John J. O’Shea

73.0k citations

323 papers · 49.8k indexed · 33 hit papers · h-index 110

Impact in

Immunology top 0.01%
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
Oncology top 0.02%
- Cytokine Signaling Pathways and Interactions

Papers in

Immunology 230
- Immune Cell Function and Interaction 137
- T-cell and B-cell Immunology 113
- IL-33, ST2, and ILC Pathways 36
- Immunodeficiency and Autoimmune Disorders 34
- Psoriasis: Treatment and Pathogenesis 25
- Immunotherapy and Immune Responses 23
Oncology 143
- Cytokine Signaling Pathways and Interactions 122

Co-authors: Arian Laurence Yuka Kanno Massimo Gadina Warren J. Leonard Alejandro V. Villarino William E. Paul Wendy T. Watford Daniella M. Schwartz
Journals: The Journal of Immunology (43 papers)Immunity (25 papers)The Journal of Experimental Medicine (17 papers)Blood (16 papers)Proceedings of the National Academy of Sciences (15 papers)
Partner nations: United States Japan United Kingdom

In The Last Decade

John J. O’Shea

317 papers receiving 48.8k citations

Hit Papers

15 papers align trajectories log scale

Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story 2023 · 71 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2023 Annals of the Rheumatic Diseases
2022 Cell
2022 Nature Reviews Rheumatology
2017 Nature Reviews Drug Discovery
2017 Nature Immunology
2015 Nature Reviews Rheumatology
2015 Annual Review of Medicine
2014 The Journal of Immunology
2013 Annals of the Rheumatic Diseases
2013 New England Journal of Medicine
2012 Immunity
2011 The Journal of Immunology
2011 Nature Immunology
2010 Science
2010 Immunity
2009 Immunological Reviews
2009 Nature Immunology
2009 Immunity
2008 The Journal of Experimental Medicine
2008 Immunity
2008 Nature
2007 Immunity
2007 Nature Immunology
2007 Journal of Biological Chemistry
2006 Nature Immunology
2006 Proceedings of the National Academy of Sciences
2002 Cell
2002 Nature reviews. Immunology
2001 Proceedings of the National Academy of Sciences
1998 Annual Review of Immunology
1995 Science
1994 Science
1992 Science

Peers

Countries citing papers authored by John J. O’Shea

Since Specialization

Citations

This map shows the geographic impact of John J. O’Shea's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John J. O’Shea with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John J. O’Shea more than expected).

Fields of papers citing papers by John J. O’Shea

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John J. O’Shea. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John J. O’Shea. The network helps show where John J. O’Shea may publish in the future.

