David R. Liu

76.7k total citations · 47 hit papers
274 papers, 52.3k citations indexed

About

David R. Liu is a scholar working on Molecular Biology, Genetics and Organic Chemistry. According to data from OpenAlex, David R. Liu has authored 274 papers receiving a total of 52.3k indexed citations (citations by other indexed papers that have themselves been cited), including 254 papers in Molecular Biology, 50 papers in Genetics and 17 papers in Organic Chemistry. Recurrent topics in David R. Liu's work include CRISPR and Genetic Engineering (123 papers), RNA and protein synthesis mechanisms (90 papers) and Advanced biosensing and bioanalysis techniques (72 papers). David R. Liu is often cited by papers focused on CRISPR and Genetic Engineering (123 papers), RNA and protein synthesis mechanisms (90 papers) and Advanced biosensing and bioanalysis techniques (72 papers). David R. Liu collaborates with scholars based in United States, China and Germany. David R. Liu's co-authors include Michael S. Packer, Alexis C. Komor, Holly A. Rees, Luke W. Koblan, John A. Zuris, Ahmed H. Badran, Andrew V. Anzalone, Gregory A. Newby, Aditya Raguram and John P. Guilinger and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David R. Liu

270 papers receiving 51.4k citations

Hit Papers

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine... 2009 2026 2014 2020 2009 2016 2019 2017 2020 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
    2009 4.4k citations Mamta Tahiliani, Kian Peng Koh et al. Science profile →
  2. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
    2016 3.6k citations John A. Zuris, David R. Liu et al. profile →
  3. Search-and-replace genome editing without double-strand breaks or donor DNA
    2019 2.9k citations Andrew V. Anzalone, Peyton B. Randolph et al. profile →
  4. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
    2017 2.8k citations Holly A. Rees, David R. Liu et al. profile →
  5. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
    2020 1.5k citations Andrew V. Anzalone, David R. Liu et al. Nature Biotechnology profile →
  6. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
    2014 1.2k citations John A. Zuris, David R. Liu et al. Nature Biotechnology profile →
  7. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
    2013 1.2k citations David R. Liu et al. Nature Biotechnology profile →
  8. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
    2018 1.2k citations Weixin Tang, Xue Gao et al. profile →
  9. Sequence-Controlled Polymers
    2013 1.1k citations David R. Liu et al. Science profile →
  10. Base editing: precision chemistry on the genome and transcriptome of living cells
    2018 1.1k citations Holly A. Rees, David R. Liu profile →
  11. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
    2016 794 citations David R. Liu et al. profile →
  12. Methods for the directed evolution of proteins
    2015 692 citations David R. Liu et al. profile →
  13. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
    2018 662 citations Jonathan M. Levy, Gregory A. Newby et al. Nature Biotechnology profile →
  14. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
    2014 651 citations David R. Liu et al. Nature Biotechnology profile →
  15. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
    2020 633 citations Michelle F. Richter, Kevin T. Zhao et al. Nature Biotechnology profile →
  16. A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog
    2009 612 citations David R. Liu et al. profile →
  17. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
    2016 583 citations David R. Liu et al. profile →
  18. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
    2017 577 citations Jonathan M. Levy, Kevin T. Zhao et al. Nature Biotechnology profile →
  19. The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing
    2010 571 citations William A. Pastor, Yinghua Shen et al. profile →
  20. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
    2017 568 citations Kevin T. Zhao, David R. Liu et al. profile →
  21. Prime genome editing in rice and wheat
    2020 556 citations Andrew V. Anzalone, Aditya Raguram et al. Nature Biotechnology profile →
  22. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
    2016 540 citations Ming Wang, John A. Zuris et al. Proceedings of the National Academy of Sciences profile →
  23. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
    2021 488 citations Peter J. Chen, Friederike Knipping et al. profile →
  24. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing
    2020 483 citations Aditya Raguram, David R. Liu et al. profile →
  25. A system for the continuous directed evolution of biomolecules
    2011 481 citations David R. Liu et al. profile →
