S.E. Greasley

3.6k citations

25 papers · 935 indexed · 1 hit paper · h-index 19

Impact in

Physiology top 5%
Molecular Biology top 10%
- Biochemical and Molecular Research
- Signaling Pathways in Disease
- Protein Structure and Dynamics

Papers in ⓘ

Physiology 3
Molecular Biology 21
- Biochemical and Molecular Research 14
- PI3K/AKT/mTOR signaling in cancer 4
- Porphyrin Metabolism and Disorders 4
- Signaling Pathways in Disease 3

Co-authors: Ian A. Wilson (10 shared papers)G. Peter Beardsley (5 shared papers)Rose Ann Ferre (7 shared papers)Dennis W. Wolan (4 shared papers)Patricia A. Horton (2 shared papers)Chuangxing Guo (5 shared papers)M. Catherine Johnson (4 shared papers)Dale L. Boger (3 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (7 papers)Biochemistry (6 papers)Journal of Biological Chemistry (4 papers)Journal of Molecular Biology (2 papers)Bioorganic & Medicinal Chemistry (1 paper)
Partner nations: United States United Kingdom Poland

In The Last Decade

S.E. Greasley

25 papers receiving 912 citations

Hit Papers

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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants 2022 · 114 citations

Peers

Countries citing papers authored by S.E. Greasley

Since Specialization

Citations

This map shows the geographic impact of S.E. Greasley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by S.E. Greasley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites S.E. Greasley more than expected).

Fields of papers citing papers by S.E. Greasley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by S.E. Greasley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by S.E. Greasley. The network helps show where S.E. Greasley may publish in the future.

Co-authors

The 25 scholars most cited alongside S.E. Greasley, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with S.E. Greasley Line = papers co-authored together S.E. Greasley links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants Journal of Biological Chemistry ·S.E. Greasley, Stephen Noell, Olga Plotnikova, Rose Ann Ferre, Wei Liu, Ben Bolaños, Kimberly F. Fennell, Jennifer Nicki, Timothy K. Craig, Yuao Zhu, Al Stewart, Claire M. Steppan Hit paper breakdown →	2022	114
2	Structure-based design of novel human Pin1 inhibitors (I) Bioorganic & Medicinal Chemistry Letters ·Chuangxing Guo, Xinjun Hou, Liming Dong, Eleanor Dagostino, S.E. Greasley, Rose Ann Ferre, Joseph Marakovits, M. Catherine Johnson, David A. Matthews, Barbara Mroczkowski, Hans E. Parge, Todd VanArsdale, Ian Popoff, Joseph Piraino, Stephen A. Margosiak, James Thomson, Gerrit Los, Brion W. Murray	2009	91
3	The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms Nature Structural & Molecular Biology ·S.E. Greasley, Harren Jhoti, Carmel G. Teahan, Roberto Solari, Amanda Fensome, Geraint Thomas, Shamshad Cockcroft, B.D. Bax	1995	89
4	Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nature Structural Biology ·S.E. Greasley, Patricia A. Horton, Joseph Ramcharan, G. Peter Beardsley, Stephen J. Benkovic, Ian A. Wilson	2001	72
5	Structure-based design of novel human Pin1 inhibitors (II) Bioorganic & Medicinal Chemistry Letters ·Liming Dong, Joseph Marakovits, Xinjun Hou, Chuangxing Guo, S.E. Greasley, Eleanor Dagostino, Rose Ann Ferre, M. Catherine Johnson, Eugenia Kraynov, James Thomson, Ved Pathak, Brion W. Murray	2010	70
6	Insights into Mechanism of Glucokinase Activation Journal of Biological Chemistry ·Shenping Liu, Mark Ammirati, Xi Song, John D. Knafels, Jeff Zhang, S.E. Greasley, Jeffrey A. Pfefferkorn, Xiayang Qiu	2012	56
7	Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates Journal of Biological Chemistry ·Cheom‐Gil Cheong, Dennis W. Wolan, S.E. Greasley, Patricia A. Horton, G. Peter Beardsley, Ian A. Wilson	2004	42
8	Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators Bioorganic & Medicinal Chemistry Letters ·Chuangxing Guo, Angelica Linton, Mehran Jalaie, Susan E. Kephart, Martha A. Ornelas, Mason Pairish, S.E. Greasley, Paul Richardson, Karen A. Maegley, Michael J. Hickey, John Li, Xin Wu, Ji X, Zhi Xie	2013	42
9	Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation Bioorganic & Medicinal Chemistry ·William F. Vernier, Wesley K. M. Chong, David A. Rewolinski, S.E. Greasley, Thomas Pauly, Morena Shaw, Dac M. Dinh, Rose Ann Ferre, Seiji Nukui, Martha A. Ornelas, Eric L. Reyner	2010	39
10	Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket Bioorganic & Medicinal Chemistry Letters ·Chuangxing Guo, Xinjun Hou, Liming Dong, Joseph Marakovits, S.E. Greasley, Eleanor Dagostino, Rose Ann Ferre, M. Catherine Johnson, Paul S. Humphries, Haitao Li, Genevieve Paderes, Joseph Piraino, Eugenia Kraynov, Brion W. Murray	2014	38
11	Unexpected Formation of an Epoxide-Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase^, Biochemistry ·S.E. Greasley, Thomas H. Marsilje, Hui Cai, Stephen Baker, Stephen J. Benkovic, Dale L. Boger, Ian A. Wilson	2001	35
12	New Insights into Inhibitor Design from the Crystal Structure and NMR Studies ofEscherichia coliGAR Transformylase in Complex with β-GAR and 10-Formyl-5,8,10-trideazafolic Acid^, Biochemistry ·S.E. Greasley, M M Yamashita, Hui Cai, Stephen J. Benkovic, Dale L. Boger, Ian A. Wilson	1999	32
13	Structural Insights into the Avian AICAR Transformylase Mechanism Biochemistry ·Dennis W. Wolan, S.E. Greasley, G. Peter Beardsley, Ian A. Wilson	2002	30
14	Structural Insights into the Human and Avian IMP Cyclohydrolase Mechanism via Crystal Structures with the Bound XMP Inhibitor^, Biochemistry ·Dennis W. Wolan, Cheom‐Gil Cheong, S.E. Greasley, Ian A. Wilson	2004	27
15	A pH-dependent stabilization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 Å Journal of Molecular Biology ·Ying Su, M M Yamashita, S.E. Greasley, Christine A Mullen, Jae Hoon Shim, Patricia A. Jennings, Steven J. Benkovic, Ian A. Wilson	1998	26
16	Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR Bioorganic & Medicinal Chemistry Letters ·Phuong Le, Hengmiao Cheng, Sacha Ninkovic, Michael Plewe, Xiao‐Jun Huang, Hai Wang, Shubha Bagrodia, Shaoxian Sun, Daniel R. Knighton, Caroline M. LaFleur Rogers, Andrew Pannifer, S.E. Greasley, Deepak Dalvie, Eric Zhang	2012	26
17	Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors Bioorganic & Medicinal Chemistry Letters ·Kevin K.‐C. Liu, Xiao‐Jun Huang, Shubha Bagrodia, Jeffrey H. Chen, S.E. Greasley, Hengmiao Cheng, Shaoxian Sun, Dan Knighton, Caroline Rodgers, Kristina Rafidi, Aihua Zou, Jiezhan Xiao, Shengyong Yan	2010	26
18	Crystal Structures of Human GAR Tfase at Low and High pH and with Substrate β-GAR^, Biochemistry ·Yan Zhang, Joel Desharnais, S.E. Greasley, G. Peter Beardsley, Dale L. Boger, Ian A. Wilson	2002	26
19	Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor β-DADF Identifies the Folate Binding Site^, Biochemistry ·Dennis W. Wolan, S.E. Greasley, Mark J. Wall, Stephen J. Benkovic, Ian A. Wilson	2003	20
20	Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery Journal of Computer-Aided Molecular Design ·M. Catherine Johnson, Qiyue Hu, Laura Lingardo, Rose Ann Ferre, S.E. Greasley, Jiangli Yan, John C. Kath, Ping Chen, Jacques Ermolieff, Gordon Alton	2011	15

About S.E. Greasley

S.E. Greasley is a scholar working on Physiology, Molecular Biology, Infectious Diseases, Oncology and Genetics, having authored 25 papers that have together received 935 indexed citations. Recurring topics across this work include Biochemical and Molecular Research (14 papers), Enzyme Structure and Function (5 papers), PI3K/AKT/mTOR signaling in cancer (4 papers), Porphyrin Metabolism and Disorders (4 papers), HIV/AIDS drug development and treatment (4 papers), Peptidase Inhibition and Analysis (4 papers), Signaling Pathways in Disease (3 papers) and Quinazolinone synthesis and applications (2 papers). The work is most often cited by research in Physiology (72 citations), Molecular Biology (726 citations), Infectious Diseases (142 citations), Computational Theory and Mathematics (115 citations) and Organic Chemistry (165 citations). S.E. Greasley has collaborated with scholars based in United States, United Kingdom and Poland. Frequent co-authors include Ian A. Wilson, G. Peter Beardsley, Rose Ann Ferre, Dennis W. Wolan, Patricia A. Horton, Chuangxing Guo, M. Catherine Johnson, Dale L. Boger, Cheom‐Gil Cheong and Joseph Marakovits. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Biochemistry, Journal of Biological Chemistry, Journal of Molecular Biology and Bioorganic & Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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