Toshio Hirano

37.6k total citations · 13 hit papers
220 papers, 29.3k citations indexed

About

Toshio Hirano is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Toshio Hirano has authored 220 papers receiving a total of 29.3k indexed citations (citations by other indexed papers that have themselves been cited), including 110 papers in Immunology, 81 papers in Molecular Biology and 75 papers in Oncology. Recurrent topics in Toshio Hirano's work include Cytokine Signaling Pathways and Interactions (61 papers), T-cell and B-cell Immunology (36 papers) and Immune Cell Function and Interaction (32 papers). Toshio Hirano is often cited by papers focused on Cytokine Signaling Pathways and Interactions (61 papers), T-cell and B-cell Immunology (36 papers) and Immune Cell Function and Interaction (32 papers). Toshio Hirano collaborates with scholars based in Japan, United States and France. Toshio Hirano's co-authors include Tadamitsu Kishimoto, Masaaki Murakami, Tetsuya Taga, Masahiko Hibi, Katsuhiko Ishihara, Keigo Nishida, Koichi Nakajima, Toshiyuki Fukada, Tadashi Matsuda and Shizuo Akira and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Toshio Hirano

216 papers receiving 28.5k citations

Hit Papers

Complementary DNA for a n... 1986 2026 1999 2012 1986 1988 1990 1990 1988 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    1986 1.8k citations Toshio Hirano, Tetsuya Taga et al. Nature profile →
  2. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    1988 1.4k citations Michio Kawano, Toshio Hirano et al. Nature profile →
  3. Molecular cloning and expression of an IL-6 signal transducer, gp130
    1990 1.1k citations Masahiko Hibi, Masaaki Murakami et al. profile →
  4. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
    1990 1.1k citations Toshio Hirano, Tetsuya Taga et al. profile →
  5. Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
    1988 919 citations Katsuhiko Yamasaki, Tetsuya Taga et al. profile →
  6. IL-6 in inflammation, autoimmunity and cancer
    2020 875 citations Toshio Hirano profile →
  7. IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    2002 688 citations Katsuhiko Ishihara, Toshio Hirano profile →
  8. Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis
    1988 679 citations Toshio Hirano, Tadashi Matsuda et al. profile →
  9. Interleukin 6 and its Receptor: Ten Years Later
    1998 659 citations Toshio Hirano International Reviews of Immunology profile →
  10. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    2003 647 citations Masaaki Murakami, Toshio Hirano et al. profile →
  11. Zinc homeostasis and signaling in health and diseases
    2011 465 citations Toshiyuki Fukada, Satoru Yamasaki et al. profile →
  12. How COVID-19 induces cytokine storm with high mortality
    2020 461 citations Shintaro Hojyo, Masaaki Murakami et al. profile →
  13. Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines
    2019 384 citations Masaaki Murakami, Daisuke Kamimura et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Toshio Hirano Japan 85 10.8k 10.2k 8.7k 2.7k 2.6k 220 29.3k
Peter C. Heinrich Germany 75 9.6k 0.9× 9.4k 0.9× 11.9k 1.4× 3.1k 1.2× 1.3k 0.5× 368 27.7k
Jo Van Damme Belgium 108 16.7k 1.5× 12.7k 1.2× 13.7k 1.6× 4.4k 1.7× 2.5k 1.0× 547 41.8k
Steven L. Kunkel United States 113 21.6k 2.0× 9.7k 0.9× 9.8k 1.1× 3.0k 1.1× 2.0k 0.8× 528 48.1k
Jack Gauldie Canada 95 9.1k 0.8× 8.2k 0.8× 4.4k 0.5× 2.1k 0.8× 1.6k 0.6× 416 31.9k
Niels Borregaard Denmark 88 13.4k 1.2× 10.2k 1.0× 2.1k 0.2× 2.3k 0.8× 2.0k 0.8× 254 30.0k
Jörg J. Goronzy United States 111 21.3k 2.0× 7.2k 0.7× 4.2k 0.5× 1.6k 0.6× 1.7k 0.6× 428 40.6k
Klaus‐Michael Debatin Germany 85 9.1k 0.8× 20.6k 2.0× 6.5k 0.7× 5.1k 1.9× 1.7k 0.7× 521 33.1k
Cornelia M. Weyand United States 112 20.4k 1.9× 7.2k 0.7× 4.0k 0.5× 1.6k 0.6× 1.5k 0.6× 435 40.8k
Naoyuki Taniguchi Japan 98 11.3k 1.0× 23.8k 2.3× 3.9k 0.4× 2.4k 0.9× 1.0k 0.4× 1.1k 41.6k
Marco Baggiolini Switzerland 105 23.1k 2.1× 9.6k 0.9× 15.4k 1.8× 2.3k 0.8× 2.0k 0.8× 274 41.0k

Countries citing papers authored by Toshio Hirano

Since Specialization
Citations

This map shows the geographic impact of Toshio Hirano's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Toshio Hirano with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Toshio Hirano more than expected).