Co-authors

The 25 scholars most cited alongside John J. O’Shea, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John J. O’Shea Line = papers co-authored together John J. O’Shea links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection Science Immunology ·Rachael L. Philips, Hans M. Moscicke, Colleen M. Lau, Tasha Morrison, Kan Jiang, Andrew T. Hutchinson, F.A. van den Ouweland, Chen Yao, Joseph C. Sun, Heather D. Hickman, Joshua D. Milner, Steven M. Holland, Yuka Kanno, Michail S. Lionakis, John J. O’Shea	2025	1
2	Doxorubicin resistance involves modulation of interferon signaling, transcriptional bursting, and gene co-expression patterns of U-ISGF3-related genes Neoplasia ·Paweł Trzaskoma, Seolkyoung Jung, Yuka Kanno, John J. O’Shea, Carson C. Chow	2024	3
3	TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis Science Signaling ·М. Г. Сядрин, Chen Yao, Tyrone Dowdy, Wenwen Jin, Jennifer Brook, Liliana Catherine Patiño, Na Liu, 茂雄杉下, Karin Kåsby, C Stanback-Fryer, Carole A. Bewley, Milena Mitrović, Daniel Martı́n, Robert J. Morell, Michael Eckhaus, Mioara Larion, Roxane Tussiwand, John J. O’Shea, Dan Kieke	2023	42
4	Protein kinases: drug targets for immunological disorders Nature reviews. Immunology ·Leslie Castelo‐Soccio, Hanna Kim, Massimo Gadina, Pamela L. Schwartzberg, Arian Laurence, John J. O’Shea	2023	64
5	Author Correction: Protein kinases: drug targets for immunological disorders Nature reviews. Immunology ·Leslie Castelo‐Soccio, Hanna Kim, Massimo Gadina, Pamela L. Schwartzberg, Arian Laurence, John J. O’Shea	2023	0
6	Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer Children ·Caleb Bupp, Elizabeth G. Ames, 李显福, Sara Caylor, David Dimmock, محمود الرنتيسي, Padmani Karna, Sung-Jin 김성진Kim, Cristian Meghea, Vinod K. Misra, Danielle Nolan, John J. O’Shea, Y. Bai, Linda S. Franck, Cha-Chi Chang	2023	17
7	Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T _FH cells Science Immunology ·Amber M. Papillion, Michael D. Powell, Danielle A. Chisolm, Holly Bachus, Michael J. Fuller, Amy S. Weinmann, Alejandro V. Villarino, John J. O’Shea, Beatriz León, Kenneth J. Oestreich, André Ballesteros‐Tato	2019	93
8	The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications Immunity ·Warren J. Leonard, Jian‐Xin Lin, John J. O’Shea	2019	241
9	NCR⁺ ILC3 maintain larger STAT4 reservoir via T‐BET to regulate type 1 features upon IL‐23 stimulation in mice European Journal of Immunology ·Yohei Mikami, A. Toniolo, Béatrice Zitti, Han‐Yu Shih, Yuka Kanno, Angela Santoni, John J. O’Shea, Giuseppe Sciumè	2018	33
10	Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury Science ·Oliver J. Harrison, Jonathan L. Linehan, Han‐Yu Shih, Nicolas Bouladoux, Seong‐Ji Han, Margery Smelkinson, Shurjo K. Sen, Allyson L. Byrd, Michel Enamorado, Chen Yao, Samira Tamoutounour, François Van Laethem, Charlotte Hurabielle, Nicholas Collins, Andrea Paun, Rosalba Salcedo, John J. O’Shea, Yasmine Belkaid	2018	220
11	STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells The Journal of Immunology ·Pavel Klápště, Jill M. Fritz, Alejandro V. Villarino, Lixin Zheng, Chrysi Kanellopoulou, Benjamin Chaigne-Delalande, Juha Grönholm, Julie E. Niemela, Behdad Afzali, Matthew Biancalana, Stefania Pittaluga, Anna Jane Buckland, José L. Cohen, Steven M. Holland, John J. O’Shea, Gülbû Uzel, Michael J. Lenardo	2017	27
12	Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells The Journal of Experimental Medicine ·Alejandro V. Villarino, Giuseppe Sciumè, Fred P. Davis, S. Iwata, Béatrice Zitti, Gertraud W. Robinson, Lothar Hennighausen, Yuka Kanno, John J. O’Shea	2017	72
13	Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 ⁺ T Cells Science ·John J. O’Shea, William E. Paul Hit paper breakdown →	2010	984
14	Nonredundant roles for Stat5a/b in directly regulating Foxp3 Blood ·Zhengju Yao, Yuka Kanno, Marc A. Kerenyi, Geoffrey L. Stephens, Lydia Durant, Wendy T. Watford, Arian Laurence, Gertraud W. Robinson, Ethan M. Shevach, Richard Moriggl, Lothar Hennighausen, Changyou Wu, John J. O’Shea	2007	471
15	Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway Blood ·Kevin M. Elias, Arian Laurence, Todd S. Davidson, Geoffrey L. Stephens, Yuka Kanno, Ethan M. Shevach, John J. O’Shea	2007	364
16	Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals The Journal of Experimental Medicine ·Alejandro V. Villarino, Cristina M. Tato, Jason S. Stumhofer, Zhengju Yao, Yongzhi Cui, Lothar Hennighausen, John J. O’Shea, Christopher A. Hunter	2007	105
17	Stat5a/b are essential for normal lymphoid development and differentiation Proceedings of the National Academy of Sciences ·Zhengju Yao, Yongzhi Cui, Wendy T. Watford, Jay H. Bream, Kunihiro Yamaoka, Bruce D. Hissong, Vitalii Gutnyk, Scott K. Durum, Qiong Jiang, Avinash Bhandoola, Lothar Hennighausen, John J. O’Shea	2006	285
18	Jak3 negatively regulates dendritic-cell cytokine production and survival Blood ·Kunihiro Yamaoka, Booki Min, فرشاد لطفی, William E. Paul, John J. O’Shea	2005	54
19	Cytokine-independent Jak3 Activation upon T Cell Receptor (TCR) Stimulation through Direct Association of Jak3 and the TCR Complex Journal of Biological Chemistry ·Kazuhiro Tomita, Kaoru Saijo, Sho Yamasaki, Tomohiko Iida, Fubito Nakatsu, Hisashi Arase, Hiroshi Ohno, Takuji Shirasawa, Takayuki Kuriyama, John J. O’Shea, Takashi Saito	2001	26
20	Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains Molecular and Cellular Biology ·Min Chen, Alan Cheng, Fabio Candotti, فرشاد لطفی, Anka Hymel, Anders Fasth, Luigi D. Notarangelo, John J. O’Shea	2000	100

About John J. O’Shea

John J. O’Shea is a scholar working on Immunology, Oncology, Genetics, Pharmacology and Hematology, having authored 323 papers that have together received 49.8k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (137 papers), Cytokine Signaling Pathways and Interactions (122 papers), T-cell and B-cell Immunology (113 papers), IL-33, ST2, and ILC Pathways (36 papers), Immunodeficiency and Autoimmune Disorders (34 papers), Psoriasis: Treatment and Pathogenesis (25 papers), Immunotherapy and Immune Responses (23 papers) and Monoclonal and Polyclonal Antibodies Research (21 papers). The work is most often cited by research in Immunology (31.2k citations), Oncology (15.2k citations), Rheumatology (5.1k citations), Hematology (3.5k citations) and Dermatology (2.4k citations). John J. O’Shea has collaborated with scholars based in United States, Japan and United Kingdom. Frequent co-authors include Arian Laurence, Yuka Kanno, Massimo Gadina, Warren J. Leonard, Alejandro V. Villarino, William E. Paul, Wendy T. Watford, Daniella M. Schwartz, Kamran Ghoreschi and Cristina M. Tato. Their work appears in journals such as The Journal of Immunology, Immunity, The Journal of Experimental Medicine, Blood and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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