Tadamitsu Kishimoto

97.9k total citations · 42 hit papers
643 papers, 77.6k citations indexed

About

Tadamitsu Kishimoto is a scholar working on Immunology, Oncology and Molecular Biology. According to data from OpenAlex, Tadamitsu Kishimoto has authored 643 papers receiving a total of 77.6k indexed citations (citations by other indexed papers that have themselves been cited), including 348 papers in Immunology, 235 papers in Oncology and 146 papers in Molecular Biology. Recurrent topics in Tadamitsu Kishimoto's work include Cytokine Signaling Pathways and Interactions (178 papers), T-cell and B-cell Immunology (137 papers) and Immune Cell Function and Interaction (129 papers). Tadamitsu Kishimoto is often cited by papers focused on Cytokine Signaling Pathways and Interactions (178 papers), T-cell and B-cell Immunology (137 papers) and Immune Cell Function and Interaction (129 papers). Tadamitsu Kishimoto collaborates with scholars based in Japan, United States and France. Tadamitsu Kishimoto's co-authors include Tetsuya Taga, Shizuo Akira, Masashi Narazaki, Toshio Hirano, Toshio Tanaka, Akihiro Kimura, Norihiro Nishimoto, Kazuyuki Yoshizaki, Tetsuji Naka and Hitoshi Kikutani and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Tadamitsu Kishimoto

634 papers receiving 75.2k citations

Hit Papers

Complementary DNA for a novel human interleukin (BSF-2) t... 1986 2026 1999 2012 1986 1989 1994 1988 1998 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    1986 1.8k citations Tadamitsu Kishimoto et al. profile →
  2. The biology of interleukin-6
    1989 1.7k citations Tadamitsu Kishimoto profile →
  3. Impaired immune and acute-phase responses in interleukin-6-deficient mice
    1994 1.5k citations Tadamitsu Kishimoto et al. profile →
  4. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    1988 1.4k citations Tadamitsu Kishimoto et al. profile →
  5. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
    1998 1.4k citations Takashi Nagasawa, Tadamitsu Kishimoto et al. Proceedings of the National Academy of Sciences profile →
  6. The biology of interleukin-6
    1989 1.3k citations Tadamitsu Kishimoto profile →
  7. IL‐6: Regulator of Treg/Th17 balance
    2010 1.3k citations Akihiro Kimura, Tadamitsu Kishimoto European Journal of Immunology profile →
  8. gp130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES
    1997 1.2k citations Tadamitsu Kishimoto et al. profile →
  9. Molecular cloning and expression of an IL-6 signal transducer, gp130
    1990 1.1k citations Tadamitsu Kishimoto et al. profile →
  10. Structure and function of a new STAT-induced STAT inhibitor
    1997 1.1k citations Tetsuji Naka, Tadamitsu Kishimoto et al. profile →
  11. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
    1990 1.1k citations Tadamitsu Kishimoto et al. profile →
  12. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    1997 1.1k citations Tadamitsu Kishimoto et al. Proceedings of the National Academy of Sciences profile →
  13. Interleukin-6 family of cytokines and gp130
    1995 1.1k citations Tadamitsu Kishimoto et al. profile →
  14. Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
    1988 919 citations Tadamitsu Kishimoto et al. profile →
  15. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
    1994 908 citations Tetsuji Naka, Tadamitsu Kishimoto et al. profile →
  16. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    1994 868 citations Tadamitsu Kishimoto et al. profile →
  17. INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology
    2004 813 citations Tadamitsu Kishimoto profile →
  18. Interleukin-6 and Its Receptor: A Paradigm for Cytokines
    1992 765 citations Tadamitsu Kishimoto et al. profile →
  19. Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130
    1994 695 citations Tadamitsu Kishimoto et al. profile →
  20. Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
    1994 688 citations Takashi Nagasawa, Tadamitsu Kishimoto et al. Proceedings of the National Academy of Sciences profile →
  21. Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis
    1988 679 citations Tadamitsu Kishimoto et al. European Journal of Immunology profile →
  22. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.
    1988 662 citations Tadamitsu Kishimoto et al. profile →
  23. Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trial
    2004 630 citations Tadamitsu Kishimoto et al. profile →
  24. IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase
    1993 629 citations Tadamitsu Kishimoto et al. profile →
  25. Double‐blind randomized controlled clinical trial of the interleukin‐6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    2006 601 citations Tadamitsu Kishimoto et al. profile →
  26. Targeting Interleukin-6 Signaling in Clinic
    2019 601 citations Sujin Kang, Toshio Tanaka et al. profile →
  27. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
    1992 593 citations Tadamitsu Kishimoto et al. profile →
  28. TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling
    2004 590 citations Tadamitsu Kishimoto et al. profile →
  29. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    2007 582 citations Naoki Nishimoto, Tadamitsu Kishimoto et al. profile →
  30. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
    2008 579 citations Tadamitsu Kishimoto et al. profile →
  31. Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
    2010 560 citations Nam‐Trung Nguyen, Akihiro Kimura et al. Proceedings of the National Academy of Sciences profile →
  32. LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor
    1993 556 citations Tadamitsu Kishimoto et al. profile →
  33. SOCS-1 Participates in Negative Regulation of LPS Responses
    2002 552 citations Tetsuji Naka, Minoru Fujimoto et al. profile →
  34. Immunotherapeutic Implications of Il-6 Blockade for Cytokine Storm
    2016 539 citations Toshio Tanaka, Tadamitsu Kishimoto et al. profile →
  35. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
    1993 527 citations Tadamitsu Kishimoto et al. Proceedings of the National Academy of Sciences profile →
  36. Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
    1998 525 citations Tadamitsu Kishimoto et al. profile →
  37. Molecular Regulation of B Lymphocyte Response
    1988 503 citations Tadamitsu Kishimoto et al. profile →
  38. Interleukin 6: from bench to bedside
    2006 501 citations Tadamitsu Kishimoto et al. profile →
  39. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.
    1988 478 citations Tadamitsu Kishimoto et al. profile →
  40. Translating IL-6 biology into effective treatments
    2020 441 citations Tadamitsu Kishimoto et al. profile →
  41. Interleukin (IL-6) Immunotherapy
    2017 293 citations Toshio Tanaka, Tadamitsu Kishimoto et al. profile →
  42. Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
    2021 203 citations Sujin Kang, Tadamitsu Kishimoto profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Tadamitsu Kishimoto Japan 145 34.0k 25.7k 22.3k 8.8k 8.2k 643 77.6k
Charles A. Dinarello United States 174 47.0k 1.4× 11.9k 0.5× 36.8k 1.7× 7.8k 0.9× 6.4k 0.8× 873 108.0k
Dan R. Littman United States 150 56.0k 1.6× 13.8k 0.5× 30.6k 1.4× 3.5k 0.4× 2.8k 0.3× 345 98.4k
Hideo Yagita∥ Japan 128 43.5k 1.3× 21.7k 0.8× 18.2k 0.8× 3.1k 0.4× 2.3k 0.3× 912 67.3k
Toshio Suda Japan 120 12.0k 0.4× 17.0k 0.7× 32.9k 1.5× 10.3k 1.2× 4.2k 0.5× 730 59.1k
Marc Feldmann United Kingdom 114 23.9k 0.7× 8.0k 0.3× 11.3k 0.5× 5.5k 0.6× 15.6k 1.9× 556 53.8k
Vijay K. Kuchroo United States 133 59.0k 1.7× 20.6k 0.8× 13.2k 0.6× 2.7k 0.3× 4.5k 0.5× 426 79.1k
Nico van Rooijen Netherlands 146 38.1k 1.1× 10.0k 0.4× 21.4k 1.0× 3.6k 0.4× 2.8k 0.3× 838 80.5k
John J. O’Shea United States 110 31.2k 0.9× 15.2k 0.6× 11.2k 0.5× 3.5k 0.4× 5.1k 0.6× 323 49.8k
Robert M. Strieter United States 133 23.9k 0.7× 17.1k 0.7× 12.7k 0.6× 2.5k 0.3× 2.9k 0.4× 509 56.9k
Jürg Tschopp Switzerland 131 43.3k 1.3× 7.7k 0.3× 52.0k 2.3× 4.1k 0.5× 4.4k 0.5× 283 87.3k

Countries citing papers authored by Tadamitsu Kishimoto

Since Specialization
Citations

This map shows the geographic impact of Tadamitsu Kishimoto's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tadamitsu Kishimoto with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tadamitsu Kishimoto more than expected).

Fields of papers citing papers by Tadamitsu Kishimoto

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tadamitsu Kishimoto. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tadamitsu Kishimoto. The network helps show where Tadamitsu Kishimoto may publish in the future.

