John S. Sack

5.9k total citations · 1 hit paper
53 papers, 3.5k citations indexed

About

John S. Sack is a scholar working on Molecular Biology, Oncology and Materials Chemistry. According to data from OpenAlex, John S. Sack has authored 53 papers receiving a total of 3.5k indexed citations (citations by other indexed papers that have themselves been cited), including 35 papers in Molecular Biology, 20 papers in Oncology and 14 papers in Materials Chemistry. Recurrent topics in John S. Sack's work include Enzyme Structure and Function (13 papers), Protein Structure and Dynamics (10 papers) and Melanoma and MAPK Pathways (9 papers). John S. Sack is often cited by papers focused on Enzyme Structure and Function (13 papers), Protein Structure and Dynamics (10 papers) and Melanoma and MAPK Pathways (9 papers). John S. Sack collaborates with scholars based in United States, Germany and Japan. John S. Sack's co-authors include Florante A. Quiocho, William J. Cook, Anthony R. Means, Trevor J. Greenhough, Y.S. Babu, Charles E. Bugg, Mark A. Saper, Kevin Kish, Susan E. Kiefer and Yongmi An and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

John S. Sack

53 papers receiving 3.4k citations

Hit Papers

Three-dimensional structu... 1985 2026 1998 2012 1985 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Three-dimensional structure of calmodulin
    1985 853 citations John S. Sack, Anthony R. Means et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
John S. Sack 2.2k 592 503 488 411 53 3.5k
Robert T. Gampe 2.0k 0.9× 210 0.4× 536 1.1× 256 0.5× 298 0.7× 49 2.9k
W.S. Somers 2.4k 1.1× 324 0.5× 648 1.3× 361 0.7× 272 0.7× 37 4.3k
Alexander Shekhtman 3.1k 1.4× 301 0.5× 321 0.6× 258 0.5× 403 1.0× 133 4.6k
Torleif Härd 4.3k 1.9× 636 1.1× 927 1.8× 272 0.6× 140 0.3× 111 5.8k
B. S. Hartley 2.3k 1.1× 562 0.9× 276 0.5× 283 0.6× 245 0.6× 46 3.5k
Gary S. Shaw 4.2k 1.9× 279 0.5× 351 0.7× 309 0.6× 82 0.2× 153 5.5k
David J. Hosfield 2.2k 1.0× 235 0.4× 448 0.9× 173 0.4× 194 0.5× 37 3.0k
Steven W. Muchmore 3.3k 1.5× 425 0.7× 491 1.0× 466 1.0× 137 0.3× 49 4.6k
Elena Papaleo 3.5k 1.6× 718 1.2× 266 0.5× 161 0.3× 87 0.2× 134 4.5k
T.L. Blundell 2.4k 1.1× 509 0.9× 256 0.5× 229 0.5× 229 0.6× 45 3.2k

Countries citing papers authored by John S. Sack

Since Specialization
Citations

This map shows the geographic impact of John S. Sack's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John S. Sack with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John S. Sack more than expected).

Fields of papers citing papers by John S. Sack

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John S. Sack. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John S. Sack. The network helps show where John S. Sack may publish in the future.

Co-authorship network of co-authors of John S. Sack

This figure shows the co-authorship network connecting the top 25 collaborators of John S. Sack. A scholar is included among the top collaborators of John S. Sack based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John S. Sack. John S. Sack is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Xie, Tao, Max Ruzanov, David Critton, et al.. (2025). Orthosteric STING inhibition elucidates molecular correction of SAVI STING. Nature Communications. 16(1). 5695–5695. 2 indexed citations
2.
Jiang, Bin, James J.‐W. Duan, Arun Kumar Gupta, et al.. (2020). Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists. Bioorganic & Medicinal Chemistry Letters. 30(17). 127392–127392. 9 indexed citations
3.
Duan, James J.‐W., Bin Jiang, Zhonghui Lu, et al.. (2020). Discovery of 2,6–difluorobenzyl ether series of phenyl ((R)–3–phenylpyrrolidin–3–yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists. Bioorganic & Medicinal Chemistry Letters. 30(19). 127441–127441. 4 indexed citations
4.
Sack, John S., Mian Gao, Susan E. Kiefer, et al.. (2016). Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor. Acta Crystallographica Section F Structural Biology Communications. 72(2). 129–134. 47 indexed citations
5.
Bhide, Rajeev S., Zheming Ruan, Carolyn A. Weigelt, et al.. (2016). Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors. Bioorganic & Medicinal Chemistry Letters. 26(17). 4256–4260. 12 indexed citations
6.
Wrobleski, Stephen T., Shuqun Lin, T. G. Murali Dhar, et al.. (2013). The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode. Bioorganic & Medicinal Chemistry Letters. 23(14). 4120–4126. 15 indexed citations
7.
Schroeder, Gretchen M., Donna Wei, Patrizia Banfi, et al.. (2012). Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorganic & Medicinal Chemistry Letters. 22(12). 3951–3956. 18 indexed citations
8.
Muckelbauer, J.K., John S. Sack, James R. Burke, et al.. (2011). X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase. Chemical Biology & Drug Design. 78(5). 739–748. 17 indexed citations
9.
Lin, Shuqun, Stephen T. Wrobleski, John Hynes, et al.. (2010). Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20(19). 5864–5868. 26 indexed citations
10.
Liu, Chunjian, James C. Lin, Sidney Pitt, et al.. (2008). Benzothiazole based inhibitors of p38α MAP kinase. Bioorganic & Medicinal Chemistry Letters. 18(6). 1874–1879. 47 indexed citations
11.
Wrobleski, Stephen T., Shuqun Lin, John Hynes, et al.. (2008). Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18(8). 2739–2744. 25 indexed citations
12.
Velaparthi, Upender, Mark D. Wittman, Peiying Liu, et al.. (2007). Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R). Bioorganic & Medicinal Chemistry Letters. 17(8). 2317–2321. 35 indexed citations
13.
Dhar, T. G. Murali, Stephen T. Wrobleski, Shuqun Lin, et al.. (2007). Synthesis and SAR of p38α MAP kinase inhibitors based on heterobicyclic scaffolds. Bioorganic & Medicinal Chemistry Letters. 17(18). 5019–5024. 20 indexed citations
14.
15.
Misra, Raj N., Hai‐Yun Xiao, David Williams, et al.. (2004). Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorganic & Medicinal Chemistry Letters. 14(11). 2973–2977. 47 indexed citations
16.
Hangeland, Jon J., Arthur M. Doweyko, Tamara Dejneka, et al.. (2004). Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta. Bioorganic & Medicinal Chemistry Letters. 14(13). 3549–3553. 47 indexed citations
17.
Misra, Raj N., David B. Rawlins, Hai-yun Xiao, et al.. (2003). 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases. Bioorganic & Medicinal Chemistry Letters. 13(6). 1133–1136. 55 indexed citations
18.
Misra, Raj N., Hai-yun Xiao, David B. Rawlins, et al.. (2003). 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorganic & Medicinal Chemistry Letters. 13(14). 2405–2408. 63 indexed citations
19.
Sack, John S. & Florante A. Quiocho. (1997). [9] CHAIN: A crystallographic modeling program. Methods in enzymology on CD-ROM/Methods in enzymology. 277. 158–173. 49 indexed citations
20.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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