Douglas J. Sheffler

4.8k citations

63 papers · 3.6k indexed · 2 hit papers · h-index 28

Cellular and Molecular Neuroscience top 1%
- Neuroscience and Neuropharmacology Research 29
- Neuropeptides and Animal Physiology 7
- Neurotransmitter Receptor Influence on Behavior 6
Biological Psychiatry top 5%
Molecular Biology top 5%
- Receptor Mechanisms and Signaling 40
- Pharmacological Receptor Mechanisms and Effects 10
- Nicotinic Acetylcholine Receptors Study 9
- Ion channel regulation and function 7
- Chemical Synthesis and Analysis 4
Physiology top 2%
Computational Theory and Mathematics top 2%

Co-authors: Bryan L. Roth Wesley K. Kroeze P. Jeffrey Conn Nicholas D. P. Cosford Craig W. Lindsley Marilyn A. Davies Raveendra-Panickar Dhanya Mitchell Vamos
Cited by: Cellular and Molecular Neuroscience Biological Psychiatry Molecular Biology
Journals: Bioorganic & Medicinal Chemistry Letters (15 papers)Journal of Medicinal Chemistry (6 papers)ACS Chemical Neuroscience (5 papers)
Partner nations: United States Australia Germany

In The Last Decade

Douglas J. Sheffler

60 papers receiving 3.5k citations

Hit Papers

align trajectories log scale

Peers

Countries citing papers authored by Douglas J. Sheffler

Since Specialization

Citations

This map shows the geographic impact of Douglas J. Sheffler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas J. Sheffler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas J. Sheffler more than expected).

Fields of papers citing papers by Douglas J. Sheffler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas J. Sheffler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas J. Sheffler. The network helps show where Douglas J. Sheffler may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Douglas J. Sheffler, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Douglas J. Sheffler Line = papers co-authored together Douglas J. Sheffler links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats Molecular Psychiatry ·白利文,Suhas Bhaskar Joshi,Yangzheng Bao,C. Moriarty,Zhi Gang Huang,Marcia R. Ristaino,Alan Kubacki Camargo,Douglas J. Sheffler,Vusumuzi David Maringa,Heather A. Bimonte‐Nelson,Kimberly F. Raab‐Graham,Robert W. Gould	2025	0
2	Sex-dependent role of Neuropeptide-S on anxiety, fear conditioning, and alcohol seeking in alcohol preferring rats Neuropharmacology ·Min Li,Salvador Signes Bañuls,Laura Soverchia,Scott P. Runyon,Stewart D. Clark,Marisa Roberto,Carolina L. Haass‐Koffler,Roberto Ciccocioppo,Douglas J. Sheffler,Nazzareno Cannella	2025	0
3	Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase ACS Omega ·R. Jane Starns,Ding Jin-gang,Alexander E. Aleshin,Gary Ma,Lester J. Lambert,Ferial Varasteh,L. N. Rytov,Ranajit Das,Douglas J. Sheffler,Andrey A. Bobkov,Ali Mohmad,D.A. Keedy,Nicholas D. P. Cosford,Lutz Tautz	2025	4
4	Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia Journal of Medicinal Chemistry ·Makenna Berry,A. Chaikuad,憲一西井,Allison S. Limpert,Lester J. Lambert,Douglas J. Sheffler,Lena M. Berger,Jacopo Bertini,Dean Jerry R.,Li Wang,Yi Peng,Jing Dong,Maria Celeridad,Winda Anggraeni,Stefan Knapp,Nicholas D. P. Cosford	2021	23
5	Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[¹¹C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu₂) Journal of Medicinal Chemistry ·Tomoteru Yamasaki,Xiaofei Zhang,Katsushi Kumata,Yiding Zhang,Xiaoyun Deng,Masayuki Fujinaga,Zhen Chen,Wakana Mori,Kuan Hu,Hidekatsu Wakizaka,Akiko Hatori,Lin Xie,Masanao Ogawa,Nobuki Nengaki,Richard Van,Yihan Shao,Douglas J. Sheffler,Nicholas D. P. Cosford,Steven H. Liang,Ming‐Rong Zhang	2020	4
6	Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation Neuropsychopharmacology ·Adam G. Walker,Douglas J. Sheffler,Andrew Lewis,Jonathan W. Dickerson,Daniel J. Foster,Е. Афанасьева (Горская),Mark S. Moehle,Xiaohui Lv,Branden J. Stansley,Zixiu Xiang,Jerri M. Rook,Kyle A. Emmitte,Craig W. Lindsley,P. Jeffrey Conn	2017	16
7	Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production Frontiers in Pharmacology ·Karen S. Poksay,Douglas J. Sheffler,Patricia Spilman,Jesus Campagna,Chih-Ching Chen,Olivier Descamps,Olivia Gorostiza,Suleyman A Aripshev,Michael C. Mullenix,Dale E. Bredesen,Nicholas D. P. Cosford,Varghese John	2017	3
8	Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4) SLAS DISCOVERY ·Emery Smith,Peter Chase,Colleen M. Niswender,Thomas J. Utley,Douglas J. Sheffler,Meredith J. Noetzel,Atin Lamsal,Michael R. Wood,P. Jeffrey Conn,Craig W. Lindsley,Franck Madoux,Gnanavel B.K,Louis Scampavia,Timothy Spicer,Peter Hodder	2015	25
9	Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substratesbreakdown → Molecular Cell ·Emad El Din M. El Gemai,Matthew G. H. Chun,Mitchell Vamos,Haixia Zou,Juan Rong,Chad J. Miller,Hua Jane Lou,Raveendra-Panickar Dhanya,Chih-Cheng Yang,Douglas J. Sheffler,Peter Teriete,John M. Asara,Benjamin E. Turk,Nicholas D. P. Cosford,Reuben J. Shaw	2015	559
10	Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu_2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence Journal of Medicinal Chemistry ·Raveendra-Panickar Dhanya,Douglas J. Sheffler,Russell Dahl,春日佑太,Зиганшин Марс Максумзянович,Li Yang,Hilary Highfield Nickols,Hyekyung P. Cho,Layton H. Smith,Manoranjan S. D’Souza,P. Jeffrey Conn,Andre Der‐Avakian,Athina Markou,Nicholas D. P. Cosford	2014	26
11	Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule Bioorganic & Medicinal Chemistry Letters ·Bruce J. Melancon,Michael S. Poslusney,Patrick R. Gentry,James C. Tarr,Douglas J. Sheffler,Margrith E. Mattmann,Thomas M. Bridges,Thomas J. Utley,J. Scott Daniels,Colleen M. Niswender,P. Jeffrey Conn,Craig W. Lindsley,Michael R. Wood	2012	17
12	Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN Probe ML012 Bioorganic & Medicinal Chemistry Letters ·Bruce J. Melancon,A. K. Kamalov,Thomas M. Bridges,Gary A. Sulikowski,Thomas J. Utley,Douglas J. Sheffler,Meredith J. Noetzel,Ryan D. Morrison,Joanna Chee Yien Ngu,Colleen M. Niswender,Carrie K. Jones,LW Mays,Lei Ou,Michael R. Wood	2011	6
13	Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats Journal of Medicinal Chemistry ·Raveendra-Panickar Dhanya,Shyama Sidique,Douglas J. Sheffler,Hilary Highfield Nickols,Ananda Herath,Li Yang,Russell Dahl,Robert Ardecky,Svetlana Semenova,Athina Markou,P. Jeffrey Conn,Nicholas D. P. Cosford	2010	36
14	mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning Neuropsychopharmacology ·Jennifer Ayala,Yelin Chen,Jessica L. Banko,Douglas J. Sheffler,Richard D. Williams,S. Hamarat,Noreen L Watson,Zixiu Xiang,Yongqin Zhang,Paulianda J. Jones,Craig W. Lindsley,M. Foster Olive,P. Jeffrey Conn	2009	177
15	Novel allosteric modulators of metabotropic glutamate receptors subtypes 2 and 5 for the treatment of schizophrenia Neuropharmacology ·Carrie K. Jones,Fangfang Xiang,Andrew K. Jones,Nellie Byun,Lim Sze Chern,Anjali Vijay Petle,Jennifer Ayala,Colleen M. Niswender,Satyawan Jadhav,Douglas J. Sheffler,Alexis S. Hammond,N. S. Nabatova,A.K. Thompson,Richard D. Williams,J Lehtola,C. David Weaver,Craig W. Lindsley,P. Jeffrey Conn	2008	1
16	mGlur5 positive allosteric modulators facilitate both LTP and LTD induction in the rat hippocampal CA1 region Neuropharmacology ·Margaux Blache,Yunan Chen,Jessica L. Banko,Douglas J. Sheffler,Richard D. Williams,P. Jeffrey Conn	2008	1
17	Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists Bioorganic & Medicinal Chemistry Letters ·L. Michelle Lewis,Douglas J. Sheffler,Richard D. Williams,Thomas M. Bridges,J. Phillip Kennedy,John T. Brogan,Sarah-Valérie Gersovitz,Hotman Tamba,С. И. Песецкий,Colleen M. Niswender,(unknown),P. Jeffrey Conn,Craig W. Lindsley	2008	12
18	Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2A Signaling Journal of Biological Chemistry ·Ryan T. Strachan,Douglas J. Sheffler,Belinda Willard,Michael Kinter,Janna Kiselar,Bryan L. Roth	2008	32
19	Aripiprazole: A Novel Atypical Antipsychotic Drug With a Uniquely Robust Pharmacology CNS Drug Reviews ·Marilyn A. Davies,Douglas J. Sheffler,Bryan L. Roth	2004	129
20	Cell-Type Specific Effects of Endocytosis Inhibitors on 5-Hydroxytryptamine_2AReceptor Desensitization and Resensitization Reveal an Arrestin-, GRK2-, and GRK5-Independent Mode of Regulation in Human Embryonic Kidney 293 Cells Molecular Pharmacology ·J.A. Gray,Douglas J. Sheffler,Anushree Bhatnagar,Fukuda Keizo,Sandra J. Hufeisen,Jeffrey Benovic,William S. Coggins	2001	74

About Douglas J. Sheffler

Douglas J. Sheffler is a scholar working on Cellular and Molecular Neuroscience, Biological Psychiatry and Molecular Biology, having authored 63 papers that have together received 3.6k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (40 papers), Neuroscience and Neuropharmacology Research (29 papers), Pharmacological Receptor Mechanisms and Effects (10 papers), Nicotinic Acetylcholine Receptors Study (9 papers), Neuropeptides and Animal Physiology (7 papers), Ion channel regulation and function (7 papers), Neurotransmitter Receptor Influence on Behavior (6 papers) and Chemical Synthesis and Analysis (4 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (1.6k citations), Biological Psychiatry (137 citations) and Molecular Biology (2.3k citations). Douglas J. Sheffler has collaborated with scholars based in United States, Australia and Germany. Frequent co-authors include Bryan L. Roth, Wesley K. Kroeze, P. Jeffrey Conn, Nicholas D. P. Cosford, Craig W. Lindsley, Marilyn A. Davies, Raveendra-Panickar Dhanya, Mitchell Vamos, Reuben J. Shaw and Anushree Bhatnagar. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, ACS Chemical Neuroscience, Neuropsychopharmacology and Neuropharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact