Edwin J. Iwanowicz

1.6k citations

43 papers · 1.0k indexed · h-index 20

Impact in

Organic Chemistry top 5%
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Catalytic C–H Functionalization Methods
Physiology top 5%

Papers in

Physiology 9
- Adenosine and Purinergic Signaling 8
Organic Chemistry 16
- Synthesis and Biological Evaluation 4

Co-authors: James C. Lin Michael A. Poss R. H. Schlessinger Joel C. Barrish Zhengxiang Gu T. G. Murali Dhar James P. Springer Diane Hollenbaugh
Journals: Bioorganic & Medicinal Chemistry Letters (19 papers)Tetrahedron Letters (5 papers)Molecular Cancer Therapeutics (1 paper)Journal of the American Chemical Society (1 paper)Organic Letters (1 paper)
Partner nations: United States Germany Australia

In The Last Decade

Edwin J. Iwanowicz

43 papers receiving 996 citations

Peers

Countries citing papers authored by Edwin J. Iwanowicz

Since Specialization

Citations

This map shows the geographic impact of Edwin J. Iwanowicz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edwin J. Iwanowicz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edwin J. Iwanowicz more than expected).

Fields of papers citing papers by Edwin J. Iwanowicz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edwin J. Iwanowicz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edwin J. Iwanowicz. The network helps show where Edwin J. Iwanowicz may publish in the future.

