Alejandro Aruffo

29.7k total citations · 11 hit papers
196 papers, 25.3k citations indexed

About

Alejandro Aruffo is a scholar working on Immunology, Molecular Biology and Immunology and Allergy. According to data from OpenAlex, Alejandro Aruffo has authored 196 papers receiving a total of 25.3k indexed citations (citations by other indexed papers that have themselves been cited), including 105 papers in Immunology, 94 papers in Molecular Biology and 71 papers in Immunology and Allergy. Recurrent topics in Alejandro Aruffo's work include Cell Adhesion Molecules Research (71 papers), Glycosylation and Glycoproteins Research (57 papers) and Monoclonal and Polyclonal Antibodies Research (57 papers). Alejandro Aruffo is often cited by papers focused on Cell Adhesion Molecules Research (71 papers), Glycosylation and Glycoproteins Research (57 papers) and Monoclonal and Polyclonal Antibodies Research (57 papers). Alejandro Aruffo collaborates with scholars based in United States, Germany and Japan. Alejandro Aruffo's co-authors include Ivan Stamenkovic, Brian Seed, J A Ledbetter, Diane Hollenbaugh, Randolph J. Noelle, Nitin K. Damle, Charles B. Underhill, Michael Melnick, Jeffrey A. Ledbetter and Jürgen Bajorath and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Alejandro Aruffo

194 papers receiving 24.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

CD44 is the principal cell surface receptor for hyaluronate

1990 2.1k citations Alejandro Aruffo, Ivan Stamenkovic et al. profile →
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 1.2k citations Christian P. Larsen, Eric T. Elwood et al. profile →
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 1.0k citations Laura S. Grosmaire, Alejandro Aruffo et al. The Journal of Experimental Medicine profile →
Recognition by Elam-1 of the Sialyl-Le ^x Determinant on Myeloid and Tumor Cells

1990 846 citations Alejandro Aruffo, M P Bevilacqua et al. profile →
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 727 citations Alejandro Aruffo, Jeffrey A. Ledbetter et al. profile →
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 698 citations R J Noelle, Ivan Stamenkovic et al. profile →
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 663 citations Alejandro Aruffo, Diane Hollenbaugh et al. profile →
4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 649 citations Deryk Loo, Anthony W. Siadak et al. The Journal of Experimental Medicine profile →
IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 539 citations Teresa M. Foy, Alejandro Aruffo et al. profile →
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

1991 515 citations Ivan Stamenkovic, Alejandro Aruffo et al. profile →
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

1996 503 citations W. Conrad Liles, Peter A. Kiener et al. The Journal of Experimental Medicine profile →

Peers

Countries citing papers authored by Alejandro Aruffo

Since Specialization

Citations

This map shows the geographic impact of Alejandro Aruffo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alejandro Aruffo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alejandro Aruffo more than expected).

Fields of papers citing papers by Alejandro Aruffo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alejandro Aruffo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alejandro Aruffo. The network helps show where Alejandro Aruffo may publish in the future.

