Wayne J. Fairbrother

18.0k citations

122 papers · 9.1k indexed · 2 hit papers · h-index 51

Molecular Biology top 0.5%
Immunology top 1%
Oncology top 1%
Cancer Research top 1%
Radiology, Nuclear Medicine and Imaging top 2%

Co-authors: Domagoj Vucic Kurt Deshayes Vishva M. Dixit Melissa A. Starovasnik Andrew J. Souers Anna Fedorova Joel Johansson Kerry Zobel
Topics: Cell death mechanisms and regulation (33 papers)Monoclonal and Polyclonal Antibodies Research (21 papers)Ubiquitin and proteasome pathways (15 papers)
Cited by: Immunology Molecular Biology Cancer Research
Journals: Nature Science Cell
Partner nations: United States France United Kingdom

In The Last Decade

Wayne J. Fairbrother

121 papers receiving 8.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

2007 1.0k citations Eugene Varfolomeev, Jasmin N. Dynek et al. profile →
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

2017 667 citations Wayne J. Fairbrother, Joel Johansson et al. profile →

Peers

Countries citing papers authored by Wayne J. Fairbrother

Since Specialization

Citations

This map shows the geographic impact of Wayne J. Fairbrother's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Wayne J. Fairbrother with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Wayne J. Fairbrother more than expected).

Fields of papers citing papers by Wayne J. Fairbrother

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Wayne J. Fairbrother. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Wayne J. Fairbrother. The network helps show where Wayne J. Fairbrother may publish in the future.

Co-authorship network of co-authors of Wayne J. Fairbrother

This figure shows the co-authorship network connecting the top 25 collaborators of Wayne J. Fairbrother. A scholar is included among the top collaborators of Wayne J. Fairbrother based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Wayne J. Fairbrother. Wayne J. Fairbrother is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition 2022 ·Cell Death and Disease ·Bruno Alicke,Eugene Varfolomeev,(unknown),Alexandra Frommlet,Savita Ubhayakar,John G. Quinn,Wayne J. Fairbrother,Robin L. Jones,Stephen E. Gould,Domagoj Vucic	3
2	Ribosomal Synthesis of Macrocyclic Peptides with Linear γ⁴- and β-Hydroxy-γ⁴-amino Acids 2021 ·ACS Chemical Biology ·Emel Adaligil,Aimin Song,Christian N. Cunningham,Wayne J. Fairbrother	16
3	Ribosomal Synthesis of Macrocyclic Peptides with β²- and β^2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries 2021 ·ACS Chemical Biology ·Emel Adaligil,Aimin Song,Kenneth K. Hallenbeck,Christian N. Cunningham,Wayne J. Fairbrother	17
4	Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models 2016 ·Molecular Cancer Therapeutics ·Elizabeth A. Punnoose,Joel Johansson,Franklin Peale,Erwin R. Boghaert,Lisa D. Belmont,Nguyen Tan,A. Young,Michael J. Mitten,Ellen Ingalla,Walter C. Darbonne,Anatol Oleksijew,Paul Tapang,Yue Peng,Jason Oeh,Leslie Lee,Sophie Maïga,Wayne J. Fairbrother,Martine Amiot,Andrew J. Souers,Deepak Sampath	223
5	Internal Motions Prime cIAP1 for Rapid Activation 2014 ·Biophysical Journal ·Aaron H. Phillips,Allyn J. Schoeffler,Tsutomu Matsui,Thomas Weiß,Erin C. Dueber,Wayne J. Fairbrother	1
6	Bcl-2/Bcl-xL Inhibition Increases the Efficacy of MEK Inhibition Alone and in Combination with PI3 Kinase Inhibition in Lung and Pancreatic Tumor Models 2013 ·Molecular Cancer Therapeutics ·Nguyen Tan,(unknown),Michelle Nannini,Rebecca Hong,Leslie B. Lee,S. Russ Price,Karen Williams,Pascal Savy,Peng Yue,Deepak Sampath,Jeffrey Settleman,Wayne J. Fairbrother,Lisa D. Belmont	61
7	Navitoclax (ABT-263) Reduces Bcl-xL–Mediated Chemoresistance in Ovarian Cancer Models 2012 ·Molecular Cancer Therapeutics ·(unknown),Nguyen Tan,Jiping Zha,Franklin Peale,Yue Peng,Wayne J. Fairbrother,Lisa D. Belmont	89
8	Navitoclax Enhances the Efficacy of Taxanes in Non–Small Cell Lung Cancer Models 2011 ·Clinical Cancer Research ·Nguyen Tan,(unknown),Jiping Zha,Yue Peng,Robert Kassees,Leanne Berry,Wayne J. Fairbrother,Deepak Sampath,Lisa D. Belmont	83
9	The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold 2011 ·Journal of Molecular Biology ·François Rousseau,Borlan Pan,Wayne J. Fairbrother,J. Fernando Bazán,Andreas Lingel	4
10	Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas 2008 ·Cancer Research ·Jasmin N. Dynek,Sara M. Chan,Jinfeng Liu,Jiping Zha,Wayne J. Fairbrother,Domagoj Vucic	82
11	Evaluation of Assay Technologies for the Identification of Protein–Peptide Interaction Antagonists 2007 ·Assay and Drug Development Technologies ·Saloumeh Kadkhodayan,Linda O. Elliott,(unknown),Heidi Ackerly Wallweber,Kurt Deshayes,Bainian Feng,Wayne J. Fairbrother	13
12	IAP (inhibitor of apoptosis) antagonist inhibits orthotopic lung tumor growth 2007 ·Molecular Cancer Therapeutics ·Hongkui Jin,Renhui Yang,Calvin Ho,Richard A.D. Carano,(unknown),Jeffrey Eastham‐Anderson,László G. Kömüves,Zhong Zheng,Jiping Zha,Wayne J. Fairbrother,John A. Flygare,Karl F. Doerner,Gail Colbern,Lesley Murray	1
13	Structure-based Design of IAP Antagonists 2007 ·Molecular Cancer Therapeutics ·Wayne J. Fairbrother	1
14	Solution structure of the heparin-binding domain of vascular endothelial growth factor 1998 ·Structure ·Wayne J. Fairbrother,Mark Champe,Hans W. Christinger,Bruce A. Keyt,Melissa A. Starovasnik	160
15	Exchanging Interleukin-8 and Melanoma Growth-stimulating Activity Receptor Binding Specificities 1996 ·Journal of Biological Chemistry ·Henry B. Lowman,(unknown),Laura DeForge,(unknown),Beth L. Gillece-Castro,James H. Bourell,Wayne J. Fairbrother	70
16	Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc 1993 ·Biochemistry ·Yuan Chen,Jonathan Reizer,Milton H. Saier,Wayne J. Fairbrother,Peter E. Wright	111
17	Assignment of proton, nitrogen-15, and carbon-13 resonances, identification of elements of secondary structure and determination of the global fold of the DNA-binding domain of GAL4 1993 ·Biochemistry ·Masahiro Shirakawa,Wayne J. Fairbrother,(unknown),T. Ohkubo,Yoshimasa Kyōgoku,Peter E. Wright	25
18	Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy 1991 ·Biochemistry ·Wayne J. Fairbrother,John Cavanagh,H. Jane Dyson,Arthur G. Palmer,Sarah L. Sutrina,Jonathan Reizer,Milton H. Saier,Peter E. Wright	41
19	NMR analysis of site‐specific mutants of yeast phosphoglycerate kinase 1989 ·European Journal of Biochemistry ·Wayne J. Fairbrother,P.A. Walker,Philippe Minard,Jennifer A. Littlechild,H.C. Watson,Robert J. P. Williams	37
20	Site‐directed mutagenesis of histidine 62 in the ‘basic patch’ region of yeast phosphoglycerate kinase 1989 ·FEBS Letters ·Wayne J. Fairbrother,Len Hall,(unknown),P.A. Walker,H.C. Watson,Robert J. P. Williams	12

About Wayne J. Fairbrother

Wayne J. Fairbrother is a scholar working on Molecular Biology, Immunology and Allergy and Immunology, having authored 122 papers that have together received 9.1k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (33 papers), Monoclonal and Polyclonal Antibodies Research (21 papers) and Ubiquitin and proteasome pathways (15 papers). The work is most often cited by research in Immunology (2.4k citations), Molecular Biology (6.7k citations) and Cancer Research (1.3k citations). Wayne J. Fairbrother has collaborated with scholars based in United States, France and United Kingdom. Frequent co-authors include Domagoj Vucic, Kurt Deshayes, Vishva M. Dixit, Melissa A. Starovasnik, Andrew J. Souers, Anna Fedorova, Joel Johansson, Kerry Zobel, Eugene Varfolomeev and Avi Ashkenazi. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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