  26. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
    2017 410 citations Xue Gao, Wei-Hsi Yeh et al. profile →
  27. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
    2022 397 citations Samagya Banskota, Aditya Raguram et al. profile →
  28. Predictable and precise template-free CRISPR editing of pathogenic variants
    2018 380 citations Max W. Shen, Mandana Arbab et al. profile →
  29. Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
    2020 344 citations Jonathan M. Levy, Wei-Hsi Yeh et al. Nature Biomedical Engineering profile →
  30. Prime editing for precise and highly versatile genome manipulation
    2022 342 citations Peter J. Chen, David R. Liu profile →
  31. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery
    2017 326 citations Holly A. Rees, Wei-Hsi Yeh et al. Nature Communications profile →
  32. Therapeutic in vivo delivery of gene editing agents
    2022 318 citations Aditya Raguram, Samagya Banskota et al. profile →
  33. Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
    2020 312 citations Aditya Raguram, Gregory A. Newby et al. Nature Biotechnology profile →
  34. Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase
    2020 237 citations Peter J. Chen, David R. Liu et al. Nature Biotechnology profile →
  35. Massively parallel assessment of human variants with base editor screens
    2021 202 citations David R. Liu et al. profile →
  36. Phage-assisted evolution and protein engineering yield compact, efficient prime editors
    2023 161 citations Meirui An, Jessie R. Davis et al. profile →
  37. Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
    2022 156 citations Mandana Arbab, Amber McElroy et al. Nature Biotechnology profile →
  38. CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA
    2022 131 citations Aditya Raguram, David R. Liu et al. Nature Biotechnology profile →
  39. DNA capture by a CRISPR-Cas9–guided adenine base editor
    2020 130 citations Michelle F. Richter, Kevin T. Zhao et al. Science profile →
  40. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo
    2024 128 citations Meirui An, Aditya Raguram et al. Nature Biotechnology profile →
  41. Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors
    2022 117 citations Jessie R. Davis, Xiao Wang et al. Nature Biomedical Engineering profile →
  42. Efficient prime editing in mouse brain, liver and heart with dual AAVs
    2023 114 citations Jessie R. Davis, Samagya Banskota et al. Nature Biotechnology profile →
  43. Small-molecule discovery through DNA-encoded libraries
    2023 113 citations David R. Liu et al. profile →
  44. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
    2023 106 citations Gregory A. Newby, Aditya Raguram et al. profile →
  45. Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice
    2023 85 citations Gregory A. Newby, Jessie R. Davis et al. Nature Biomedical Engineering profile →
  46. Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing
    2024 70 citations Xin D. Gao, Amber McElroy et al. Nature Biomedical Engineering profile →
  47. Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
    2024 63 citations David R. Liu et al. Nature Biotechnology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David R. Liu United States 105 46.8k 10.4k 4.2k 3.5k 2.7k 274 52.3k
Jonathan S. Weissman United States 131 67.8k 1.4× 8.2k 0.8× 4.1k 1.0× 531 0.1× 1.2k 0.4× 292 78.7k
Jennifer A. Doudna United States 123 71.4k 1.5× 12.3k 1.2× 7.8k 1.9× 336 0.1× 5.4k 2.0× 363 78.6k
Wendell A. Lim United States 84 24.0k 0.5× 4.0k 0.4× 2.2k 0.5× 490 0.1× 685 0.3× 162 30.8k
Feng Zhang United States 86 76.6k 1.6× 14.9k 1.4× 7.7k 1.8× 232 0.1× 6.3k 2.3× 181 85.6k
Osamu Nureki Japan 74 19.5k 0.4× 3.0k 0.3× 1.9k 0.5× 452 0.1× 886 0.3× 367 23.8k
Phillip A. Sharp United States 156 76.5k 1.6× 17.3k 1.7× 5.8k 1.4× 495 0.1× 390 0.1× 433 92.7k
Dinshaw J. Patel United States 120 45.2k 1.0× 3.5k 0.3× 5.6k 1.3× 2.1k 0.6× 195 0.1× 558 51.6k
Yi Zhang United States 110 52.9k 1.1× 9.3k 0.9× 3.6k 0.9× 418 0.1× 286 0.1× 420 60.2k
Robert Tjian United States 136 56.0k 1.2× 13.9k 1.3× 5.6k 1.3× 630 0.2× 151 0.1× 337 69.6k
Eva Nogales United States 82 19.9k 0.4× 2.1k 0.2× 2.3k 0.5× 1.1k 0.3× 410 0.2× 235 24.9k

Countries citing papers authored by David R. Liu

Since Specialization
Citations

This map shows the geographic impact of David R. Liu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David R. Liu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David R. Liu more than expected).

Fields of papers citing papers by David R. Liu

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David R. Liu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David R. Liu. The network helps show where David R. Liu may publish in the future.

Co-authorship network of co-authors of David R. Liu

This figure shows the co-authorship network connecting the top 25 collaborators of David R. Liu. A scholar is included among the top collaborators of David R. Liu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David R. Liu. David R. Liu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Du, Samuel W., Grażyna Palczewska, Zhiqian Dong, et al.. (2025). TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches. Proceedings of the National Academy of Sciences. 122(35). e2506257122–e2506257122.
2.
Arbab, Mandana, Żaneta Matuszek, Gregory A. Newby, et al.. (2023). Base editing rescue of spinal muscular atrophy in cells and in mice. Science. 380(6642). eadg6518–eadg6518. 74 indexed citations
3.
Davis, Jessie R., Samagya Banskota, Jonathan M. Levy, et al.. (2023). Efficient prime editing in mouse brain, liver and heart with dual AAVs. Nature Biotechnology. 42(2). 253–264. 114 indexed citations breakdown →
4.
Suh, Susie, Elliot H. Choi, Aditya Raguram, David R. Liu, & Krzysztof Palczewski. (2022). Precision genome editing in the eye. Proceedings of the National Academy of Sciences. 119(39). e2210104119–e2210104119. 33 indexed citations
5.
Choi, Elliot H., Susie Suh, Andrzej T. Foik, et al.. (2022). In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nature Communications. 13(1). 1830–1830. 60 indexed citations
6.
Suh, Susie, Elliot H. Choi, Henri Leinonen, et al.. (2020). Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature Biomedical Engineering. 4(11). 1119–1119. 4 indexed citations
7.
Osborn, Mark J., Gregory A. Newby, Amber McElroy, et al.. (2019). Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs. Journal of Investigative Dermatology. 140(2). 338–347.e5. 75 indexed citations
8.
Tang, Weixin & David R. Liu. (2018). Rewritable multi-event analog recording in bacterial and mammalian cells. Science. 360(6385). 173 indexed citations
9.
Ham, Hyun Ok, Zheng Qu, Carolyn A. Haller, et al.. (2016). In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A. Nature Communications. 7(1). 31 indexed citations
10.
Wang, Ming, John A. Zuris, Fantao Meng, et al.. (2016). Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proceedings of the National Academy of Sciences. 113(11). 2868–2873. 540 indexed citations breakdown →
11.
Chen, Irwin, Brent M. Dorr, & David R. Liu. (2011). A general strategy for the evolution of bond-forming enzymes using yeast display. Proceedings of the National Academy of Sciences. 108(28). 11399–11404. 431 indexed citations
12.
Kleiner, Ralph E., Christoph E. Dumelin, Gerald C. Tiu, Kaori Sakurai, & David R. Liu. (2010). In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors. Journal of the American Chemical Society. 132(33). 11779–11791. 133 indexed citations
13.
Tahiliani, Mamta, Kian Peng Koh, Yinghua Shen, et al.. (2009). Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1. Science. 324(5929). 930–935. 4364 indexed citations breakdown →
14.
Kowtoniuk, Walter E., Yinghua Shen, Jennifer M. Heemstra, Isha Agarwal, & David R. Liu. (2009). A chemical screen for biological small molecule–RNA conjugates reveals CoA-linked RNA. Proceedings of the National Academy of Sciences. 106(19). 7768–7773. 87 indexed citations
15.
Fischbach, Michael A., Hening Lin, Lu Zhou, et al.. (2006). The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proceedings of the National Academy of Sciences. 103(44). 16502–16507. 246 indexed citations
16.
Gartner, Zev J., et al.. (2004). DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. Science. 305(5690). 1601–1605. 430 indexed citations
17.
Fischbach, Michael A., Hening Lin, David R. Liu, & Christopher T. Walsh. (2004). In vitro characterization of IroB, a pathogen-associated C -glycosyltransferase. Proceedings of the National Academy of Sciences. 102(3). 571–576. 142 indexed citations
18.
Buskirk, Allen R., et al.. (2004). Directed evolution of ligand dependence: Small-molecule-activated protein splicing. Proceedings of the National Academy of Sciences. 101(29). 10505–10510. 128 indexed citations
19.
Li, Xiaoyu, et al.. (2004). Translation of DNA into Synthetic N -Acyloxazolidines. Journal of the American Chemical Society. 126(16). 5090–5092. 41 indexed citations
20.
Bittker, Joshua A., et al.. (2004). Directed evolution of protein enzymes using nonhomologous random recombination. Proceedings of the National Academy of Sciences. 101(18). 7011–7016. 46 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Jonathan S. Weissman Breakdown of academic impact, for papers by Jennifer A. Doudna Breakdown of academic impact, for papers by Wendell A. Lim Breakdown of academic impact, for papers by Feng Zhang Breakdown of academic impact, for papers by Osamu Nureki Breakdown of academic impact, for papers by Phillip A. Sharp Breakdown of academic impact, for papers by Dinshaw J. Patel Breakdown of academic impact, for papers by Yi Zhang Breakdown of academic impact, for papers by Robert Tjian Breakdown of academic impact, for papers by Eva Nogales
Rankless by CCL
2026