Alexandra C. Newton

25.0k citations

195 papers · 20.5k indexed · 9 hit papers · h-index 72

Molecular Biology top 0.1%
Cell Biology top 0.1%
Cellular and Molecular Neuroscience top 0.5%
Oncology top 1%
Immunology top 1%

Co-authors: Alex Toker Roger Y. Tsien Jonathan D. Violin Tianyan Gao David A. Zacharias John Brognard Frank B. Furnari Maya T. Kunkel
Topics: Protein Kinase Regulation and GTPase Signaling (115 papers)PI3K/AKT/mTOR signaling in cancer (50 papers)Receptor Mechanisms and Signaling (35 papers)
Cited by: Molecular Biology Cell Biology Biophysics
Journals: Science Cell Chemical Reviews
Partner nations: United States United Kingdom Canada

In The Last Decade

Alexandra C. Newton

195 papers receiving 20.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 1.9k citations David A. Zacharias, Jonathan D. Violin et al. Science profile →
Protein Kinase C: Structure, Function, and Regulation

1995 1.4k citations Alexandra C. Newton Journal of Biological Chemistry profile →
Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 813 citations Alexandra C. Newton profile →
Regulation of protein kinase C

1997 803 citations Alexandra C. Newton profile →
PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

2005 725 citations Tianyan Gao, Alexandra C. Newton et al. Molecular Cell profile →
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

2003 649 citations Alexandra C. Newton Biochemical Journal profile →
Protein kinase C isozymes and the regulation of diverse cell responses

2000 632 citations Alexandra C. Newton et al. profile →
Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 548 citations Alexandra C. Newton, Alex Toker et al. profile →
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

2003 460 citations Jonathan D. Violin, Jin Zhang et al. The Journal of Cell Biology profile →

Peers

Countries citing papers authored by Alexandra C. Newton

Since Specialization

Citations

This map shows the geographic impact of Alexandra C. Newton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexandra C. Newton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexandra C. Newton more than expected).

Fields of papers citing papers by Alexandra C. Newton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexandra C. Newton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexandra C. Newton. The network helps show where Alexandra C. Newton may publish in the future.

