William J. Pitts

5.7k citations

34 papers · 4.4k indexed · 2 hit papers · h-index 20

Molecular Biology top 5%
Organic Chemistry top 2%
Oncology top 5%
Immunology top 5%
Cellular and Molecular Neuroscience top 5%

Co-authors: Robert A. Copeland Ronald L. Magolda James M. Trzăskos Frank W. Hobbs Peggy Scherle Richard A. Earl Margaret Favata Elizabeth J. Manos
Topics: Biochemical and Molecular Research (11 papers)Adenosine and Purinergic Signaling (5 papers)Cytokine Signaling Pathways and Interactions (5 papers)
Cited by: Molecular Biology Organic Chemistry Immunology and Allergy
Journals: Science Journal of Biological Chemistry The Journal of Immunology
Partner nations: United States Sweden Germany

In The Last Decade

William J. Pitts

34 papers receiving 4.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 2.8k citations Margaret Favata, Kurumi Y. Horiuchi et al. Journal of Biological Chemistry profile →
Practical olefin hydroamination with nitroarenes

2015 452 citations Jinghan Gui, Ying Jin et al. Science profile →

Peers

Countries citing papers authored by William J. Pitts

Since Specialization

Citations

This map shows the geographic impact of William J. Pitts's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William J. Pitts with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William J. Pitts more than expected).

Fields of papers citing papers by William J. Pitts

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William J. Pitts. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William J. Pitts. The network helps show where William J. Pitts may publish in the future.

