Jan H.J. Hoeijmakers

63.1k citations

399 papers · 48.0k indexed · 18 hit papers · h-index 107

Molecular Biology top 0.01%
Cancer Research top 0.05%
Oncology top 0.1%
Genetics top 0.1%
Physiology top 0.2%

Co-authors: D. Bootsma Wim Vermeulen Roland Kanaar Jan de Wit Gijsbertus T. J. van der Horst Dik C. van Gent Jan Vijg Harry van Steeg
Topics: DNA Repair Mechanisms (268 papers)CRISPR and Genetic Engineering (81 papers)Carcinogens and Genotoxicity Assessment (60 papers)
Cited by: Aging Cancer Research Molecular Biology
Journals: Nature Science New England Journal of Medicine
Partner nations: Netherlands United States Germany

In The Last Decade

Jan H.J. Hoeijmakers

396 papers receiving 47.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Genome maintenance mechanisms for preventing cancer

2001 3.0k citations Jan H.J. Hoeijmakers profile →
DNA repair and mutagenesis

1996 1.9k citations D. Bootsma, Jan H.J. Hoeijmakers profile →
DNA Damage, Aging, and Cancer

2009 1.6k citations Jan H.J. Hoeijmakers profile →
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

2014 1.4k citations Jan Vijg, Harry van Steeg et al. profile →
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 1.1k citations Gijsbertus T. J. van der Horst, Jan de Wit et al. profile →
Chromosomal stability and the DNA double-stranded break connection

2001 939 citations Dik C. van Gent, Jan H.J. Hoeijmakers et al. profile →
Molecular mechanism of nucleotide excision repair

1999 900 citations Jan H.J. Hoeijmakers et al. profile →
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

2007 852 citations Jan H.J. Hoeijmakers et al. profile →
Understanding nucleotide excision repair and its roles in cancer and ageing

2014 843 citations Jurgen A. Marteijn, Hannes Lans et al. Nature Reviews Molecular Cell Biology profile →
Cellular senescence drives age-dependent hepatic steatosis

2017 732 citations Jan H.J. Hoeijmakers, Sander Barnhoorn et al. profile →
Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair

1998 728 citations Kaoru Sugasawa, Chikahide Masutani et al. profile →
DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor

1993 687 citations Wim Vermeulen, Jan H.J. Hoeijmakers et al. Science profile →
Sequential Assembly of the Nucleotide Excision Repair Factors In Vivo

2001 643 citations Wim Vermeulen, Jan H.J. Hoeijmakers et al. profile →
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

1992 608 citations Jan de Wit, Wim Vermeulen et al. profile →
Nucleotide excision repair and human syndromes

2000 536 citations Jan de Boer, Jan H.J. Hoeijmakers profile →
The central role of DNA damage in the ageing process

2021 527 citations Joris Pothof, Jan Vijg et al. profile →
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

2006 524 citations Laura J. Niedernhofer, Anja Raams et al. profile →
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

2016 278 citations Hiroyuki Matsumura, Yasuaki Mohri et al. Science profile →

Peers

Countries citing papers authored by Jan H.J. Hoeijmakers

Since Specialization

Citations

This map shows the geographic impact of Jan H.J. Hoeijmakers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jan H.J. Hoeijmakers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jan H.J. Hoeijmakers more than expected).

Fields of papers citing papers by Jan H.J. Hoeijmakers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jan H.J. Hoeijmakers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jan H.J. Hoeijmakers. The network helps show where Jan H.J. Hoeijmakers may publish in the future.