Co-authors

The 25 scholars most cited alongside Edwin J. Iwanowicz, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Edwin J. Iwanowicz Line = papers co-authored together Edwin J. Iwanowicz links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells in vitro Leukemia & lymphoma ·Adetayo Kasim, Yandong Shen, 赵鹏英, C. Z. Ramalho, Lauren A. Thurgood, Edwin J. Iwanowicz, Martin Greve, Donald S. Karanewsky, Richard I. Christopherson, Stephen P. Mulligan, Giles Best	2024	2
2	TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells Molecular Cancer Therapeutics ·Nestor Galeano, Joseph F. LaComb, Joanne T. O'Hern, Yumia Mudi Sari, Janaína Gomes Da Silva, Lee M. Graves, Edwin J. Iwanowicz, Agnieszka B. Bialkowska	2024	4
3	Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer Frontiers in Pharmacology ·大吾相内, Eric C. J. M. Heezius, Wimal Pathmasiri, Blake R. Rushing, Natalie K. Barker, Kim N de Jonge, Yuanyuan Li, 敦子荻原, Yoshimi Endo Greer, Laura E. Herring, Stanley Lipkowitz, Susan Sumner, Edwin J. Iwanowicz, Lee M. Graves	2023	13
4	Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis Cancer Research Communications ·Yoshimi Endo Greer, Lídia Hernandez, 大吾相内, 丁玉萍, Donna Voeller, Raj Chari, 晋角田, Thomas S.K. Gilbert, Mai-Lan Ho, Binwu Tang, Markus Hafner, Qingrong Chen, Daoud Meerzaman, Edwin J. Iwanowicz, Christina M. Annunziata, Lee M. Graves, Stanley Lipkowitz	2022	20
5	Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome Structure ·Mark Mabanglo, Keith S. Wong, Angen Yu, Elisa Leung, 聖隆山口, 宏史佐脇, Takashi Asaoka, Cassandra J. Wong, Shen Zhang, Martin Greve, Donald S. Karanewsky, Sh.G. Gulova Gulova, Lee M. Graves, Edwin J. Iwanowicz, Anne‐Claude Gingras, Walid A. Houry	2022	31
6	Characterization of TR ‐107, a novel chemical activator of the human mitochondrial protease ClpP Pharmacology Research & Perspectives ·大吾相内, Eric C. J. M. Heezius, ا.د. حامد حمزة حمد, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Sh.G. Gulova Gulova, Hani Ashamalla, Ekhson Holmuhamedov, Martin Greve, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves	2022	24
7	De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold Bioorganic & Medicinal Chemistry Letters ·Dominique Potin, N. Satcitta, Eric Nicolaï, Marcus Walckling, Guan-Hua Lee, F. Caussade, Marta Miralles, Stacey Skala, Dawn K. Stetsko, Gordon Todderud, Brett R. Beno, Daniel L. Cheney, ChiehYing Chang, S. Sheriff, Diane Hollenbaugh, Joel C. Barrish, Edwin J. Iwanowicz, Suzanne J. Suchard, T. G. Murali Dhar	2005	12
8	Novel inhibitors of IMPDH Bioorganic & Medicinal Chemistry Letters ·Scott H. Watterson, Brena Marques Sbardelotto, T. G. Murali Dhar, Zhongqi Shen, William J. Pitts, Junqing Guo, Henry H. Gu, Derek Norris, John S. Chorba, Ping Chen, Daniel L. Cheney, Mark R. Witmer, Catherine Fleener, Katherine A. Rouleau, Robert M. Townsend, Diane Hollenbaugh, Edwin J. Iwanowicz	2003	23
9	Identification of novel and potent isoquinoline aminooxazole-Based IMPDH inhibitors Bioorganic & Medicinal Chemistry Letters ·Ping Chen, Derek Norris, R.D. Wordy, T. G. Murali Dhar, William J. Pitts, Scott H. Watterson, Daniel L. Cheney, Donna A. Bassolino, Catherine Fleener, Katherine A. Rouleau, Diane Hollenbaugh, A Rutkowski, Joel C. Barrish, Edwin J. Iwanowicz	2003	21
10	3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–Activity relationships Bioorganic & Medicinal Chemistry Letters ·T. G. Murali Dhar, Zhongqi Shen, Henry H. Gu, Ping Chen, Derek Norris, Scott H. Watterson, Shelley K. Ballentine, Catherine Fleener, Katherine A. Rouleau, Joel C. Barrish, Robert M. Townsend, Diane Hollenbaugh, Edwin J. Iwanowicz	2003	31
11	Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3 Bioorganic & Medicinal Chemistry Letters ·Scott H. Watterson, T. G. Murali Dhar, Shelley K. Ballentine, Zhongqi Shen, Joel C. Barrish, Daniel L. Cheney, Catherine Fleener, Katherine A. Rouleau, Robert M. Townsend, Diane Hollenbaugh, Edwin J. Iwanowicz	2003	30
12	Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety Bioorganic & Medicinal Chemistry Letters ·Edwin J. Iwanowicz, Scott H. Watterson, Junqing Guo, William J. Pitts, T. G. Murali Dhar, Zhongqi Shen, Ping Chen, Henry H. Gu, Catherine Fleener, Katherine A. Rouleau, Daniel L. Cheney, Robert M. Townsend, Diane Hollenbaugh	2003	18
13	Molecular design and structure–Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664 Bioorganic & Medicinal Chemistry Letters ·Jagabandhu Das, S. David Kimball, Steven E. Hall, Soo-Yeon Ko, Edwin J. Iwanowicz, James C. Lin, Robert V. Moquin, 曹渊 Yuan CAO, John S. Sack, Mary F. Malley, ChiehYing Y. Chang, Saeho Chong, David Wang‐Iverson, Daniel G. Roberts, Steven M. Seiler, William A. Schumacher, Martin L. Ogletree	2002	10
14	The TosMIC approach to 3-(Oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors Bioorganic & Medicinal Chemistry Letters ·T. G. Murali Dhar, Zhongqi Shen, Catherine Fleener, Katherine A. Rouleau, Joel C. Barrish, Diane Hollenbaugh, Edwin J. Iwanowicz	2002	16
15	Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck Bioorganic & Medicinal Chemistry Letters ·Ping Chen, Derek Norris, Edwin J. Iwanowicz, Steven H. Spergel, James C. Lin, Henry H. Gu, Zhongqi Shen, John Wityak, Tai-An Lin, Suhong Pang, H. Fex, Sidney Pitt, Ding Ren Shen, Arthur M. Doweyko, Donna A. Bassolino, Jacques Y. Roberge, Michael A. Poss, Bang‐Chi Chen, Gary L. Schieven, Joel C. Barrish	2002	28
16	Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase Bioorganic & Medicinal Chemistry Letters ·William J. Pitts, Junqing Guo, T. G. Murali Dhar, Zhongqi Shen, Henry H. Gu, Scott H. Watterson, Mark S. Bednarz, 明子西村, Joel C. Barrish, Donna A. Bassolino, Daniel L. Cheney, Catherine Fleener, Katherine A. Rouleau, Diane Hollenbaugh, Edwin J. Iwanowicz	2002	31
17	Novel amide-based inhibitors of inosine 5′-monophosphate dehydrogenase Bioorganic & Medicinal Chemistry Letters ·Scott H. Watterson, Chunjian Liu, T. G. Murali Dhar, Henry H. Gu, William J. Pitts, Joel C. Barrish, Catherine Fleener, Katherine A. Rouleau, A. Kryzwanski, Diane Hollenbaugh, Edwin J. Iwanowicz	2002	11
18	Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency Bioorganic & Medicinal Chemistry Letters ·Ping Chen, Edwin J. Iwanowicz, Derek Norris, Henry H. Gu, James C. Lin, Robert V. Moquin, Jagabandhu Das, John Wityak, Steven H. Spergel, Imre Mikelsaar, Suhong Pang, Kirti, Ding Ren Shen, Gary L. Schieven, Joel C. Barrish	2002	13
19	Novel guanidine-Based inhibitors of inosine monophosphate dehydrogenase Bioorganic & Medicinal Chemistry Letters ·Edwin J. Iwanowicz, Scott H. Watterson, Chunjian Liu, Henry H. Gu, Toomas Mitt, Katerina Leftheris, Joel C. Barrish, Catherine Fleener, Katherine A. Rouleau, A. Kryzwanski, Diane Hollenbaugh	2002	18
20	Retro-Binding Tripeptide Thrombin Active-Site Inhibitors: Discovery, Synthesis, and Molecular Modeling Journal of Medicinal Chemistry ·Edwin J. Iwanowicz, 中島幸彦, James C. Lin, Daniel G. Roberts, Steven M. Seiler	1994	18

About Edwin J. Iwanowicz

Edwin J. Iwanowicz is a scholar working on Physiology, Organic Chemistry, Genetics, Molecular Biology and Hematology, having authored 43 papers that have together received 1.0k indexed citations. Recurring topics across this work include Biochemical and Molecular Research (13 papers), Chemical Synthesis and Analysis (10 papers), Adenosine and Purinergic Signaling (8 papers), Cytomegalovirus and herpesvirus research (7 papers), Peptidase Inhibition and Analysis (6 papers), HIV/AIDS drug development and treatment (5 papers), Blood Coagulation and Thrombosis Mechanisms (4 papers) and Synthesis and Biological Evaluation (4 papers). The work is most often cited by research in Organic Chemistry (560 citations), Physiology (74 citations), Molecular Biology (574 citations), Hematology (60 citations) and Genetics (55 citations). Edwin J. Iwanowicz has collaborated with scholars based in United States, Germany and Australia. Frequent co-authors include James C. Lin, Michael A. Poss, R. H. Schlessinger, Joel C. Barrish, Zhengxiang Gu, T. G. Murali Dhar, James P. Springer, Diane Hollenbaugh, Steven M. Seiler and Daniel G. Roberts. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Molecular Cancer Therapeutics, Journal of the American Chemical Society and Organic Letters.

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