Paul E. Fraser

10.9k total citations · 1 hit paper
34 papers, 4.0k citations indexed

About

Paul E. Fraser is a scholar working on Physiology, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Paul E. Fraser has authored 34 papers receiving a total of 4.0k indexed citations (citations by other indexed papers that have themselves been cited), including 30 papers in Physiology, 17 papers in Molecular Biology and 7 papers in Cellular and Molecular Neuroscience. Recurrent topics in Paul E. Fraser's work include Alzheimer's disease research and treatments (30 papers), Computational Drug Discovery Methods (5 papers) and Dementia and Cognitive Impairment Research (5 papers). Paul E. Fraser is often cited by papers focused on Alzheimer's disease research and treatments (30 papers), Computational Drug Discovery Methods (5 papers) and Dementia and Cognitive Impairment Research (5 papers). Paul E. Fraser collaborates with scholars based in Canada, United States and United Kingdom. Paul E. Fraser's co-authors include Peter St George‐Hyslop, JoAnne McLaurin, Euijung Jo, Howard T.J. Mount, Christopher M. Yip, Christopher Janus, M. Azhar Chishti, David Westaway, Patrick Horne and Jacqueline A. French and has published in prestigious journals such as Nature, Journal of Biological Chemistry and Nature Medicine.

In The Last Decade

Paul E. Fraser

33 papers receiving 3.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 1.2k citations Christopher Janus, Jacqueline Pearson et al. Nature profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Paul E. Fraser	2.8k	1.7k	799	728	707	34	4.0k
Takami Tomiyama	2.9k 1.0×	1.5k 0.9×	787 1.0×	610 0.8×	712 1.0×	83	3.9k
Takeshi Kawarabayashi	4.1k 1.5×	2.2k 1.3×	1.3k 1.6×	1.0k 1.4×	889 1.3×	129	5.7k
Urmi Sengupta	3.3k 1.2×	1.9k 1.1×	1.1k 1.4×	1.2k 1.7×	663 0.9×	69	4.7k
Mar Pérez	2.8k 1.0×	2.3k 1.4×	1.2k 1.6×	714 1.0×	681 1.0×	81	4.6k
Malcolm A. Leissring	3.1k 1.1×	2.4k 1.4×	1.1k 1.4×	497 0.7×	881 1.2×	65	5.0k
Cristian A. Lasagna‐Reeves	2.8k 1.0×	1.5k 0.9×	956 1.2×	1.2k 1.6×	551 0.8×	52	4.2k
Mei Yue	2.7k 1.0×	1.5k 0.9×	1.5k 1.9×	969 1.3×	646 0.9×	52	4.3k
Alfredo Lorenzo	3.1k 1.1×	2.1k 1.2×	874 1.1×	582 0.8×	776 1.1×	35	4.6k
Oksana Berezovska	2.5k 0.9×	2.2k 1.3×	889 1.1×	381 0.5×	653 0.9×	85	4.1k
Julia V. Fadeeva	4.1k 1.4×	2.1k 1.3×	1.3k 1.6×	686 0.9×	1.1k 1.5×	12	4.8k

Countries citing papers authored by Paul E. Fraser

Since Specialization

Citations

This map shows the geographic impact of Paul E. Fraser's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul E. Fraser with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul E. Fraser more than expected).

Fields of papers citing papers by Paul E. Fraser

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul E. Fraser. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul E. Fraser. The network helps show where Paul E. Fraser may publish in the future.

Co-authorship network of co-authors of Paul E. Fraser

This figure shows the co-authorship network connecting the top 25 collaborators of Paul E. Fraser. A scholar is included among the top collaborators of Paul E. Fraser based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paul E. Fraser. Paul E. Fraser is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Fraser, Paul E., et al.. (2025). Parkinson’s disease beyond the brain: implications for treatments. Frontiers in Aging Neuroscience. 17. 1600782–1600782.

