Samuel Klein

71.3k total citations · 26 hit papers
383 papers, 48.5k citations indexed

About

Samuel Klein is a scholar working on Physiology, Endocrinology, Diabetes and Metabolism and Epidemiology. According to data from OpenAlex, Samuel Klein has authored 383 papers receiving a total of 48.5k indexed citations (citations by other indexed papers that have themselves been cited), including 218 papers in Physiology, 98 papers in Endocrinology, Diabetes and Metabolism and 86 papers in Epidemiology. Recurrent topics in Samuel Klein's work include Diet and metabolism studies (129 papers), Adipose Tissue and Metabolism (93 papers) and Muscle metabolism and nutrition (62 papers). Samuel Klein is often cited by papers focused on Diet and metabolism studies (129 papers), Adipose Tissue and Metabolism (93 papers) and Muscle metabolism and nutrition (62 papers). Samuel Klein collaborates with scholars based in United States, Italy and Greece. Samuel Klein's co-authors include Jeffrey I. Gordon, Ruth E. Ley, Peter J. Turnbaugh, Bruce W. Patterson, Elisa Fabbrini, Luigi Fontana, Bettina Mittendorfer, B. Selma Mohammed, Dennis T. Villareal and Shelby Sullivan and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Samuel Klein

373 papers receiving 47.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Human gut microbes associated with obesity

2006 6.9k citations Samuel Klein et al. profile →
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 1.6k citations Samuel Klein et al. profile →
Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic, and Clinical Implications

2009 1.6k citations Elisa Fabbrini, Samuel Klein et al. profile →
A Randomized Trial of a Low-Carbohydrate Diet for Obesity

2003 1.2k citations B. Selma Mohammed, Samuel Klein et al. profile →
Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans

2007 1.1k citations J. Christopher Eagon, Samuel Klein et al. profile →
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

2009 762 citations Elisa Fabbrini, Faidon Magkos et al. Proceedings of the National Academy of Sciences profile →
Assessing Adiposity

2011 681 citations Samuel Klein et al. Circulation profile →
Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease

2004 677 citations Samuel Klein, George A. Bray et al. Circulation profile →
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

2004 670 citations Samuel Klein et al. Proceedings of the National Academy of Sciences profile →
An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein

1997 648 citations Samuel Klein et al. profile →
Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society

2005 636 citations Samuel Klein et al. American Journal of Clinical Nutrition profile →
Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

2016 623 citations Faidon Magkos, Jun Yoshino et al. profile →
Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study

2013 610 citations Priscilla Hollander, Samuel Klein et al. profile →
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease

2004 561 citations Samuel Klein, Bruce W. Patterson et al. profile →
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

2019 534 citations Gordon I. Smith, Mahalakshmi Shankaran et al. Journal of Clinical Investigation profile →
Why does obesity cause diabetes?

2022 508 citations Samuel Klein et al. profile →
Energy balance and its components: implications for body weight regulation

2012 480 citations Kevin D. Hall, Samuel Klein et al. American Journal of Clinical Nutrition profile →
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

2012 460 citations Nada A. Abumrad, Samuel Klein et al. profile →
Metabolically healthy obesity: facts and fantasies

2019 404 citations Gordon I. Smith, Bettina Mittendorfer et al. Journal of Clinical Investigation profile →
Fish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults

2015 369 citations Gordon I. Smith, Dominic N. Reeds et al. American Journal of Clinical Nutrition profile →
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

2021 277 citations Dmitri Samovski, Samuel Klein et al. profile →
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

2021 259 citations Jun Yoshino, Gary J. Patti et al. profile →
Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

2021 245 citations Sabine Daemen, Anastasiia Gainullina et al. Cell Reports profile →
The energy balance model of obesity: beyond calories in, calories out

2022 179 citations Kevin D. Hall, I. Sadaf Farooqi et al. American Journal of Clinical Nutrition profile →
Is Weight Loss–Induced Muscle Mass Loss Clinically Relevant?

2024 96 citations Kevin D. Hall, Samuel Klein et al. profile →
Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity

2024 50 citations Max C. Petersen, Gordon I. Smith et al. profile →

Peers

Countries citing papers authored by Samuel Klein

Since Specialization

Citations

This map shows the geographic impact of Samuel Klein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Samuel Klein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Samuel Klein more than expected).

Fields of papers citing papers by Samuel Klein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Samuel Klein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Samuel Klein. The network helps show where Samuel Klein may publish in the future.