Co-authorship network of co-authors of Jan H.J. Hoeijmakers

This figure shows the co-authorship network connecting the top 25 collaborators of Jan H.J. Hoeijmakers. A scholar is included among the top collaborators of Jan H.J. Hoeijmakers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jan H.J. Hoeijmakers. Jan H.J. Hoeijmakers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Emotional labour in midwifery care: Balancing between woman’s autonomy and clinical control during childbirth through watchful attendance 2025 ·SSM - Qualitative Research in Health ·Giulia Sinatti,(unknown),Jan H.J. Hoeijmakers,(unknown),Corine Verhoeven,Ank de Jonge	0
2	A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression 2025 ·Nature Aging ·Daisy Sproviero,César Payán‐Gómez,Chiara Milanese,Sander Barnhoorn,Shixiang Sun,Ákos Gyenis,Domenico Delia,Tammaryn Lashley,Jan H.J. Hoeijmakers,Jan Vijg,Pier G. Mastroberardino	2
3	Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice 2024 ·Molecular Imaging and Biology ·Bibi S. van Thiel,Martine de Boer,Yanto Ridwan,(unknown),Nicole van Vliet,(unknown),(unknown),(unknown),Wilbert P. Vermeij,Jan H.J. Hoeijmakers,A.H. Jan Danser,Roland Kanaar,Dirk J. Duncker,Ingrid van der Pluijm,Jeroen Essers	2
4	Genome-wide RNA polymerase stalling shapes the transcriptome during aging 2023 ·Nature Genetics ·Ákos Gyenis,Jiang Chang,(unknown),(unknown),Sander Barnhoorn,Renata M. C. Brandt,Marjolein P. Baar,Marko Rašeta,Kasper Derks,Jan H.J. Hoeijmakers,Joris Pothof	71
5	Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice 2023 ·European Thyroid Journal ·Sander Barnhoorn,Marcel E. Meima,Robin P. Peeters,Veerle Darras,(unknown),Jan H.J. Hoeijmakers,Wilbert P. Vermeij,W. Edward Visser	3
6	Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation 2023 ·EMBO Molecular Medicine ·Arjan F. Theil,Alex Pines,(unknown),José María Heredia‐Genestar,Anja Raams,Marion Rietveld,Sriram Sridharan,Sabine E.J. Tanis,Klaas W. Mulder,Nesimi Bűyúkbabani,Birsen Karaman,Zehra Oya Uyguner,Hülya Kayserili,Jan H.J. Hoeijmakers,Hannes Lans,Jeroen Demmers,Joris Pothof,Umut Altunoğlu,Abdoelwaheb El Ghalbzouri,Wim Vermeulen	8
7	Different responses to DNA damage determine ageing differences between organs 2022 ·Aging Cell ·(unknown),(unknown),Wilbert P. Vermeij,Marjolein P. Baar,(unknown),(unknown),Ewart Kuijk,Myrthe Jager,Sarra Merzouk,Renata M. C. Brandt,(unknown),Ruben van Boxtel,Edwin Cuppen,Joris Pothof,Jan H.J. Hoeijmakers	27
8	The DNA damage response to transcription stress 2019 ·Nature Reviews Molecular Cell Biology ·Hannes Lans,Jan H.J. Hoeijmakers,Wim Vermeulen,Jurgen A. Marteijn	225
9	DNA damage‐induced replication stress results in PA 200‐proteasome‐mediated degradation of acetylated histones 2018 ·EMBO Reports ·Imke K. Mandemaker,Marit E. Geijer,(unknown),Karel Bezstarosti,Erikjan Rijkers,Anja Raams,Roel C. Janssens,Hannes Lans,Jan H.J. Hoeijmakers,Jeroen Demmers,Wim Vermeulen,Jurgen A. Marteijn	40
10	Vitamin E Supplementation Reduces Cellular Loss in the Brain of a Premature Aging Mouse Model. 2017 ·PubMed ·Giorgio La Fata,Nicole van Vliet,Sander Barnhoorn,Renata M. C. Brandt,(unknown),(unknown),(unknown),Nicole Seifert,Peter Weber,Jan H.J. Hoeijmakers,M. Hasan Mohajeri,Wilbert P. Vermeij	21
11	Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly agingErcc1Δ/−mice 2017 ·Clinical Science ·Haiyan Wu,Bibi S. van Thiel,Paula K. Bautista‐Niño,Erwin Reiling,Matej Durik,Frank Leijten,Yanto Ridwan,Renata M. C. Brandt,Harry van Steeg,Martijn E.T. Dollé,Wilbert P. Vermeij,Jan H.J. Hoeijmakers,Jeroen Essers,Ingrid van der Pluijm,A.H. Jan Danser,Anton J.M. Roks	14
12	Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysisbreakdown → 2016 ·Science ·Hiroyuki Matsumura,Yasuaki Mohri,Nguyễn Thanh Bình,Hironobu Morinaga,Makoto Fukuda,Mayumi Ito,Sotaro Kurata,Jan H.J. Hoeijmakers,Emi K. Nishimura	278
13	Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment 2014 ·Clinical Cancer Research ·Kishan A.T. Naipal,Nicole S. Verkaik,Najim Ameziane,Carolien H. M. van Deurzen,Petra ter Brugge,Matty Meijers,Anieta M. Sieuwerts,John W.M. Martens,Mark J. O’Connor,Harry Vrieling,Jan H.J. Hoeijmakers,Jos Jonkers,Roland Kanaar,Johan P. de Winter,Maaike P.G. Vreeswijk,Agnes Jager,Dik C. van Gent	124
14	Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation 2009 ·PLoS Biology ·Giuseppina Giglia‐Mari,Arjan F. Theil,Pierre‐Olivier Mari,(unknown),Julie Nonnekens,Lise O. Andrieux,Jan de Wit,Catherine Miquel,Nils Wijgers,Alex Maas,Maria Fousteri,Jan H.J. Hoeijmakers,Wim Vermeulen	42
15	The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks 2004 ·Molecular and Cellular Biology ·Laura J. Niedernhofer,Hanny Odijk,Magda Budzowska,Ellen van Drunen,Alex Maas,Arjan F. Theil,Jan de Wit,N.G.J. Jaspers,H. Berna Beverloo,Jan H.J. Hoeijmakers,Roland Kanaar	407
16	Premature Aging in Mice Deficient in DNA Repair and Transcription 2002 ·Science ·Jan de Boer,Jaan‐Olle Andressoo,Jan de Wit,J. G. M. Huijmans,(unknown),Harry van Steeg,Geert Weeda,Gijsbertus T. J. van der Horst,(unknown),Axel P. N. Themmen,M. Meradji,Jan H.J. Hoeijmakers	426
17	2000 ·Data Archiving and Networked Services (DANS) ·Yoshimichi Nakatsu,Hiroshi Asahina,Elisabetta Citterio,Suzanne Rademakers,Wim Vermeulen,Shinya Kamiuchi,(unknown),(unknown),Masafumi Saijo,Naohiko Kodo,Toshiro Matsuda,Jan H.J. Hoeijmakers,Kiyoji Tanaka	112
18	HHR23B, a Human Rad23 Homolog, Stimulates XPC Protein in Nucleotide Excision Repair In Vitro 1996 ·Molecular and Cellular Biology ·Kaoru Sugasawa,Chikahide Masutani,Akio Uchida,Takafumi Maekawa,Peter J. van der Spek,D. Bootsma,Jan H.J. Hoeijmakers,Fumio Hanaoka	141
19	The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I. 1989 ·Data Archiving and Networked Services (DANS) ·Marcel van Duin,(unknown),Lynne V. Mayne,Hanny Odijk,Wim Vermeulen,(unknown),(unknown),Jan H.J. Hoeijmakers,D. Bootsma,A. Westerveld	64
20	Structure, function and evolution of kinetoplast DNA. 1981 ·Parasitology ·Piet Borst,Jan H.J. Hoeijmakers,Stephen L. Hajduk	13

About Jan H.J. Hoeijmakers

Jan H.J. Hoeijmakers is a scholar working on Aging, Molecular Biology and Cancer Research, having authored 399 papers that have together received 48.0k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (268 papers), CRISPR and Genetic Engineering (81 papers) and Carcinogens and Genotoxicity Assessment (60 papers). The work is most often cited by research in Aging (2.6k citations), Cancer Research (8.4k citations) and Molecular Biology (38.1k citations). Jan H.J. Hoeijmakers has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include D. Bootsma, Wim Vermeulen, Roland Kanaar, Jan de Wit, Gijsbertus T. J. van der Horst, Dik C. van Gent, Jan Vijg, Harry van Steeg, Wouter de Laat and Geert Weeda. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact