John Blenis

67.4k total citations · 33 hit papers
222 papers, 51.9k citations indexed

About

John Blenis is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, John Blenis has authored 222 papers receiving a total of 51.9k indexed citations (citations by other indexed papers that have themselves been cited), including 191 papers in Molecular Biology, 30 papers in Oncology and 29 papers in Cancer Research. Recurrent topics in John Blenis's work include PI3K/AKT/mTOR signaling in cancer (71 papers), Protein Kinase Regulation and GTPase Signaling (65 papers) and Melanoma and MAPK Pathways (34 papers). John Blenis is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (71 papers), Protein Kinase Regulation and GTPase Signaling (65 papers) and Melanoma and MAPK Pathways (34 papers). John Blenis collaborates with scholars based in United States, Germany and Canada. John Blenis's co-authors include Philippe P. Roux, Diane C. Fingar, Xiaoju Max, Andrew R. Tee, Rey‐Huei Chen, Peter Juo, Lewis C. Cantley, Leon O. Murphy, Bryan A. Ballif and Michael E. Greenberg and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

John Blenis

218 papers receiving 51.2k citations

Hit Papers

Akt Promotes Cell Survival by Phosphorylating and Inhibit... 1992 2026 2003 2014 1999 2009 2004 2011 2002 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
    1999 5.5k citations John Blenis et al. profile →
  2. Molecular mechanisms of mTOR-mediated translational control
    2009 2.0k citations John Blenis et al. profile →
  3. ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions
    2004 2.0k citations John Blenis et al. profile →
  4. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
    2011 1.4k citations John Blenis et al. profile →
  5. Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
    2002 1.3k citations Brendan D. Manning, Andrew R. Tee et al. Molecular Cell profile →
  6. Signal transduction via the MAP kinases: proceed at your own RSK.
    1993 1.1k citations John Blenis Proceedings of the National Academy of Sciences profile →
  7. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
    1992 1.0k citations John Blenis et al. profile →
  8. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    2004 1.0k citations Diane C. Fingar, John Blenis profile →
  9. Nuclear localization and regulation of erk- and rsk-encoded protein kinases.
    1992 967 citations Rey‐Huei Chen, John Blenis et al. Molecular and Cellular Biology profile →
  10. mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
    2005 962 citations John Blenis et al. profile →
  11. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
    2003 949 citations Andrew R. Tee, Brendan D. Manning et al. profile →
  12. Rapamycin: One Drug, Many Effects
    2014 939 citations John Blenis et al. profile →
  13. Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation
    1994 913 citations Bentley Cheatham, Chris J. Vlahos et al. Molecular and Cellular Biology profile →
  14. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    2002 872 citations Diane C. Fingar, John Blenis et al. Genes & Development profile →
  15. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
    1992 842 citations John Blenis et al. profile →
  16. Molecular interpretation of ERK signal duration by immediate early gene products
    2002 766 citations Rey‐Huei Chen, Diane C. Fingar et al. profile →
  17. mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E
    2003 733 citations Diane C. Fingar, Andrew R. Tee et al. Molecular and Cellular Biology profile →
  18. FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2
    2000 678 citations John Blenis et al. profile →
  19. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
    2011 672 citations Gregory R. Hoffman, Lewis C. Cantley et al. profile →
  20. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
    1994 650 citations John Blenis et al. profile →
  21. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    2002 647 citations Andrew R. Tee, Diane C. Fingar et al. Proceedings of the National Academy of Sciences profile →
  22. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    2008 646 citations Sang-Oh Yoon, John Blenis et al. Proceedings of the National Academy of Sciences profile →
  23. Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos
    2003 617 citations John Blenis et al. profile →
  24. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    2004 611 citations John Blenis et al. Proceedings of the National Academy of Sciences profile →
  25. The RSK family of kinases: emerging roles in cellular signalling
    2008 605 citations John Blenis et al. profile →
  26. RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation
    2007 575 citations John Blenis et al. profile →
  27. MAPK signal specificity: the right place at the right time
    2006 567 citations John Blenis et al. profile →
  28. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
    1994 555 citations Bentley Cheatham, Chris J. Vlahos et al. Molecular and Cellular Biology profile →
  29. STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation
    1997 551 citations John Blenis et al. Molecular and Cellular Biology profile →
  30. Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes
    1995 518 citations John Blenis et al. profile →
  31. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
    1992 515 citations John Blenis et al. profile →
  32. Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules
    2001 501 citations John Blenis et al. profile →
  33. A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1
    1996 500 citations John Blenis, Lewis C. Cantley et al. Molecular and Cellular Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
John Blenis United States 101 39.2k 8.2k 6.5k 6.3k 5.6k 222 51.9k
Hediye Erdjument‐Bromage United States 125 53.4k 1.4× 7.4k 0.9× 6.9k 1.1× 7.7k 1.2× 6.0k 1.1× 285 68.1k
Guy S. Salvesen United States 110 37.2k 0.9× 9.0k 1.1× 9.6k 1.5× 5.5k 0.9× 8.2k 1.5× 295 54.7k
Gérard I. Evan United Kingdom 93 29.9k 0.8× 11.9k 1.5× 5.7k 0.9× 4.2k 0.7× 5.6k 1.0× 245 43.0k
James R. Woodgett Canada 108 35.7k 0.9× 5.8k 0.7× 4.8k 0.7× 5.8k 0.9× 4.4k 0.8× 293 47.6k
Dario R. Alessi United Kingdom 124 50.6k 1.3× 7.7k 0.9× 4.9k 0.8× 10.1k 1.6× 5.6k 1.0× 313 65.6k
Paul Tempst United States 143 62.1k 1.6× 8.3k 1.0× 9.0k 1.4× 8.7k 1.4× 7.6k 1.4× 320 80.8k
Erwin F. Wagner Austria 115 33.7k 0.9× 14.2k 1.7× 7.5k 1.2× 3.4k 0.5× 8.0k 1.4× 364 50.7k
Brian A. Hemmings Switzerland 102 33.2k 0.8× 5.1k 0.6× 3.8k 0.6× 7.2k 1.1× 3.4k 0.6× 313 42.4k
Pier Giuseppe Pelicci Italy 106 31.6k 0.8× 9.6k 1.2× 5.6k 0.9× 3.4k 0.5× 3.9k 0.7× 532 45.6k
Junying Yuan United States 103 36.5k 0.9× 5.1k 0.6× 10.4k 1.6× 8.1k 1.3× 4.9k 0.9× 254 52.9k

