Michael J. Orwat

1.2k citations

16 papers · 782 indexed · h-index 13

Organic Chemistry top 10%
Cardiology and Cardiovascular Medicine top 10%
Hematology top 5%
Molecular Biology
Internal Medicine top 5%

Co-authors: Donald Pinto Ruth R. Wexler Robert M. Knabb Patrick Y. S. Lam Joseph M. Luettgen Pancras C. Wong Karen A. Rossi Richard Alexander
Topics: Blood Coagulation and Thrombosis Mechanisms (6 papers)Inflammatory mediators and NSAID effects (5 papers)Atrial Fibrillation Management and Outcomes (3 papers)
Cited by: Internal Medicine Hematology Cardiology and Cardiovascular Medicine
Journals: Journal of Medicinal Chemistry Tetrahedron Letters Chemical Research in Toxicology
Partner nations: United States Germany

In The Last Decade

Michael J. Orwat

16 papers receiving 749 citations

Peers

Countries citing papers authored by Michael J. Orwat

Since Specialization

Citations

This map shows the geographic impact of Michael J. Orwat's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael J. Orwat with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael J. Orwat more than expected).

Fields of papers citing papers by Michael J. Orwat

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael J. Orwat. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael J. Orwat. The network helps show where Michael J. Orwat may publish in the future.

Co-authorship network of co-authors of Michael J. Orwat

This figure shows the co-authorship network connecting the top 25 collaborators of Michael J. Orwat. A scholar is included among the top collaborators of Michael J. Orwat based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael J. Orwat. Michael J. Orwat is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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16 of 16 papers shown