Co-authorship network of co-authors of Alejandro Aruffo

This figure shows the co-authorship network connecting the top 25 collaborators of Alejandro Aruffo. A scholar is included among the top collaborators of Alejandro Aruffo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alejandro Aruffo. Alejandro Aruffo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Constitutive Expression of Functional 4-1BB (CD137) Ligand on Carcinoma Cells 2000 ·The Journal of Immunology ·Helmut R. Salih, (unknown), (unknown), Gary C. Starling, Deryk Loo, Francis Lee, Alejandro Aruffo, Pamela A. Trail, Peter A. Kiener	70
2	CD44 is not an adhesive receptor for osteopontin 1999 ·Journal of Cellular Biochemistry ·Laura L. Smith, B. W. Greenfield, Alejandro Aruffo, Cecilia M. Giachelli	23
3	PROLONGED ACCEPTANCE OF CONCORDANT AND DISCORDANT XENOGRAFTS WITH COMBINED CD40 AND CD28 PATHWAY BLOCKADE1 1998 ·Transplantation ·Eric T. Elwood, Christian P. Larsen, Hong Rae Cho, Matthias Corbascio, Shannon C. Ritchie, Diane Z. Alexander, Carol Tucker‐Burden, Peter S. Linsley, Alejandro Aruffo, Diane Hollenbaugh, Kevin J. Winn, Thomas C. Pearson	102
4	Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5. 1997 ·PubMed ·J A Ledbetter, J A Francisco, Clay B. Siegall, Lisa K. Gilliland, Diane Hollenbaugh, Alejandro Aruffo, Anthony W. Siadak, (unknown), Laura S. Grosmaire, (unknown), T J Brown, (unknown), Robert S. Mittler, Peter A. Kiener, Steven G. Nadler	5
5	CD6 recognizes the neural adhesion molecule BEN 1997 ·Protein Science ·John E. Skonier, Michael A. Bowen, Alejandro Aruffo, Jürgen Bajorath	7
6	Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. breakdown → 1996 ·The Journal of Experimental Medicine ·W. Conrad Liles, Peter A. Kiener, J A Ledbetter, Alejandro Aruffo, S J Klebanoff	503
7	Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. 1996 ·The Journal of Experimental Medicine ·Yao Guo, Yan Wu, (unknown), Man‐Sun Sy, Alejandro Aruffo, Yang Liu	100
8	Cleavable CD40Ig fusion proteins and the binding to sgp39 1995 ·Journal of Immunological Methods ·Diane Hollenbaugh, (unknown), (unknown), Alejandro Aruffo	20
9	Comparison of a protein model with its x-ray structure: The ligand binding domain of E-selectin 1995 ·Bioconjugate Chemistry ·(unknown), Ronald E. Stenkamp, Alejandro Aruffo	10
10	Cloning and Expression of the Gene for the Melanoma-Associated ME20 Antigen 1994 ·DNA and Cell Biology ·Grace A. Maresh, John Marken, Michael Neubauer, Alejandro Aruffo, Ingegerd Hellström, Karl Erik Hellström, Hans Marquardt	22
11	The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1. 1994 ·Journal of Clinical Investigation ·Diane Hollenbaugh, Liangyu Wu, Hans D. Ochs, Shigeaki Nonoyama, Laura S. Grosmaire, J A Ledbetter, Randolph J. Noelle, Helen Hill, Alejandro Aruffo	48
12	gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. 1994 ·The Journal of Experimental Medicine ·Teresa M. Foy, Jon D. Laman, J A Ledbetter, Alejandro Aruffo, E Claassen, R J Noelle	358
13	B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells. 1993 ·The Journal of Experimental Medicine ·Shigeaki Nonoyama, Diane Hollenbaugh, Alejandro Aruffo, J A Ledbetter, HD Ochs	129
14	CD4, CD8 and the role of CD45 in T-cell activation 1993 ·Current Opinion in Immunology ·Jeffrey A. Ledbetter, Julie P. Deans, Alejandro Aruffo, Laura S. Grosmaire, Steven B. Kanner, Joseph B. Bolen, Gary L. Schieven	42
15	Selectins: Adhesion Molecules with Multiple Carbohydrate Ligands. 1992 ·Trends in Glycoscience and Glycotechnology ·Alejandro Aruffo	9
16	Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. 1992 ·The Journal of Experimental Medicine ·Yang Liu, Barry Jones, Alejandro Aruffo, Kathleen M. Sullivan, Peter S. Linsley, C A Janeway	224
17	Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. 1992 ·The Journal of Experimental Medicine ·Andrew G. Farr, Melissa L. Berry, (unknown), Andrew Nelson, (unknown), Alejandro Aruffo	142
18	CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation 1992 ·Immunology Today ·Randolph J. Noelle, Jeffrey A. Ledbetter, Alejandro Aruffo	264
19	The Hyaluronate Receptor (CD44). 1991 ·Trends in Glycoscience and Glycotechnology ·Alejandro Aruffo, Ivan Stamenkovic	3
20	Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1. 1991 ·PubMed ·Darren B. Taichman, Myron I. Cybulsky, Isabelle Djaffar, (unknown), Joaquı́n Teixidó, Gregory E. Rice, Alejandro Aruffo, M P Bevilacqua	118

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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