Bryan Laffitte

10.0k citations

32 papers · 7.4k indexed · 6 hit papers · h-index 20

Impact in

Surgery top 0.2%
- Cholesterol and Lipid Metabolism
Biochemistry top 0.5%
- Lipid metabolism and biosynthesis

Papers in ⓘ

Architecture 1
Cancer Research 8
- Cancer, Lipids, and Metabolism 7

Co-authors: Peter Tontonoz (14 shared papers)Sean B. Joseph (12 shared papers)David J. Mangelsdorf (6 shared papers)Peter A. Edwards (5 shared papers)Damien C. Wilpitz (5 shared papers)Antonio Castrillo (4 shared papers)Jon L. Collins (4 shared papers)Robert Walczak (5 shared papers)
Journals: Proceedings of the National Academy of Sciences (6 papers)Journal of Biological Chemistry (4 papers)Journal of Hepatology (3 papers)Molecular and Cellular Biology (2 papers)Nature Medicine (1 paper)
Partner nations: United States United Kingdom India

In The Last Decade

Bryan Laffitte

32 papers receiving 7.2k citations

Hit Papers

6 papers align trajectories log scale

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors 2003 · 981 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2003 Nature Medicine
2002 Journal of Biological Chemistry
2002 Proceedings of the National Academy of Sciences
2001 Molecular Cell
2001 Proceedings of the National Academy of Sciences
2000 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Bryan Laffitte

Since Specialization

Citations

This map shows the geographic impact of Bryan Laffitte's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bryan Laffitte with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bryan Laffitte more than expected).

Fields of papers citing papers by Bryan Laffitte

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bryan Laffitte. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bryan Laffitte. The network helps show where Bryan Laffitte may publish in the future.

Co-authors

The 25 scholars most cited alongside Bryan Laffitte, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Bryan Laffitte Line = papers co-authored together Bryan Laffitte links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 32 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis Molecular Cell ·Ajay Chawla, William A. Boisvert, Chih‐Hao Lee, Bryan Laffitte, Yaacov Barak, Sean B. Joseph, Debbie Liao, László Nagy, Peter A. Edwards, Linda K. Curtiss, Ronald M. Evans, Peter Tontonoz Hit paper breakdown →	2001	1155
2	Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nature Medicine ·Sean B. Joseph, Antonio Castrillo, Bryan Laffitte, David J. Mangelsdorf, Peter Tontonoz Hit paper breakdown →	2003	981
3	Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα Proceedings of the National Academy of Sciences ·Asha Venkateswaran, Bryan Laffitte, Sean B. Joseph, Puiying A. Mak, Damien C. Wilpitz, Peter A. Edwards, Peter Tontonoz Hit paper breakdown →	2000	836
4	Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proceedings of the National Academy of Sciences ·Sean B. Joseph, Elaine McKilligin, Liming Pei, Michael A. Watson, Alan R. Collins, Bryan Laffitte, Mingyi Chen, Grace Noh, Joanne Goodman, Graham N. Hagger, Jonathan Tran, Tim K. Tippin, Xuping Wang, Aldons J. Lusis, Willa A. Hsueh, Ronald E. Law, Jon L. Collins, Timothy M. Willson, Peter Tontonoz Hit paper breakdown →	2002	778
5	Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors Journal of Biological Chemistry ·Sean B. Joseph, Bryan Laffitte, Parthive H. Patel, Michael A. Watson, Karen Matsukuma, Robert Walczak, Jon L. Collins, Timothy F. Osborne, Peter Tontonoz Hit paper breakdown →	2002	631
6	LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes Proceedings of the National Academy of Sciences ·Bryan Laffitte, Joyce J. Repa, Sean B. Joseph, Damien C. Wilpitz, Heidi R. Kast-Woelbern, David J. Mangelsdorf, Peter Tontonoz Hit paper breakdown →	2001	560
7	Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Proceedings of the National Academy of Sciences ·Bryan Laffitte, Lily C. Chao, Jing Li, Robert Walczak, Sarah Hummasti, Sean B. Joseph, Antonio Castrillo, Damien C. Wilpitz, David J. Mangelsdorf, Jon L. Collins, Enrique Sáez, Peter Tontonoz	2003	411
8	Identification of macrophage liver X receptors as inhibitors of atherosclerosis Proceedings of the National Academy of Sciences ·Rajendra K. Tangirala, Eric D. Bischoff, Sean B. Joseph, Brandee Wagner, Robert Walczak, Bryan Laffitte, Chris Daige, Diane Thomas, Richard A. Heyman, David J. Mangelsdorf, Xuping Wang, Aldons J. Lusis, Peter Tontonoz, Ira G. Schulman	2002	359
9	Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids Molecular Endocrinology ·Heidi R. Kast-Woelbern, Catherine Nguyen, Christopher J. Sinal, Stacey A. Jones, Bryan Laffitte, Karen Reue, Frank J. Gonzalez, Timothy M. Willson, Peter A. Edwards	2001	286
10	Autoregulation of the Human Liver X Receptor α Promoter Molecular and Cellular Biology ·Bryan Laffitte, Sean B. Joseph, Robert Walczak, Liming Pei, Damien C. Wilpitz, Jon L. Collins, Peter Tontonoz	2001	270
11	Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor Journal of Biological Chemistry ·Bryan Laffitte, Heidi R. Kast-Woelbern, Catherine Nguyen, Ann Marie Zavacki, David D. Moore, Peter A. Edwards	2000	235
12	Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages Journal of Biological Chemistry ·Puiying A. Mak, Bryan Laffitte, Catherine Desrumaux, Sean B. Joseph, Linda K. Curtiss, David J. Mangelsdorf, Peter Tontonoz, Peter A. Edwards	2002	196
13	The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions Molecular and Cellular Biology ·Bryan Laffitte, Sean B. Joseph, Mingyi Chen, Antonio Castrillo, Joyce J. Repa, Damien C. Wilpitz, David J. Mangelsdorf, Peter Tontonoz	2003	129
14	Liver X receptors are regulators of adipocyte gene expression but not differentiation Journal of Lipid Research ·Sarah Hummasti, Bryan Laffitte, Michael A. Watson, Cristin M. Galardi, Lily C. Chao, Lakshman Ramamurthy, John T. Moore, Peter Tontonoz	2004	99
15	Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening Journal of the American Chemical Society ·Weijun Shen, Matthew S. Tremblay, V. Deshmukh, Weidong Wang, Christophe Filippi, George Harb, You-qing Zhang, Anwesh Kamireddy, Janine Baaten, Qihui Jin, Tom Wu, Jonathan G. Swoboda, Charles Y. Cho, Jing Li, Bryan Laffitte, Peter McNamara, Richard Glynne, Xu Wu, Ann Herman, Peter G. Schultz	2013	74
16	Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth Oncotarget ·Jinyun Chen, Franklin Chung, Guizhi Yang, Minying Pu, Hui Gao, Wei Jiang, Hong Yin, Vladimı́r Čápka, Shailaja Kasibhatla, Bryan Laffitte, Savina Jaeger, Raymond Pagliarini, Yaoyu Chen, Wenlai Zhou	2013	64
17	Transcription of the Vascular Endothelial Growth Factor Gene in Macrophages Is Regulated by Liver X Receptors Journal of Biological Chemistry ·Robert Walczak, Sean B. Joseph, Bryan Laffitte, Antonio Castrillo, Liming Pei, Peter Tontonoz	2004	61
18	Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers Clinical Pharmacology in Drug Development ·Michael K. Badman, Jin Chen, Sachin N. Desai, Soniya Vaidya, Srikanth Neelakantham, Jie Zhang, Lu Gan, Kate Danis, Bryan Laffitte, Lloyd B. Klickstein	2019	59
19	Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids Proceedings of the National Academy of Sciences ·Jan Grünewald, Grady S. Hunt, Liqun Dong, Frank Niessen, Ben G. Wen, Meng-Lin Tsao, Roshan Perera, Mingchao Kang, Bryan Laffitte, Sassan M. Azarian, Wolfram Ruf, Marc Nasoff, Richard A. Lerner, Peter G. Schultz, Vaughn V. Smider	2009	53
20	Liver X receptor modulators: a review of recently patented compounds (2009 – 2012) Expert Opinion on Therapeutic Patents ·Jon C. Loren, Zhihong Huang, Bryan Laffitte, Valentina Molteni	2013	35

About Bryan Laffitte

Bryan Laffitte is a scholar working on Architecture, Cancer Research, Surgery, Molecular Biology and Oncology, having authored 32 papers that have together received 7.4k indexed citations. Recurring topics across this work include Cholesterol and Lipid Metabolism (16 papers), Peroxisome Proliferator-Activated Receptors (15 papers), Cancer, Lipids, and Metabolism (7 papers), Drug Transport and Resistance Mechanisms (7 papers), Pancreatic function and diabetes (5 papers), Diabetes Management and Research (2 papers), Metabolism, Diabetes, and Cancer (2 papers) and Retinoids in leukemia and cellular processes (2 papers). The work is most often cited by research in Surgery (5.1k citations), Biochemistry (770 citations), Oncology (2.6k citations), Cancer Research (1.3k citations) and Molecular Biology (4.2k citations). Bryan Laffitte has collaborated with scholars based in United States, United Kingdom and India. Frequent co-authors include Peter Tontonoz, Sean B. Joseph, David J. Mangelsdorf, Peter A. Edwards, Damien C. Wilpitz, Antonio Castrillo, Jon L. Collins, Robert Walczak, Heidi R. Kast-Woelbern and Puiying A. Mak. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, Journal of Hepatology, Molecular and Cellular Biology and Nature Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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