Misato Hashizume

3.5k total citations · 2 hit papers
39 papers, 2.7k citations indexed

About

Misato Hashizume is a scholar working on Oncology, Rheumatology and Immunology. According to data from OpenAlex, Misato Hashizume has authored 39 papers receiving a total of 2.7k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Oncology, 16 papers in Rheumatology and 15 papers in Immunology. Recurrent topics in Misato Hashizume's work include Rheumatoid Arthritis Research and Therapies (11 papers), Cytokine Signaling Pathways and Interactions (10 papers) and Cell Adhesion Molecules Research (8 papers). Misato Hashizume is often cited by papers focused on Rheumatoid Arthritis Research and Therapies (11 papers), Cytokine Signaling Pathways and Interactions (10 papers) and Cell Adhesion Molecules Research (8 papers). Misato Hashizume collaborates with scholars based in Japan, United States and Switzerland. Misato Hashizume's co-authors include Masahiko Mihara, Miho Suzuki, Hiroto Yoshida, Masashi Shiina, Naohiko Hayakawa, Tsutomu Takeuchi, Ernest Choy, Markus R. John, Tadamitsu Kishimoto and Fabrizio De Benedetti and has published in prestigious journals such as PLoS ONE, Biochemical and Biophysical Research Communications and Antimicrobial Agents and Chemotherapy.

In The Last Decade

Misato Hashizume

39 papers receiving 2.6k citations

Hit Papers

IL-6/IL-6 receptor system and its role in physiological a... 2011 2026 2016 2021 2011 2020 200 400 600
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. IL-6/IL-6 receptor system and its role in physiological and pathological conditions
    2011 686 citations Masahiko Mihara, Misato Hashizume et al. profile →
  2. Translating IL-6 biology into effective treatments
    2020 441 citations Ernest Choy, Fabrizio De Benedetti et al. Nature Reviews Rheumatology profile →

Peers

Misato Hashizume
Hiroki Mitoma Japan
Jeng‐Hsien Yen Taiwan
Chul‐Soo Cho South Korea
George D. Kalliolias United States
Atsuhisa Ueda Japan
Anwen S. Williams United Kingdom
Steven E. Carsons United States
Norito Katoh Japan
Kyoung‐Woon Kim South Korea
Onelia Bistoni Italy
Hiroki Mitoma Japan
Misato Hashizume
Citations per year, relative to Misato Hashizume Misato Hashizume (= 1×) peers Hiroki Mitoma

Countries citing papers authored by Misato Hashizume

Since Specialization
Citations

This map shows the geographic impact of Misato Hashizume's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Misato Hashizume with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Misato Hashizume more than expected).

Fields of papers citing papers by Misato Hashizume

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Misato Hashizume. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Misato Hashizume. The network helps show where Misato Hashizume may publish in the future.

Co-authorship network of co-authors of Misato Hashizume

This figure shows the co-authorship network connecting the top 25 collaborators of Misato Hashizume. A scholar is included among the top collaborators of Misato Hashizume based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Misato Hashizume. Misato Hashizume is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Choy, Ernest, Fabrizio De Benedetti, Tsutomu Takeuchi, et al.. (2020). Translating IL-6 biology into effective treatments. Nature Reviews Rheumatology. 16(6). 335–345. 441 indexed citations breakdown →
2.
Hashizume, Misato. (2020). Outlook of IL-6 signaling blockade for COVID-19 pneumonia. Inflammation and Regeneration. 40(1). 24–24. 19 indexed citations
3.
O’Mahony, Alison, Markus R. John, Hanna Cho, Misato Hashizume, & Ernest Choy. (2018). Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate. Journal of Translational Medicine. 16(1). 156–156. 6 indexed citations
4.
Belle, Ludovic, Kara L. Stuhr, Margaret Beatka, et al.. (2017). Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD. JCI Insight. 2(14). 13 indexed citations
5.
6.
7.
Hashizume, Misato & Masahiko Mihara. (2012). Blockade of IL-6 and TNF-α inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction. European Journal of Pharmacology. 689(1-3). 249–254. 41 indexed citations
8.
Hashizume, Misato & Masahiko Mihara. (2012). Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors. Cytokine. 58(3). 424–430. 86 indexed citations
9.
Hashizume, Misato, Yoshinobu Higuchi, Yasushi Uchiyama, & Masahiko Mihara. (2011). IL-6 plays an essential role in neutrophilia under inflammation. Cytokine. 54(1). 92–99. 70 indexed citations
10.
Yoshida, Hiroto, Misato Hashizume, Miho Suzuki, & Masahiko Mihara. (2010). Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice. Rheumatology International. 31(11). 1445–1449. 16 indexed citations
11.
Hashizume, Misato, Nobuo Koike, Hiroto Yoshida, Miho Suzuki, & Masahiko Mihara. (2010). High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis. Modern Rheumatology. 20(5). 432–438. 31 indexed citations
12.
Yoshida, Hiroto, Misato Hashizume, & Masahiko Mihara. (2010). IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis. Rheumatology International. 31(1). 127–131. 19 indexed citations
13.
Suzuki, Miho, Misato Hashizume, Hiroto Yoshida, Masashi Shiina, & Masahiko Mihara. (2010). IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Cytokine. 51(2). 178–183. 43 indexed citations
14.
Furihata, Tomomi, et al.. (2010). Characterization of ribavirin uptake systems in human hepatocytes. Journal of Hepatology. 52(4). 486–492. 41 indexed citations
15.
Yoshida, Hiroto, Misato Hashizume, Miho Suzuki, & Masahiko Mihara. (2010). Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells. European Journal of Pharmacology. 634(1-3). 178–183. 28 indexed citations
16.
Hashizume, Misato & Masahiko Mihara. (2009). Desirable effect of combination therapy with high molecular weight hyaluronate and NSAIDs on MMP production. Osteoarthritis and Cartilage. 17(11). 1513–1518. 40 indexed citations
17.
Suzuki, Miho, Misato Hashizume, Hiroto Yoshida, & Masahiko Mihara. (2009). Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule. Rheumatology International. 30(3). 309–315. 56 indexed citations
18.
Hashizume, Misato, et al.. (2009). Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Rheumatology International. 30(7). 917–923. 63 indexed citations
19.
Hashizume, Misato & Masahiko Mihara. (2008). Influence of humanized anti-IL-6R antibody, tocilizumab on the activity of soluble gp130, natural inhibitor of IL-6 signaling. Rheumatology International. 29(4). 397–401. 8 indexed citations
20.
Hashizume, Misato, Naohiko Hayakawa, & Masahiko Mihara. (2008). IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-  and IL-17. Lara D. Veeken. 47(11). 1635–1640. 280 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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