Paul E. Fraser

10.9k total citations · 1 hit paper
34 papers, 4.0k citations indexed

About

Paul E. Fraser is a scholar working on Physiology, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Paul E. Fraser has authored 34 papers receiving a total of 4.0k indexed citations (citations by other indexed papers that have themselves been cited), including 30 papers in Physiology, 17 papers in Molecular Biology and 7 papers in Cellular and Molecular Neuroscience. Recurrent topics in Paul E. Fraser's work include Alzheimer's disease research and treatments (30 papers), Computational Drug Discovery Methods (5 papers) and Dementia and Cognitive Impairment Research (5 papers). Paul E. Fraser is often cited by papers focused on Alzheimer's disease research and treatments (30 papers), Computational Drug Discovery Methods (5 papers) and Dementia and Cognitive Impairment Research (5 papers). Paul E. Fraser collaborates with scholars based in Canada, United States and United Kingdom. Paul E. Fraser's co-authors include Peter St George‐Hyslop, JoAnne McLaurin, Euijung Jo, Howard T.J. Mount, Christopher Janus, Christopher M. Yip, M. Azhar Chishti, David Westaway, Patrick Horne and Jacqueline Pearson and has published in prestigious journals such as Nature, Journal of Biological Chemistry and Nature Medicine.

In The Last Decade

Paul E. Fraser

33 papers receiving 3.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 1.2k citations Christopher Janus, JoAnne McLaurin et al. profile →

Peers

Countries citing papers authored by Paul E. Fraser

Since Specialization

Citations

This map shows the geographic impact of Paul E. Fraser's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul E. Fraser with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul E. Fraser more than expected).

Fields of papers citing papers by Paul E. Fraser

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul E. Fraser. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul E. Fraser. The network helps show where Paul E. Fraser may publish in the future.

