William J. Metzler

2.1k citations

45 papers · 1.4k indexed · h-index 22

Immunology and Allergy top 5%
- Allergic Rhinitis and Sensitization 3
- Food Allergy and Anaphylaxis Research 3
Spectroscopy top 5%
Molecular Biology top 10%
- Protein Structure and Dynamics 12
- RNA and protein synthesis mechanisms 4
- DNA and Nucleic Acid Chemistry 3
Computational Theory and Mathematics top 5%
Cell Biology
Materials Chemistry
- Enzyme Structure and Function 11
Oncology
- Peptidase Inhibition and Analysis 3
Radiology, Nuclear Medicine and Imaging
- Monoclonal and Polyclonal Antibodies Research 3

Co-authors: Luciano Mueller Thomas Lavoie Mark S. Friedrichs Keith L. Constantine Bennett T. Farmer Aneka Bell Eileen Ernst Michael Wittekind
Cited by: Immunology and Allergy Spectroscopy Molecular Biology
Journals: Journal of the American Chemical Society (3 papers)Journal of Biological Chemistry (4 papers)The Journal of Immunology (1 paper)
Partner nations: United States Germany Japan

In The Last Decade

William J. Metzler

45 papers receiving 1.3k citations

Peers

Countries citing papers authored by William J. Metzler

Since Specialization

Citations

This map shows the geographic impact of William J. Metzler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William J. Metzler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William J. Metzler more than expected).

Fields of papers citing papers by William J. Metzler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William J. Metzler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William J. Metzler. The network helps show where William J. Metzler may publish in the future.

Co-authorship network

The 25 scholars most cited alongside William J. Metzler, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William J. Metzler Line = papers co-authored together William J. Metzler links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	An improved protocol for amino acid type-selective isotope labeling in insect cells Journal of Biomolecular NMR ·Yaqun Zhang,Hui Wei,Dianlin Xie,Deepa Calambur,Andrew Douglas,Mian Gao,Frank Marsilio,William J. Metzler,Nicolas Szapiel,Ping Zhang,Mark R. Witmer,Luciano Mueller,David Hedin	2017	7
2	Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target Analytical Biochemistry ·Charu Chaudhry,Jonathan H. Davis,Yong Zhang,Shana Posy,Ming Lei,Henry Shen,Chunhong Yan,Brigitte Devaux,Litao Zhang,Yuval Blat,William J. Metzler,R. M. Borzilleri,Randy Talbott	2015	3
3	Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Kevin Kish,Patricia A. McDonnell,Valentina Goldfarb,Mian Gao,William J. Metzler,David R. Langley,James W. Bryson,Susan E. Kiefer,Brian Carpenter,Walter A. Kostich,Ryan S. Westphal,S. Sheriff	2011	2
4	Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation Protein Science ·William J. Metzler,Joseph Yanchunas,Carolyn A. Weigelt,Kevin Kish,Herbert E. Klei,Dianlin Xie,Yaqun Zhang,Martin J. Corbett,James Tamura,Bin He,Lawrence G. Hamann,Mark Kirby,Jovita Marcinkeviciene	2008	103
5	Multiple and Single Binding Modes of Fragment-Like Kinase Inhibitors Revealed by Molecular Modeling, Residue Type-Selective Protonation, and Nuclear Overhauser Effects Journal of Medicinal Chemistry ·Keith L. Constantine,Luciano Mueller,William J. Metzler,Patricia A. McDonnell,Gordon Todderud,Valentina Goldfarb,Yi Fan,John A. Newitt,Susan E. Kiefer,Mian Gao,David R. Tortolani,Wayne Vaccaro,John S. Tokarski	2008	11
6	NMR Structure of a Potent Small Molecule Inhibitor Bound to Human Keratinocyte Fatty Acid-Binding Protein Journal of Medicinal Chemistry ·Patricia A. McDonnell,Keith L. Constantine,Valentina Goldfarb,Stephen R. Johnson,Richard Sulsky,David R. Magnin,Jeffrey A. Robl,Thomas J. Caulfield,Rex A. Parker,David S. Taylor,Leonard P. Adam,William J. Metzler,Luciano Mueller,Bennett T. Farmer	2006	4
7	Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) Bioorganic & Medicinal Chemistry Letters ·Soong‐Hoon Kim,Andrew T. Pudzianowski,Kenneth J. Leavitt,Joseph Barbosa,Patricia A. McDonnell,William J. Metzler,Bruce Rankin,Richard Y. Liu,Wayne Vaccaro,William J. Pitts	2005	80
8	Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118) Archives of Biochemistry and Biophysics ·Young B. Kim,Lisa M. Kopcho,Mark Kirby,Lawrence G. Hamann,Carolyn A. Weigelt,William J. Metzler,Jovita Marcinkeviciene	2005	62
9	Kinetic Studies on β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE) Journal of Biological Chemistry ·Larisa Toulokhonova,William J. Metzler,Mark R. Witmer,Robert A. Copeland,Jovita Marcinkeviciene	2003	37
10	Characterization of the Three-Dimensional Solution Structure of Human Profilin: 1H, 13C, and 15N NMR Assignments amd Global Folding Pattern Europe PMC (PubMed Central) ·William J. Metzler,Keith L. Constantine,Mark S. Friedrichs,Aneka Bell,Eileen Ernst,Thomas Lavoie,Luciano Mueller	2001	74
11	Analysis of the three-dimensional antigenic structure of giant ragweed allergen, Amb t 5 Molecular Immunology ·Þórunn Rafnar,Mary Brummet,Donna Bassolino‐Klimas,William J. Metzler,David G. Marsh	1998	12
12	Simulated annealing with restrained molecular dynamics using a flexible restraint potential: Theory and evaluation with simulated NMR constraints Protein Science ·Donna Bassolino‐Klimas,Roberto Tejero,Stanley R. Krystek,William J. Metzler,G.T. Montelione,Robert E. Bruccoleri	1996	26
13	Refined solution structure of human profilin I Protein Science ·William J. Metzler,Bennett T. Farmer,Keith L. Constantine,Mark S. Friedrichs,Luciano Mueller,Thomas Lavoie	1995	35
14	The Ligand Binding Domain of the Human Retinoic Acid Receptor γ Is Predominantly α-Helical with a Trp Residue in the Ligand Binding Site Journal of Biological Chemistry ·John A. Lupisella,Joyce E. Driscoll,William J. Metzler,Peter R. Reczek	1995	13
15	A Simple Method for Methionyl ϵ-Methyl 1H and 13C Chemical-Shift Identification in 13C-Labeled Proteins Journal of Magnetic Resonance Series B ·B.T Farmer,Thomas Lavoie,Luciano Mueller,William J. Metzler	1995	1
16	Solution structure of the calcium channel antagonist ω‐conotoxin GVIA Protein Science ·Jack J. Skalicky,Daniel Cieśla,Arthur Pardi,William J. Metzler,Alphonse Galdes	1993	34
17	Relaxation study of the backbone dynamics of human profilin by two‐dimensional ¹H‐¹⁵N NMR FEBS Letters ·Keith L. Constantine,Mark S. Friedrichs,Aneka Bell,Thomas Lavoie,Luciano Mueller,William J. Metzler	1993	4
18	Characterization of the three-dimensional solution structure of human profilin: proton, carbon-13, and nitrogen-15 NMR assignments and global folding pattern Biochemistry ·William J. Metzler,Keith L. Constantine,Mark S. Friedrichs,Aneka Bell,Eileen Ernst,Thomas Lavoie,Luciano Mueller	1993	113
19	Determining local conformational variations in DNA Journal of Molecular Biology ·William J. Metzler,Chuan Wang,Douglas B. Kitchen,Ronald M. Levy,Arthur Pardi	1990	63
20	Limited sampling of conformational space by the distance geometry algorithm: implications for structures generated from NMR data Biochemistry ·William J. Metzler,Dennis R. Hare,Arthur Pardi	1989	54

About William J. Metzler

William J. Metzler is a scholar working on Immunology and Allergy, Biophysics and Spectroscopy, having authored 45 papers that have together received 1.4k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (12 papers), Enzyme Structure and Function (11 papers), RNA and protein synthesis mechanisms (4 papers), Allergic Rhinitis and Sensitization (3 papers), DNA and Nucleic Acid Chemistry (3 papers), Peptidase Inhibition and Analysis (3 papers), Monoclonal and Polyclonal Antibodies Research (3 papers) and Food Allergy and Anaphylaxis Research (3 papers). The work is most often cited by research in Immunology and Allergy (136 citations), Spectroscopy (217 citations) and Molecular Biology (900 citations). William J. Metzler has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include Luciano Mueller, Thomas Lavoie, Mark S. Friedrichs, Keith L. Constantine, Bennett T. Farmer, Aneka Bell, Eileen Ernst, Michael Wittekind, Jovita Marcinkeviciene and Ponzy Lu. Their work appears in journals such as Journal of the American Chemical Society, Journal of Biological Chemistry and The Journal of Immunology.

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