Chen, Wei, Xiu-Rong Ren, Christopher Nelson, et al.. (2004). Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2. Science. 306(5705). 2257–2260. 221 indexed citations
19.
Lucas, Sophie, Nico Ghilardi, Ji Li, & Frédéric J. de Sauvage. (2003). IL-27 regulates IL-12 responsiveness of naïve CD4 + T cells through Stat1-dependent and -independent mechanisms. Proceedings of the National Academy of Sciences. 100(25). 15047–15052. 394 indexed citations
20.
Gurney, Austin & Frédéric J. de Sauvage. (1996). Dissection of c‐Mpl and Thrombopoietin Function: Studies of Knockout Mice and Receptor Signal Transduction. Stem Cells. 14(S1). 116–123. 18 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Joan S. Brugge Breakdown of academic impact, for papers by Karl Tryggvason Breakdown of academic impact, for papers by Lothar Hennighausen Breakdown of academic impact, for papers by Martine F. Roussel Breakdown of academic impact, for papers by Hartmut Beug Breakdown of academic impact, for papers by Daniel Birnbaum Breakdown of academic impact, for papers by Thomas M. Roberts Breakdown of academic impact, for papers by A. Thomas Look Breakdown of academic impact, for papers by Jon C. Aster Breakdown of academic impact, for papers by Leonard D. Shultz
Rankless by CCL
2026