Philippe Froguel

131.1k total citations · 11 hit papers
529 papers, 37.3k citations indexed

About

Philippe Froguel is a scholar working on Genetics, Molecular Biology and Surgery. According to data from OpenAlex, Philippe Froguel has authored 529 papers receiving a total of 37.3k indexed citations (citations by other indexed papers that have themselves been cited), including 225 papers in Genetics, 224 papers in Molecular Biology and 195 papers in Surgery. Recurrent topics in Philippe Froguel's work include Pancreatic function and diabetes (181 papers), Metabolism, Diabetes, and Cancer (93 papers) and Genetic Associations and Epidemiology (85 papers). Philippe Froguel is often cited by papers focused on Pancreatic function and diabetes (181 papers), Metabolism, Diabetes, and Cancer (93 papers) and Genetic Associations and Epidemiology (85 papers). Philippe Froguel collaborates with scholars based in France, United Kingdom and United States. Philippe Froguel's co-authors include Martine Vaxillaire, Gilberto Velho, Christian Dina, Andrew J. Walley, Takashi Kadowaki, Toshimasa Yamauchi, B Guy-Grand, Amélie Bonnefond, Stephen Eyre and Satoshi Kimura and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Philippe Froguel

522 papers receiving 36.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 3.4k citations Philippe Froguel et al. profile →
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 1.7k citations Karine Clément, Christian Dina et al. profile →
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

2002 984 citations Philippe Froguel et al. profile →
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

2003 845 citations Philippe Froguel et al. profile →
Genetic associations with human longevity at the APOE and ACE loci

1994 835 citations Philippe Froguel et al. profile →
Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines

2013 833 citations Philippe Froguel et al. PubMed profile →
Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome 3q27-qter and Independent Replication of a Type 2–Diabetes Locus on Chromosome 1q21–q24

2000 576 citations Cécile Lecœur, Christian Dina et al. profile →
Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus

1993 517 citations Philippe Froguel, Martine Vaxillaire et al. profile →
Genetic Variation in the β₃-Adrenergic Receptor and an Increased Capacity to Gain Weight in Patients with Morbid Obesity

1995 501 citations B Guy-Grand, Alan R. Shuldiner et al. profile →
Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

2009 294 citations Giles S.H. Yeo, Stephen Eyre et al. profile →
Monogenic diabetes

2023 71 citations Amélie Bonnefond, Martine Vaxillaire et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Philippe Froguel France	93	13.2k	11.8k	10.7k	10.0k	8.7k	529	37.3k
Stephen O’Rahilly United Kingdom	108	16.7k 1.3×	8.1k 0.7×	16.2k 1.5×	6.0k 0.6×	9.8k 1.1×	429	46.8k
Christopher B. Newgard United States	106	24.1k 1.8×	5.5k 0.5×	17.5k 1.6×	11.2k 1.1×	7.4k 0.8×	397	44.6k
Mitchell A. Lazar United States	125	30.0k 2.3×	8.8k 0.7×	16.7k 1.6×	3.7k 0.4×	12.7k 1.5×	325	56.1k
Leif Groop Sweden	90	12.4k 0.9×	10.4k 0.9×	7.5k 0.7×	10.1k 1.0×	5.5k 0.6×	555	36.8k
Domenico Accili United States	92	18.8k 1.4×	4.9k 0.4×	7.8k 0.7×	10.0k 1.0×	4.7k 0.5×	271	31.5k
Bo Åhrén Sweden	91	10.1k 0.8×	3.1k 0.3×	7.6k 0.7×	12.7k 1.3×	4.5k 0.5×	720	33.1k
Morris F. White United States	121	32.8k 2.5×	4.5k 0.4×	11.5k 1.1×	12.4k 1.2×	6.5k 0.7×	346	51.4k
Daniel J. Drucker Canada	127	20.3k 1.5×	5.5k 0.5×	9.8k 0.9×	24.1k 2.4×	5.4k 0.6×	425	59.5k
Michael Stümvoll Germany	87	9.8k 0.7×	2.5k 0.2×	11.9k 1.1×	4.6k 0.5×	9.3k 1.1×	582	32.0k
Clifton Bogardus United States	80	8.5k 0.6×	3.2k 0.3×	13.6k 1.3×	3.9k 0.4×	5.2k 0.6×	281	27.9k

Countries citing papers authored by Philippe Froguel

Since Specialization

Citations

This map shows the geographic impact of Philippe Froguel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Philippe Froguel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Philippe Froguel more than expected).

Fields of papers citing papers by Philippe Froguel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Philippe Froguel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Philippe Froguel. The network helps show where Philippe Froguel may publish in the future.

Co-authorship network of co-authors of Philippe Froguel

This figure shows the co-authorship network connecting the top 25 collaborators of Philippe Froguel. A scholar is included among the top collaborators of Philippe Froguel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Philippe Froguel. Philippe Froguel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Burrows, Kimberley, Anni Heiskala, Jonathan P. Bradfield, et al.. (2024). A framework for conducting GWAS using repeated measures data with an application to childhood BMI. Nature Communications. 15(1). 10067–10067.

Kouidrat, Youssef, Martine Vaxillaire, Aurélie Dechaume, et al.. (2023). Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: Lessons for precision medicine. Diabetes & Metabolism. 50(1). 101507–101507. 3 indexed citations

Heuson, Egon, Adrien Herlédan, Frédérik Oger, et al.. (2023). High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry. Cells. 12(6). 849–849. 3 indexed citations

Delemer, Brigitte, Christine Poitou, Martine Vaxillaire, et al.. (2023). Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use. Genetics in Medicine. 25(7). 100857–100857. 10 indexed citations

Khamis, Amna, Beverley Balkau, Amélie Bonnefond, et al.. (2022). Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort. Diabetes & Metabolism. 48(4). 101347–101347. 2 indexed citations

Mitchell, Rebecca, Foram N. Ashar, Marjo‐Riitta Järvelin, et al.. (2019). Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death. Journal of the American Heart Association. 8(23). e013751–e013751. 8 indexed citations

Field, Yair, Evan A. Boyle, Natalie Telis, et al.. (2016). Detection of human adaptation during the past 2000 years. Science. 354(6313). 760–764. 233 indexed citations

Mardinoğlu, Adil, Rasmus Ågren, Caroline Kampf, et al.. (2013). Integration of clinical data with a genome‐scale metabolic model of the human adipocyte. Molecular Systems Biology. 9(1). 649–649. 182 indexed citations

Jääskeläinen, Anne, Ursula Schwab, Marjukka Kolehmainen, et al.. (2013). Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986. STM:n Hallinnonalan avoin julkaisuarkisto (Julkari). 1 indexed citations

10.

Rouskas, Konstantinos, Stephen Eyre, Fanny Stutzmann, et al.. (2012). Loss‐of‐Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population. Obesity. 20(11). 2278–2282. 16 indexed citations

11.

Walley, Andrew J., Peter Jacobson, Mario Falchi, et al.. (2011). Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue. International Journal of Obesity. 36(1). 137–147. 36 indexed citations

12.

Smith, Adam J. de, Carolin Purmann, Robin Walters, et al.. (2009). Elucidating the aetiology of Prader-Willi syndrome: deletion of the HBII-85 class of snoRNA is associated with hyperphagia, obesity and hypogonadism. Journal of Medical Genetics. 46. 1 indexed citations

13.

Choquet, Hélène, Stephen Eyre, Hassen Kamoun, et al.. (2009). TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia. Pathologie Biologie. 58(6). 426–429. 14 indexed citations

14.

Prokopenko, Inga, Eleftheria Zeggini, Christopher J. Groves, et al.. (2008). Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q are not confirmed in large-scale follow-up studies. Diabetes. 57. 1 indexed citations

15.

Smith, Adam J. de, Anya Tsalenko, Nick Sampas, et al.. (2007). Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Human Molecular Genetics. 16(23). 2783–2794. 176 indexed citations

16.

Gibson, F A & Philippe Froguel. (2004). Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians. HAL (Le Centre pour la Communication Scientifique Directe). 1 indexed citations

17.

Vaxillaire, Martine, et al.. (2002). Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France. Diabetologia. 45(3). 454–455. 19 indexed citations

18.

Froguel, Philippe, et al.. (2000). Génétique de l'obésité: vers la compréhension d'un syndrome complexe.. La Presse Médicale. 29(10). 2 indexed citations

19.

Dupont, Sophie, et al.. (1999). Absence of replication in the French population of the association between beta 2/NEUROD-A45T polymorphism and type 1 diabetes.. PubMed. 25(6). 516–7. 16 indexed citations

20.

Blanché, Hélène, Jörg Hager, Feng Sun, et al.. (1994). Nonradioactive screening of glucokinase mutations in maturity onset diabetes of the young.. PubMed. 16(5). 866–8, 870, 873. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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