Co-authorship network of co-authors of Samuel Klein

This figure shows the co-authorship network connecting the top 25 collaborators of Samuel Klein. A scholar is included among the top collaborators of Samuel Klein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Samuel Klein. Samuel Klein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	N-acetylaspartate from fat cells regulates postprandial body temperature 2025 ·Nature Metabolism ·(unknown), Pradip Saha, Evelyn Groot, Lin Tan, Robert Sharp, (unknown), (unknown), (unknown), (unknown), (unknown), Christie M. Ballantyne, Christopher I. Amos, Philip L. Lorenzi, Samuel Klein, Xia Gao, Sean M. Hartig	0
2	Effect of Marked Weight Loss on Adipose Tissue Biology in People With Obesity and Type 2 Diabetes 2025 ·Diabetes Care ·Dmitri Samovski, Gordon I. Smith, Hector H. Palacios, Terri Pietka, Anja Fuchs, Gary J. Patti, Allah Nawaz, C. Ronald Kahn, Samuel Klein	3
3	Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice 2024 ·Journal of Clinical Investigation ·(unknown), Jason Singer, Daniel Ferguson, Trevor M. Shew, (unknown), Hector H. Palacios, Rachael L. Field, (unknown), (unknown), Mahalakshmi Shankaran, Gordon I. Smith, Jun Yoshino, Mai He, Gary J. Patti, Marc K. Hellerstein, Samuel Klein, Jonathan R. Brestoff, E. Matthew Morris, Brian N. Finck, (unknown)	0
4	Impaired plasma glucose clearance is a key determinant of fasting hyperglycemia in people with obesity 2024 ·Obesity ·Bettina Mittendorfer, Stephan van Vliet, Gordon I. Smith, Max C. Petersen, Bruce W. Patterson, Samuel Klein	2
5	Methods and validation of velacur determined fat fraction in patients with MASLD 2024 ·SHILAP Revista de lepidopterología ·(unknown), Julio Lobo, Caitlin Schneider, Samuel Klein, Gordon I. Smith, Rohit Loomba, Alnoor Ramji, Tarek Hassanein, Eric M. Yoshida, (unknown), Michael P. Curry, Nezam H. Afdhal	1
6	Early intervention and intensive management of patients with diabetes, cardiorenal, and metabolic diseases 2023 ·Journal of Diabetes and its Complications ·Yehuda Handelsman, Javed Butler, George L. Bakris, Ralph A. DeFronzo, Gregg C. Fonarow, Jennifer B. Green, George Grunberger, James L. Januzzi, Samuel Klein, Pamela Kushner, Darren K. McGuire, Erin D. Michos, Javier Morales, Richard E. Pratley, Matthew R. Weir, Eugene E. Wright, Vivian Fonseca	43
7	Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease 2023 ·JHEP Reports ·Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Yang, (unknown), Li He, (unknown), Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling	14
8	The energy balance model of obesity: beyond calories in, calories out breakdown → 2022 ·American Journal of Clinical Nutrition ·Kevin D. Hall, I. Sadaf Farooqi, (unknown), Samuel Klein, Ruth J. F. Loos, David J. Mangelsdorf, Stephen O’Rahilly, Éric Ravussin, Leanne M. Redman, Donna H. Ryan, John R. Speakman, Deirdre K. Tobias	179
9	Preparing for the NASH epidemic: A call to action 2021 ·Obesity ·Fasiha Kanwal, Jay H. Shubrook, Zobair M. Younossi, Yamini Natarajan, Elisabetta Bugianesi, Mary E. Rinella, Stephen A. Harrison, Christos S. Mantzoros, Kim Pfotenhauer, Samuel Klein, Robert H. Eckel, Davida Kruger, Hashem El‐Serag, Kenneth Cusi	11
10	Heterogeneity in insulin-stimulated glucose uptake among different muscle groups in healthy lean people and people with obesity 2021 ·Diabetologia ·Han‐Chow E. Koh, Stephan van Vliet, Gretchen A. Meyer, Richard Laforest, Robert J. Gropler, Samuel Klein, Bettina Mittendorfer	19
11	Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH breakdown → 2021 ·Cell Reports ·Sabine Daemen, Anastasiia Gainullina, Gowri Kalugotla, Li He, Mandy M. Chan, Joseph W. Beals, Kim Liss, Samuel Klein, Ariel E. Feldstein, Brian N. Finck, Maxim N. Artyomov, Joel D. Schilling	245
12	Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial 2018 ·Obesity ·Maria Chondronikola, Faidon Magkos, Jun Yoshino, Adewole L. Okunade, Bruce W. Patterson, Michael J. Muehlbauer, Christopher B. Newgard, Samuel Klein	18
13	The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle‐aged women is not caused by leucine alone 2018 ·The Journal of Physiology ·Stephan van Vliet, Gordon I. Smith, (unknown), R. Ramaswamy, Dominic N. Reeds, Adewole L. Okunade, Jun Yoshino, Samuel Klein, Bettina Mittendorfer	10
14	Design and rationale for a real-world observational cohort of patients with nonalcoholic fatty liver disease: The TARGET-NASH study 2017 ·Contemporary Clinical Trials ·A. Sidney Barritt, Norman Gitlin, Samuel Klein, Anna S. Lok, Rohit Loomba, (unknown), (unknown), Miriam B. Vos, Laurence Weiss, Kenneth Cusi, Brent A. Neuschwander‐Tetri, Arun J. Sanyal	39
15	Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity breakdown → 2009 ·Proceedings of the National Academy of Sciences ·Elisa Fabbrini, Faidon Magkos, B. Selma Mohammed, Terri Pietka, Nada A. Abumrad, Bruce W. Patterson, Adewole L. Okunade, Samuel Klein	762
16	Abstract 1563: Weight Loss Improves Right Atrial and Ventricular Function and Metabolism in Obese Humans 2009 ·Circulation ·(unknown), Cheng‐Hung Lin, Pilar Herrero, (unknown), (unknown), Alan D. Waggoner, Richard I. Stein, J. Christopher Eagon, Samuel Klein, Robert J. Gropler, Linda R. Peterson	0
17	Obezite Tedavisi İçin Para Ödemek Para Ediyor mu 2005 ·Gastroenterology ·Samuel Klein	2
18	Metabolic Effects of Treatment With Atypical Antipsychotics 2004 ·The Journal of Clinical Psychiatry ·John M. Kane, (unknown), Daniel E. Casey, Christoph U. Correll, Alan J. Gelenberg, Samuel Klein, John W. Newcomer	58
19	A 6‐Month Randomized, Placebo‐Controlled, Dose‐Ranging Trial of Topiramate for Weight Loss in Obesity 2003 ·Obesity Research ·George A. Bray, Priscilla Hollander, Samuel Klein, Robert F. Kushner, Brian Levy, M. Fitchet, Barbara H. Perry	263
20	Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects. 1986 ·Journal of Clinical Investigation ·Samuel Klein, V. R. Young, George L. Blackburn, B R Bistrian, Robert R. Wolfe	115

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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