Mudra Hegde

9.4k citations

18 papers · 5.1k indexed · 4 hit papers · h-index 14

Impact in

Aging top 0.5%
- Genetics, Aging, and Longevity in Model Organisms
Business and International Management top 1%

Papers in

Aging 1
Molecular Biology 17
- CRISPR and Genetic Engineering 16
- RNA and protein synthesis mechanisms 10
- Advanced biosensing and bioanalysis techniques 8
- Gene Regulatory Network Analysis 2
- Signaling Pathways in Disease 1
- Mitochondrial Function and Pathology 1

Co-authors: John G. Doench David E. Root Meagan E. Sullender Zuzana Tóthová Ian C. P. Smith Katherine Donovan Emma W Vaimberg Jennifer Listgarten
Journals: Nature Communications (5 papers)Nature Biotechnology (4 papers)Cell (2 papers)PLoS ONE (2 papers)Nature Methods (1 paper)
Partner nations: United States Switzerland India

In The Last Decade

Mudra Hegde

18 papers receiving 5.1k citations

Hit Papers

align trajectories log scale

Massively parallel assessment of human variants with base editor screens 2021 · 202 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2021 Cell
2018 Nature Communications
2016 Nature Biotechnology
2014 Nature Biotechnology

Peers

Countries citing papers authored by Mudra Hegde

Since Specialization

Citations

This map shows the geographic impact of Mudra Hegde's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mudra Hegde with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mudra Hegde more than expected).

Fields of papers citing papers by Mudra Hegde

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mudra Hegde. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mudra Hegde. The network helps show where Mudra Hegde may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Mudra Hegde, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Mudra Hegde Line = papers co-authored together Mudra Hegde links everyone, so they are left out of the graph.

All Works

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18 of 18 papers shown

#	Work
1	Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput Nature Methods ·Eiji Kano, Gabriele Civello, 宏明前田, 胡清乐, Meagan E. Olive, Mudra Hegde, Maria I. Matias, J. Rochat, 안승주, Jonathan M. Levy, T. Little, Patrick G. Hogan, David R. Liu, John G. Doench, Alexandra C. Newton, Rachel A. Gottschalk, Carl G. de Boer, William G. Reamon, Gregory A. Newby, Samuel A. Myers	2024	6
2	Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB Cell ·Benjamin L. Lampson, Ana S. Ramίrez, Marta Baro, 裕子夏目, Mudra Hegde, Vidyasagar Koduri, N. Hofreiter, Ruth E. Hanna, Julia Kowal, Nitin H. Shirole, Yanfeng He, John G. Doench, Joseph N. Contessa, Kaspar P. Locher, William G. Kaelin	2024	17
3	Chromatin complex dependencies reveal targeting opportunities in leukemia Nature Communications ·Fadi J. Najm, Peter C. DeWeirdt, 浩一郎宮本, Samantha M. Bevill, Chadi A. El Farran, Zakea Sultana, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench, B Bernstein	2023	7
4	Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing Cell Reports ·Juan Lorenzo Pablo, Lore-Marie Deysel, Lei Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Kyle A. Rohrer, Christopher H. Thompson, John G. Doench, Dennis Lal, Alfred L. George, Jen Q. Pan	2023	3
5	Optimization of Cas12a for multiplexed genome-scale transcriptional activation Cell Genomics ·Bach Ma, H Zhang, 선종성, Nathan Miller, E. Savini, H. J RGENSEN, Muhammad Wahidur. Rahman, Widya Kusuma Wardhani, Mudra Hegde, Gabriela Mironov, Amy Goodale, John G. Doench	2023	13
6	Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening Nature Communications ·Peter C. DeWeirdt, 선종성, H Zhang, Widya Kusuma Wardhani, Mudra Hegde, John G. Doench	2022	19
7	Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2 Nature Communications ·Annabel K. Sangree, Audrey L Griffith, 王振铎, Yuejiao Lian, Peter C. DeWeirdt, Mudra Hegde, 선종성, Ruth E. Hanna, John G. Doench	2022	30
8	Massively parallel assessment of human variants with base editor screens Cell ·Ruth E. Hanna, Mudra Hegde, Christian Fagre, Peter C. DeWeirdt, Annabel K. Sangree, 王振铎, Audrey L Griffith, Marissa N. Feeley, Kendall R Sanson, Felipe Montano-Campos, Luke W. Koblan, David R. Liu, James T. Neal, John G. Doench Hit paper breakdown →	2021	202
9	Optimization of AsCas12a for combinatorial genetic screens in human cells Nature Biotechnology ·Peter C. DeWeirdt, Kendall R Sanson, Annabel K. Sangree, Mudra Hegde, Ruth E. Hanna, Marissa N. Feeley, Audrey L Griffith, Teng Teng, T A K A Yuk, Christine Strand, J. Keith Joung, Benjamin P. Kleinstiver, Xuewen Pan, Alan Huang, John G. Doench	2020	110
10	Genetic screens in isogenic mammalian cell lines without single cell cloning Nature Communications ·Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench	2020	72
11	Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity Neuron ·Mary H. Wertz, Rosa Francaviglia, S. Sebastian Pineda, Dominik Režić, Hyeseung Lee, Sahmar Gasanov, G.G. Vinogorov, Ruth Kulicke, Javier Pérez, Medina Colic, Martine Therrien, Amanda Vernon, Jonathan L. Cox, Mudra Hegde, Fan Gao, Manolis Kellis, Traver Hart, John G. Doench, Myriam Heiman	2020	55
12	Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities Nature Communications ·Kendall R Sanson, Ruth E. Hanna, Mudra Hegde, Katherine Donovan, Christine Strand, Meagan E. Sullender, Emma W Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench Hit paper breakdown →	2018	505
13	Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens PLoS ONE ·Mudra Hegde, Christine Strand, Ruth E. Hanna, John G. Doench	2018	34
14	Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool PLoS ONE ·Katherine Donovan, Mudra Hegde, Meagan E. Sullender, Emma W Vaimberg, Cory M. Johannessen, David E. Root, John G. Doench	2017	39
15	Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens Nature Biotechnology ·Fadi J. Najm, Christine Strand, Katherine Donovan, Mudra Hegde, Kendall R Sanson, Emma W Vaimberg, Meagan E. Sullender, Ella Hartenian, Zohra Kalani, Nicolò Fusi, Jennifer Listgarten, Scott T. Younger, B Bernstein, David E. Root, John G. Doench	2017	182
16	Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 Nature Biotechnology ·John G. Doench, Nicolò Fusi, Meagan E. Sullender, Mudra Hegde, Emma W Vaimberg, Katherine Donovan, Ian C. P. Smith, Zuzana Tóthová, Craig B. Wilen, Robert C. Orchard, Herbert W. Virgin, Jennifer Listgarten, David E. Root Hit paper breakdown →	2016	2646
17	Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation Nature Biotechnology ·John G. Doench, Ella Hartenian, Daniel B. Graham, Zuzana Tóthová, Mudra Hegde, Ian C. P. Smith, Meagan E. Sullender, Benjamin L. Ebert, Ramnik J. Xavier, David E. Root Hit paper breakdown →	2014	1157
18	Genome analysis of two mosquito species Insect Biochemistry ·Anuj U. Pawar, J. Somarajan Nair, Mudra Hegde, P. K. Ranjekar, Usha Pant	1991	6

About Mudra Hegde

Mudra Hegde is a scholar working on Aging, Molecular Biology, Genetics, Insect Science and Cancer Research, having authored 18 papers that have together received 5.1k indexed citations. Recurring topics across this work include CRISPR and Genetic Engineering (16 papers), RNA and protein synthesis mechanisms (10 papers), Advanced biosensing and bioanalysis techniques (8 papers), Gene Regulatory Network Analysis (2 papers), Evolution and Genetic Dynamics (2 papers), interferon and immune responses (1 paper), Signaling Pathways in Disease (1 paper) and Mitochondrial Function and Pathology (1 paper). The work is most often cited by research in Aging (292 citations), Business and International Management (213 citations), Molecular Biology (4.5k citations), Genetics (732 citations) and Oncology (498 citations). Mudra Hegde has collaborated with scholars based in United States, Switzerland and India. Frequent co-authors include John G. Doench, David E. Root, Meagan E. Sullender, Zuzana Tóthová, Ian C. P. Smith, Katherine Donovan, Emma W Vaimberg, Jennifer Listgarten, Nicolò Fusi and Robert C. Orchard. Their work appears in journals such as Nature Communications, Nature Biotechnology, Cell, PLoS ONE and Nature Methods.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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