Co-authorship network of co-authors of Tadamitsu Kishimoto

This figure shows the co-authorship network connecting the top 25 collaborators of Tadamitsu Kishimoto. A scholar is included among the top collaborators of Tadamitsu Kishimoto based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tadamitsu Kishimoto. Tadamitsu Kishimoto is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ishibashi, Tomohiko, Tadakatsu Inagaki, Makoto Okazawa, et al.. (2024). IL-6/gp130 signaling in CD4 + T cells drives the pathogenesis of pulmonary hypertension. Proceedings of the National Academy of Sciences. 121(16). e2315123121–e2315123121. 7 indexed citations
2.
Nyati, Kishan Kumar, Shigeru Hashimoto, Shailendra Kumar Singh, et al.. (2021). The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway. Cancer Letters. 520. 295–306. 23 indexed citations
3.
Metwally, Hozaifa, Toshio Tanaka, Songling Li, et al.. (2020). Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production. Science Signaling. 13(624). 35 indexed citations
4.
Kishimoto, Tadamitsu. (2019). Discovery of IL-6 and Development of Anti-IL-6R Antibody. The Keio Journal of Medicine. 68(4). 96–96. 9 indexed citations
5.
Nakagawa, Satoshi, Satoshi Serada, Kosuke Hiramatsu, et al.. (2018). Intratumoral Delivery of an Adenoviral Vector Carrying the SOCS-1 Gene Enhances T-Cell–Mediated Antitumor Immunity By Suppressing PD-L1. Molecular Cancer Therapeutics. 17(9). 1941–1950. 8 indexed citations
6.
Sugase, Takahito, Tsuyoshi Takahashi, Satoshi Serada, et al.. (2017). SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma. Cancer Research. 77(24). 6975–6986. 37 indexed citations
7.
Hanieh, Hamza, Kazuya Masuda, Hozaifa Metwally, et al.. (2017). Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem‐loop structure in its 3′UTR. European Journal of Immunology. 48(4). 593–604. 37 indexed citations
8.
Kishimoto, Tadamitsu, et al.. (2015). OPTIMAL LOCATION OF ROUTE AND STOPS OF PUBLIC TRANSPORTATION. 2 indexed citations
9.
Masuda, Kazuya, Barry Ripley, Riko Nishimura, et al.. (2013). Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proceedings of the National Academy of Sciences. 110(23). 9409–9414. 173 indexed citations
10.
Okada, Masaji, Yoko Kita, Noriko Kanamaru, et al.. (2011). Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice. SHILAP Revista de lepidopterología. 2011. 1–9. 20 indexed citations
11.
Masuda, Kazuya, Akihiro Kimura, Hamza Hanieh, et al.. (2011). Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. International Immunology. 23(10). 637–645. 79 indexed citations
12.
Ohguro, Nobuyuki, Kei Nakai, Fumitaka Terabe, et al.. (2010). Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses. Experimental Eye Research. 91(2). 162–170. 82 indexed citations
13.
Vesely, Paul, Brigitte Hantusch, Michaela Schlederer, et al.. (2009). Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proceedings of the National Academy of Sciences. 106(48). 20423–20428. 57 indexed citations
14.
Kimura, Akihiro, Tetsuji Naka, Keiko Nohara, Yoshiaki Fujii‐Kuriyama, & Tadamitsu Kishimoto. (2008). Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proceedings of the National Academy of Sciences. 105(28). 9721–9726. 429 indexed citations
15.
16.
Ara, Toshiaki, Yuri Nakamura, Takeshi Egawa, et al.. (2003). Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proceedings of the National Academy of Sciences. 100(9). 5319–5323. 257 indexed citations
17.
Tone, Eiroh, Keita Kunisada, Atsushi Kumanogoh, et al.. (2000). gp130-DEPENDENT SIGNALLING PATHWAY IS NOT ENHANCED IN gp130 TRANSGENIC HEART AFTER LIF STIMULATION. Cytokine. 12(10). 1512–1518. 17 indexed citations
18.
Kuroda, Toshifumi, et al.. (1999). Hepatoma-Derived Growth Factor-Related Protein (HRP)-1 Gene in Spermatogenesis in Mice. Biochemical and Biophysical Research Communications. 262(2). 433–437. 17 indexed citations
19.
Saeki, Yukihiko, Shiro Ohshima, Naoki Nishimoto, et al.. (1995). Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints.. Journal of Clinical Investigation. 96(4). 1746–1758. 44 indexed citations
20.
Okano, Akira, Chieko Suzuki, Fumihiko Takatsuki, et al.. (1989). EFFECTS OF INTERLEUKIN-6 ON HEMATOPOIESIS IN BONE MARROW-TRANSPLANTED MICE. Transplantation. 47(4). 738–739. 27 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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