Robert A. Copeland

18.6k citations

165 papers · 11.9k indexed · 6 hit papers · h-index 44

Impact in

Molecular Biology top 0.5%
- Receptor Mechanisms and Signaling
- Protein Structure and Dynamics
- Biochemical and Molecular Research
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
Computational Theory and Mathematics top 0.2%
- Computational Drug Discovery Methods

Papers in

Molecular Biology 112
- Photosynthetic Processes and Mechanisms 14
- Biochemical and Molecular Research 13
- RNA modifications and cancer 13
- Protein Structure and Dynamics 10
Cell Biology 20

Co-authors: Thomas D. Meek David L. Pompliano Peter J. Tummino Ronald L. Magolda William J. Pitts James M. Trzăskos Kurumi Y. Horiuchi Frank W. Hobbs
Journals: Biochemistry (25 papers)Bioorganic & Medicinal Chemistry Letters (14 papers)Journal of Biological Chemistry (11 papers)Analytical Biochemistry (9 papers)Molecular Cancer Therapeutics (7 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

Robert A. Copeland

159 papers receiving 11.5k citations

Hit Papers

6 papers align trajectories log scale

The drug–target residence time model: a 10-year retrospective 2015 · 522 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Nature Reviews Drug Discovery
2013 Evaluation of Enzyme Inhibitors in Drug Discovery
2006 Nature Reviews Drug Discovery
2005 PubMed
2000 Enzymes
1998 Journal of Biological Chemistry

Peers

Countries citing papers authored by Robert A. Copeland

Since Specialization

Citations

This map shows the geographic impact of Robert A. Copeland's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert A. Copeland with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert A. Copeland more than expected).