Fields of papers citing papers by Toshio Hirano

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Toshio Hirano. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Toshio Hirano. The network helps show where Toshio Hirano may publish in the future.

Co-authorship network of co-authors of Toshio Hirano

This figure shows the co-authorship network connecting the top 25 collaborators of Toshio Hirano. A scholar is included among the top collaborators of Toshio Hirano based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Toshio Hirano. Toshio Hirano is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Murakami, Masaaki, Yuko Okuyama, Hideki Ogura, et al.. (2012). Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells. The Journal of Experimental Medicine. 209(12). 2321–2321. 1 indexed citations
2.
Murakami, Masaaki, Yuko Okuyama, Hideki Ogura, et al.. (2011). Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells. The Journal of Experimental Medicine. 208(1). 103–114. 88 indexed citations
3.
Bin, Bum-Ho, Toshiyuki Fukada, Toshiaki Hosaka, et al.. (2011). Biochemical Characterization of Human ZIP13 Protein. Journal of Biological Chemistry. 286(46). 40255–40265. 127 indexed citations
4.
Hirano, Toshio, Masaaki Murakami, Toshiyuki Fukada, et al.. (2008). Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule. Advances in immunology. 97. 149–176. 189 indexed citations
5.
Murakami, Masaaki, Chika Kitabayashi, Naoko Ueda, et al.. (2007). Homeostatically proliferating CD4+ T cells are involved in the pathogenesis of an Omenn syndrome murine model. Journal of Clinical Investigation. 117(5). 1270–1281. 58 indexed citations
6.
Kamimura, Daisuke, Hokuto Kamon, Mika Nishihara, et al.. (2006). Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells. The Journal of Experimental Medicine. 203(6). 1459–1470. 136 indexed citations
7.
Kamimura, Daisuke, et al.. (2006). IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb. The Journal of Immunology. 177(1). 306–314. 58 indexed citations
8.
Suda, Yoko, et al.. (2004). Zinc finger gene fez‐like functions in the formation of subplate neurons and thalamocortical axons. Developmental Dynamics. 230(3). 546–556. 97 indexed citations
9.
Kamimura, Daisuke, Naoko Ueda, Yukihisa Sawa, et al.. (2004). Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells. The Journal of Immunology. 173(10). 6041–6049. 23 indexed citations
10.
Nishida, Keigo & Toshio Hirano. (2003). The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer Science. 94(12). 1029–1033. 160 indexed citations
11.
Itoh, Shousaku, Motoyuki Itoh, Keigo Nishida, et al.. (2002). Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses. The Journal of Immunology. 168(10). 5110–5116. 24 indexed citations
12.
Hirano, Toshio, Toshiyuki Fukada, Yuichi Yoshida, et al.. (1998). シンポジウム抄録. Japanese Journal of Clinical Immunology. 21(supplement). 13–21. 3 indexed citations
13.
Kim, Cheol‐Hee, Young‐Ki Bae, Yojiro Yamanaka, et al.. (1997). Overexpression of neurogenin induces ectopic expression of HuC in zebrafish. Neuroscience Letters. 239(2-3). 113–116. 67 indexed citations
14.
Sekimoto, Toshihiro, Koichi Nakajima, Taro Tachibana, Toshio Hirano, & Yoshihiro Yoneda. (1996). Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4. Journal of Biological Chemistry. 271(49). 31017–31020. 100 indexed citations
15.
Hirano, Toshio, A Hizuta, Nobuyuki Tanaka, & K Orita. (1996). Enhancement of experimental metastasis by gamma-interferon in a murine adenocarcinoma.. Okayama University Scientific Achievement Repository (Okayama University). 50(1). 11–6. 1 indexed citations
16.
Matsuda, Tadashi, Katsuhiko Yamasaki, Tetsuya Taga, Toshio Hirano, & Tadamitsu Kishimoto. (1989). Current Concepts of B Cell Modulation. International Reviews of Immunology. 5(2). 97–109. 14 indexed citations
17.
Kawano, Michio, Toshio Hirano, Tadashi Matsuda, et al.. (1988). Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 332(6159). 83–85. 1414 indexed citations breakdown →
18.
Satoh, Takaya, Shun Nakamura, Tetsuya Taga, et al.. (1988). Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6. Molecular and Cellular Biology. 8(8). 3546–3549. 371 indexed citations
19.
Satoh, Kunihiko, et al.. (1984). . QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY. 2(3). 495–502.
20.
Satoh, Kunihiko, et al.. (1983). . QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY. 1(2). 160–167. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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