Norman E. Sharpless

46.8k total citations · 14 hit papers
205 papers, 28.1k citations indexed

About

Norman E. Sharpless is a scholar working on Molecular Biology, Oncology and Physiology. According to data from OpenAlex, Norman E. Sharpless has authored 205 papers receiving a total of 28.1k indexed citations (citations by other indexed papers that have themselves been cited), including 94 papers in Molecular Biology, 65 papers in Oncology and 46 papers in Physiology. Recurrent topics in Norman E. Sharpless's work include Telomeres, Telomerase, and Senescence (39 papers), Cancer-related Molecular Pathways (34 papers) and DNA Repair Mechanisms (14 papers). Norman E. Sharpless is often cited by papers focused on Telomeres, Telomerase, and Senescence (39 papers), Cancer-related Molecular Pathways (34 papers) and DNA Repair Mechanisms (14 papers). Norman E. Sharpless collaborates with scholars based in United States, Germany and China. Norman E. Sharpless's co-authors include William R. Jeck, Ronald A. DePinho, Shenghui He, Christin E. Burd, Janakiraman Krishnamurthy, Jessica A. Sorrentino, Michael K. Slevin, William F. Marzluff, Kai Wang and Jinze Liu and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Norman E. Sharpless

196 papers receiving 27.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Circular RNAs are abundant, conserved, and associated with ALU repeats

2012 3.4k citations William R. Jeck, Jessica A. Sorrentino et al. profile →
Detecting and characterizing circular RNAs

2014 2.1k citations William R. Jeck, Norman E. Sharpless profile →
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

2015 1.3k citations Janakiraman Krishnamurthy, Norman E. Sharpless et al. profile →
Senescence in Health and Disease

2017 1.3k citations Norman E. Sharpless et al. Cell profile →
Ink4a/Arf expression is a biomarker of aging

2004 1.2k citations Janakiraman Krishnamurthy, Chad Torrice et al. Journal of Clinical Investigation profile →
Forging a signature of in vivo senescence

2015 826 citations Norman E. Sharpless et al. profile →
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

2006 818 citations Viktor Janzen, Randolf Forkert et al. Nature profile →
p16INK4a induces an age-dependent decline in islet regenerative potential

2006 785 citations Janakiraman Krishnamurthy, Matthew R. Ramsey et al. Nature profile →
The Regulation of INK4/ARF in Cancer and Aging

2006 772 citations William Y. Kim, Norman E. Sharpless Cell profile →
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

2006 733 citations Janakiraman Krishnamurthy, Norman E. Sharpless et al. Nature profile →
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

2010 730 citations Christin E. Burd, William R. Jeck et al. profile →
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

2001 661 citations Norman E. Sharpless, Daniel R. Carrasco et al. Nature profile →
How stem cells age and why this makes us grow old

2007 640 citations Norman E. Sharpless, Ronald A. DePinho profile →
Epidermal growth factor receptor and Ink4a/Arf

2002 501 citations Keith L. Ligon, Norman E. Sharpless et al. profile →

Peers

Countries citing papers authored by Norman E. Sharpless

Since Specialization

Citations

This map shows the geographic impact of Norman E. Sharpless's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Norman E. Sharpless with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Norman E. Sharpless more than expected).

Fields of papers citing papers by Norman E. Sharpless

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Norman E. Sharpless. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Norman E. Sharpless. The network helps show where Norman E. Sharpless may publish in the future.