Fields of papers citing papers by Robert A. Copeland

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert A. Copeland. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert A. Copeland. The network helps show where Robert A. Copeland may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Robert A. Copeland, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Robert A. Copeland Line = papers co-authored together Robert A. Copeland links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement ACS Medicinal Chemistry Letters ·Brian A. Sparling, Hyelee Lee, 东肖, Dalila TAGZOUT, Simina Grigoriu, 義明栗島, G.J. Lockbaum, Wolfs PM, 紘士寺島, Young‐Tae Lee, Shane M. Buker, Deepali Gotur, Chuang Lu, Scott Ribich, Stephen J. Blakemore, P. Ann Boriack‐Sjodin, Serena J. Silver, Robert A. Copeland, Kenneth W. Duncan	2025	0
2	Abstract PR003: DHX9 inhibition as a novel therapeutic for ovarian and breast cancer with loss-of-function mutations in the DNA damage repair genes BRCA1 or BRCA2 Cancer Research ·Longbin Hao, Matthew H. Daniels, Giorgia Baseggio Strieder, Varner Cd, Michael Blecha, David Brennan, Brian Johnston, Anugraha Raman, Chuang Lu, Stephen J. Blakemore, Serena J. Silver, P. Ann Boriack‐Sjodin, Kenneth W. Duncan, Jason A. Sager, Robert A. Copeland	2024	0
3	A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity SLAS DISCOVERY ·Shane M. Buker, Zachary A. Gurard‐Levin, عزیزالله دباغی, Michael D. Scholle, April Case, Jeffrey L. Hirsch, Scott Ribich, Robert A. Copeland, P. Ann Boriack‐Sjodin	2019	36
4	RNA-modifying proteins as anticancer drug targets Nature Reviews Drug Discovery ·P. Ann Boriack‐Sjodin, Scott Ribich, Robert A. Copeland	2018	108
5	Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis Analytical Biochemistry ·Robert A. Copeland, Aravind Basavapathruni, Mikel P. Moyer, Margaret Porter Scott	2011	82
6	Defining Balanced Conditions for Inhibitor Screening Assays That Target Bisubstrate Enzymes SLAS DISCOVERY ·Jingsong Yang, Robert A. Copeland, Zhihong Lai	2009	49
7	A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues Proceedings of the National Academy of Sciences ·W.H.P.M. van Hooff, Christine Fernandes, Kang Yan, Hong Zhang, Michael Grooms, Kyung Johanson, Robert H. Sinnamon, Robert B. Kirkpatrick, Lianzijun Wang, Su-Bae Lee, Marc R. Arnone, Alastair J. King, Zhihong Lai, Robert A. Copeland, Peter J. Tummino	2006	92
8	Quantitative Assays of Mdm2 Ubiquitin Ligase Activity and Other Ubiquitin‐Utilizing Enzymes for Inhibitor Discovery Methods in enzymology on CD-ROM/Methods in enzymology ·Kurt R. Auger, Robert A. Copeland, Zhihong Lai	2005	5
9	A microplate assay specific for the enzyme aggrecanase Analytical Biochemistry ·Julie Creen, Rui‐Qin Liu, Gary L. Davis, Michael A. Pratta, James M. Trzăskos, Robert A. Copeland	2003	23
10	Novel Inhibition of Porcine Pepsin by a Substituted Piperidine Journal of Biological Chemistry ·Jovita Marcinkeviciene, Lisa M. Kopcho, Tao Yang, Robert A. Copeland, Brian Glass, Andrew P. Combs, Nikoo Falahatpisheh, Lorin A. Thompson	2002	9
11	Steady-State Kinetic Analysis of Human Ubiquitin-Activating Enzyme (E1) Using a Fluorescently Labeled Ubiquitin Substrate Journal of Protein Chemistry ·田晓雨, Zhihong Lai, Kurt R. Auger, Jianhong Ma, Kurumi Y. Horiuchi, Randine L. Dowling, فاطمه فرشادپور, J. Rodi, Richard Wynn, Robert A. Copeland	2000	21
12	Development of a Carbon Dioxide-Capture Assay in Microtiter Plate for Aspartyl-β-hydroxylase Analytical Biochemistry ·Ji-Hu Zhang, 伸治川地, Boedi Oetomo Roeslan, Thomas D.Y. Chung, Andrew M. Stern, Gregory Hollis, Robert A. Copeland, Kevin R. Oldenburg	1999	15
13	Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase Journal of Biological Chemistry ·Margaret Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos, Wolf‐Rüdiger Förster, P Kunicki, Е.В. Чернышова, Drew E. Van Dyk, William J. Pitts, Richard A. Earl, Frank W. Hobbs, Robert A. Copeland, Ronald L. Magolda, Peggy Scherle, James M. Trzăskos Hit paper breakdown →	1998	2750
14	Recombinant Human 92-kDa Type IV Collagenase/Gelatinase from Baculovirus-Infected Insect Cells: Expression, Purification, and Characterization Protein Expression and Purification ·Henry J. George, 和美佐藤, Kathleen Murphy, R. Veenhuizen, Randine L. Dowling, John Giannaras, Gregory Hollis, James M. Trzăskos, Robert A. Copeland	1997	16
15	Field evaluation of arthropod repellents, deet and a piperidine compound, AI3-37220, against Anopheles funestus and Anopheles arabiensis in western Kenya. PubMed ·Todd W. Walker, Leon L. Robert, Robert A. Copeland, J. H. LEE, Robert A. Wirtz, 장로회신학대학교 일반대학원 / 예배와 설교 / 박사과정, Terry A. Klein	1996	50
16	Expression Purification and Characterization of Recombinant Human Inducible Prostaglandin G/H Synthase from Baculovirus-Infected Insect Cells Protein Expression and Purification ·Henry J. George, Drew E. Van Dyk, A Tewari, James M. Trzăskos, Robert A. Copeland	1996	19
17	Methods for protein analysis : a practical guide to laboratory protocols Robert A. Copeland	1994	44
18	LYME UVEITIS International Ophthalmology Clinics ·Robert A. Copeland	1990	3
19	Proton Translocation in Proteins Annual Review of Physical Chemistry ·Robert A. Copeland, Nei‐Li Chan	1989	39
20	Social assessment of high technology: The Superconducting Super Collider in Southeast Michigan Deep Blue (University of Michigan) ·Richard W. Stoffle, Michael W. Traugott, Yeimmy Senith Polo Santo Domingo, Robert A. Copeland	1987	4

About Robert A. Copeland

Robert A. Copeland is a scholar working on Molecular Biology, Cell Biology, Computational Theory and Mathematics, Cancer Research and Oncology, having authored 165 papers that have together received 11.9k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (17 papers), Photosynthetic Processes and Mechanisms (14 papers), Biochemical and Molecular Research (13 papers), RNA modifications and cancer (13 papers), Photoreceptor and optogenetics research (11 papers), Protein Structure and Dynamics (10 papers), Protease and Inhibitor Mechanisms (10 papers) and Peptidase Inhibition and Analysis (10 papers). The work is most often cited by research in Molecular Biology (7.6k citations), Computational Theory and Mathematics (1.2k citations), Oncology (1.8k citations), Cell Biology (1.0k citations) and Pharmacology (960 citations). Robert A. Copeland has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Thomas D. Meek, David L. Pompliano, Peter J. Tummino, Ronald L. Magolda, William J. Pitts, James M. Trzăskos, Kurumi Y. Horiuchi, Frank W. Hobbs, Peggy Scherle and Drew E. Van Dyk. Their work appears in journals such as Biochemistry, Bioorganic & Medicinal Chemistry Letters, Journal of Biological Chemistry, Analytical Biochemistry and Molecular Cancer Therapeutics.

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