Co-authorship network of co-authors of William J. Pitts

This figure shows the co-authorship network connecting the top 25 collaborators of William J. Pitts. A scholar is included among the top collaborators of William J. Pitts based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William J. Pitts. William J. Pitts is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors 2017 ·Bioorganic & Medicinal Chemistry Letters ·Rajeev S. Bhide,(unknown),Carolyn A. Weigelt,John S. Sack,Robert J. Schmidt,Shuqun Lin,Hai‐Yun Xiao,Steven H. Spergel,James Kempson,William J. Pitts,Julie Carman,Michael A. Poss	17
2	Practical olefin hydroamination with nitroarenesbreakdown → 2015 ·Science ·Jinghan Gui,(unknown),Ying Jin,Tian Qin,Julian C. Lo,(unknown),Steven H. Spergel,Michael Mertzman,William J. Pitts,Thomas E. La Cruz,Michael A. Schmidt,Nitin B. Darvatkar,S. Natarajan,Phil S. Baran	452
3	Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain 2015 ·Journal of Biological Chemistry ·John S. Tokarski,Adriana Zupa-Fernandez,Jeffrey Tredup,Kristen Pike,ChiehYing Y. Chang,Dianlin Xie,Lihong Cheng,Donna L. Pedicord,J.K. Muckelbauer,Stephen R. Johnson,(unknown),Suzanne C. Edavettal,Hong Yang,Mark R. Witmer,Lisa Elkin,Yuval Blat,William J. Pitts,David S. Weinstein,James R. Burke	84
4	One-Pot Synthesis of Azaindoles via Palladium-Catalyzed α-Heteroarylation of Ketone Enolates 2010 ·The Journal of Organic Chemistry ·Steven H. Spergel,(unknown),William J. Pitts	27
5	Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase 2009 ·Bioorganic & Medicinal Chemistry Letters ·James Kempson,Junqing Guo,Jagabandhu Das,Robert V. Moquin,Steven H. Spergel,Scott H. Watterson,Charles M. Langevine,Alaric J. Dyckman,Mark A. Pattoli,James R. Burke,Xiao-Xia Yang,Kathleen M. Gillooly,Kim W. McIntyre,(unknown),John H. Dodd,Murray McKinnon,Joel C. Barrish,William J. Pitts	16
6	Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE) 2006 ·Bioorganic & Medicinal Chemistry Letters ·James J.‐W. Duan,Lihua Chen,Zhonghui Lu,Bin Jiang,Naoyuki Asakawa,James E. Sheppeck,Rui‐Qin Liu,Maryanne Covington,William J. Pitts,Soong‐Hoon Kim,Carl P. Decicco	45
7	Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) 2005 ·Bioorganic & Medicinal Chemistry Letters ·Soong‐Hoon Kim,Andrew T. Pudzianowski,Kenneth J. Leavitt,Joseph Barbosa,Patricia A. McDonnell,William J. Metzler,Bruce Rankin,Richard Y. Liu,Wayne Vaccaro,William J. Pitts	80
8	Identification of purine inhibitors of phosphodiesterase 7 (PDE7) 2004 ·Bioorganic & Medicinal Chemistry Letters ·William J. Pitts,Wayne Vaccaro,Tram Huynh,Katerina Leftheris,Jacques Y. Roberge,Joseph Barbosa,Junqing Guo,(unknown),Andrew J. Watson,Karen Donaldson,Gary C. Starling,Peter A. Kiener,Michael A. Poss,John H. Dodd,Joel C. Barrish	38
9	Phosphodiesterase 7A-Deficient Mice Have Functional T Cells 2003 ·The Journal of Immunology ·(unknown),Kim W. McIntyre,(unknown),Henry Shen,William J. Pitts,John H. Dodd,Steven G. Nadler,Murray McKinnon,Andrew J. Watson	79
10	Novel inhibitors of IMPDH 2003 ·Bioorganic & Medicinal Chemistry Letters ·Scott H. Watterson,(unknown),T. G. Murali Dhar,Zhongqi Shen,William J. Pitts,Junqing Guo,Henry H. Gu,Derek Norris,John S. Chorba,Ping Chen,Daniel L. Cheney,Mark R. Witmer,Catherine Fleener,Katherine A. Rouleau,Robert M. Townsend,Diane Hollenbaugh,Edwin J. Iwanowicz	23
11	Identification of novel and potent isoquinoline aminooxazole-Based IMPDH inhibitors 2003 ·Bioorganic & Medicinal Chemistry Letters ·Ping Chen,Derek Norris,(unknown),T. G. Murali Dhar,William J. Pitts,Scott H. Watterson,Daniel L. Cheney,Donna A. Bassolino,Catherine Fleener,Katherine A. Rouleau,Diane Hollenbaugh,(unknown),Joel C. Barrish,Edwin J. Iwanowicz	21
12	Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety 2003 ·Bioorganic & Medicinal Chemistry Letters ·Edwin J. Iwanowicz,Scott H. Watterson,Junqing Guo,William J. Pitts,T. G. Murali Dhar,Zhongqi Shen,Ping Chen,Henry H. Gu,Catherine Fleener,Katherine A. Rouleau,Daniel L. Cheney,Robert M. Townsend,Diane Hollenbaugh	18
13	Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase 2002 ·Bioorganic & Medicinal Chemistry Letters ·William J. Pitts,Junqing Guo,T. G. Murali Dhar,Zhongqi Shen,Henry H. Gu,Scott H. Watterson,Mark S. Bednarz,(unknown),Joel C. Barrish,Donna A. Bassolino,Daniel L. Cheney,Catherine Fleener,Katherine A. Rouleau,Diane Hollenbaugh,Edwin J. Iwanowicz	31
14	Novel amide-based inhibitors of inosine 5′-monophosphate dehydrogenase 2002 ·Bioorganic & Medicinal Chemistry Letters ·Scott H. Watterson,Chunjian Liu,T. G. Murali Dhar,Henry H. Gu,William J. Pitts,Joel C. Barrish,Catherine Fleener,Katherine A. Rouleau,(unknown),Diane Hollenbaugh,Edwin J. Iwanowicz	11
15	Novel diamide-Based inhibitors of IMPDH 2002 ·Bioorganic & Medicinal Chemistry Letters ·Henry H. Gu,Edwin J. Iwanowicz,Junqing Guo,Scott H. Watterson,Zhongqi Shen,William J. Pitts,T. G. Murali Dhar,Catherine Fleener,Katherine A. Rouleau,(unknown),Mark R. Witmer,Jeffrey Tredup,Diane Hollenbaugh	17
16	Retinoic Acid and Vitamin E Modulate Expression and Release of CD178 in Carcinoma Cells: Consequences for Induction of Apoptosis in CD95-Sensitive Cells 2001 ·Experimental Cell Research ·Helmut R. Salih,Gary C. Starling,Markus Knauff,(unknown),Patricia M. Davis,William J. Pitts,Alejandro Aruffo,Peter A. Kiener	9
17	Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: Identification of αvβ3 antagonists lead compounds 1999 ·Bioorganic & Medicinal Chemistry Letters ·Arlene L. Rockwell,Maria Rafalski,William J. Pitts,Douglas G. Batt,Joseph J. Petraitis,William F. DeGrado,Shaker A. Mousa,Prabhakar K. Jadhav	22
18	Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs 1999 ·Bioorganic & Medicinal Chemistry Letters ·Donald Pinto,Douglas G. Batt,William J. Pitts,Joseph J. Petraitis,Michael J. Orwat,Shuaige Wang,James W. Jetter,(unknown),(unknown),Robert A. Copeland,Maryanne Covington,James M. Trzăskos,Ronald L. Magolda	17
19	Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinasebreakdown → 1998 ·Journal of Biological Chemistry ·Margaret Favata,Kurumi Y. Horiuchi,Elizabeth J. Manos,(unknown),(unknown),(unknown),Drew E. Van Dyk,William J. Pitts,Richard A. Earl,Frank W. Hobbs,Robert A. Copeland,Ronald L. Magolda,Peggy Scherle,James M. Trzăskos	2750
20	Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium 1998 ·Bioorganic & Medicinal Chemistry Letters ·William J. Pitts,James W. Jetter,Donald Pinto,Michael J. Orwat,Douglas G. Batt,(unknown),Joseph J. Petraitis,(unknown),Robert A. Copeland,Randine L. Dowling,Bruce Jaffee,(unknown),Elizabeth A. Jones,Ronald L. Magolda	15

About William J. Pitts

William J. Pitts is a scholar working on Physiology, Organic Chemistry and Immunology and Allergy, having authored 34 papers that have together received 4.4k indexed citations. Recurring topics across this work include Biochemical and Molecular Research (11 papers), Adenosine and Purinergic Signaling (5 papers) and Cytokine Signaling Pathways and Interactions (5 papers). The work is most often cited by research in Molecular Biology (2.4k citations), Organic Chemistry (965 citations) and Immunology and Allergy (195 citations). William J. Pitts has collaborated with scholars based in United States, Sweden and Germany. Frequent co-authors include Robert A. Copeland, Ronald L. Magolda, James M. Trzăskos, Frank W. Hobbs, Peggy Scherle, Richard A. Earl, Margaret Favata, Elizabeth J. Manos, Kurumi Y. Horiuchi and Drew E. Van Dyk. Their work appears in journals such as Science, Journal of Biological Chemistry and The Journal of Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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