Co-authorship network of co-authors of Norman E. Sharpless

This figure shows the co-authorship network connecting the top 25 collaborators of Norman E. Sharpless. A scholar is included among the top collaborators of Norman E. Sharpless based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Norman E. Sharpless. Norman E. Sharpless is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging 2017 ·Cancer Research ·Hailey E. Brighton, Steven P. Angus, Tao Bo, Jose Roques, (unknown), David B. Darr, Kübra Karagoz, Noah Sciaky, Michael L. Gatza, Norman E. Sharpless, Gary L. Johnson, James E. Bear	57
2	Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma 2017 ·Cancer Discovery ·Aayoung Hong, Gatien Moriceau, Lu Sun, Shirley H. Lomeli, Marco Piva, Robert Damoiseaux, Sheri L. Holmen, Norman E. Sharpless, Willy Hugo, Roger S. Lo	72
3	Lamellipodia are crucial for haptotactic sensing and response 2016 ·Journal of Cell Science ·Samantha J. King, Sreeja B. Asokan, Elizabeth M. Haynes, Seth P. Zimmerman, Jeremy D. Rotty, James G. Alb, (unknown), Devon R. Blake, Irina P. Lebedeva, (unknown), Heath E. Johnson, Maddy Parsons, Norman E. Sharpless, Brian Kuhlman, Jason M. Haugh, James E. Bear	58
4	Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma 2014 ·Cancer Discovery ·Christin E. Burd, Wenjin Liu, (unknown), (unknown), (unknown), Kelly S. Clark, (unknown), (unknown), William R. Jeck, George P. Souroullas, David B. Darr, Daniel C. Zedek, Michael J. Miley, Bruce C. Baguley, Sharon L. Campbell, Norman E. Sharpless	135
5	Defining the toxicology of aging 2014 ·Trends in Molecular Medicine ·Jessica A. Sorrentino, Hanna K. Sanoff, Norman E. Sharpless	48
6	Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice 2013 ·Clinical Cancer Research ·Jerry Usary, Wei Zhao, David B. Darr, Patrick J. Roberts, Mei Liu, (unknown), Olga Karginova, (unknown), Austin J. Combest, Arlene S. Bridges, Aleix Prat, Maggie C.U. Cheang, Jason I. Herschkowitz, Jeffrey M. Rosen, William C. Zamboni, Norman E. Sharpless, Charles M. Perou	40
7	Co-Clinical Trials Demonstrate Superiority of Crizotinib to Chemotherapy in ALK -Rearranged Non–Small Cell Lung Cancer and Predict Strategies to Overcome Resistance 2013 ·Clinical Cancer Research ·Zhao Chen, Esra A. Akbay, Oliver R. Mikse, Tanya Tupper, Katherine A. Cheng, Yuchuan Wang, Xiaohong Tan, Abigail Altabef, (unknown), Liang Chen, Jacob B. Reibel, Pasi A. Jänne, Norman E. Sharpless, Jeffrey A. Engelman, Geoffrey I. Shapiro, Andrew L. Kung, Kwok‐Kin Wong	51
8	p16INK4a reporter mice reveal age-promoting effects of environmental toxicants 2013 ·Journal of Clinical Investigation ·Jessica A. Sorrentino, Janakiraman Krishnamurthy, Stephen L. Tilley, James G. Alb, Christin E. Burd, Norman E. Sharpless	66
9	Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models 2012 ·Clinical Cancer Research ·Patrick J. Roberts, Jerry Usary, David B. Darr, Patrick M. Dillon, Adam D. Pfefferle, Martin C. Whittle, James S. Duncan, Søren M. Johnson, Austin J. Combest, Jian Jin, William C. Zamboni, Gary L. Johnson, Charles M. Perou, Norman E. Sharpless	107
10	Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy 2012 ·JNCI Journal of the National Cancer Institute ·Patrick J. Roberts, John Bisi, Jay C. Strum, Austin J. Combest, David B. Darr, Jerry Usary, William C. Zamboni, Kwok‐Kin Wong, Charles M. Perou, Norman E. Sharpless	215
11	Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition 2010 ·Journal of Clinical Investigation ·Søren M. Johnson, Chad Torrice, (unknown), Kimberly B. Monahan, Qi Jiang, Yong Wang, Matthew R. Ramsey, Jian Jin, Kwok‐Kin Wong, Lishan Su, Daohong Zhou, Norman E. Sharpless	134
12	HIF2α cooperates with RAS to promote lung tumorigenesis in mice 2009 ·Journal of Clinical Investigation ·William Y. Kim, Samanthi A. Perera, Bing Zhou, Julián Carretero, Jen Jen Yeh, Samuel A. Heathcote, Autumn L. Jackson, Petros Nikolinakos, Beatriz Ospina, George N. Naumov, K. Brandstetter, Victor Weigman, Sara Zaghlul, D. Neil Hayes, Robert F. Padera, John V. Heymach, Andrew L. Kung, Norman E. Sharpless, William G. Kaelin, Kwok‐Kin Wong	120
13	10 Aging in Mammalian Stem Cells and Other Self-renewing Compartments 2008 ·Cold Spring Harbor Monograph Archive ·Derrick J. Rossi, Norman E. Sharpless	3
14	Lack of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Shows a New Type of Melanoma 2007 ·Cancer Research ·Janiel M. Shields, Nancy E. Thomas, Melissa A. Cregger, Aaron J. Berger, (unknown), Chad Torrice, Honglin Hao, Shannon Penland, Jack L. Arbiser, Glynis Scott, Tong Zhou, Menashe Bar‐Eli, James E. Bear, Channing J. Der, William K. Kaufmann, David L. Rimm, Norman E. Sharpless	66
15	Expression of p16Ink4a Compensates for p18Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues 2007 ·Cancer Research ·Matthew R. Ramsey, Janakiraman Krishnamurthy, Xin‐Hai Pei, Chad Torrice, Weili Lin, Daniel R. Carrasco, Keith L. Ligon, Yue Xiong, Norman E. Sharpless	53
16	Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a breakdown → 2006 ·Nature ·Viktor Janzen, Randolf Forkert, Heather E. Fleming, Yoriko Saito, Michael T. Waring, David Dombkowski, Tao Cheng, Ronald A. DePinho, Norman E. Sharpless, David T. Scadden	818
17	The Regulation of INK4/ARF in Cancer and Aging breakdown → 2006 ·Cell ·William Y. Kim, Norman E. Sharpless	772
18	Telomeres, stem cells, senescence, and cancer 2004 ·Journal of Clinical Investigation ·Norman E. Sharpless, Ronald A. DePinho	357
19	In Vivo Pattern of Lipopolysaccharide and Anti-CD3-Induced NF-κB Activation Using a Novel Gene-Targeted Enhanced GFP Reporter Gene Mouse 2004 ·The Journal of Immunology ·Scott T. Magness, Humberto Jijon, (unknown), Norman E. Sharpless, David A. Brenner, Christian Jobin	95
20	A mouse model of human oral-esophageal cancer 2002 ·Journal of Clinical Investigation ·Oliver G. Opitz, Hideki Harada, Yasir Suliman, Ben Rhoades, Norman E. Sharpless, Ralph Kent, Levy Kopelovich, Hiroshi Nakagawa, Anil K. Rustgi	87

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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