Co-authorship network of co-authors of Paul E. Fraser

This figure shows the co-authorship network connecting the top 25 collaborators of Paul E. Fraser. A scholar is included among the top collaborators of Paul E. Fraser based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paul E. Fraser. Paul E. Fraser is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Parkinson’s disease beyond the brain: implications for treatments 2025 ·Frontiers in Aging Neuroscience ·(unknown), (unknown), Paul E. Fraser, Anurag Tandon	0
2	Longitudinal evaluation of Tau‐P301L transgenic mice reveals no cognitive impairments at 17 months of age 2017 ·Brain and Behavior ·Brianne A. Kent, Christopher J. Heath, Chi Hun Kim, Rosemary Ahrens, Paul E. Fraser, Peter St George‐Hyslop, Timothy J. Bussey, Lisa M. Saksida	16
3	Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways 2015 ·Molecular and Cellular Neuroscience ·Christopher Böhm, F. Chen, Jean Sévalle, Seema Qamar, Roger B. Dodd, (unknown), Gerold Schmitt‐Ulms, Paul E. Fraser, Peter St George‐Hyslop	50
4	Structural biology of presenilin 1 complexes 2014 ·Molecular Neurodegeneration ·Yi Li, Christopher Böhm, Roger B. Dodd, Fusheng Chen, Seema Qamar, Gerold Schmitt‐Ulms, Paul E. Fraser, Peter St George‐Hyslop	35
5	Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice 2013 ·Neuroscience ·Soshi Kanemoto, Jennifer K. Griffin, Kelly Markham-Coultes, Isabelle Aubert, A Tandon, Peter St George‐Hyslop, Paul E. Fraser	14
6	Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes 2013 ·Structure ·Yi Li, (unknown), Ching‐Ju Tsai, Christopher Böhm, Seema Qamar, Roger B. Dodd, William Meadows, (unknown), (unknown), Fusheng Chen, Muriel Arimon, Oksana Berezovska, Bradley T. Hyman, Taisuke Tomita, Takeshi Iwatsubo, Christopher M. Johnson, Lindsay A. Farrer, Gerold Schmitt‐Ulms, Paul E. Fraser, Peter St George‐Hyslop	53
7	Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β₄₂from Isolated Intact Nerve Terminals 2010 ·Journal of Neuroscience ·Soong Ho Kim, Paul E. Fraser, David Westaway, Peter St George‐Hyslop, Michelle E. Ehrlich, Sam Gandy	74
8	TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage 2009 ·Journal of Biological Chemistry ·Raphaëlle Pardossi‐Piquard, Christopher Böhm, Fusheng Chen, Soshi Kanemoto, Frédéric Checler, Gerold Schmitt‐Ulms, Peter St George‐Hyslop, Paul E. Fraser	23
9	TMP21 regulates Aβ production but does not affect caspase-3, p53, and neprilysin 2008 ·Biochemical and Biophysical Research Communications ·Virginia Dolcini, Julie Dunys, Jean Sévalle, Fusheng Chen, Marie‐Victoire Guillot‐Sestier, Peter St George‐Hyslop, Paul E. Fraser, Frédéric Checler	11
10	Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model 2006 ·Nature Medicine ·JoAnne McLaurin, (unknown), Mary E. Brown, Cheryl A. Hawkes, Mark H. L. Lambermon, Amie L. Phinney, Audrey A. Darabie, (unknown), (unknown), (unknown), Fusheng Chen, (unknown), Howard T.J. Mount, Paul E. Fraser, David Westaway, Peter St George‐Hyslop	295
11	Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles 2003 ·Journal of Neurochemistry ·Anurag Tandon, Wai Haung Yu, Linda Wang, Ekaterina Rogaeva, Christine Sato, M. Azhar Chishti, Toshitaka Kawarai, Hiroshi Hasegawa, Fusheng Chen, Peter Davies, Paul E. Fraser, David Westaway, Peter St George‐Hyslop	64
12	The levels of mature glycosylated nicastrin are regulated and correlate with γ‐secretase processing of amyloid β‐precursor protein 2002 ·Journal of Neurochemistry ·Shigeki Arawaka, Hiroshi Hasegawa, Anurag Tandon, Christopher Janus, Fusheng Chen, Gang Yu, Kenji Kikuchi, Shingo Koyama, Takeo Kato, Paul E. Fraser, Peter St George‐Hyslop	34
13	Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis 2002 ·Nature Medicine ·JoAnne McLaurin, (unknown), (unknown), Tian Xu, Amie L. Phinney, Marilena Manea, (unknown), Mark H. L. Lambermon, Audrey A. Darabie, Mary E. Brown, Christopher Janus, M. Azhar Chishti, Patrick Horne, David Westaway, Paul E. Fraser, Howard T.J. Mount, Michael Przybylski, Peter St George‐Hyslop	359
14	Defective membrane interactions of familial Parkinson’s disease mutant A30P α-synuclein 1 1Edited by I. B. Holland 2002 ·Journal of Molecular Biology ·Euijung Jo, Nola Fuller, R.P. Rand, Peter St George‐Hyslop, Paul E. Fraser	189
15	Increased Production of β-Amyloid and Vulnerability to Endoplasmic Reticulum Stress by an Aberrant Spliced Form of Presenilin 2 2001 ·Journal of Biological Chemistry ·Naoya Sato, Kazunori Imaizumi, Takayuki Manabe, Manabu Taniguchi, Junichi Hitomi, Taiichi Katayama, Takunari Yoneda, Takashi Morihara, Yuichi Yasuda, Tsutomu Takagi, Takashi Kudo, Takehide Tsuda, Yasuto Itoyama, Takao Makifuchi, Paul E. Fraser, Peter St George‐Hyslop, Masaya Tohyama	101
16	Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition 2001 ·Neurobiology of Aging ·Kazuhiro Ishii, Carol F. Lippa, Takami Tomiyama, (unknown), Kazuharu Ozawa, Akira Tamaoka, Takashi Hasegawa, Paul E. Fraser, Shin’ichi Shoji, Linda E. Nee, (unknown), Peter St George‐Hyslop, Kunio Ii, Toshiyuki Ohtake, Rajesh N. Kalaria, Martin N. Rossor, P. L. Lantos, Nigel J. Cairns, Lindsay A. Farrer, Hiroshi Mori	18
17	Presenilin structure, function and role in Alzheimer disease 2000 ·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Paul E. Fraser, Dun-Sheng Yang, Gang Yu, Lyne Lévesque, Masaki Nishimura, Shigeki Arawaka, Louise C. Serpell, Ekaterina Rogaeva, Peter St George‐Hyslop	74
18	α-Synuclein Membrane Interactions and Lipid Specificity 2000 ·Journal of Biological Chemistry ·Euijung Jo, JoAnne McLaurin, Christopher M. Yip, Peter St George‐Hyslop, Paul E. Fraser	488
19	The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin 1998 ·Journal of Biological Chemistry ·Gang Yu, Fusheng Chen, Georges Lévesque, Masaki Nishimura, Dongmei Zhang, Lyne Lévesque, (unknown), Donghong Xu, Yan Liang, Monika Duthie, Peter St George‐Hyslop, Paul E. Fraser	314
20	Analysis of the 5′ Sequence, Genomic Structure, and Alternative Splicing of thepresenilin-1Gene (PSEN1) Associated with Early Onset Alzheimer Disease 1997 ·Genomics ·Е. И. Рогаев, Robin Sherrington, Chenyan Wu, Georges Lévesque, Yuh‐Jin Liang, Ekaterina Rogaeva, Masaki Ikeda, K. Holman, Chiao‐Feng Lin, Walter J. Lukiw, Pieter J. de Jong, Paul E. Fraser, Johanna M. Rommens, Peter St George‐Hyslop	112

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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