#	Work	Indexed citations
1	Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group 2016 ·Bioorganic & Medicinal Chemistry ·James R. Corte,Tianan Fang,Donald Pinto,Michael J. Orwat,Alan R. Rendina,Joseph M. Luettgen,Karen A. Rossi,Anzhi Wei,Vidhyashankar Ramamurthy,Joseph E. Myers,S. Sheriff,Rangaraj Narayanan,Timothy W. Harper,Joanna J. Zheng,Yixin Li,Dietmar Seiffert,Ruth R. Wexler,Mimi L. Quan	15
2	Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties 2014 ·Bioorganic & Medicinal Chemistry Letters ·Michael J. Orwat,Jennifer X. Qiao,Kan He,Alan R. Rendina,Joseph M. Luettgen,Karen A. Rossi,Baomin Xin,Robert M. Knabb,Ruth R. Wexler,Patrick Y. S. Lam,Donald Pinto	7
3	Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Jeffrey Varnes,Dean A. Wacker,Donald Pinto,Michael J. Orwat,Jay Theroff,(unknown),(unknown),Joseph M. Luettgen,Robert M. Knabb,Steven Bai,Kan He,Patrick Y. S. Lam,Ruth R. Wexler	29
4	Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa 2007 ·Journal of Medicinal Chemistry ·Donald Pinto,Michael J. Orwat,Stephanie C. Koch,Karen A. Rossi,Richard Alexander,Angela Smallwood,Pancras C. Wong,Alan R. Rendina,Joseph M. Luettgen,Robert M. Knabb,Kan He,Baomin Xin,Ruth R. Wexler,Patrick Y. S. Lam	320
5	Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties 2006 ·Bioorganic & Medicinal Chemistry Letters ·Donald Pinto,Robert A. Galemmo,Mimi L. Quan,Michael J. Orwat,(unknown),Renhua Li,(unknown),Francis J. Woerner,Richard Alexander,Karen A. Rossi,Angela Smallwood,Pancras C. Wong,Joseph M. Luettgen,Alan R. Rendina,Robert M. Knabb,Kan He,Ruth R. Wexler,Patrick Y. S. Lam	23
6	Structure-Based Design of Novel Guanidine/Benzamidine Mimics: Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants 2003 ·Journal of Medicinal Chemistry ·Patrick Y. S. Lam,Charles G. Clark,Renhua Li,Donald Pinto,Michael J. Orwat,Robert A. Galemmo,John M. Fevig,Christopher A. Teleha,Richard Alexander,Angela Smallwood,Karen A. Rossi,Matthew Wright,Stephen A. Bai,Kan He,Joseph M. Luettgen,Pancras C. Wong,Robert M. Knabb,Ruth R. Wexler	70
7	Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core 2001 ·Bioorganic & Medicinal Chemistry Letters ·John M. Fevig,Donald Pinto,Qi Han,Mimi L. Quan,James R. Pruitt,(unknown),Robert A. Galemmo,Shuaige Wang,Michael J. Orwat,Lori L. Bostrom,Robert M. Knabb,Pancras C. Wong,Patrick Y. S. Lam,Ruth R. Wexler	31
8	Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa 2001 ·Journal of Medicinal Chemistry ·Donald Pinto,Michael J. Orwat,Shuaige Wang,John M. Fevig,Mimi L. Quan,(unknown),Joseph Cacciola,Karen A. Rossi,Richard Alexander,Angela Smallwood,Joseph M. Luettgen,Li Liang,Bruce J. Aungst,Matthew Wright,Robert M. Knabb,Pancras C. Wong,Ruth R. Wexler,Patrick Y. S. Lam	139
9	Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR 2001 ·Chemical Research in Toxicology ·Abdul Mutlib,John P. Shockcor,Shiang-Yuan Chen,Robert Espina,Donald Pinto,Michael J. Orwat,Shimoga R. Prakash,Liang‐Shang Gan	21
10	Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs 1999 ·Bioorganic & Medicinal Chemistry Letters ·Donald Pinto,Douglas G. Batt,William J. Pitts,Joseph J. Petraitis,Michael J. Orwat,Shuaige Wang,James W. Jetter,(unknown),(unknown),Robert A. Copeland,Maryanne Covington,James M. Trzăskos,Ronald L. Magolda	17
11	Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium 1998 ·Bioorganic & Medicinal Chemistry Letters ·William J. Pitts,James W. Jetter,Donald Pinto,Michael J. Orwat,Douglas G. Batt,(unknown),Joseph J. Petraitis,(unknown),Robert A. Copeland,Randine L. Dowling,Bruce Jaffee,(unknown),Elizabeth A. Jones,Ronald L. Magolda	15
12	Comparative Effects of Selective Cyclooxygenase 1 and Cyclooxygenase 2 Inhibitors on Myeloperoxidase and 3α-Hydroxysteroid Dehydrogenase 1996 ·Journal of enzyme inhibition ·Nicholas L. Rider,Donald Pinto,Maryanne Covington,Michael J. Orwat,John Giannaras,Sherrill Nurnberg,Randine L. Dowling,June P. Davis,Jean Williams,James M. Trzăskos,Robert A. Copeland	2
13	Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors 1996 ·Bioorganic & Medicinal Chemistry Letters ·Donald Pinto,Robert A. Copeland,Maryanne Covington,William J. Pitts,Douglas G. Batt,Michael J. Orwat,Gilbert N. Lam,Amita Joshi,(unknown),Shuaige Wang,James M. Trzăskos,Ronald L. Magolda,David M. Kornhauser	30
14	Metabolism resistant isothiazolone inhibitors of cartilage breakdown 1995 ·Bioorganic & Medicinal Chemistry ·Stephen W. Wright,Joseph J. Petraitis,Douglas G. Batt,(unknown),(unknown),Bruce Freimark,John Giannaras,Michael J. Orwat,Donald Pinto,Michael A. Pratta,(unknown),Herman F. Stampfli,Jean Williams,Ronald L. Magolda,Elizabeth C. Arner	10
15	Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivatives 1995 ·Bioorganic & Medicinal Chemistry Letters ·Douglas G. Batt,Robert A. Copeland,Randine L. Dowling,(unknown),Elizabeth A. Jones,Michael J. Orwat,Donald Pinto,William J. Pitts,Ronald L. Magolda,Bruce Jaffee	23
16	Enantioselective synthesis of the α,α-dimethyl-β-hydroxy 1989 ·Tetrahedron Letters ·Andrew S. Kende,Kuniaki Kawamura,Michael J. Orwat	30

About Michael J. Orwat

Michael J. Orwat is a scholar working on Hematology, Pharmacology and Genetics, having authored 16 papers that have together received 782 indexed citations. Recurring topics across this work include Blood Coagulation and Thrombosis Mechanisms (6 papers), Inflammatory mediators and NSAID effects (5 papers) and Atrial Fibrillation Management and Outcomes (3 papers). The work is most often cited by research in Internal Medicine (120 citations), Hematology (226 citations) and Cardiology and Cardiovascular Medicine (271 citations). Michael J. Orwat has collaborated with scholars based in United States and Germany. Frequent co-authors include Donald Pinto, Ruth R. Wexler, Robert M. Knabb, Patrick Y. S. Lam, Joseph M. Luettgen, Pancras C. Wong, Karen A. Rossi, Richard Alexander, Angela Smallwood and Kan He. Their work appears in journals such as Journal of Medicinal Chemistry, Tetrahedron Letters and Chemical Research in Toxicology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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