Bryan Laffitte

10.0k total citations · 6 hit papers
32 papers, 7.4k citations indexed

About

Bryan Laffitte is a scholar working on Surgery, Molecular Biology and Oncology. According to data from OpenAlex, Bryan Laffitte has authored 32 papers receiving a total of 7.4k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Surgery, 21 papers in Molecular Biology and 8 papers in Oncology. Recurrent topics in Bryan Laffitte's work include Cholesterol and Lipid Metabolism (16 papers), Peroxisome Proliferator-Activated Receptors (15 papers) and Drug Transport and Resistance Mechanisms (7 papers). Bryan Laffitte is often cited by papers focused on Cholesterol and Lipid Metabolism (16 papers), Peroxisome Proliferator-Activated Receptors (15 papers) and Drug Transport and Resistance Mechanisms (7 papers). Bryan Laffitte collaborates with scholars based in United States, United Kingdom and India. Bryan Laffitte's co-authors include Peter Tontonoz, Sean B. Joseph, David J. Mangelsdorf, Peter A. Edwards, Damien C. Wilpitz, Antonio Castrillo, Jon L. Collins, Robert Walczak, Heidi R. Kast-Woelbern and Puiying A. Mak and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

Bryan Laffitte

32 papers receiving 7.2k citations

Hit Papers

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in C... 2000 2026 2008 2017 2001 2003 2000 2002 2002 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
    2001 1.2k citations Ajay Chawla, William A. Boisvert et al. Molecular Cell profile →
  2. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    2003 981 citations Sean B. Joseph, Antonio Castrillo et al. Nature Medicine profile →
  3. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα
    2000 836 citations Bryan Laffitte, Sean B. Joseph et al. Proceedings of the National Academy of Sciences profile →
  4. Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    2002 778 citations Sean B. Joseph, Liming Pei et al. Proceedings of the National Academy of Sciences profile →
  5. Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors
    2002 631 citations Sean B. Joseph, Bryan Laffitte et al. Journal of Biological Chemistry profile →
  6. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    2001 560 citations Bryan Laffitte, Joyce J. Repa et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bryan Laffitte United States 20 5.1k 4.2k 2.6k 1.3k 1.1k 32 7.4k
Noam Zelcer Netherlands 43 3.1k 0.6× 3.3k 0.8× 3.2k 1.2× 1.1k 0.8× 1.3k 1.2× 95 8.6k
Nicolas Duverger France 38 3.3k 0.6× 2.9k 0.7× 1.3k 0.5× 968 0.8× 1.0k 1.0× 67 6.2k
Omar L. Francone United States 34 3.6k 0.7× 2.5k 0.6× 1.6k 0.6× 946 0.8× 451 0.4× 71 5.2k
Silvia Santamarina-Fojo United States 49 4.4k 0.9× 2.7k 0.6× 1.8k 0.7× 1.0k 0.8× 421 0.4× 86 6.7k
Bernardo L. Trigatti Canada 34 2.8k 0.5× 2.4k 0.6× 971 0.4× 834 0.7× 927 0.9× 93 5.6k
Ken Ohashi Japan 37 2.5k 0.5× 3.2k 0.8× 958 0.4× 1.1k 0.9× 531 0.5× 85 6.4k
Knut Erik Berge Norway 33 4.2k 0.8× 2.3k 0.5× 2.0k 0.8× 753 0.6× 349 0.3× 103 6.3k
Marcelo Amar United States 44 2.8k 0.5× 1.9k 0.4× 1.0k 0.4× 829 0.7× 591 0.5× 85 5.2k
Russell A. DeBose‐Boyd United States 35 3.1k 0.6× 3.8k 0.9× 660 0.3× 1.1k 0.9× 439 0.4× 62 6.4k
Rajendra K. Tangirala United States 37 1.9k 0.4× 2.2k 0.5× 963 0.4× 769 0.6× 1.9k 1.7× 44 5.6k

Countries citing papers authored by Bryan Laffitte

Since Specialization
Citations

This map shows the geographic impact of Bryan Laffitte's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bryan Laffitte with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bryan Laffitte more than expected).

Fields of papers citing papers by Bryan Laffitte

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bryan Laffitte. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bryan Laffitte. The network helps show where Bryan Laffitte may publish in the future.

