Nicholas Denko

12.7k total citations · 2 hit papers
93 papers, 10.2k citations indexed

About

Nicholas Denko is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, Nicholas Denko has authored 93 papers receiving a total of 10.2k indexed citations (citations by other indexed papers that have themselves been cited), including 66 papers in Molecular Biology, 49 papers in Cancer Research and 13 papers in Oncology. Recurrent topics in Nicholas Denko's work include Cancer, Hypoxia, and Metabolism (41 papers), Mitochondrial Function and Pathology (17 papers) and ATP Synthase and ATPases Research (15 papers). Nicholas Denko is often cited by papers focused on Cancer, Hypoxia, and Metabolism (41 papers), Mitochondrial Function and Pathology (17 papers) and ATP Synthase and ATPases Research (15 papers). Nicholas Denko collaborates with scholars based in United States, Slovakia and United Kingdom. Nicholas Denko's co-authors include Ioanna Papandreou, Rob A. Cairns, Amato J. Giaccia, Ai Lin Lim, Lucrezia Fontana, Quynh‐Thu Le, Albert C. Koong, Ramon C. Sun, Thomas D. Stamato and Amato Giaccia and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Nature Genetics.

In The Last Decade

Nicholas Denko

92 papers receiving 10.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

2006 1.8k citations Ioanna Papandreou, Rob A. Cairns et al. profile →
Hypoxia, HIF1 and glucose metabolism in the solid tumour

2008 1.4k citations Nicholas Denko Nature reviews. Cancer profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Nicholas Denko United States	44	6.5k	5.0k	1.5k	1.4k	1.2k	93	10.2k
Christian M. Metallo United States	51	8.2k 1.3×	4.8k 1.0×	1.3k 0.9×	945 0.7×	1.3k 1.1×	125	12.3k
Diana Whitaker‐Menezes United States	49	6.1k 0.9×	4.6k 0.9×	2.0k 1.4×	1.2k 0.9×	1.3k 1.1×	93	9.4k
Alex von Kriegsheim United Kingdom	38	5.8k 0.9×	4.0k 0.8×	1.3k 0.9×	1.4k 1.0×	699 0.6×	120	9.2k
Arkaitz Carracedo Spain	49	8.5k 1.3×	3.2k 0.6×	2.1k 1.4×	1.0k 0.8×	1.2k 1.0×	96	12.7k
Nathalie M. Mazure France	39	5.5k 0.8×	4.1k 0.8×	1.0k 0.7×	589 0.4×	1.6k 1.3×	87	8.4k
Zhimin Lu China	62	10.6k 1.6×	5.8k 1.2×	2.5k 1.7×	1.4k 1.0×	1.1k 0.9×	207	14.7k
Jung‐whan Kim United States	30	6.3k 1.0×	5.3k 1.1×	1.2k 0.8×	489 0.4×	825 0.7×	46	10.3k
Edurne Berra France	43	6.0k 0.9×	4.7k 0.9×	1.1k 0.7×	770 0.6×	469 0.4×	69	9.4k
Paul N. Span Netherlands	57	5.1k 0.8×	3.1k 0.6×	2.5k 1.7×	984 0.7×	762 0.6×	233	9.7k
Kevin P. Claffey United States	52	7.6k 1.2×	2.5k 0.5×	3.0k 2.0×	1.2k 0.9×	536 0.4×	98	11.7k

Countries citing papers authored by Nicholas Denko

Since Specialization

Citations

This map shows the geographic impact of Nicholas Denko's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nicholas Denko with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nicholas Denko more than expected).

Fields of papers citing papers by Nicholas Denko

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nicholas Denko. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nicholas Denko. The network helps show where Nicholas Denko may publish in the future.