Kent, Brianne A., Christopher J. Heath, Chi Hun Kim, et al.. (2017). Longitudinal evaluation of Tau‐P301L transgenic mice reveals no cognitive impairments at 17 months of age. Brain and Behavior. 8(1). e00896–e00896. 16 indexed citations

Böhm, Christopher, F. Chen, Jean Sévalle, et al.. (2015). Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways. Molecular and Cellular Neuroscience. 66(Pt A). 3–11. 50 indexed citations

Li, Yi, Christopher Böhm, Roger B. Dodd, et al.. (2014). Structural biology of presenilin 1 complexes. Molecular Neurodegeneration. 9(1). 59–59. 35 indexed citations

Li, Yi, Ching‐Ju Tsai, Christopher Böhm, et al.. (2013). Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes. Structure. 22(1). 125–135. 53 indexed citations

Kim, Soong Ho, Paul E. Fraser, David Westaway, et al.. (2010). Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β₄₂from Isolated Intact Nerve Terminals. Journal of Neuroscience. 30(11). 3870–3875. 74 indexed citations

Pardossi‐Piquard, Raphaëlle, Christopher Böhm, Fusheng Chen, et al.. (2009). TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage. Journal of Biological Chemistry. 284(42). 28634–28641. 23 indexed citations

Pardossi‐Piquard, Raphaëlle, Seung‐Pil Yang, Soshi Kanemoto, et al.. (2009). APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes. Journal of Biological Chemistry. 284(24). 16298–16307. 29 indexed citations

McLaurin, JoAnne, Mary E. Brown, Cheryl A. Hawkes, et al.. (2006). Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Medicine. 12(7). 801–808. 295 indexed citations

10.

Tandon, Anurag, Wai Haung Yu, Linda Wang, et al.. (2003). Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. Journal of Neurochemistry. 86(3). 572–581. 64 indexed citations

11.

Arawaka, Shigeki, Hiroshi Hasegawa, Anurag Tandon, et al.. (2002). The levels of mature glycosylated nicastrin are regulated and correlate with γ‐secretase processing of amyloid β‐precursor protein. Journal of Neurochemistry. 83(5). 1065–1071. 34 indexed citations

12.

McLaurin, JoAnne, Tian Xu, Amie L. Phinney, et al.. (2002). Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis. Nature Medicine. 8(11). 1263–1269. 359 indexed citations

13.

Jo, Euijung, Nola Fuller, R.P. Rand, Peter St George‐Hyslop, & Paul E. Fraser. (2002). Defective membrane interactions of familial Parkinson’s disease mutant A30P α-synuclein 1 1Edited by I. B. Holland. Journal of Molecular Biology. 315(4). 799–807. 189 indexed citations

14.

Chen, Fusheng, Gang Yu, Shigeki Arawaka, et al.. (2001). Nicastrin binds to membrane-tethered Notch. Nature Cell Biology. 3(8). 751–754. 108 indexed citations

15.

Sato, Naoya, Kazunori Imaizumi, Takayuki Manabe, et al.. (2001). Increased Production of β-Amyloid and Vulnerability to Endoplasmic Reticulum Stress by an Aberrant Spliced Form of Presenilin 2. Journal of Biological Chemistry. 276(3). 2108–2114. 101 indexed citations

16.

Ishii, Kazuhiro, Carol F. Lippa, Takami Tomiyama, et al.. (2001). Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiology of Aging. 22(3). 367–376. 18 indexed citations

17.

Fraser, Paul E., Dun-Sheng Yang, Gang Yu, et al.. (2000). Presenilin structure, function and role in Alzheimer disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1502(1). 1–15. 74 indexed citations

18.

Janus, Christopher, Jacqueline Pearson, JoAnne McLaurin, et al.. (2000). Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408(6815). 979–982. 1183 indexed citations breakdown →

19.

Jo, Euijung, JoAnne McLaurin, Christopher M. Yip, Peter St George‐Hyslop, & Paul E. Fraser. (2000). α-Synuclein Membrane Interactions and Lipid Specificity. Journal of Biological Chemistry. 275(44). 34328–34334. 488 indexed citations

20.

Lévesque, Georges, Gang Yu, Masaki Nishimura, et al.. (1999). Presenilins Interact with Armadillo Proteins Including Neural‐Specific Plakophilin‐Related Protein and β‐Catenin. Journal of Neurochemistry. 72(3). 999–1008. 92 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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