Co-authorship network of co-authors of Bryan Laffitte

This figure shows the co-authorship network connecting the top 25 collaborators of Bryan Laffitte. A scholar is included among the top collaborators of Bryan Laffitte based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bryan Laffitte. Bryan Laffitte is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Hohmeier, Hans E., Lu Zhang, Brandon L. Taylor, et al.. (2020). Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells. PLoS ONE. 15(3). e0224344–e0224344. 19 indexed citations
2.
Huang, Zhihong, Matthew S. Tremblay, Tom Wu, et al.. (2019). Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes. ACS Omega. 4(2). 3571–3581. 9 indexed citations
3.
Badman, Michael K., Sachin N. Desai, Soniya Vaidya, et al.. (2019). Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers. Clinical Pharmacology in Drug Development. 9(3). 395–410. 59 indexed citations
4.
Laffitte, Bryan, Paul V. Rucker, D. CHIANELLI, et al.. (2018). LJN452 (tropifexor) attenuates steatohepatitis, inflammation, and fibrosis in dietary mouse models of nonalcoholic steatohepatitis. Journal of Hepatology. 68. S341–S342. 2 indexed citations
5.
Jacintho, Jason, Christopher Baccei, Austin Chen, et al.. (2018). Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies. Bioorganic & Medicinal Chemistry Letters. 29(3). 503–508. 7 indexed citations
6.
Huttner, Kenneth, Marc F. DeCristofaro, Bryan Laffitte, et al.. (2017). First-in-Human study of LMB763, a novel, orally-available farnesoid X receptor agonist that demonstrates modulation of the pharmacodynamic markers FGF19 and C4 in healthy subjects. Journal of Hepatology. 66(1). S425–S425. 2 indexed citations
7.
Hao, Xueshi, Qihui Jin, Porino Va, et al.. (2016). Pancreas‐Specific Delivery of β‐Cell Proliferating Small Molecules. ChemMedChem. 11(11). 1129–1132. 5 indexed citations
8.
Loren, Jon C., Zhihong Huang, Bryan Laffitte, & Valentina Molteni. (2013). Liver X receptor modulators: a review of recently patented compounds (2009 – 2012). Expert Opinion on Therapeutic Patents. 23(10). 1317–1335. 35 indexed citations
9.
Chanoit, Guillaume, et al.. (2009). A laparoscopic knot-tying device for minimally invasive cardiac surgery☆. European Journal of Cardio-Thoracic Surgery. 37(3). 626–630. 18 indexed citations
10.
Hummasti, Sarah, Bryan Laffitte, Michael A. Watson, et al.. (2004). Liver X receptors are regulators of adipocyte gene expression but not differentiation. Journal of Lipid Research. 45(4). 616–625. 99 indexed citations
11.
Walczak, Robert, Sean B. Joseph, Bryan Laffitte, et al.. (2004). Transcription of the Vascular Endothelial Growth Factor Gene in Macrophages Is Regulated by Liver X Receptors. Journal of Biological Chemistry. 279(11). 9905–9911. 61 indexed citations
12.
Laffitte, Bryan, et al.. (2004). A Novel System for Automated RNA Isolation: Increasing Throughput without Increasing Footprint. JALA Journal of the Association for Laboratory Automation. 9(3). 146–149. 2 indexed citations
13.
Joseph, Sean B., Antonio Castrillo, Bryan Laffitte, David J. Mangelsdorf, & Peter Tontonoz. (2003). Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Medicine. 9(2). 213–219. 981 indexed citations breakdown →
14.
Mak, Puiying A., Bryan Laffitte, Catherine Desrumaux, et al.. (2002). Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages. Journal of Biological Chemistry. 277(35). 31900–31908. 196 indexed citations
15.
Joseph, Sean B., Bryan Laffitte, Parthive H. Patel, et al.. (2002). Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors. Journal of Biological Chemistry. 277(13). 11019–11025. 631 indexed citations breakdown →
16.
Laffitte, Bryan & Peter Tontonoz. (2002). Orphan nuclear receptors find a home in the arterial wall. Current Atherosclerosis Reports. 4(3). 213–221. 18 indexed citations
17.
Kast-Woelbern, Heidi R., Catherine Nguyen, Christopher J. Sinal, et al.. (2001). Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids. Molecular Endocrinology. 15(10). 1720–1728. 286 indexed citations
18.
Chawla, Ajay, William A. Boisvert, Chih‐Hao Lee, et al.. (2001). A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis. Molecular Cell. 7(1). 161–171. 1155 indexed citations breakdown →
19.
Laffitte, Bryan, Joyce J. Repa, Sean B. Joseph, et al.. (2001). LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proceedings of the National Academy of Sciences. 98(2). 507–512. 560 indexed citations breakdown →
20.
Laffitte, Bryan, Heidi R. Kast-Woelbern, Catherine Nguyen, et al.. (2000). Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor. Journal of Biological Chemistry. 275(14). 10638–10647. 235 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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