Co-authorship network of co-authors of Alexandra C. Newton

This figure shows the co-authorship network connecting the top 25 collaborators of Alexandra C. Newton. A scholar is included among the top collaborators of Alexandra C. Newton based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexandra C. Newton. Alexandra C. Newton is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration 2022 ·Frontiers in Cell and Developmental Biology ·(unknown),Alexandra C. Newton	7
2	mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif 2021 ·Science Signaling ·Timothy R. Baffi,Gema Lordén,Jacob M. Wozniak,(unknown),Wayland Yeung,Alexandr P. Kornev,Charles C. King,(unknown),(unknown),Julius Bogomolovas,Christine M. Gould,Ju Chen,Eileen J. Kennedy,Natarajan Kannan,David J. Gonzalez,Eduard Stefan,Susan S. Taylor,Alexandra C. Newton	72
3	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus 2020 ·Nature Communications ·Xin Zhou,(unknown),Olivia Molinar‐Inglis,Maya T. Kunkel,Ming‐Yuan Chen,Tengqian Sun,Jiao Zhang,(unknown),JoAnn Trejo,Alexandra C. Newton,Jin Zhang	38
4	Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter 2019 ·Science Signaling ·Taketoshi Kajimoto,(unknown),Irene S. Tobias,Taro Okada,(unknown),(unknown),J. Andrew McCammon,Shun‐ichi Nakamura,Alexandra C. Newton	44
5	Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources 2018 ·Scientific Reports ·Liang‐Chin Huang,Karen Ross,Timothy R. Baffi,Harold Drabkin,Krzysztof Kochut,Zheng Ruan,Peter D’Eustachio,Daniel McSkimming,Cecilia N. Arighi,Chuming Chen,Darren A. Natale,Cynthia L. Smith,Pascale Gaudet,Alexandra C. Newton,Cathy Wu,Natarajan Kannan	23
6	Protein kinase C: perfectly balanced 2018 ·Critical Reviews in Biochemistry and Molecular Biology ·Alexandra C. Newton	219
7	KinView: a visual comparative sequence analysis tool for integrated kinome research 2016 ·Molecular BioSystems ·Daniel McSkimming,(unknown),Timothy R. Baffi,Dominic P. Byrne,Samantha Ferries,(unknown),Alexandra C. Newton,Claire E. Eyers,Krzysztof Kochut,Patrick A. Eyers,Natarajan Kannan	35
8	Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation 2015 ·Biochemical Journal ·Irene S. Tobias,Manuel Kaulich,Peter K. Kim,(unknown),Estela Jacinto,Steven F. Dowdy,Charles C. King,Alexandra C. Newton	27
9	Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes 2012 ·Journal of Biological Chemistry ·Hilde Abrahamsen,Audrey O’Neill,Natarajan Kannan,(unknown),Susan S. Taylor,Patricia A. Jennings,Alexandra C. Newton	40
10	Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1) 2011 ·Journal of Biological Chemistry ·Malik M. Keshwani,Sventja von Daake,Alexandra C. Newton,Thomas K. Harris,Susan S. Taylor	35
11	PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms 2007 ·Molecular Cell ·John Brognard,Emma Sierecki,Tianyan Gao,Alexandra C. Newton	469
12	Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter 2004 ·Journal of Biological Chemistry ·Maya T. Kunkel,Qiang Ni,Roger Y. Tsien,Jin Zhang,Alexandra C. Newton	178
13	A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase Cbreakdown → 2003 ·The Journal of Cell Biology ·Jonathan D. Violin,Jin Zhang,Roger Y. Tsien,Alexandra C. Newton	460
14	Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cellsbreakdown → 2002 ·Science ·David A. Zacharias,Jonathan D. Violin,Alexandra C. Newton,Roger Y. Tsien	1851
15	Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site 2000 ·Journal of Biological Chemistry ·Alex Toker,Alexandra C. Newton	417
16	p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Kinase-1 (PDK1) 2000 ·Journal of Biological Chemistry ·Charles C. King,Elisabeth Gardiner,Frank T. Zenke,Benjamin P. Bohl,Alexandra C. Newton,Brian A. Hemmings,Gary Bokoch	194
17	Cellular Signaling 2000 ·Cell ·Alex Toker,Alexandra C. Newton	348
18	Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C 1997 ·Journal of Biological Chemistry ·A. Edwards,Alexandra C. Newton	134
19	Contribution of Protein Kinase C to the Phosphorylation of Rhodopsin in Intact Retinas 1997 ·Journal of Biological Chemistry ·Igor P. Udovichenko,Alexandra C. Newton,David S. Williams	17
20	Kinetics and Localization of the Phosphorylation of Rhodopsin by Protein Kinase C 1995 ·Journal of Biological Chemistry ·(unknown),David S. Williams,Alexandra C. Newton	27

About Alexandra C. Newton

Alexandra C. Newton is a scholar working on Cell Biology, Molecular Biology and Cellular and Molecular Neuroscience, having authored 195 papers that have together received 20.5k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (115 papers), PI3K/AKT/mTOR signaling in cancer (50 papers) and Receptor Mechanisms and Signaling (35 papers). The work is most often cited by research in Molecular Biology (16.4k citations), Cell Biology (3.6k citations) and Biophysics (771 citations). Alexandra C. Newton has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include Alex Toker, Roger Y. Tsien, Jonathan D. Violin, Tianyan Gao, David A. Zacharias, John Brognard, Frank B. Furnari, Maya T. Kunkel, Lisa M. Keranen and Jeffrey W. Orr. Their work appears in journals such as Science, Cell and Chemical Reviews.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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