Co-authorship network of co-authors of Nicholas Denko

This figure shows the co-authorship network connecting the top 25 collaborators of Nicholas Denko. A scholar is included among the top collaborators of Nicholas Denko based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nicholas Denko. Nicholas Denko is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Tailor, Arun, Robert Parker, Ioanna Papandreou, et al.. (2025). Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation. The EMBO Journal. 44(3). 903–922. 10 indexed citations

Haines, Ben, Martin Benej, Shabber Mohammed, et al.. (2025). Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer. Journal of Medicinal Chemistry. 68(21). 23140–23162.

Wolfe, Adam R., Tiantian Cui, Amy Webb, et al.. (2024). Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions. Science Advances. 10(9). eadj3551–eadj3551. 5 indexed citations

Hoyd, Rebecca, Ning Jin, Nicholas Denko, et al.. (2023). Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data. Cancer Research Communications. 3(11). 2375–2385. 4 indexed citations

Moraes, L.E., et al.. (2021). Effect of glucose concentration and cryopreservation on mitochondrial functions of bull spermatozoa and relationship with sire conception rate. Animal Reproduction Science. 230. 106779–106779. 15 indexed citations

Mohan, Vijay, Jinghai Wu, Martin Benej, et al.. (2021). Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth. SHILAP Revista de lepidopterología. 9(1). 39–39. 28 indexed citations

Benej, Martin, Jinghai Wu, Ioanna Papandreou, et al.. (2021). Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors. Cancers. 13(7). 1696–1696. 7 indexed citations

Kaul, Kirti, Martin Benej, Sanjay Mishra, et al.. (2021). Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity. Frontiers in Immunology. 12. 753477–753477. 18 indexed citations

Wu, Jinghai, et al.. (2019). HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors. Molecular Cancer Research. 17(10). 2089–2101. 51 indexed citations

10.

Yang, Zhifen, Jing Zhang, Dadi Jiang, et al.. (2018). A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation. Molecular Cancer Research. 16(5). 745–753. 9 indexed citations

11.

Jiang, Dadi, Arvin B. Tam, Muthuraman Alagappan, et al.. (2016). Acridine Derivatives as Inhibitors of the IRE1α–XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Molecular Cancer Therapeutics. 15(9). 2055–2065. 27 indexed citations

12.

Alagappan, Muthuraman, Dadi Jiang, Nicholas Denko, & Albert C. Koong. (2016). A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA). Advances in experimental medicine and biology. 899. 253–268. 6 indexed citations

13.

Jiang, Dadi, Connor Lynch, Bruno C. Medeiros, et al.. (2016). Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response. Scientific Reports. 6(1). 33353–33353. 29 indexed citations

14.

Cerniglia, George J., Souvik Dey, Shannon M. Gallagher‐Colombo, et al.. (2015). The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Molecular Cancer Therapeutics. 14(8). 1928–1938. 55 indexed citations

15.

Cairns, Rob A., Kevin L. Bennewith, Edward E. Graves, et al.. (2009). Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104. Clinical Cancer Research. 15(23). 7170–7174. 28 indexed citations

16.

Renault, Valérie M., Victoria A. Rafalski, Alex A. Morgan, et al.. (2009). FoxO3 Regulates Neural Stem Cell Homeostasis. Cell stem cell. 5(5). 527–539. 456 indexed citations

17.

Denko, Nicholas. (2008). Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nature reviews. Cancer. 8(9). 705–713. 1389 indexed citations breakdown →

18.

Dong, Shumin, Catherine L. Nutt, Rebecca A. Betensky, et al.. (2005). Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma. Journal of Neuropathology & Experimental Neurology. 64(11). 948–955. 77 indexed citations

19.

Le, Quynh‐Thu, Nicholas Denko, & Amato Giaccia. (2004). Hypoxic gene expression and metastasis. Cancer and Metastasis Reviews. 23(3-4). 293–310. 393 indexed citations

20.

Wouters, Bradly G., Amato J. Giaccia, Nicholas Denko, & Jeremy Brown. (1997). Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.. PubMed. 57(21). 4703–6. 99 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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