Ciara Metcalfe

2.8k total citations · 2 hit papers
33 papers, 1.6k citations indexed

About

Ciara Metcalfe is a scholar working on Pulmonary and Respiratory Medicine, Genetics and Molecular Biology. According to data from OpenAlex, Ciara Metcalfe has authored 33 papers receiving a total of 1.6k indexed citations (citations by other indexed papers that have themselves been cited), including 19 papers in Pulmonary and Respiratory Medicine, 19 papers in Genetics and 14 papers in Molecular Biology. Recurrent topics in Ciara Metcalfe's work include Advanced Breast Cancer Therapies (18 papers), Estrogen and related hormone effects (15 papers) and Breast Cancer Treatment Studies (6 papers). Ciara Metcalfe is often cited by papers focused on Advanced Breast Cancer Therapies (18 papers), Estrogen and related hormone effects (15 papers) and Breast Cancer Treatment Studies (6 papers). Ciara Metcalfe collaborates with scholars based in United States, United Kingdom and Spain. Ciara Metcalfe's co-authors include Frédéric J. de Sauvage, Mariann Bienz, Noelyn M. Kljavin, Ryan Ybarra, Thomas Schwarz, Juliusz Mieszczanek, Carolina Mendoza-Topaz, Sarat Chandarlapaty, Marie Will and Elaine E. Storm and has published in prestigious journals such as Nature, Journal of Clinical Oncology and Nature reviews. Cancer.

In The Last Decade

Ciara Metcalfe

32 papers receiving 1.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

2013 427 citations Ciara Metcalfe, Noelyn M. Kljavin et al. Cell stem cell profile →
Therapeutic resistance to anti-oestrogen therapy in breast cancer

2023 84 citations Marie Will, Ciara Metcalfe et al. Nature reviews. Cancer profile →

Peers

Ciara Metcalfe

ONCOL

GENET

PRM

Sarah Hatsell United States

Cameron N. Johnstone Australia

Keiji Furuuchi Japan

Victor Stastny United States

Heidi L. Kenerson United States

Shilpa Bhatia United States

Pinaki Bose Canada

Raffaella Zamponi Italy

Siddhartha Deb Australia

Yongping Crawford United States

Sarah Hatsell United States

Ciara Metcalfe

951 ×0.9

469 ×0.8

ONCOL

250 ×0.8

GENET

152 ×0.8

147 ×0.8

PRM

Citations per year, relative to Ciara Metcalfe Ciara Metcalfe (= 1×) peers Sarah Hatsell

Countries citing papers authored by Ciara Metcalfe

Since Specialization

Citations

This map shows the geographic impact of Ciara Metcalfe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ciara Metcalfe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ciara Metcalfe more than expected).

Fields of papers citing papers by Ciara Metcalfe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ciara Metcalfe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ciara Metcalfe. The network helps show where Ciara Metcalfe may publish in the future.

Co-authorship network of co-authors of Ciara Metcalfe

This figure shows the co-authorship network connecting the top 25 collaborators of Ciara Metcalfe. A scholar is included among the top collaborators of Ciara Metcalfe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ciara Metcalfe. Ciara Metcalfe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Maulding, Nathan D, Jun Zou, Wei Zhou, et al.. (2025). Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer. npj Systems Biology and Applications. 11(1). 5–5. 1 indexed citations

Yao, Xiaosai, Patrick Aouad, Lisa Crocker, et al.. (2025). ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer. Nature Cancer. 6(2). 357–371. 3 indexed citations

Metcalfe, Ciara, Thomas Hunsaker, Tomislav Hafner, et al.. (2025). Abstract ND02: GDC-2992: A heterobifunctional Androgen Receptor (AR) antagonist and degrader for the treatment of AR wild-type and mutant prostate cancer. Cancer Research. 85(8_Supplement_2). ND02–ND02.