Countries citing papers authored by John Blenis

Since Specialization
Citations

This map shows the geographic impact of John Blenis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Blenis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Blenis more than expected).

Fields of papers citing papers by John Blenis

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Blenis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Blenis. The network helps show where John Blenis may publish in the future.

Co-authorship network of co-authors of John Blenis

This figure shows the co-authorship network connecting the top 25 collaborators of John Blenis. A scholar is included among the top collaborators of John Blenis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Blenis. John Blenis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
He, Long, Sungyun Cho, & John Blenis. (2024). mTORC1, the maestro of cell metabolism and growth. Genes & Development. 39(1-2). 109–131. 12 indexed citations
2.
Cho, Sungyun, Yujin Chun, Long He, et al.. (2023). FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1. Molecular Cell. 83(16). 3010–3026.e8. 17 indexed citations
3.
Low, Vivien, Zhongchi Li, & John Blenis. (2022). Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment. Science Signaling. 15(759). eabj4220–eabj4220. 25 indexed citations
4.
Li, Zhongchi, Vivien Low, Valbona Luga, et al.. (2022). Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature Communications. 13(1). 6239–6239. 44 indexed citations
5.
Gomes, Ana P., Didem Ilter, Vivien Low, et al.. (2022). Altered propionate metabolism contributes to tumour progression and aggressiveness. Nature Metabolism. 4(4). 435–443. 54 indexed citations
6.
Tang, Hong-Wen, Jui–Hsia Weng, Yanhui Hu, et al.. (2021). mTORC1-chaperonin CCT signaling regulates m 6 A RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences. 118(10). 53 indexed citations
7.
Krishnamoorthy, Gnana P., Natalie R. Davidson, Steven D. Leach, et al.. (2018). EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer Discovery. 9(2). 264–281. 71 indexed citations
8.
Li, Jing, Sejeong Shin, Yang Sun, et al.. (2016). mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress. Cancer Research. 76(16). 4816–4827. 20 indexed citations
9.
Mullarky, Edouard, Natasha C. Lucki, Reza Beheshti Zavareh, et al.. (2016). Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences. 113(7). 1778–1783. 251 indexed citations
10.
Liu, Pengda, Wenjian Gan, Y. Rebecca Chin, et al.. (2015). PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5(11). 1194–1209. 307 indexed citations
11.
Fendt, Sarah‐Maria, Eric L. Bell, Mark A. Keibler, et al.. (2013). Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism. Cancer Research. 73(14). 4429–4438. 7 indexed citations
12.
Gu, Xiaoxiao, et al.. (2013). Integration of mTOR and estrogen–ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proceedings of the National Academy of Sciences. 110(37). 14960–14965. 55 indexed citations
13.
Hoffman, Gregory R., et al.. (2010). A High-Throughput, Cell-Based Screening Method for siRNA and Small Molecule Inhibitors of mTORC1 Signaling Using the In Cell Western Technique. Assay and Drug Development Technologies. 8(2). 186–199. 30 indexed citations
14.
Mahoney, Sarah J., Jamie M. Dempsey, & John Blenis. (2009). Chapter 2 Cell Signaling in Protein Synthesis. Progress in molecular biology and translational science. 90. 53–107. 65 indexed citations
15.
Blenis, John, et al.. (2006). Rheb Activation of mTOR and S6K1 Signaling. Methods in enzymology on CD-ROM/Methods in enzymology. 407. 542–555. 19 indexed citations
16.
Tee, Andrew R., Diane C. Fingar, Brendan D. Manning, et al.. (2002). Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences. 99(21). 13571–13576. 647 indexed citations breakdown →
17.
Manning, Brendan D., et al.. (2002). Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway. Molecular Cell. 10(1). 151–162. 1281 indexed citations breakdown →
18.
19.
Cheatham, Bentley, et al.. (1994). Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation. Molecular and Cellular Biology. 14(7). 4902–4911. 913 indexed citations breakdown →
20.
Erikson, E, D. Stefanović, John Blenis, R L Erikson, & James L. Maller. (1987). Antibodies to Xenopus Egg S6 Kinase II Recognize S6 Kinase from Progesterone- and Insulin-Stimulated Xenopus Oocytes and from Proliferating Chicken Embryo Fibroblasts. Molecular and Cellular Biology. 7(9). 3147–3155. 21 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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