Weiru Wang

10.5k citations

67 papers · 3.9k indexed · 1 hit paper · h-index 32

Impact in

Molecular Biology top 2%
- Protein Kinase Regulation and GTPase Signaling
- Biochemical and Molecular Research
- TGF-β signaling in diseases
- Melanoma and MAPK Pathways
- Protein Structure and Dynamics
- Cancer-related gene regulation
Geriatrics and Gerontology top 5%

Papers in ⓘ

Molecular Biology 46
- Protein Kinase Regulation and GTPase Signaling 11
- Biochemical and Molecular Research 9
- Melanoma and MAPK Pathways 8
- Cancer-related gene regulation 4
Oncology 15
- Peptidase Inhibition and Analysis 4

Co-authors: Sung‐Hou Kim (7 shared papers)Guowei Fang (3 shared papers)Rosalind Kim (8 shared papers)Hisao Yokota (7 shared papers)Joachim Rudolph (9 shared papers)Jaru Jancarik (4 shared papers)Eric Martens (1 shared paper)Shannon L. Stroschein (1 shared paper)
Journals: Proceedings of the National Academy of Sciences (9 papers)Bioorganic & Medicinal Chemistry Letters (6 papers)Journal of Medicinal Chemistry (5 papers)Structure (4 papers)Nature Communications (3 papers)
Partner nations: United States France China

In The Last Decade

Weiru Wang

66 papers receiving 3.8k citations

Hit Papers

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity 2012 · 479 citations

Peers

Countries citing papers authored by Weiru Wang

Since Specialization

Citations

This map shows the geographic impact of Weiru Wang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Weiru Wang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Weiru Wang more than expected).

Fields of papers citing papers by Weiru Wang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Weiru Wang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Weiru Wang. The network helps show where Weiru Wang may publish in the future.

Co-authors

The 25 scholars most cited alongside Weiru Wang, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Weiru Wang Line = papers co-authored together Weiru Wang links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 67 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Proceedings of the National Academy of Sciences ·Till Maurer, Lindsay S. Garrenton, Angela Oh, Keith Pitts, Daniel J. Anderson, Nicholas J. Skelton, Benjamin P. Fauber, Borlan Pan, Shiva Malek, David Stokoe, Mary J. C. Ludlam, Krista K. Bowman, Jian Wu, Anthony M. Giannetti, Melissa A. Starovasnik, Ira Mellman, Peter K. Jackson, Joachim Rudolph, Weiru Wang, Guowei Fang Hit paper breakdown →	2012	479
2	The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling Genes & Development ·Kunxin Luo, Shannon L. Stroschein, Weiru Wang, David Y. Chen, Eric Martens, S. Zhou, Qiang Zhou	1999	378
3	A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo Science Translational Medicine ·Jasvinder K. Atwal, Yongmei Chen, Cecilia Chiu, Deborah L. Mortensen, William J. Meilandt, Yichin Liu, Christopher E. Heise, Kwame Hoyte, Wilman Luk, Yanmei Lu, Kun Peng, Ping Wu, Lionel Rougé, Yingnan Zhang, Robert A. Lazarus, Kimberly Scearce‐Levie, Weiru Wang, Yan Wu, Marc Tessier‐Lavigne, Ryan J. Watts	2011	214
4	An ARL3–UNC119–RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium Genes & Development ·Kevin J. Wright, Lisa M. Baye, Anique Olivier-Mason, Saikat Mukhopadhyay, Liyun Sang, Mandy Kwong, Weiru Wang, Pamela R. Pretorius, Val C. Sheffield, Piali Sengupta, Diane C. Slusarski, Peter K. Jackson	2011	185
5	Structural Characterization of the Reaction Pathway in Phosphoserine Phosphatase: Crystallographic “snapshots” of Intermediate States Journal of Molecular Biology ·Weiru Wang, Ho S. Cho, Rosalind Kim, Jaru Jancarik, Hisao Yokota, Henry Nguyen, Igor V. Grigoriev, David E. Wemmer, Sung‐Hou Kim	2002	161
6	Targeting Protein-Protein Interaction by Small Molecules The Annual Review of Pharmacology and Toxicology ·Lingyan Jin, Weiru Wang, Guowei Fang	2013	156
7	Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6 Structure ·Eric Bourhis, Weiru Wang, Christine Tam, Ji‐Young Hwang, Yingnan Zhang, Didier Spittler, Oscar W. Huang, Yan Gong, Alberto Estevez, Inna Zilberleyb, Lionel Rougé, Cecilia Chiu, Yan Wu, Mike Costa, Rami N. Hannoush, Yvonne Franke, Andrea G. Cochran	2011	135
8	Dynamic and clustering model of bacterial chemotaxis receptors: Structural basis for signaling and high sensitivity Proceedings of the National Academy of Sciences ·Sung‐Hou Kim, Weiru Wang, Kyeong Kyu Kim	2002	128
9	The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1 Proceedings of the National Academy of Sciences ·Weiru Wang, Chao Zhang, Adhirai Marimuthu, Heike I. Krupka, M. Tabrizizad, R. Shelloe, Upasana Mehra, Kevin H. Eng, Hoa Nguyen, Calvin Settachatgul, Ben Powell, Michael V. Milburn, Brian L. West	2005	126
10	Crystal Structure of Phosphoserine Phosphatase from Methanococcus jannaschii, a Hyperthermophile, at 1.8 Å Resolution Structure ·Weiru Wang, Rosalind Kim, Jaru Jancarik, Hisao Yokota, Sung‐Hou Kim	2001	125
11	BeF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation}{\mathrm{_{3}^{-}}}\end{equation}\end{document} acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation}{\mathrm{_{3}^{-}}}\end{equation}\end{document} complex with phosphoserine phosphatase Proceedings of the National Academy of Sciences ·Ho Cho, Weiru Wang, Rosalind Kim, Hisao Yokota, Steven M. Damo, Sung‐Hou Kim, David E. Wemmer, Sydney Kustu, Dalai Yan	2001	119
12	Regulation of the oncoprotein Smoothened by small molecules Nature Chemical Biology ·Hayley J. Sharpe, Weiru Wang, Rami N. Hannoush, Frédéric J. de Sauvage	2015	97
13	Crystal structure of an intracellular protease fromPyrococcus horikoshiiat 2-Å resolution Proceedings of the National Academy of Sciences ·Xinlin Du, In‐Geol Choi, Rosalind Kim, Weiru Wang, Jaru Jancarik, Hisao Yokota, Sung‐Hou Kim	2000	92
14	Inhibitors of p21-Activated Kinases (PAKs) Journal of Medicinal Chemistry ·Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, Weiru Wang	2014	91
15	Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin Scientific Reports ·Mark Ultsch, Bing Li, Till Maurer, Mary Mathieu, Oskar Adolfsson, Andreas Muhs, Andrea Pfeifer, Maria Pihlgren, Travis W. Bainbridge, Mike Reichelt, James A. Ernst, Charles Eigenbrot, Germaine Fuh, Jasvinder K. Atwal, Ryan J. Watts, Weiru Wang	2016	90
16	Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding Proceedings of the National Academy of Sciences ·Aaron H. Nile, Susmith Mukund, Karen Stanger, Weiru Wang, Rami N. Hannoush	2017	88
17	Ras inhibition via direct Ras binding—is there a path forward? Bioorganic & Medicinal Chemistry Letters ·Weiru Wang, Guowei Fang, Joachim Rudolph	2012	82
18	Crystal Structure and Mechanism of Catalysis of a Pyrazinamidase from Pyrococcus horikoshii Biochemistry ·Xinlin Du, Weiru Wang, Rosalind Kim, Hisao Yakota, Huy L. Nguyên, Sung‐Hou Kim	2001	82
19	A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells Nature Chemical Biology ·Aaron H. Nile, Felipe de Sousa e Melo, Susmith Mukund, Robert Piskol, Simon Hansen, Lijuan Zhou, Yingnan Zhang, Yue Fu, Emily Gogol, László G. Kömüves, Zora Modrušan, Stéphane Angers, Yvonne Franke, Christopher M. Koth, Wayne J. Fairbrother, Weiru Wang, Frédéric J. de Sauvage, Rami N. Hannoush	2018	66
20	Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase Proceedings of the National Academy of Sciences ·Weiru Wang, Adhirai Marimuthu, James Tsai, Abhinav Kumar, Heike I. Krupka, Chao Zhang, Ben Powell, Yoshihisa Suzuki, Hoa Nguyen, M. Tabrizizad, Catherine A. Luu, Brian L. West	2006	61

About Weiru Wang

Weiru Wang is a scholar working on Molecular Biology, Oncology, Materials Chemistry, Organic Chemistry and Epidemiology, having authored 67 papers that have together received 3.9k indexed citations. Recurring topics across this work include Enzyme Structure and Function (12 papers), Protein Kinase Regulation and GTPase Signaling (11 papers), Biochemical and Molecular Research (9 papers), Melanoma and MAPK Pathways (8 papers), Sirtuins and Resveratrol in Medicine (5 papers), Computational Drug Discovery Methods (5 papers), Cancer-related gene regulation (4 papers) and Peptidase Inhibition and Analysis (4 papers). The work is most often cited by research in Molecular Biology (2.9k citations), Geriatrics and Gerontology (101 citations), Oncology (705 citations), Cell Biology (353 citations) and Physiology (93 citations). Weiru Wang has collaborated with scholars based in United States, France and China. Frequent co-authors include Sung‐Hou Kim, Guowei Fang, Rosalind Kim, Hisao Yokota, Joachim Rudolph, Jaru Jancarik, Eric Martens, Shannon L. Stroschein, Kunxin Luo and Qiang Zhou. Their work appears in journals such as Proceedings of the National Academy of Sciences, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Structure and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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