Chibly, Alejandro, Pablo Ernesto Pérez, Heather M. Moore, et al.. (2024). CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape. npj Breast Cancer. 10(1). 15–15. 10 indexed citations

Harper‐Wynne, Catherine, Yeon Hee Park, Fábio Franke, et al.. (2024). heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with previously untreated HER2-positive, estrogen receptor-positive locally advanced or metastatic breast cancer. BMC Cancer. 24(1). 641–641. 4 indexed citations

Chandarlapaty, Sarat, Maura N. Dickler, José Alejandro Pérez Fidalgo, et al.. (2023). An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer. Clinical Cancer Research. 29(15). 2781–2790. 7 indexed citations

Will, Marie, et al.. (2023). Therapeutic resistance to anti-oestrogen therapy in breast cancer. Nature reviews. Cancer. 23(10). 673–685. 84 indexed citations breakdown →

Ingalla, Ellen, Xiaosai Yao, Jennifer M. Giltnane, et al.. (2022). Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer. Science Translational Medicine. 14(663). eabo5959–eabo5959. 9 indexed citations

Metcalfe, Ciara & Jennifer Lauchle. (2022). Clinical Translation: Targeting the Estrogen Receptor. Advances in experimental medicine and biology. 1390. 297–309. 3 indexed citations

10.

Chen, Ya‐Chi, Jiajie Yu, Ciara Metcalfe, et al.. (2021). Latest generation estrogen receptor degraders for the treatment of hormone receptor-positive breast cancer. Expert Opinion on Investigational Drugs. 31(6). 515–529. 48 indexed citations

11.

Daemen, Anneleen, Jill M. Spoerke, Wei Zhou, et al.. (2020). Abstract P2-11-05: ER pathway activity signature as a biomarker for endocrine agent GDC-9545. Cancer Research. 80(4_Supplement). P2–11. 1 indexed citations

12.

Moore, Heather M., Heidi Savage, Carol O’Brien, et al.. (2019). Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models. Molecular Cancer Therapeutics. 19(1). 292–303. 8 indexed citations

13.

Storm, Elaine E., Steffen Durinck, Felipe de Sousa e Melo, et al.. (2015). Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. Nature. 529(7584). 97–100. 181 indexed citations

14.

Junttila, Melissa R., Vidusha Devasthali, Jason Chia‐Hsien Cheng, et al.. (2014). Modeling Targeted Inhibition of MEK and PI3 Kinase in Human Pancreatic Cancer. Molecular Cancer Therapeutics. 14(1). 40–47. 43 indexed citations

15.

Büller, Nikè V.J.A., Sanne L. Rosekrans, Ciara Metcalfe, et al.. (2014). Stromal Indian Hedgehog Signaling Is Required for Intestinal Adenoma Formation in Mice. Gastroenterology. 148(1). 170–180.e6. 32 indexed citations

16.

Metcalfe, Ciara, Bruno Alicke, Ailey Crow, et al.. (2013). PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition. Cancer Research. 73(23). 7034–7042. 44 indexed citations

17.

Metcalfe, Ciara, Noelyn M. Kljavin, Ryan Ybarra, & Frédéric J. de Sauvage. (2013). Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration. Cell stem cell. 14(2). 149–159. 427 indexed citations breakdown →

18.

Metcalfe, Ciara & Frédéric J. de Sauvage. (2011). Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists. Cancer Research. 71(15). 5057–5061. 134 indexed citations

19.

Metcalfe, Ciara, Ashraf E.K. Ibrahim, Marc de la Roche, et al.. (2010). Dvl2 Promotes Intestinal Length and Neoplasia in the Apc Min Mouse Model for Colorectal Cancer. Cancer Research. 70(16). 6629–6638. 46 indexed citations

20.

Schwarz, Thomas, Ciara Metcalfe, & Mariann Bienz. (2007). Dynamic recruitment of axin by Dishevelled protein assemblies. Journal of Cell Science. 120(14). 2402–2412. 182 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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