Jan Paul Medema

49.5k total citations · 8 hit papers
266 papers, 21.8k citations indexed

About

Jan Paul Medema is a scholar working on Oncology, Molecular Biology and Immunology. According to data from OpenAlex, Jan Paul Medema has authored 266 papers receiving a total of 21.8k indexed citations (citations by other indexed papers that have themselves been cited), including 126 papers in Oncology, 111 papers in Molecular Biology and 57 papers in Immunology. Recurrent topics in Jan Paul Medema's work include Cancer Cells and Metastasis (57 papers), Genetic factors in colorectal cancer (33 papers) and Colorectal Cancer Treatments and Studies (28 papers). Jan Paul Medema is often cited by papers focused on Cancer Cells and Metastasis (57 papers), Genetic factors in colorectal cancer (33 papers) and Colorectal Cancer Treatments and Studies (28 papers). Jan Paul Medema collaborates with scholars based in Netherlands, United States and France. Jan Paul Medema's co-authors include Louis Vermeulen, Giorgio Stassi, Felipe de Sousa e Melo, Matilde Todaro, Pramudita R. Prasetyanti, Kristel Kemper, Jan H. Kessler, Franziska B. Mullauer, Dick J. Richel and Tijana Borovski and has published in prestigious journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Jan Paul Medema

265 papers receiving 21.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

2010 1.4k citations Louis Vermeulen, Felipe de Sousa e Melo et al. profile →
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 1.0k citations Jan Paul Medema The EMBO Journal profile →
Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4

2007 836 citations Louis Vermeulen, Jan Paul Medema et al. profile →
Sequential cancer mutations in cultured human intestinal stem cells

2015 789 citations Jarno Drost, Cheryl Zimberlin et al. Nature profile →
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

2008 597 citations Louis Vermeulen, Martin R. Sprick et al. profile →
Cancer stem cells: The challenges ahead

2013 585 citations Jan Paul Medema profile →
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

2013 572 citations Felipe de Sousa e Melo, Xin Wang et al. profile →
Intra-tumor heterogeneity from a cancer stem cell perspective

2017 570 citations Pramudita R. Prasetyanti, Jan Paul Medema profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Jan Paul Medema Netherlands	73	11.0k	9.7k	5.0k	4.7k	1.9k	266	21.8k
Ruggero De Maria Italy	72	13.1k 1.2×	9.1k 0.9×	4.0k 0.8×	6.1k 1.3×	971 0.5×	257	22.8k
Surinder K. Batra United States	84	14.4k 1.3×	9.3k 1.0×	4.1k 0.8×	4.1k 0.9×	1.1k 0.6×	580	25.5k
Ben Z. Stanger United States	69	11.0k 1.0×	9.0k 0.9×	5.4k 1.1×	5.0k 1.1×	637 0.3×	153	22.3k
Owen J. Sansom United Kingdom	80	14.4k 1.3×	8.8k 0.9×	2.8k 0.6×	4.9k 1.0×	1.9k 1.0×	311	23.8k
Anil K. Rustgi United States	73	9.9k 0.9×	9.6k 1.0×	2.2k 0.4×	4.1k 0.9×	1.5k 0.8×	302	20.2k
Andrew L. Kung United States	81	16.6k 1.5×	6.6k 0.7×	2.9k 0.6×	4.6k 1.0×	1.2k 0.7×	285	24.2k
Yong Li China	68	11.5k 1.0×	4.6k 0.5×	3.9k 0.8×	6.4k 1.4×	1.0k 0.6×	439	19.5k
Yibin Kang United States	77	15.7k 1.4×	11.2k 1.2×	2.5k 0.5×	8.3k 1.8×	1.8k 0.9×	193	25.3k
Zora Modrušan United States	69	10.6k 1.0×	4.9k 0.5×	5.0k 1.0×	3.6k 0.8×	1.3k 0.7×	166	19.7k
Yi Li China	65	9.7k 0.9×	5.4k 0.6×	3.5k 0.7×	3.2k 0.7×	1.2k 0.6×	695	19.1k

Countries citing papers authored by Jan Paul Medema

Since Specialization

Citations

This map shows the geographic impact of Jan Paul Medema's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jan Paul Medema with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jan Paul Medema more than expected).

Fields of papers citing papers by Jan Paul Medema

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jan Paul Medema. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jan Paul Medema. The network helps show where Jan Paul Medema may publish in the future.

Co-authorship network of co-authors of Jan Paul Medema

This figure shows the co-authorship network connecting the top 25 collaborators of Jan Paul Medema. A scholar is included among the top collaborators of Jan Paul Medema based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jan Paul Medema. Jan Paul Medema is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Koopman, Miriam, et al.. (2024). NanoCMSer : a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples. Molecular Oncology. 19(5). 1332–1346. 1 indexed citations

Longobardi, Ciro, et al.. (2024). A Method to Study Migration and Invasion of Mouse Intestinal Organoids. SHILAP Revista de lepidopterología. 3(3). 194–202. 1 indexed citations

Buikhuisen, Joyce Y., Kate Cameron, Saskia J.E. Suijkerbuijk, et al.. (2023). Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer. Journal of Experimental & Clinical Cancer Research. 42(1). 56–56. 4 indexed citations

Neerven, Sanne M. van, Nina E. de Groot, Karen-Sue Carlson, et al.. (2022). The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biology Open. 11(12). 8 indexed citations

Braak, Robert R.J. Coebergh van den, Sanne ten Hoorn, Anieta M. Sieuwerts, et al.. (2020). Interconnectivity between molecular subtypes and tumor stage in colorectal cancer. BMC Cancer. 20(1). 850–850. 21 indexed citations

Kroon, Féline P B, Frédérique Gandjbakhch, Charles Peterfy, et al.. (2018). Longitudinal Reliability of the OMERACT Thumb Base Osteoarthritis Magnetic Resonance Imaging Scoring System (TOMS). The Journal of Rheumatology. 46(9). 1228–1231. 5 indexed citations

Salerno, Fiamma, Sander Engels, Maartje van den Biggelaar, et al.. (2018). Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells. Nature Immunology. 19(8). 828–837. 85 indexed citations

Cate, Rosemarie ten, Jan Paul Medema, Harry Vrieling, et al.. (2017). Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination. Cancer Research. 77(6). 1485–1491. 16 indexed citations

Trinh, Anne, Kari Trumpi, Felipe de Sousa e Melo, et al.. (2016). Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. Clinical Cancer Research. 23(2). 387–398. 132 indexed citations

10.

Fessler, Evelyn, Jarno Drost, Sander R. van Hooff, et al.. (2016). TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Molecular Medicine. 8(7). 745–760. 120 indexed citations

11.

Fessler, Evelyn, Marnix Jansen, Felipe de Sousa e Melo, et al.. (2016). A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype. Oncogene. 35(46). 6026–6037. 46 indexed citations

12.

Oei, Arlene L., Caspar M. van Leeuwen, Rosemarie ten Cate, et al.. (2015). Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. Cancer Research. 75(23). 5120–5129. 49 indexed citations

13.

Calpe, Silvia, Koen Wagner, Mohamed El Khattabi, et al.. (2015). Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies. Molecular Cancer Therapeutics. 14(11). 2527–2540. 16 indexed citations

14.

Rocha, Cecilia, Laura Papon, Wulfran Cacheux, et al.. (2014). Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon (vol 33, pg 2247, 2014). The EMBO Journal. 33(22). 2 indexed citations

15.

Kemper, Kristel, Miranda Versloot, Katherine Cameron, et al.. (2012). Mutations in the Ras–Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer. Clinical Cancer Research. 18(11). 3132–3141. 76 indexed citations

16.

Reijmers, Rogier M., Richard W.J. Groen, Annemieke Kuil, et al.. (2011). Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. Blood. 117(23). 6162–6171. 45 indexed citations

17.

Medema, Jan Paul & Louis Vermeulen. (2011). Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature. 474(7351). 318–326. 355 indexed citations

18.

Kemper, Kristel, Martin R. Sprick, Alessandro Scopelliti, et al.. (2010). The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation. Cancer Research. 70(2). 719–729. 288 indexed citations

19.

Sottoriva, Andrea, Joost J.C. Verhoeff, Tijana Borovski, et al.. (2010). Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity. Cancer Research. 70(1). 46–56. 151 indexed citations

20.

Pronk, Gijsbertus J., et al.. (1995). Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS.. Data Archiving and Networked Services (DANS). 10(5). 919–25. 16 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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